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1. 发明申请

US20100056569A1 Heterocyclic Non-Nucleoside Compounds, Their Preparation, Pharmaceutical Composition And Their Use As Antiviral Agents 失效
标题翻译：杂环非核苷化合物，其制备，药物组合物及其作为抗病毒剂的用途
公开(公告)号：US20100056569A1
公开(公告)日：2010-03-04
申请号：US12304598
申请日：2007-06-13
申请人： Fajun Nan , Jianping Zuo , Haijun Chen , Guifeng Wang , Min Gu , Fenghua Zhu , Wei Tang
发明人： Fajun Nan , Jianping Zuo , Haijun Chen , Guifeng Wang , Min Gu , Fenghua Zhu , Wei Tang
IPC分类号： A61K31/4439 , C07D401/04 , A61K31/4709 , A61P31/12
CPC分类号： C07D417/04 , C07D263/32 , C07D263/34 , C07D277/24 , C07D277/56 , C07D513/04
摘要： The invention relates a kind of antiviral agents, more concretely, relates to a kind of heterocyclic non-nucleoside compounds with the following structures, their preparation and pharmaceutical compositions including the compounds. The said compounds can be used as antiviral agents and as medicaments for treating diseases such as hepatitis B, influenza, herpes, HIV and so on.
摘要翻译：本发明涉及一种抗病毒剂，更具体地说，涉及一种具有以下结构的杂环非核苷化合物，其制备方法和包括该化合物的药物组合物。所述化合物可用作抗病毒剂和用作治疗诸如乙型肝炎，流感，疱疹，HIV等疾病的药物。

2. 发明授权

US08653115B2 Heterocyclic non-nucleoside compounds, their preparation, pharmaceutical composition and their use as antiviral agents 失效
标题翻译：杂环非核苷化合物，其制备方法，药物组合物及其作为抗病毒剂的用途
公开(公告)号：US08653115B2
公开(公告)日：2014-02-18
申请号：US12304598
申请日：2007-06-13
申请人： Fajun Nan , Jianping Zuo , Haijun Chen , Guifeng Wang , Min Gu , Fenghua Zhu , Wei Tang
发明人： Fajun Nan , Jianping Zuo , Haijun Chen , Guifeng Wang , Min Gu , Fenghua Zhu , Wei Tang
IPC分类号： A61K31/426 , C07D277/24
CPC分类号： C07D417/04 , C07D263/32 , C07D263/34 , C07D277/24 , C07D277/56 , C07D513/04
摘要： The invention relates a kind of antiviral agents, more concretely, relates to a kind of heterocyclic non-nucleoside compounds with the following structures, their preparation and pharmaceutical compositions including the compounds. The said compounds can be used as antiviral agents and as medicaments for treating diseases such as hepatitis B, influenza, herpes, HIV and so on.
摘要翻译：本发明涉及一种抗病毒剂，更具体地说，涉及一种具有以下结构的杂环非核苷化合物，其制备方法和包括该化合物的药物组合物。所述化合物可用作抗病毒剂和用作治疗诸如乙型肝炎，流感，疱疹，HIV等疾病的药物。

3. 发明授权

US07741348B2 Bisheterocycle tandem compounds useful as antiviral agents, the uses thereof and the compositions comprising such compounds 失效
标题翻译：可用作抗病毒剂的双组分串联化合物，其用途和包含这些化合物的组合物
公开(公告)号：US07741348B2
公开(公告)日：2010-06-22
申请号：US11886593
申请日：2006-01-24
申请人： Fajun Nan , Jianping Zuo , Wenlong Wang , Guifeng Wang , Haijun Chen , Peilan He
发明人： Fajun Nan , Jianping Zuo , Wenlong Wang , Guifeng Wang , Haijun Chen , Peilan He
IPC分类号： A61K31/427 , C07D277/20
CPC分类号： C07D277/56 , C07D277/68 , C07D403/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention provides small molecule compounds of bisheterocycle in tandem having the structural formula of P1-P2, and the use thereof as well as a composition containing the compounds, each of P1 and P2 is an unsaturated 5-member heterocyclic ring having one or two heteroatoms. This compound may effectively inhibit the replication of influenza virus, the DNA replication of hepatitis B virus (HBV), and the formation of HBsAg and HBeAg. These compounds can be used for the preparation of a medicament for viral diseases, and may overcome the limitations of the known nucleosides drugs, including cytotoxicity, the requirement of other drugs having different structures for against the drug-resistant virus variants induced by long-term therapy. The structure of the compounds according to the invention is relatively simple and easy to be prepared.
摘要翻译：本发明提供了具有P1-P2结构式的双杂环的小分子化合物及其用途以及含有这些化合物的组合物，P1和P2各自为不饱和的5元杂环，具有一个或两个杂原子。该化合物可有效抑制流感病毒的复制，乙型肝炎病毒（HBV）的DNA复制，以及HBsAg和HBeAg的形成。这些化合物可用于制备用于病毒性疾病的药物，并且可以克服已知的核苷类药物的限制，包括细胞毒性，对于长期诱导的抗药性病毒变体具有不同结构的其它药物的要求治疗。根据本发明的化合物的结构相对简单且易于制备。

