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1. 发明申请

US20090137785A1 RAB9 PROTEIN CRYSTAL STRUCTURES AND METHODS FOR IDENTIFYING RAB9 MODULATORS 审中-公开
标题翻译： RAB9蛋白晶体结构和识别RAB9调节剂的方法
公开(公告)号：US20090137785A1
公开(公告)日：2009-05-28
申请号：US11933636
申请日：2007-11-01
申请人： Edward J. Meehan , Liqing Chen , Enrico L. DiGiammarino , Thomas W. Hodge
发明人： Edward J. Meehan , Liqing Chen , Enrico L. DiGiammarino , Thomas W. Hodge
IPC分类号： C07K14/00
CPC分类号： C12N9/16 , C07K2299/00 , G01N2500/04
摘要： The present invention relates to crystalline Rab9 in complex with either GDP or the GTP analog Guanosine 5′-(β,γ-imido) triphosphate (GppNHp), the three dimensional coordinates and structures of Rab9 in Rab9-GDP and Rab9-GppNHp complexes, and uses thereof for drug design. In particular, the present invention relates to methods for producing Rab9 crystals of sufficient quality to obtain a determination of the three dimensional structure of Rab9 to a high resolution in both its GTP-bound (on/active) and GDP-bound (off/inactive) conformations. The present invention also relates to a computer-readable medium encoded with the three dimensional coordinates of Rab9 in Rab9-GDP and Rab9-GppNHp complexes wherein, using a graphical display software program, the three dimensional coordinates create an electronic file that can be visualized on a computer capable of representing the electronic file as a three dimensional image.
摘要翻译：本发明涉及与GDP或GTP类似物鸟苷5' - （β，γ-亚氨基）三磷酸（GppNHp）复合的结晶Rab9，Rab9-GDP和Rab9-GppNHp复合物中Rab9的三维坐标和结构，并将其用于药物设计。特别地，本发明涉及用于生产足够质量的Rab9晶体的方法，以在其GTP结合（开/主动）和GDP-结合（关/非活性）两者中获得Rab9的三维结构确定为高分辨率）构象。本发明还涉及用Rab9-GDP和Rab9-GppNHp复合物中的Rab9的三维坐标编码的计算机可读介质，其中使用图形显示软件程序，三维坐标创建可以在能够将电子文件表示为三维图像的计算机。

2. 发明授权

US07745158B2 Detection of secreted aspartyl proteases from Candida species 有权
标题翻译：检测念珠菌属分泌的天冬氨酰蛋白酶
公开(公告)号：US07745158B2
公开(公告)日：2010-06-29
申请号：US11302975
申请日：2005-12-14
申请人： Erica M. Phillips , Enrico L. DiGiammarino , Kevin P. McGrath
发明人： Erica M. Phillips , Enrico L. DiGiammarino , Kevin P. McGrath
IPC分类号： G01N33/53 , G01N33/558
CPC分类号： G01N33/56961 , C12Q1/37 , G01N33/558
摘要： Methods and devices for the detection of proteins secreted by the hyphal growth form of Candida species are disclosed. The disclosed devices may constitute a method for the diagnosis of acute or chronic infections, including candidiasis, caused by microorganisms of the species Candida, such as C. albicans, for example. The devices of the present invention incorporate antibodies specific to secreted aspartyl protease proteins whose expression is upregulated upon the conversion of the Candida species from the commensal to the pathogenic form. The antibodies may be used in assays to allow the diagnosis of candidal infections and disease conditions. Either monoclonal antibodies or polyclonal antibodies may be used, and in the case of the monoclonals, the specific epitopes of the SAP protein may be detected as well as the SAP protein itself.
摘要翻译：公开了用于检测由假丝酵母属菌丝生长形式分泌的蛋白质的方法和装置。所公开的装置可以构成用于诊断例如由假丝酵母属物种的微生物引起的急性或慢性感染（包括念珠菌病）的方法，例如白色念珠菌。本发明的装置包含对分泌的天冬氨酰蛋白酶蛋白特异性的抗体，其在将假丝酵母菌种从共生转化为致病形式时，其表达被上调。抗体可用于测定以允许诊断念珠菌感染和疾病状况。可以使用单克隆抗体或多克隆抗体，并且在单克隆的情况下，可以检测SAP蛋白的特异性表位以及SAP蛋白本身。

