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1. 发明申请

US20140113911A1 BENZOPYRONE DERIVATIVE AND USE THEREOF 有权
标题翻译：苯并噻吩衍生物及其用途
公开(公告)号：US20140113911A1
公开(公告)日：2014-04-24
申请号：US14009581
申请日：2012-04-06
申请人： Guisen Zhang , Yin Chen , Xiangqing Xu , Bifeng Liu , Xin Liu , Song Zhao , Shicheng Liu , Minquan Yu , Heng Zhang , Xinghua Liu
发明人： Guisen Zhang , Yin Chen , Xiangqing Xu , Bifeng Liu , Xin Liu , Song Zhao , Shicheng Liu , Minquan Yu , Heng Zhang , Xinghua Liu
IPC分类号： C07D417/12 , C07D413/14
CPC分类号： C07D417/12 , A61K31/454 , A61K31/496 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The present invention relates to the field of pharmaceutical chemistry, and in particular, to a benzopyrone derivative and a use thereof. The benzopyrone derivative is compound having a structure of formula (I) or a pharmaceutically acceptable salt thereof. It has been found by experiments that, this type of compounds is useful in prevention or treatment of neuropsychical diseases.
摘要翻译：本发明涉及药物化学领域，特别涉及苯并吡喃酮衍生物及其应用。苯并吡喃酮衍生物是具有式（I）结构的化合物或其药学上可接受的盐。通过实验发现，这种类型的化合物可用于预防或治疗神经精神疾病。

2. 发明授权

US09315496B2 Benzopyrone derivative and use thereof 有权
标题翻译：苯并吡喃酮衍生物及其用途
公开(公告)号：US09315496B2
公开(公告)日：2016-04-19
申请号：US14009581
申请日：2012-04-06
申请人： Guisen Zhang , Yin Chen , Xiangqing Xu , Bifeng Liu , Xin Liu , Song Zhao , Shicheng Liu , Minquan Yu , Heng Zhang , Xinghua Liu
发明人： Guisen Zhang , Yin Chen , Xiangqing Xu , Bifeng Liu , Xin Liu , Song Zhao , Shicheng Liu , Minquan Yu , Heng Zhang , Xinghua Liu
IPC分类号： A61K31/496 , A61K31/454 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D417/12 , A61K31/454 , A61K31/496 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The present invention relates to the field of pharmaceutical chemistry, and in particular, to a benzopyrone derivative and a use thereof. The benzopyrone derivative is compound having a structure of formula (I) or a pharmaceutically acceptable salt thereof. It has been found by experiments that, this type of compounds is useful in prevention or treatment of neuropsychical diseases.
摘要翻译：本发明涉及药物化学领域，特别涉及苯并吡喃酮衍生物及其应用。苯并吡喃酮衍生物是具有式（I）结构的化合物或其药学上可接受的盐。通过实验发现，这种类型的化合物可用于预防或治疗神经精神疾病。

3. 发明授权

US08993575B2 [1,3,4] oxadiazole derivative and application thereof 有权
标题翻译： [1,3,4]恶二唑衍生物及其应用
公开(公告)号：US08993575B2
公开(公告)日：2015-03-31
申请号：US14008693
申请日：2012-04-01
申请人： Guisen Zhang , Yin Chen , Xiangqing Xu , Bifeng Liu , Xiaojun Feng , Song Zhao , Shicheng Liu , Minquan Yu , Yu Lan , Yinli Qiu
发明人： Guisen Zhang , Yin Chen , Xiangqing Xu , Bifeng Liu , Xiaojun Feng , Song Zhao , Shicheng Liu , Minquan Yu , Yu Lan , Yinli Qiu
IPC分类号： A61K31/496 , A61K31/454 , A61K31/4545 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D417/12 , C07D413/14 , C07D417/14
摘要： The present invention belongs to the medicinal chemistry field, and specifically discloses a [1,3,4]oxadiazole derivative with the structure of general formula (I) and pharmaceutically acceptable salt thereof. The compound can be used to prepare a medicine for preventing or treating a disease of the central nervous system.
摘要翻译：本发明属于药物化学领域，具体公开了具有通式（I）结构的[1,3,4]恶二唑衍生物及其药学上可接受的盐。该化合物可用于制备用于预防或治疗中枢神经系统疾病的药物。