4. 发明申请

US20120264793A1 Pharmaceutical Use of 2',2-Bis-Thiazole Non-Nucleoside Compounds as Hepatitis C Virus Inhibitor 审中-公开
标题翻译： 2'，2-双噻唑非核苷化合物作为丙型肝炎病毒抑制剂的药物用途
公开(公告)号：US20120264793A1
公开(公告)日：2012-10-18
申请号：US13518549
申请日：2010-11-24
申请人： Fajun Nan , Jianping Zuo , Yangming Zhang , Feihong Ji , Haijun Chen , Xiankun Tong
发明人： Fajun Nan , Jianping Zuo , Yangming Zhang , Feihong Ji , Haijun Chen , Xiankun Tong
IPC分类号： A61K31/427 , C07D417/14 , A61P31/14 , C07D417/04
CPC分类号： A61K31/427
摘要： The present invention discloses the pharmaceutical use of a 2′,2-bis-thiazole non-nucleoside compound of formula I as an inhibitor of hepatitis C virus (HCV). The 2′,2-bis-thiazole non-nucleoside compound can inhibit the replication of HCV, and thus has an anti-HCV activity and is useful for treating hepatitis C.
摘要翻译：本发明公开了作为丙型肝炎病毒（HCV）抑制剂的式I的2'，2-双噻唑非核苷化合物的药物用途。 2'，2-双噻唑非核苷化合物可以抑制HCV的复制，因此具有抗HCV活性，可用于治疗丙型肝炎。

5. 发明申请

US20080306121A1 Bisheterocycle Tandem Compounds Useful as Antiviral Agents, the Uses Thereof and the Compositions Comprising Such Compounds 失效
标题翻译：用作抗病毒剂的Bisheterocycle Tandem Compounds，其用途和包含这些化合物的组合物
公开(公告)号：US20080306121A1
公开(公告)日：2008-12-11
申请号：US11886593
申请日：2006-01-24
申请人： Fajun Nan , Jianping Zuo , Wenlong Wang , Haijun Chen , Peilan He
发明人： Fajun Nan , Jianping Zuo , Wenlong Wang , Haijun Chen , Peilan He
IPC分类号： A61K31/4439 , A61K31/427 , C07D417/04 , C07D409/04 , A61K31/4178 , A61P31/22 , A61P31/18 , A61P31/12 , C07D413/04 , A61K31/422 , C07D417/14
CPC分类号： C07D277/56 , C07D277/68 , C07D403/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention provides small molecule compounds of bisheterocycle in tandem having the structural formula of P1-P2, and the use thereof as well as a composition containing the compounds, each of P1 and P2 is an unsaturated 5-member heterocyclic ring having one or two heteroatoms. This compound may effectively inhibit the replication of influenza virus, the DNA replication of hepatitis B virus (HBV), and the formation of HBsAg and HBeAg. These compounds can be used for the preparation of a medicament for viral diseases, and may overcome the limitations of the known nucleosides drugs, including cytotoxicity, the requirement of other drugs having different structures for against the drug-resistant virus variants induced by long-term therapy. The structure of the compounds according to the invention is relatively simple and easy to be prepared.
摘要翻译：本发明提供具有P1-P2结构式的串联双杂环的小分子化合物及其用途以及含有该化合物的组合物，P1和P2各自为不饱和的5元杂环，具有一个或两个杂原子。该化合物可有效抑制流感病毒的复制，乙型肝炎病毒（HBV）的DNA复制，以及HBsAg和HBeAg的形成。这些化合物可用于制备用于病毒性疾病的药物，并且可以克服已知的核苷类药物的限制，包括细胞毒性，对于长期诱导的抗药性病毒变体具有不同结构的其它药物的要求治疗。根据本发明的化合物的结构相对简单且易于制备。

