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1. 发明申请

US20070117112A1 Materials and methods for the generation of fully 2'-modified nucleic acid transcripts 有权
标题翻译：用于产生完全2'-修饰的核酸转录物的材料和方法
公开(公告)号：US20070117112A1
公开(公告)日：2007-05-24
申请号：US11480188
申请日：2006-06-30
申请人： John Diener , Anthony Keefe , Kristin Thompson , Chunhua Wang , Shuhao Zhu
发明人： John Diener , Anthony Keefe , Kristin Thompson , Chunhua Wang , Shuhao Zhu
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34 , C12N9/22 , C12N15/74 , C12N1/21
CPC分类号： C12N15/1048 , C12N9/1247 , C12N15/115 , C12N2310/16 , C12N2310/321 , C12N2330/30 , C12Q1/6846 , C12Q1/6865 , G01N2333/9125 , C12Q2525/117 , C12Q2521/119 , C12N2310/3521
摘要： Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence.
摘要翻译：提供材料和方法用于产生具有并入其序列的完全修饰的三磷酸核苷酸的适体治疗剂。

2. 发明授权

US08090946B2 Inter-system binding method and application based on hardware security unit 有权
标题翻译：基于硬件安全单元的系统间绑定方法和应用
公开(公告)号：US08090946B2
公开(公告)日：2012-01-03
申请号：US11772779
申请日：2007-07-02
申请人： Xizhe Li , Chunhua Wang , Xu Wang , Song Cheng
发明人： Xizhe Li , Chunhua Wang , Xu Wang , Song Cheng
IPC分类号： H04L9/32
CPC分类号： G06F21/445 , H04L9/0897 , H04L9/3234 , H04L9/3268
摘要： The present invention discloses an inter-trusted-computing-system binding method based on hardware security unit, comprising steps of: configuring binding requirements for hardware security units of trusted computing systems; exchanging hardware security unit information between the hardware security units of the trusted computing systems to be bound, and checking device validities of the counter-party hardware security unit; and if passing the validation check, it continues to the following steps; otherwise, exiting the binding procedure; respectively verifying whether the binding meets their respective binding requirements by the hardware security units of the trusted computing systems to be bound; and if passing the verification, it continues to the following steps; otherwise, exiting the binding procedure; and respectively storing platform information and hardware security unit binding information by the hardware security units of the trusted computing systems. The present method provides a processing mechanism based on hardware security unit in order to establish trusts between trusted computing systems.
摘要翻译：本发明公开了一种基于硬件安全单元的可信互联计算系统绑定方法，包括以下步骤：配置可信计算系统硬件安全单元的绑定要求; 在要约束的可信计算系统的硬件安全单元之间交换硬件安全单元信息，以及检查对方硬件安全单元的设备有效性; 如果通过验证检查，则继续执行以下步骤; 否则，退出绑定过程; 分别验证所绑定的可信计算系统的硬件安全单元是否满足其各自的绑定要求; 如果通过验证，则继续执行以下步骤; 否则，退出绑定过程; 并分别由可信计算系统的硬件安全单元存储平台信息和硬件安全单元绑定信息。本方法提供了基于硬件安全单元的处理机制，以便在可信计算系统之间建立信任。

3. 外观设计

USD957719S1 Candle wick holder 有权
公开(公告)号：USD957719S1
公开(公告)日：2022-07-12
申请号：US29784316
申请日：2021-05-19
申请人： Chunhua Wang
设计人： Chunhua Wang

