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    • 6. 发明申请
    • Tubular monitor systems and methods
    • 管状监测系统和方法
    • US20050103123A1
    • 2005-05-19
    • US10713568
    • 2003-11-14
    • Kenneth Newman
    • Kenneth Newman
    • E21B47/00G01L1/22G01L3/10G01L9/00
    • G01L9/0002E21B47/0006G01L1/2218G01L3/108
    • A system for measuring parameters of a structure, the system in certain aspects having a plurality of strain gauges emplaceable on the structure, signal transmission apparatus associated with the plurality of strain gauges for transmitting signals therefrom indicative of gauge measurements to computer apparatus for processing the signals, the gauges, in one aspect, including at least three strain gauge apparatuses for providing axial strain measurements, and computer apparatus for receiving signals from the transmitting apparatus indicative of the measurements and for determining bending moment and bending direction of the structure at a location of the gauge apparatuses, and in one aspect wherein the computer apparatus is programmed to calculate internal pressure and/or bending direction of the structure based on the measurements, and in one aspect to do so in real time.
    • 一种用于测量结构参数的系统,该系统在某些方面具有可在该结构上放置的多个应变计,与多个应变计相关联的信号传输装置,用于将来自其的信号传输到计算机装置,用于处理信号 在一个方面,量度器包括至少三个用于提供轴向应变测量的应变计装置,以及用于从发送装置接收指示测量结果的信号和用于确定结构的位置处的弯矩和弯曲方向的计算机装置 在一个方面,其中计算机设备被编程为基于测量来计算结构的内部压力和/或弯曲方向,并且在一个方面实时地进行。
    • 7. 发明申请
    • Method of treating acute pain with a unitary dosage form comprising ibuprofen and oxycodone
    • 用单一剂型治疗急性疼痛的方法,其包含布洛芬和羟可待酮
    • US20050059690A1
    • 2005-03-17
    • US10925783
    • 2004-08-23
    • Kenneth NewmanWattanaporn AbramowitzAndreas GrillPablo Davila-ZavalaFuxing Tang
    • Kenneth NewmanWattanaporn AbramowitzAndreas GrillPablo Davila-ZavalaFuxing Tang
    • A61K31/192A61K31/485
    • A61K31/192A61K31/485A61K2300/00
    • The present invention is a method of achieving fast onset of pain relief for acute pain in a patient in need thereof comprising orally administering a unitary formulation (or oral dosage form) containing an effective analgesic amount of (a) oxycodone or a pharmaceutically acceptable salt thereof and (b) ibuprofen or a pharmaceutically acceptable salt thereof. Preferably, the unitary formulation contains (a) oxycodone or a pharmaceutically acceptable salt thereof and (b) ibuprofen or a pharmaceutically acceptable salt thereof at a weight ratio of from about 1:20 to about 1:100 and more preferably about 1:40 to about 1:80, based on the weights of molar equivalents of oxycodone hydrochloride and ibuprofen, respectively. Preferably, an amount of oxycodone and ibuprofen effective to provide partial or complete pain relief within 30 minutes is administered. More preferably, the amount is sufficient to provide partial or complete pain relief within 25 minutes. It has been discovered that administration of an oral dosage form containing both oxycodone and ibuprofen provides earlier onset of pain relief than administration of either active ingredient alone. Moreover, the earlier onset of pain relief may be attributable at least in part to administration of a single dosage form containing both active ingredients as opposed to administering oxycodone and ibuprofen in separate oral dosage forms (i.e., administration of a first dosage form containing oxycodone and a second dosage form containing ibuprofen). The method of the present invention is particularly useful for treating acute postoperative pain, including, but not limited to, moderate and/or severe acute postoperative pain (such as that resulting from dental surgery).
    • 本发明是一种在有需要的患者中实现急性疼痛缓解疼痛的快速发展的方法,其包括口服施用含有有效止痛剂量的(a)羟考酮或其药学上可接受的盐的单一制剂(或口服剂型) 和(b)布洛芬或其药学上可接受的盐。 优选地,整体制剂包含(a)羟考酮或其药学上可接受的盐和(b)布洛芬或其药学上可接受的盐,其重量比为约1:20至约1:100,更优选约1:40至 约1:80,分别为盐酸羟考酮和布洛芬的摩尔当量的重量。 优选地,给予有效地在30分钟内提供部分或完全疼痛缓解的羟考酮和布洛芬的量。 更优选地,该量足以在25分钟内提供部分或完全的疼痛缓解。 已经发现,含有羟考酮和布洛芬的口服剂型的给药比单独使用任一种活性成分提供了较早的疼痛缓解发作。 此外,疼痛缓解的早期发作可能至少部分归因于施用含有两种活性成分的单一剂型,而不是以单独的口服剂型施用羟考酮和布洛芬(即,施用含有羟考酮的第一剂型和 含有布洛芬的第二剂型)。 本发明的方法特别可用于治疗急性术后疼痛,包括但不限于中度和/或严重急性术后疼痛(例如由牙科手术引起的疼痛)。
    • 10. 发明授权
    • Enterprise management system and method which includes statistical recreation of system resource usage for more accurate monitoring, prediction, and performance workload characterization
    • 企业管理系统和方法,包括系统资源使用的统计娱乐,以更准确的监测,预测和性能工作负载表征
    • US06691067B1
    • 2004-02-10
    • US09287601
    • 1999-04-07
    • Yiping DingKenneth Newman
    • Yiping DingKenneth Newman
    • G06F1900
    • G06F11/3495G06F11/3419G06F11/3447G06F11/3452G06F2201/86G06F2201/88
    • A system and method for estimating statistics concerning system metrics to provide for the accurate and efficient monitoring of one or more computer systems. The system preferably comprises a distributed computing environment, i.e., an enterprise, which comprises a plurality of interconnected computer systems. At least one of the computer systems is an agent computer system which includes agent software and/or system software for the collection of data relating to one or more metrics, i.e., measurements of system resources. Metric data is continually collected over the course of a measurement interval, regularly placed into a registry of metrics, and then periodically sampled from the registry indirectly. Sampling-related uncertainty and inaccuracy arise from two primary sources: the unsampled residual segments of seen (i.e., sampled and therefore known) events, and unseen (i.e., unsampled and therefore unknown) events. The total unsampled utilization and the total unseen utilization are accurately estimated according to the properties of one or more process service time distributions. The total unseen utilization is also estimated with an iterative method using gradations of the sample interval. The length distribution of the unseen processes is determined with the same iterative method.
    • 一种用于估计关于系统度量的统计量以提供对一个或多个计算机系统的准确和有效的监测的系统和方法。 该系统优选地包括分布式计算环境,即包括多个互连的计算机系统的企业。 至少一个计算机系统是代理计算机系统,其包括用于收集与一个或多个度量相关的数据的代理软件和/或系统软件,即系统资源的测量。 在测量间隔的过程中不断收集公制数据,定期放置在度量标准的注册表中,然后间接从注册表中定期抽样。 采样相关的不确定性和不准确性来自两个主要来源:所观察到的未采样的残差段(即采样和因此已知的)事件,以及看不见的(即未采样的和因此未知的)事件。 根据一个或多个过程服务时间分布的属性,可以准确地估计总的非抽样利用率和总的不可见利用率。 也可以通过使用样本间隔的梯度的迭代方法来估计总体看不到的利用率。 未知过程的长度分布由相同的迭代法确定。