6. 发明授权

US09409787B2 Transition-metal-containing zeolite 有权
公开(公告)号：US09409787B2
公开(公告)日：2016-08-09
申请号：US13993566
申请日：2012-06-19
申请人： Haijun Chen , Takahiko Takewaki , Takeshi Matsuo
发明人： Haijun Chen , Takahiko Takewaki , Takeshi Matsuo
IPC分类号： B01J20/18 , C01B39/54 , B01D53/94 , B01J20/30 , B01J29/85 , B01D53/28 , B01J29/76 , B01J29/84 , B01J35/00 , B01J20/28 , B01J35/10 , B01J37/10
CPC分类号： C01B39/54 , B01D53/28 , B01D53/94 , B01D53/9418 , B01D2251/2062 , B01D2253/108 , B01D2253/1085 , B01D2253/25 , B01D2255/20738 , B01D2255/20761 , B01D2255/50 , B01D2255/9207 , B01J20/18 , B01J20/28064 , B01J20/3078 , B01J29/763 , B01J29/84 , B01J29/85 , B01J35/002 , B01J35/1023 , B01J37/10 , B01J2229/186 , Y10T428/2982
摘要： A transition-metal-containing silicoaluminophosphate zeolite having excellent high-temperature hydrothermal durability is easily and efficiently produced. A method for producing a transition-metal-containing zeolite that contains a silicon atom, a phosphorus atom, and an aluminum atom in at least its framework structure includes hydrothermal synthesis using an aqueous gel containing a silicon atom raw material, an aluminum atom raw material, a phosphorus atom raw material, a transition metal raw material, and a polyamine (other than diamines). A transition-metal-containing silicoaluminophosphate zeolite produced by hydrothermal synthesis using a zeolite raw material and the aqueous gel containing the transition metal raw material and the polyamine has excellent high-temperature hydrothermal durability and high catalytic activity.

7. 发明申请

US20150057248A1 BIVALENT AMPA RECEPTOR POSITIVE ALLOSTERIC MODULATORS 有权
标题翻译：双极AMPA受体阳性独立调制器
公开(公告)号：US20150057248A1
公开(公告)日：2015-02-26
申请号：US14474258
申请日：2014-09-01
申请人： Jia Zhou , Haijun Chen , Kenneth M. Johnson , Cheng Z. Wang
发明人： Jia Zhou , Haijun Chen , Kenneth M. Johnson , Cheng Z. Wang
IPC分类号： C07F5/02 , C07D213/82 , C07C311/03 , C07D401/06 , C07D209/14 , C07D471/04 , C07D209/08
CPC分类号： C07F5/025 , C07C311/03 , C07D207/27 , C07D209/08 , C07D209/14 , C07D213/82 , C07D231/56 , C07D401/06 , C07D401/12 , C07D471/04
摘要： Embodiments of the invention are directed to compounds that are positive allosteric modulators of AMPA receptors.
摘要翻译：本发明的实施方案涉及作为AMPA受体的正变构调节剂的化合物。

8. 发明申请

US20130005563A1 CATALYST FOR REDUCING NITROGEN OXIDES AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：用于还原氮氧化物的催化剂及其生产方法
公开(公告)号：US20130005563A1
公开(公告)日：2013-01-03
申请号：US13616487
申请日：2012-09-14
申请人： Takeshi Matsuo , Takahiko Takewaki , Daisuke Nishioka , Kazunori Oshima , Haijun Chen , Hiroyuki Kakiuchi
发明人： Takeshi Matsuo , Takahiko Takewaki , Daisuke Nishioka , Kazunori Oshima , Haijun Chen , Hiroyuki Kakiuchi
IPC分类号： B01J29/85 , C01B39/54
CPC分类号： B01J29/85 , B01D53/9418 , B01D2255/20738 , B01D2255/20761 , B01D2255/50 , B01D2255/65 , B01D2255/707 , B01D2255/9202 , B01D2258/012 , B01J23/72 , B01J29/83 , B01J35/002 , B01J35/006 , B01J35/023 , B01J35/04 , B01J37/0009 , B01J37/0045 , B01J2229/20 , F01N2510/063
摘要： The object is to provide a nitrogen oxide reduction catalyst, which comprises zeolite containing at least a silicon atom, a phosphorus atom and an aluminium atom, and has an adsorption retention rate of at least 80%, when tested in a water vapor cyclic adsorption/desorption test at 90° C. It is also an object to provide a nitrogen oxide reduction device containing the foregoing catalyst on a honeycomb-structure formed article.
摘要翻译：本发明的目的是提供一种氮氧化物还原催化剂，其包含至少含有硅原子，磷原子和铝原子的沸石，并且当在水蒸气循环吸附/反应器中进行测试时，其吸附保持率至少为80％在90℃下的解吸试验。也是在蜂窝结构成形体上设置含有上述催化剂的氮氧化物还原装置。