4. 发明申请

US20140024656A1 [1,3,4] OXADIAZOLE DERIVATIVE AND APPLICATION THEREOF 有权
标题翻译： [1,3,4] OXADIAZOLE DERIVATIVE AND APPLICATION WITHEROF
公开(公告)号：US20140024656A1
公开(公告)日：2014-01-23
申请号：US14008693
申请日：2012-04-01
申请人： Guisen Zhang , Yin Chen , Xiangqing Xu , Bifeng Liu , Xiaojun Feng , Song Zhao , Shicheng Liu , Minquan Yu , Yu Lan , Yinli Qiu
发明人： Guisen Zhang , Yin Chen , Xiangqing Xu , Bifeng Liu , Xiaojun Feng , Song Zhao , Shicheng Liu , Minquan Yu , Yu Lan , Yinli Qiu
IPC分类号： C07D417/12 , C07D413/14
CPC分类号： C07D417/12 , C07D413/14 , C07D417/14
摘要： The present invention belongs to the medicinal chemistry field, and specifically discloses a [1,3,4]oxadiazole derivative with the structure of general formula (I) and pharmaceutically acceptable salt thereof. The compound can be used to prepare a medicine for preventing or treating a disease of the central nervous system.
摘要翻译：本发明属于药物化学领域，具体公开了具有通式（I）结构的[1,3,4]恶二唑衍生物及其药学上可接受的盐。该化合物可用于制备用于预防或治疗中枢神经系统疾病的药物。

5. 发明授权

US09018213B2 Alicyclic[c] benzopyrone derivatives and uses thereof 有权
标题翻译：脂环式[c]苯并吡喃酮衍生物及其用途
公开(公告)号：US09018213B2
公开(公告)日：2015-04-28
申请号：US14236208
申请日：2012-07-31
申请人： Guisen Zhang , Yin Chen , Xiangqing Xu , Xin Liu , Song Zhao , Bifeng Liu , Minquan Yu , Yinli Qiu
发明人： Guisen Zhang , Yin Chen , Xiangqing Xu , Xin Liu , Song Zhao , Bifeng Liu , Minquan Yu , Yinli Qiu
IPC分类号： A61K31/496 , A61K31/453 , A61K31/454 , C07D311/94 , C07D405/12 , C07D417/12 , C07D417/14 , C07D413/14 , C07D311/80 , C07D409/12
CPC分类号： C07D311/94 , A61K31/453 , A61K31/454 , A61K31/496 , C07D311/80 , C07D405/12 , C07D409/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Disclosed are alicyclic[c]benzopyrone derivatives and use thereof. The alicyclic[c]benzopyrone derivatives are compounds represented by formula I or their salts. The present compounds not only significantly improve high activity induced by MK-801, but also effectively improve clambering symptom induced by Apomorphine and do not cause EPS within effective dose. These in vitro targets and in vivo pharmacological models are closely related to diseases of the nervous system caused by dopamine dysfunction, especially schizophrenia. Therefore the present compounds can be used for the treatment of central nervous system diseases, especially schizophrenia. ED50 is lower and effect is stronger in two animal models i.e. high activity induced by MK-801 and clambering symptom induced by Apomorphine, while ED50 is higher and therapeutic index is greater in animal models of catalepsy.
摘要翻译：公开了脂环族[c]苯并吡喃酮衍生物及其用途。脂环式[c]苯并吡喃酮衍生物是由式I表示的化合物或其盐。本发明化合物不仅显着改善了MK-801诱导的高活性，而且有效地改善了阿扑吗啡引起的痉挛症状，不会有效剂量引起EPS。这些体外靶标和体内药理学模型与由多巴胺功能障碍，特别是精神分裂症引起的神经系统疾病密切相关。因此，本发明化合物可用于治疗中枢神经系统疾病，特别是精神分裂症。 ED50较低，两种动物模型中效果更强，即由MK-801诱导的高活性和阿扑吗啡引起的痉挛症状，而ED50较高，而在僵住症的动物模型中治疗指数更高。