4. 发明授权

US08105813B2 Materials and methods for the generation of fully 2′-modified nucleic acid transcripts 有权
标题翻译：用于产生完全2'-修饰的核酸转录物的材料和方法
公开(公告)号：US08105813B2
公开(公告)日：2012-01-31
申请号：US11480188
申请日：2006-06-30
申请人： John L. Diener , Anthony Dominic Keefe , Kristin Thompson , Chunhua Wang , Shuhao Zhu
发明人： John L. Diener , Anthony Dominic Keefe , Kristin Thompson , Chunhua Wang , Shuhao Zhu
IPC分类号： C12N9/12
CPC分类号： C12N15/1048 , C12N9/1247 , C12N15/115 , C12N2310/16 , C12N2310/321 , C12N2330/30 , C12Q1/6846 , C12Q1/6865 , G01N2333/9125 , C12Q2525/117 , C12Q2521/119 , C12N2310/3521
摘要： Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence.
摘要翻译：提供材料和方法用于产生具有并入其序列的完全修饰的三磷酸核苷酸的适体治疗剂。

5. 发明申请

US20080126802A1 INTER-SYSTEM BINDING METHOD AND APPLICATION BASED ON HARDWARE SECURITY UNIT 有权
标题翻译：基于硬件安全单元的系统间绑定方法和应用
公开(公告)号：US20080126802A1
公开(公告)日：2008-05-29
申请号：US11772779
申请日：2007-07-02
申请人： Xizhe Li , Chunhua Wang , Xu Wang , Song Cheng
发明人： Xizhe Li , Chunhua Wang , Xu Wang , Song Cheng
IPC分类号： H04L9/12
CPC分类号： G06F21/445 , H04L9/0897 , H04L9/3234 , H04L9/3268
摘要： The present invention discloses an inter-trusted-computing-system binding method based on hardware security unit, comprising steps of: configuring binding requirements for hardware security units of trusted computing systems; exchanging hardware security unit information between the hardware security units of the trusted computing systems to be bound, and checking device validities of the counter-party hardware security unit; and if passing the validation check, it continues to the following steps; otherwise, exiting the binding procedure; respectively verifying whether the binding meets their respective binding requirements by the hardware security units of the trusted computing systems to be bound; and if passing the verification, it continues to the following steps; otherwise, exiting the binding procedure; and respectively storing platform information and hardware security unit binding information by the hardware security units of the trusted computing systems. The present method provides a processing mechanism based on hardware security unit in order to establish trusts between trusted computing systems.
摘要翻译：本发明公开了一种基于硬件安全单元的可信互联计算系统绑定方法，包括以下步骤：配置可信计算系统硬件安全单元的绑定要求; 在要约束的可信计算系统的硬件安全单元之间交换硬件安全单元信息，以及检查对方硬件安全单元的设备有效性; 如果通过验证检查，则继续执行以下步骤; 否则，退出绑定过程; 分别验证所绑定的可信计算系统的硬件安全单元是否满足其各自的绑定要求; 如果通过验证，则继续执行以下步骤; 否则，退出绑定过程; 并分别由可信计算系统的硬件安全单元存储平台信息和硬件安全单元绑定信息。本方法提供了基于硬件安全单元的处理机制，以便在可信计算系统之间建立信任。

