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    • 1. 发明申请
    • COMPOSITIONS COMPRISING HYPSIZYGUS ULMARIUS EXTRACT
    • 包含超临界萃取物的组合物
    • WO2007041327A1
    • 2007-04-12
    • PCT/US2006/038116
    • 2006-09-29
    • ELC MANAGEMENT LLCCHEN, ChiaWEIL, Andrew
    • CHEN, ChiaWEIL, Andrew
    • A61K36/07A61P29/00
    • A61K36/07A61K8/9706A61K36/068A61K36/074A61Q19/08A61K2300/00
    • Disclosed are topical compositions comprising extracts of Hypsizygus ulmarius in amounts that are effective to influence LTB4-mediated chemotaxis and/or IL-1β mediated adhesion of polymorphonuclear leukocytes. The hypsizygus ulmarius extract may be used alone or in combination with secondary anti-inflammatory and skin active agents, such as other mushroom and/or natural extracts. The secondary anti-inflammatory agents may or may not function by antagonizing LTB4-mediated chemotaxis and IL-1β mediated adhesion. The extract may be incorporated into a cosmetically acceptable vehicle. The present invention includes methods of treating skin inflammation by applying to inflamed skin, anti-inflammatory effective amounts of Hypsizygus ulmarius extract in a defined treatment regimen.
    • 公开了包含有效影响LTB4介导的趋化性和/或IL-1β介导的多形核白细胞粘附的量的硫酸伊斯匹克氏囊菌提取物的局部组合物。 hypsizggus ulmarius提取物可以单独使用或与次级抗炎和皮肤活性剂如其它蘑菇和/或天然提取物组合使用。 次要抗炎剂可能或可能通过拮抗LTB4介导的趋化性和IL-1β介导的粘附而起作用。 提取物可以并入到化妆品可接受的载体中。 本发明包括通过在定义的治疗方案中施用于发炎的皮肤,抗炎有效量的乌司他啶提取物来治疗皮肤炎症的方法。