6. 发明申请

US20140171442A1 ALICYCLIC[C] BENZOPYRONE DERIVATIVES AND USES THEREOF 有权
标题翻译： ALICYCLIC [C]苯并噻吩衍生物及其用途
公开(公告)号：US20140171442A1
公开(公告)日：2014-06-19
申请号：US14236208
申请日：2012-07-31
申请人： Guisen Zhang , Yin Chen , Xiangqing Xu , Xin Liu , Song Zhao , Bifeng Liu , Miquan Yu , Yinli Qiu
发明人： Guisen Zhang , Yin Chen , Xiangqing Xu , Xin Liu , Song Zhao , Bifeng Liu , Miquan Yu , Yinli Qiu
IPC分类号： C07D311/94 , C07D413/14 , C07D417/12 , C07D409/12
CPC分类号： C07D311/94 , A61K31/453 , A61K31/454 , A61K31/496 , C07D311/80 , C07D405/12 , C07D409/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Disclosed are alicyclic[c]benzopyrone derivatives and use thereof. The alicyclic[c]benzopyrone derivatives are compounds represented by formula I or their salts. The present compounds not only significantly improve high activity induced by MK-801, but also effectively improve clambering symptom induced by Apomorphine and do not cause EPS within effective dose. These in vitro targets and in vivo pharmacological models are closely related to diseases of the nervous system caused by dopamine dysfunction, especially schizophrenia. Therefore the present compounds can be used for the treatment of central nervous system diseases, especially schizophrenia. ED50 is lower and effect is stronger in two animal models i.e. high activity induced by MK-801 and clambering symptom induced by Apomorphine, while ED50 is higher and therapeutic index is greater in animal models of catalepsy.
摘要翻译：公开了脂环族[c]苯并吡喃酮衍生物及其用途。脂环式[c]苯并吡喃酮衍生物是由式I表示的化合物或其盐。本发明化合物不仅显着改善了MK-801诱导的高活性，而且有效地改善了阿扑吗啡引起的痉挛症状，不会有效剂量引起EPS。这些体外靶标和体内药理学模型与由多巴胺功能障碍，特别是精神分裂症引起的神经系统疾病密切相关。因此，本发明化合物可用于治疗中枢神经系统疾病，特别是精神分裂症。 ED50较低，两种动物模型中效果更强，即由MK-801诱导的高活性和阿扑吗啡引起的痉挛症状，而ED50较高，而在僵住症的动物模型中治疗指数更高。

7. 发明授权

US08828958B2 Single-stranded antimicrobial oligonucleotides and uses thereof 有权
标题翻译：单链抗体寡核苷酸及其用途
公开(公告)号：US08828958B2
公开(公告)日：2014-09-09
申请号：US11664052
申请日：2005-09-28
申请人： Yin Chen , Xin Xing Tan
发明人： Yin Chen , Xin Xing Tan
IPC分类号： C07H21/04 , C12N15/11 , C12N15/00
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/111 , C12N2310/16 , C12N2320/11 , C12N2320/30 , C12N2330/31 , C12N2330/50
摘要： The current invention is directed to oligonucleotide sequences isolated from a sequence designated rbl-1 [SEQ ID NO. 19] that either kill or inhibit growth, or prevent the production of endogenously expressed toxin, of microorganisms. These ssDNA sequences, identified through use of a screening method, appear to act as modulators of essential growth functions which may act at the level of triplex formation, antisense inhibition, or as aptamers that alter gene function. The sequences, referred to as minimum functional regions, or MFRs, are useful inter alia as therapeutic agents for treatment of sepsis and other pathologies caused by microorganisms such as sepsis and/or in which microorganisms are contributory agents.
摘要翻译：本发明涉及从命名为rbl-1 [SEQ ID NO.1]的序列分离的寡核苷酸序列。 19]可以杀死或抑制微生物的生长，或阻止生成内源性表达的毒素。通过使用筛选方法鉴定的这些ssDNA序列似乎可以作为必需生长功能的调节剂，其可以在三重形成，反义抑制水平或作为改变基因功能的适体的作用下起作用。称为最小功能区域或MFR的序列尤其可用作治疗败血症的治疗剂和由诸如败血症和/或其中微生物是贡献剂的微生物引起的其它病症。