9. 发明授权

US08123247B2 Passenger side airbag door for instrument panel and its manufacturing method 有权
标题翻译：仪表板乘客侧安全气囊门及其制造方法
公开(公告)号：US08123247B2
公开(公告)日：2012-02-28
申请号：US13157348
申请日：2011-06-10
申请人： Yunju Chen , Haijun Chen , Jianfeng Hou , Shaihua Zhou
发明人： Yunju Chen , Haijun Chen , Jianfeng Hou , Shaihua Zhou
IPC分类号： B60R21/205
CPC分类号： B60R21/2165 , B29C44/1228 , Y10T29/49622
摘要： The present invention relates to an airbag door for instrument panel and its manufacturing method. A passenger side airbag (PAB) door for instrument panel includes a substrate with airbag opening, skin layer and foam layer, a PAB door reinforcement board which covers the airbag opening is connected to the instrument panel substrate. This PAB door reinforcement board is a cellulosic composite material board which is soaked by thermoplastic plastic or thermoplastic elastomer, formed through thermoforming. In present invention, the turnover and movable portion of the airbag door is lighten greatly. The airbag door with the light composite material can prevent the windshields from being broken effectively when the airbag deploys sufficiently and impacts against the windshields.
摘要翻译：本发明涉及一种仪表板安全气囊门及其制造方法。用于仪表板的乘客侧面安全气囊（PAB）门包括具有安全气囊开口的基板，表层和泡沫层，覆盖安全气囊开口的PAB门加强板连接到仪表板基板。该PAB门加强板是由热塑性塑料或热塑性弹性体浸渍的纤维素复合材料板，通过热成型形成。在本发明中，气囊门的翻转和移动部分大大减轻。具有轻质复合材料的安全气囊门可以防止当气囊充分展开并撞击挡风玻璃时挡风玻璃被有效地破坏。

10. 发明申请

US20120028789A1 CATALYST FOR REDUCING NITROGEN OXIDES AND METHOD FOR PRODUCING THE SAME 审中-公开
公开(公告)号：US20120028789A1
公开(公告)日：2012-02-02
申请号：US13189858
申请日：2011-07-25
申请人： Takeshi MATSUO , Takahiko Takewaki , Daisuke Nishioka , Kazunori Oshima , Haijun Chen , Hiroyuki Kakiuchi
发明人： Takeshi MATSUO , Takahiko Takewaki , Daisuke Nishioka , Kazunori Oshima , Haijun Chen , Hiroyuki Kakiuchi
IPC分类号： B01J29/85 , B82Y30/00
CPC分类号： B01J29/85 , B01D53/9418 , B01D2255/20738 , B01D2255/20761 , B01D2255/50 , B01D2255/65 , B01D2255/707 , B01D2255/9202 , B01D2258/012 , B01J23/72 , B01J29/83 , B01J35/002 , B01J35/006 , B01J35/023 , B01J35/04 , B01J37/0009 , B01J37/0045 , B01J2229/20 , F01N2510/063
摘要： The object is to provide an exhaust gas reduction catalyst that exhibit high nitrogen oxide reduction performance, and to provide a simple and efficient method for producing the catalyst, in which the amount of the waste liquid is reduced, further, an object of the invention is to provide a zeolite-containing catalyst for reducing nitrogen oxides, which does not use an expensive noble metal or the like and which has high nitrogen oxide reduction performance. The present invention relates to a catalyst for reducing nitrogen oxides, which comprises: zeolite at least containing an aluminium atom and a phosphorus atom in the framework thereof; and a metal supported on the zeolite, wherein a coefficient of variation of intensity of the metal is at least 20%, when performing an elemental mapping of the metal in the catalyst with an electron probe microanalyzer, and, a catalyst for reducing nitrogen oxides, which comprises the zeolite containing at least a silicon atom, a phosphorus atom and an aluminium atom, and having an adsorption retention rate of at least 80% in a water vapor cyclic adsorption/desorption test at 90° C.

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