3. 发明授权

US08377379B2 Lateral flow assay device 有权
标题翻译：侧流测定装置
公开(公告)号：US08377379B2
公开(公告)日：2013-02-19
申请号：US11640435
申请日：2006-12-15
申请人： Shawn R. Feaster , Kaiyuan Yang , Ning Wei , Chibueze O. Chidebelu-Eze , James M. Takeuchi , Rosann M. Kaylor , Enrico L. DiGiammarino , Jeffrey E. Fish
发明人： Shawn R. Feaster , Kaiyuan Yang , Ning Wei , Chibueze O. Chidebelu-Eze , James M. Takeuchi , Rosann M. Kaylor , Enrico L. DiGiammarino , Jeffrey E. Fish
IPC分类号： G01N30/96
CPC分类号： B01L3/5023 , A61B5/150022 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150717 , A61B5/150824 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15186 , A61B5/1519 , A61B5/157 , B01L2200/0605 , B01L2200/16 , B01L2300/0672 , B01L2300/0867 , B01L2400/0683 , G01N33/491
摘要： A lateral flow assay device includes a housing, and a test strip disposed within the housing having a membrane with a detection region and a collection region. A sample meter includes a first end for absorption of a test sample, and a storage section that receives and stores at least a component of the test sample. An opening in the housing is sized for insertion of the sample meter into the housing such that the storage section of the sample meter is disposed adjacent the collection region of the membrane. The test sample component is transferable from the storage section to the collection region for subsequent migration to the detection region. An activatable isolation mechanism is provided within the housing and is disposed so as to isolate portions of the sample meter storage section upon activation thereof such that a defined length of the storage section is presented to the collection region of the membrane.
摘要翻译：侧流测定装置包括壳体和设置在壳体内的测试条，其具有带有检测区域和收集区域的膜。样品计量器包括用于吸收测试样品的第一端和接收并存储至少测试样品的组分的存储部分。壳体中的开口的尺寸用于将样品计量器插入到壳体中，使得样品计量器的存储部分邻近膜的收集区域设置。测试样本组件可从存储部分转移到收集区域，以便随后迁移到检测区域。在壳体内提供可激活的隔离机构，并且被设置成在启动时分离样品计量存储部分的部分，使得存储部分的限定长度被呈现给膜的收集区域。

4. 发明申请

US20080145272A1 Lateral flow assay device 有权
标题翻译：侧流测定装置
公开(公告)号：US20080145272A1
公开(公告)日：2008-06-19
申请号：US11640435
申请日：2006-12-15
申请人： Shawn R. Feaster , Kaiyuan Yang , Ning Wei , Chibueze O. Chidebelu-Eze , James M. Takeuchi , Rosann M. Kaylor , Enrico L. DiGiammarino , Jeffrey E. Fish
发明人： Shawn R. Feaster , Kaiyuan Yang , Ning Wei , Chibueze O. Chidebelu-Eze , James M. Takeuchi , Rosann M. Kaylor , Enrico L. DiGiammarino , Jeffrey E. Fish
IPC分类号： B01L11/00 , G01N33/00
CPC分类号： B01L3/5023 , A61B5/150022 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150717 , A61B5/150824 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15186 , A61B5/1519 , A61B5/157 , B01L2200/0605 , B01L2200/16 , B01L2300/0672 , B01L2300/0867 , B01L2400/0683 , G01N33/491
摘要： A lateral flow assay device includes a housing, and a test strip disposed within the housing having a membrane with a detection region and a collection region. A sample meter includes a first end for absorption of a test sample, and a storage section that receives and stores at least a component of the test sample. An opening in the housing is sized for insertion of the sample meter into the housing such that the storage section of the sample meter is disposed adjacent the collection region of the membrane. The test sample component is transferable from the storagesection to the collection region for subsequent migration to the detection region. An activatable isolation mechanism is provided within the housing and is disposed so as to isolate portions of the sample meter storage section upon activation thereof such that a defined length of the storage section is presented to the collection region of the membrane.
摘要翻译：侧流测定装置包括壳体和设置在壳体内的测试条，其具有带有检测区域和收集区域的膜。样品计量器包括用于吸收测试样品的第一端和接收并存储至少测试样品的组分的存储部分。壳体中的开口的尺寸用于将样品计量器插入到壳体中，使得样品计量器的存储部分邻近膜的收集区域设置。测试样品组分可以从储存区转移到收集区域，以便随后迁移到检测区域。在壳体内提供可激活的隔离机构，并且被设置成在启动时分离样品计量存储部分的部分，使得存储部分的限定长度被呈现给膜的收集区域。

5. 发明授权

US08323651B2 Antibodies to receptor of advanced glycation end products (RAGE) and uses thereof 有权
标题翻译：晚期糖基化终产物（RAGE）的受体抗体及其用途
公开(公告)号：US08323651B2
公开(公告)日：2012-12-04
申请号：US12437715
申请日：2009-05-08
申请人： Jijie Gu , Chung-Ming Hsieh , Zhen Wu , Enrico L. DiGiammarino , Feng Luo , Gerard B. Fox , John E. Harlan , Martin Schmidt , Ralf Loebbert , Reinhold Mueller , Ulrich Ebert , Volker Nimmrich
发明人： Jijie Gu , Chung-Ming Hsieh , Zhen Wu , Enrico L. DiGiammarino , Feng Luo , Gerard B. Fox , John E. Harlan , Martin Schmidt , Ralf Loebbert , Reinhold Mueller , Ulrich Ebert , Volker Nimmrich
IPC分类号： A61K39/395 , C07H21/04 , C07K16/00 , A61P25/28 , C12N15/63 , C12N5/10 , C12P21/02
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/28 , C07K16/464 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12P21/005 , Y02A50/466
摘要： The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example misfolded proteins like amyloid β and advanced glycation-end-products.
摘要翻译：本申请涉及分离的蛋白质，特别是单克隆抗体，特别是结合RAGE蛋白质的CDR-移植的人源化抗体。具体地说，这些抗体具有抑制RAGE与其各种配体结合的能力。本申请中描述的抗体或其部分可用于治疗由RAGE的病理生理学配体表征或诱导的疾病或病症，例如错误折叠的蛋白质如淀粉样蛋白和bgr; 和晚期糖基化终产物。

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