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1. 发明专利

AU7986998A Antigenomic oligodeoxynucleotides for treatment of infection by negative-stranded nonsegmented rna viruses 未知
公开(公告)号：AU7986998A
公开(公告)日：1999-01-19
申请号：AU7986998
申请日：1998-06-26
申请人： DIETZSCHOLD BERNHARD , FU ZHEN FANG , KOPROWSKI HILARY , WICKSTROM ERIC
发明人： FU ZHEN FANG , WICKSTROM ERIC , DIETZSCHOLD BERNHARD , KOPROWSKI HILARY
IPC分类号： A61K38/00 , C12N15/113 , A61K48/00 , C07H21/04 , C12Q1/68

2. 发明申请

WO2005002511A3 RECOMBINANT ANTIBODIES AND COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
标题翻译：重组抗体及其组合物及其制备和使用方法
公开(公告)号：WO2005002511A3
公开(公告)日：2005-09-15
申请号：PCT/US2004018613
申请日：2004-06-10
申请人： UNIV JEFFERSON , HOOPER DOUGLAS CRAIG , DIETZSCHOLD BERNHARD
发明人： HOOPER DOUGLAS CRAIG , DIETZSCHOLD BERNHARD
IPC分类号： A61P31/14 , C07K16/10 , C12N5/20 , C12N15/12 , A61K39/42 , C07H21/02 , C07K16/00 , C12N5/06 , C12N15/00 , C12N15/63 , C12P19/34 , G01N33/53
CPC分类号： C07K16/10 , A61K2039/505 , C07K2317/21
摘要： Methods and compositions are provided for the use of rabies virusneutralizing antibodies for postexposure prophylactic treatment of subjects exposed to rabies virus. Compositions comprising mixtures of rabies virusneutralizing antibodies, as well as nucleotide and amino acid sequences encoding these antibodies, can be used in the treatment of subjects exposed to rabies virus. The invention also provides methods of producing recombinant rabies virus-neutralizing human antibodies in mammalian cells using recombinant expression vectors.
摘要翻译：提供方法和组合物用于使用狂犬病病毒中和抗体进行暴露于狂犬病病毒的受试者的暴露后预防性治疗。包含狂犬病毒中和抗体混合物的组合物以及编码这些抗体的核苷酸和氨基酸序列可用于治疗暴食于狂犬病病毒的受试者。本发明还提供了使用重组表达载体在哺乳动物细胞中产生重组狂犬病毒中和人抗体的方法。

3. 发明申请

WO2006078272A3 RHABDOVIRAL N-FUSION PROTEINS AS CARRIER FOR FOREIGN ANTIGENS 审中-公开
标题翻译： RHABDOVIRAL N-FUSION蛋白作为外源抗体携带者
公开(公告)号：WO2006078272A3
公开(公告)日：2009-04-16
申请号：PCT/US2005013298
申请日：2005-04-19
申请人： UNIV JEFFERSON , SCHNELL MATTHIAS , DIETZSCHOLD BERNHARD
发明人： SCHNELL MATTHIAS , DIETZSCHOLD BERNHARD
IPC分类号： A61K39/205
CPC分类号： C07K14/005 , A61K39/00 , A61K39/07 , A61K39/12 , A61K39/205 , A61K39/385 , A61K2039/6075 , C07K2319/00 , C07K2319/40 , C07K2319/55 , C07K2319/60 , C12N2760/20122 , C12N2760/20134 , C12N2760/20143
摘要： Rabies virus (RV) nucleoprotein (N) tightly encapsidates the genomic and antigenomic RNA thereby forming the ribonucleoprotein (RNP) complex. Antigens presented in a rigid and repetitive organization are sufficient to activate B cells to proliferate. In addition to the repetitive organization, it has been shown that RV N protein induces potent T-helper responses resulting in long-lasting and strong humoral immune responses against RV. The possibility to directly manipulate the genome of RV allows us to examine whether the immunogenicity of foreign antigens can be enhanced via incorporation into the RNP structure. A recombinant RV expressing an RV N-green fluorescent protein (GFP) fusion protein. The chimeric N-GFP fusion protein was efficiently expressed and incorporated into RV RNP and virions. Moreover, the recombinant RNP induces a strong humoral immune response against GFP in mice. In contrast, mice inoculated with GFP alone or a combination of wild-type RV RNPs and GFP did not trigger any GFP-specific humoral responses using the same immunization schedule. These results indicate the usefulness of RV-based vectors as killed vaccines against other infectious diseases.
摘要翻译：狂犬病病毒（RV）核蛋白（N）紧密地包裹基因组和反基因组RNA，从而形成核糖核蛋白（RNP）复合物。呈现在刚性和重复组织中的抗原足以激活B细胞增殖。除了重复组织之外，已经显示RVN蛋白诱导有效的T辅助反应，导致针对RV的持久和强烈的体液免疫应答。直接操纵RV基因组的可能性使得我们能够检查外源抗原的免疫原性是否可以通过纳入RNP结构来增强。表达RVN-绿色荧光蛋白（GFP）融合蛋白的重组RV。嵌合的N-GFP融合蛋白被有效表达并并入RV RNP和病毒粒子中。此外，重组RNP在小鼠中诱导针对GFP的强烈的体液免疫应答。相比之下，用GFP单独接种的小鼠或野生型RV RNP和GFP的组合的小鼠不使用相同的免疫程序触发任何GFP特异性体液应答。这些结果表明基于RV的载体作为针对其他感染性疾病的灭活疫苗的有用性。

