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1. 发明授权

US09458489B2 Microfluidics sorter for cell detection and isolation 有权
标题翻译：微流体分选仪用于细胞检测和分离
公开(公告)号：US09458489B2
公开(公告)日：2016-10-04
申请号：US13582263
申请日：2011-03-04
申请人： Chwee Teck Lim , Jongyoon Han , Han Wei Hou , Ali Asgar Bhagat , Krystyn J. Van Vliet , Wong Cheng Lee
发明人： Chwee Teck Lim , Jongyoon Han , Han Wei Hou , Ali Asgar Bhagat , Krystyn J. Van Vliet , Wong Cheng Lee
IPC分类号： G01N33/574 , C12Q1/04 , B01L3/00 , C12Q1/02 , G01N15/14
CPC分类号： C12Q1/04 , B01L3/50273 , B01L3/502761 , B01L2200/0636 , B01L2300/0864 , B01L2400/0457 , B01L2400/086 , C12Q1/025 , G01N2015/1415 , G01N2015/149
摘要： A method of detecting one or more diseased blood cells in a blood sample includes introducing a blood sample into at least one inlet of a microfluidic device comprising one or more linear channels wherein each channel has a length and a cross-section of a height and a width defining an aspect ratio adapted to isolate diseased blood cells along at least one portion of the cross-section of the channel based on reduced deformability of diseased blood cells as compared to non-diseased blood cells, wherein diseased blood cells flow along a first portion of the channel to a first outlet and non-diseased blood cells flow along a second portion of the channel to a second outlet. The one or more channels can be adapted to isolate cells along portions of the cross-section of the channel based on cell size. In some embodiments, the one or more channels can be spiral channels.
摘要翻译：一种检测血液样本中的一种或多种患病血细胞的方法包括将血液样品引入到包括一个或多个线性通道的微流体装置的至少一个入口中，其中每个通道具有高度的长度和横截面宽度限定适于根据与非病变血细胞相比减少的患病血细胞的可变形性，沿着所述通道的横截面的至少一部分来隔离患病血细胞，其中患病血细胞沿第一部分流动通道的第一出口和非患病血液细胞沿着通道的第二部分流动到第二出口。一个或多个信道可以适于基于小区大小来隔离信道横截面的部分。在一些实施例中，一个或多个通道可以是螺旋通道。

2. 发明申请

US20130130226A1 Microfluidics Sorter For Cell Detection And Isolation 有权
标题翻译：微流控分选机用于细胞检测和分离
公开(公告)号：US20130130226A1
公开(公告)日：2013-05-23
申请号：US13582263
申请日：2011-03-04
申请人： Chwee Teck Lim , Jongyoon Han , Han Wei Hou , Ali Asgar Bhagat , Krystyn J. Van Vliet , Wong Cheng Lee
发明人： Chwee Teck Lim , Jongyoon Han , Han Wei Hou , Ali Asgar Bhagat , Krystyn J. Van Vliet , Wong Cheng Lee
IPC分类号： C12Q1/04 , C12Q1/02
CPC分类号： C12Q1/04 , B01L3/50273 , B01L3/502761 , B01L2200/0636 , B01L2300/0864 , B01L2400/0457 , B01L2400/086 , C12Q1/025 , G01N2015/1415 , G01N2015/149
摘要： A method of detecting one or more diseased blood cells in a blood sample includes introducing a blood sample into at least one inlet of a microfluidic device comprising one or more linear channels wherein each channel has a length and a cross-section of a height and a width defining an aspect ratio adapted to isolate diseased blood cells along at least one portion of the cross-section of the channel based on reduced deformability of diseased blood cells as compared to non-diseased blood cells, wherein diseased blood cells flow along a first portion of the channel to a first outlet and non-diseased blood cells flow along a second portion of the channel to a second outlet. The one or more channels can be adapted to isolate cells along portions of the cross-section of the channel based on cell size. In some embodiments, the one or more channels can be spiral channels.
摘要翻译：一种检测血液样本中的一种或多种患病血细胞的方法包括将血液样品引入到包括一个或多个线性通道的微流体装置的至少一个入口中，其中每个通道具有高度的长度和横截面宽度限定适于根据与非病变血细胞相比减少的患病血细胞的可变形性，沿着所述通道的横截面的至少一部分来隔离患病血细胞，其中患病血细胞沿第一部分流动通道的第一出口和非患病血液细胞沿着通道的第二部分流动到第二出口。一个或多个信道可以适于基于小区大小来隔离信道横截面的部分。在一些实施例中，一个或多个通道可以是螺旋通道。