6. 发明申请

US20130172536A1 Intravenous Cytomegalovirus Human Immune Globulin and Manufacturing Method Thereof 审中-公开
标题翻译：静脉注射巨细胞病毒人免疫球蛋白及其制备方法
公开(公告)号：US20130172536A1
公开(公告)日：2013-07-04
申请号：US13821991
申请日：2011-08-16
申请人： Yunjia Zhang , Caiping Guo , Yujiang Ding , Qingshuang Song , Xin Zhang , Jincai Wang , Enying Wu , Pei Zhang , Yuqin Chen , Hui Li , Weirong Huang , Meilan Dai , Yanpeng Zhang , Chunhua Wang , Shan Luo , Qiaoyun Huang , Yongdi Liu , Kaiyong Wu
发明人： Yunjia Zhang , Caiping Guo , Yujiang Ding , Qingshuang Song , Xin Zhang , Jincai Wang , Enying Wu , Pei Zhang , Yuqin Chen , Hui Li , Weirong Huang , Meilan Dai , Yanpeng Zhang , Chunhua Wang , Shan Luo , Qiaoyun Huang , Yongdi Liu , Kaiyong Wu
IPC分类号： C07K1/36 , B65B1/04 , C07K16/08
CPC分类号： C07K1/36 , B65B1/04 , C07K16/065 , C07K16/088 , C07K2317/21
摘要： The present invention discloses an intravenous cytomegalovirus human immune globulin and a manufacturing method thereof, wherein the technical problem to be solved is to improve the purity, yield, and safety of the product. The intravenous cytomegalovirus human immune globulin of the present invention has a specific activity of no less than 2.5 PEI-U/mg, an anti-CMV titer of no less than 100 PEI-U/ml, a purity of greater than 98.2%, and a protein content of 51˜55 mg/ml. The present invention employs caprylic acid precipitation and anion exchange chromatography for replacing the step of ethanol precipitation in the conventional cold ethanol method to keep IgG in the supernatant and maintain the activity of the IgG; the present invention employing processes of caprylic acid inactivation of virus and nanometer film virus removal can effectively protect the safety of the product, and studies show that the preparing method of the present invention not only improves the purity, yield, and safety of the product; but also saves energy and reduces the cost of production.
摘要翻译：本发明公开了一种静脉注射巨细胞病毒人免疫球蛋白及其制备方法，其中要解决的技术问题是提高产品的纯度，产率和安全性。本发明的静脉内巨细胞病毒人免疫球蛋白具有不低于2.5 PEI-U / mg的比活性，不低于100PEI-U / ml的抗CMV滴度，大于98.2％的纯度，以及蛋白质含量为51〜55mg / ml。本发明采用辛酸沉淀和阴离子交换层析法，代替常规冷乙醇方法中乙醇沉淀的步骤，以保持上清液中的IgG，并保持IgG的活性; 本发明采用甲基丙烯酸灭活病毒和纳米膜病毒去除方法，可有效保护产品的安全性，研究表明，本发明的制备方法不仅提高了产品的纯度，产率和安全性; 而且节约能源，降低生产成本。

7. 发明授权

US07336599B2 Apparatus and method for joint detection receiving irrespective of orthogonal code length in mobile communication system 失效
标题翻译：用于联合检测接收的装置和方法，不论移动通信系统中的正交码长度如何
公开(公告)号：US07336599B2
公开(公告)日：2008-02-26
申请号：US10657669
申请日：2003-09-08
申请人： Sung-Oh Hwang , Ping Wang , Gang Liu , Tao Fan , Hye-Young Lee , Jin-Weon Chang , Hyeon-Woo Lee , Chunhua Wang
发明人： Sung-Oh Hwang , Ping Wang , Gang Liu , Tao Fan , Hye-Young Lee , Jin-Weon Chang , Hyeon-Woo Lee , Chunhua Wang
IPC分类号： H04J11/00
CPC分类号： H04B1/71052 , H04B2201/70703
摘要： A joint detection reception apparatus and method, which are utilized irrespective of a length of an orthogonal code in a TD-CDMA communication system. The joint detection reception method for creating a system matrix associated with a joint detection receiver in the same time slot includes the steps of a) repeating and partitioning individual channelization codes having variable lengths, and creating channelization code blocks having the same lengths, b) performing a convolution operation between the repeated and partitioned channelization code blocks and a channel impulse response, and acquiring combined impulse responses, c) grouping the combined impulse responses to construct sub-block matrices for a joint detection system, d) arranging the sub-block matrices for the joint detection system to be shifted by a predetermined column distance, and constructing a joint detection system matrix, and e) extending the joint detection system matrix to a squared-format matrix to create a block-circulant squared matrix.
摘要翻译：无论TD-CDMA通信系统中的正交码的长度如何，都使用联合检测接收装置和方法。用于在相同时隙中创建与联合检测接收机相关联的系统矩阵的联合检测接收方法包括以下步骤：a）重复和分割具有可变长度的各个信道化码，并创建具有相同长度的信道化码块，b）执行重复和分割的信道化码块之间的卷积运算和信道脉冲响应，以及获取组合脉冲响应，c）将组合的脉冲响应分组以构建用于联合检测系统的子块矩阵; d）将子块矩阵用于使联合检测系统偏移预定列距离，以及构建联合检测系统矩阵，以及e）将联合检测系统矩阵扩展为平方格式矩阵以创建块循环平方矩阵。