4. 发明申请

WO03016501A2 RECOMBINANT ANTIBODIES, AND COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
标题翻译：重组抗体及其制备和使用方法的组合物和方法
公开(公告)号：WO03016501A2
公开(公告)日：2003-02-27
申请号：PCT/US0226584
申请日：2002-08-21
申请人： UNIV JEFFERSON , HOOPER DOUGLAS C , DIETZSCHOLD BERNHARD
发明人： HOOPER DOUGLAS C , DIETZSCHOLD BERNHARD
IPC分类号： C12N15/12 , C07K16/10 , C12N
CPC分类号： C07K16/10 , A61K2039/505 , C07K2317/21
摘要： Recombinant antibodies are disclosed. The nucleic acid and encoded amino acid sequences of the heavy and light chain immunoglobulins of human monoclonal rabies virus neutralizing antibodies, and their use, are described.
摘要翻译：公开了重组抗体。描述了人单克隆狂犬病病毒中和抗体的重链和轻链免疫球蛋白的核酸和编码的氨基酸序列及其用途。

5. 发明申请

WO2006017276A3 RECOMBINANT RABIES VIRUS COMPOSITIONS 审中-公开
标题翻译：重组RABIES病毒组合物
公开(公告)号：WO2006017276A3
公开(公告)日：2007-05-03
申请号：PCT/US2005024671
申请日：2005-07-12
申请人： UNIV JEFFERSON , DIETZSCHOLD BERNHARD , FABER MARIE LUISE , FABER MILOSZ , SCHNELL MATTHIAS
发明人： DIETZSCHOLD BERNHARD , FABER MARIE LUISE , FABER MILOSZ , SCHNELL MATTHIAS
IPC分类号： A61K39/205 , C07K14/00 , C12N7/00 , C12N15/00
CPC分类号： C12N7/00 , A61K35/13 , C07K14/005 , C12N2760/20121 , C12N2760/20122 , C12N2760/20161
摘要： Recombinant rabies viruses in which the arginine residue of the glycoprotein (G) at amino acid position 333 is exchanged, renders these viruses nonpathogenic for immunocompetent mammals regardless of the route of infection. Some of these recombinant rabies viruses after several serial virus passages in newborn mice can become pathogenic for adult mice. The reversion to the pathogenic phenotype is associated with a thymidine to adenosine mutation (TôA) at position 639 of the G gene, which results in an asparagine to lysine exchange at position 194 of G. The codon at position 637-639 was changed by site directed mutagenesis to replace asparagine at position 194 by an amino acid that minimized the possibility for an AsnôLys exchange at amino acid position 194 of G and prevents reversion to a pathogenic form of the virus.
摘要翻译：在氨基酸位置333处交换糖蛋白（G）的精氨酸残基的重组狂犬病毒使得这些病毒对于免疫活性的哺乳动物是非致病性的，而不管感染途径如何。这些重组狂犬病病毒中的一些在新生小鼠中经过几次连续病毒传代后，可能成为成年小鼠致病的。对病原性表型的逆转与G基因位置639处的胸苷与腺苷突变（TôA）相关，其导致在G位置194处的天冬酰胺至赖氨酸交换。位置637-639处的密码子被位点定点突变以通过最小化G的氨基酸位置194处的AsnôLys交换的可能性的氨基酸来替代194位的天冬酰胺，并防止逆转到病毒形式的病原体。

6. 发明申请

WO0216437A3 RHABDOVIRUS-BASED VECTORS TO EXPRESS HIGH LEVELS OF FUNCTIONAL HUMAN ANTIBODIES 审中-公开
标题翻译：基于RHABDAVIRUS的载体表达高水平的功能性人抗体
公开(公告)号：WO0216437A3
公开(公告)日：2002-08-01
申请号：PCT/US0124744
申请日：2001-08-07
申请人： UNIV JEFFERSON , DIETZSCHOLD BERNHARD , SCHNELL MATTHIAS J
发明人： DIETZSCHOLD BERNHARD , SCHNELL MATTHIAS J
IPC分类号： A61K38/00 , A61P31/14 , C07K16/00 , C07K16/10 , C12N15/86
CPC分类号： C07K16/10 , A61K38/00 , C07K16/00 , C07K2317/21 , C12N15/86 , C12N2760/20122 , C12N2760/20143 , C12N2760/20145 , C12N2760/20222 , C12N2810/6081
摘要： The current expression systems for the production of a specific antibody are time consuming, inadequate and costly. The present invention describes a novel recombinant expression vector using non-segmented, negative-stranded RNA virus vectors to express functional antibody. A high yield of pure antibody is obtained from this expression system and is used to neutralize the effect of an antigen. For example, antibody is used in prophylactic therapeutics, as well as in the treatment of an existing diseased condition.
摘要翻译：目前用于生产特异性抗体的表达系统是耗时的，不足且成本高昂的。本发明描述了使用非分节负链RNA病毒载体表达功能性抗体的新型重组表达载体。从该表达系统获得高产量的纯抗体并用于中和抗原的作用。例如，抗体用于预防性治疗，以及用于治疗现有的疾病状况。

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