3. 发明申请

US20130337500A1 SYSTEM AND METHOD FOR ISOLATION OF CELLS 审中-公开
标题翻译：用于分离细胞的系统和方法
公开(公告)号：US20130337500A1
公开(公告)日：2013-12-19
申请号：US12765576
申请日：2010-04-22
申请人： Swee Jin Tan , Chwee Teck Lim
发明人： Swee Jin Tan , Chwee Teck Lim
IPC分类号： C12Q1/06 , C12N5/078 , C12Q1/04 , C12M1/00
CPC分类号： G01N33/5091 , B01L3/502753 , B01L2200/0668 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2400/086 , G01N33/5005 , G01N33/57407 , G01N2800/52 , Y02A50/53 , Y02A50/58
摘要： In accordance with an embodiment of the invention, there is provided a microfluidic device for isolating cells from a biological fluid. The device comprises an inlet receiving the biological fluid flowed into the device, and at least one array of a plurality of isolation wells receiving the biological fluid from the inlet. At least one isolation well of the plurality of isolation wells comprises a cell trap of a size and shape suitable to mechanically isolate a cell within the cell trap. The cell trap comprises at least one gap of a size and shape suitable to prevent passage of the cells to be isolated but to permit passage of other components of the biological fluid through the cell trap.
摘要翻译：根据本发明的实施例，提供了一种用于从生物流体中分离细胞的微流体装置。该装置包括接收流入装置的生物流体的入口和从入口接收生物流体的多个隔离井的至少一个阵列。多个隔离井中的至少一个隔离井包括适于机械隔离细胞陷阱内的细胞的尺寸和形状的细胞捕获器。细胞捕获器包括尺寸和形状的至少一个间隙，其适于防止待分离的细胞通过，但允许生物流体的其它组分通过细胞捕获器。

4. 发明申请

US20090202616A1 Composite, Method of Producing the Composite and Uses of the Same 审中-公开
标题翻译：复合材料的制备方法及其应用
公开(公告)号：US20090202616A1
公开(公告)日：2009-08-13
申请号：US11664164
申请日：2005-09-29
申请人： Ee Jay Chong , Chwee Teck Lim , Seeram Ramakrishna , Toan Thang Phan , Ivor Jiun Lim
发明人： Ee Jay Chong , Chwee Teck Lim , Seeram Ramakrishna , Toan Thang Phan , Ivor Jiun Lim
IPC分类号： A61K9/00 , C12N5/08 , B29C47/04 , A61P17/02
CPC分类号： D01D5/0084 , A61L15/26 , A61L27/18 , A61L27/38 , A61L27/60 , C08L75/04
摘要： The invention relates to a composite comprising a semi-permeable barrier layer that is permeable to oxygen and impermeable to moisture; and a scaffold fiber layer formed by electrospinning fibers on one side of the barrier layer.
摘要翻译：本发明涉及一种复合材料，其包括可渗透氧气并且不透水的半透性阻挡层; 以及通过在阻挡层的一侧上静电纺丝而形成的支架纤维层。

5. 发明授权

US06508103B1 Impact drop tester for portable consumer products 失效
标题翻译：便携式消费类产品的跌落试验机
公开(公告)号：US06508103B1
公开(公告)日：2003-01-21
申请号：US09592262
申请日：2000-06-13
申请人： Victor Phyau Wui Shim , Chwee Teck Lim
发明人： Victor Phyau Wui Shim , Chwee Teck Lim
IPC分类号： G01N1902
CPC分类号： G01N3/303 , G01N3/30
摘要： A drop tester (1) including a gripper mechanism (2) for holding a product (37) to be tested, a guide track, a slider block (3) which is mounted to slide along the guide track and advance the mechanism toward a target location (41) and a release device (40) for triggering release of the product from the mechanism to impact at the target location, characterised in that the gripper mechanism includes gripper arms (15, 16) coupled to the slider block, the gripper arms being rotatable relative to the slider block to enable the orientation of the product to be varied, relative to the target location. The slider block is preferably releasably coupled to a hoisting block (4) which is positionable at a predetermined location along the guide track. More preferably, the gripper arms are pivotally mounted to a housing (23) and coupled to a piston (22) provided within the housing, the arms pivoting between a gripping position and a release position upon advancement of the piston through the housing.
摘要翻译：一种包括用于保持待测试产品（37）的夹持机构（2）的跌落测试器（1），导轨，滑块（3），其被安装成沿着导轨滑动并将机构朝向目标位置（41）和释放装置（40），用于触发所述产品从所述机构释放以在所述目标位置处冲击，其特征在于，所述夹持器机构包括联接到所述滑块的夹持臂（15,16），所述夹持臂相对于滑动块可旋转，以使产品的取向相对于目标位置变化。滑动块优选地可释放地联接到提升块（4），该起重块可沿着导轨定位在预定位置处。更优选地，夹持臂枢转地安装到壳体（23）并且联接到设置在壳体内的活塞（22），当活塞通过壳体前进时，臂在夹持位置和释放位置之间枢转。

6. 发明申请

US20130122534A1 Microfluidic Assay 审中-公开
标题翻译：微流控测定
公开(公告)号：US20130122534A1
公开(公告)日：2013-05-16
申请号：US13664526
申请日：2012-10-31
申请人： Chwee Teck Lim , Eric Lim , Andee Tay
发明人： Chwee Teck Lim , Eric Lim , Andee Tay
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , B01L3/5027 , G01N1/312 , G01N2035/00158
摘要： A process for carrying out hematoxylin and eosin staining in a microfluidic device is described.
摘要翻译：描述了在微流体装置中进行苏木精和伊红染色的方法。

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