8. 发明授权

US07579450B2 Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics 失效
标题翻译：对免疫球蛋白E特异性的核酸配体及其作为特应性疾病治疗剂的用途
公开(公告)号：US07579450B2
公开(公告)日：2009-08-25
申请号：US11115780
申请日：2005-04-26
申请人： Paula Burmeister , Sharon Cload , John L. Diener , Anthony Dominic Keefe , Sara Chesworth Keene , Markus Kurz , H. A. Daniel Lagassé , Harold Nicholas Marsh , Pooja Sawhney , Chunhua Wang
发明人： Paula Burmeister , Sharon Cload , John L. Diener , Anthony Dominic Keefe , Sara Chesworth Keene , Markus Kurz , H. A. Daniel Lagassé , Harold Nicholas Marsh , Pooja Sawhney , Chunhua Wang
IPC分类号： C07H21/04
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/331 , C12N2310/336 , C12N2310/351 , C12N2310/3521
摘要： The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE.
摘要翻译：本发明公开了能够结合免疫球蛋白E（“IgE”）的适体，其可用作特应性疾病和/或其中涉及IgE的其它疾病或病症的治疗剂和诊断。本发明还涉及用于施用能够结合IgE的适体的材料和方法。

9. 发明申请

US20090081679A1 Compositions and methods for in vivo SELEX 审中-公开
标题翻译：用于体内SELEX的组合物和方法
公开(公告)号：US20090081679A1
公开(公告)日：2009-03-26
申请号：US12220327
申请日：2008-07-21
申请人： Anthony Dominic Keefe , Charles Wilson , Chunhua Wang
发明人： Anthony Dominic Keefe , Charles Wilson , Chunhua Wang
IPC分类号： C12Q1/68
CPC分类号： C12N15/1048
摘要： The invention describes methods for the in vivo selection of oligonucleotides, preferably aptamers, that persist in biological compartments. In one embodiment, the biological compartment comprises at least one tissue which, in a preferred embodiment, is the blood within the circulatory system of a living mammal. The invention also contemplates oligonucleotides, preferably aptamers, selected through in vivo SELEX that may be linked to therapeutic or diagnostic compositions including other oligonucleotides.
摘要翻译：本发明描述了用于体内选择存在于生物室中的寡核苷酸，优选适体的方法。在一个实施方案中，生物室包含至少一个组织，其在优选的实施方案中是活的哺乳动物的循环系统内的血液。本发明还考虑通过体内SELEX选择的寡核苷酸，优选适配体，其可以与包括其它寡核苷酸的治疗或诊断组合物连接。

10. 发明申请

US20070009907A1 Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics 失效
标题翻译：对免疫球蛋白E特异性的核酸配体及其作为特应性疾病治疗剂的用途
公开(公告)号：US20070009907A1
公开(公告)日：2007-01-11
申请号：US11115780
申请日：2005-04-26
申请人： Paula Burmeister , Sharon Cload , John Diener , Anthony Keefe , Sara Keene , Markus Kurz , H.A. Lagasse , Harold Marsh , Pooja Sawhney , Chunhua Wang
发明人： Paula Burmeister , Sharon Cload , John Diener , Anthony Keefe , Sara Keene , Markus Kurz , H.A. Lagasse , Harold Marsh , Pooja Sawhney , Chunhua Wang
IPC分类号： C12Q1/68 , C08G63/91
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/331 , C12N2310/336 , C12N2310/351 , C12N2310/3521
摘要： The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE.
摘要翻译：本发明公开了能够结合免疫球蛋白E（“IgE”）的适体，其可用作特应性疾病和/或其中涉及IgE的其它疾病或病症的治疗剂和诊断。本发明还涉及用于施用能够结合IgE的适体的材料和方法。

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