8. 发明申请

US20070040211A1 Nonvolatile memory device and method of forming the same 有权
标题翻译：非易失存储器件及其形成方法
公开(公告)号：US20070040211A1
公开(公告)日：2007-02-22
申请号：US11209145
申请日：2005-08-22
申请人： Shao Ku , Yin Chen , Wenpin Lu , Tahui Wang
发明人： Shao Ku , Yin Chen , Wenpin Lu , Tahui Wang
IPC分类号： H01L29/792
CPC分类号： H01L29/7923 , H01L29/1045
摘要： A multi-bit memory cell includes a substrate; a multi-bit charge-trapping cell over the substrate, the multi-bit charge-trapping cell having a first lateral side and a second lateral side; a source region in the substrate, a portion of the source region being under the first side of the multi-bit charge-trapping cell; a drain region in the substrate, a portion of the drain region being under the second side of the multi-bit charge-trapping cell; and a channel region in the substrate between the source region and the drain region. The channel region has one of a p-type doping and an n-type doping, and the doping is configured to provide a highest doping concentration near the central portion of the channel region.
摘要翻译：多位存储单元包括基板; 位于衬底上的多位电荷俘获电池，所述多位电荷俘获电池具有第一侧面和第二侧面; 源区域，源区域中的一部分位于多位电荷捕获单元的第一侧之下; 所述衬底中的漏极区域，所述漏极区域的一部分位于所述多位电荷俘获电池的第二侧的下方; 以及在源极区域和漏极区域之间的衬底中的沟道区域。沟道区具有p型掺杂和n型掺杂之一，并且掺杂被配置为在沟道区的中心部分附近提供最高的掺杂浓度。

9. 发明申请

US20080206154A1 Single-Stranded Antimicrobial Oligonucleotides and Uses Thereof 有权
标题翻译：单链抗菌寡核苷酸及其用途
公开(公告)号：US20080206154A1
公开(公告)日：2008-08-28
申请号：US11664052
申请日：2005-09-28
申请人： Yin Chen , Xin Xing Tan
发明人： Yin Chen , Xin Xing Tan
IPC分类号： A61K31/713 , C07H21/02 , C12N15/66 , A61P31/00 , C07H21/04 , C12N5/00
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/111 , C12N2310/16 , C12N2320/11 , C12N2320/30 , C12N2330/31 , C12N2330/50
摘要： The current invention is directed to oligonucleotide sequences isolated from a sequence designated rbl-1 [SEQ ID NO. 19] that either kill or inhibit growth, or prevent the production of endogenously expressed toxin, of microorganisms. These ssDNA sequences, identified through use of a screening method, appear to act as modulators of essential growth functions which may act at the level of triplex formation, antisense inhibition, or as aptamers that alter gene function. The sequences, referred to as minimum functional regions, or MFRs, are useful inter alia as therapeutic agents for treatment of sepsis and other pathologies caused by microorganisms such as sepsis and/or in which microorganisms are contributory agents.
摘要翻译：本发明涉及从命名为rbl-1 [SEQ ID NO.1]的序列分离的寡核苷酸序列。 19]可以杀死或抑制微生物的生长，或阻止生成内源性表达的毒素。通过使用筛选方法鉴定的这些ssDNA序列似乎可以作为必需生长功能的调节剂，其可以在三重生成，反义抑制水平或作为改变基因功能的适体的作用下起作用。称为最小功能区域或MFR的序列尤其可用作治疗败血症的治疗剂和由诸如败血症和/或其中微生物是贡献剂的微生物引起的其它病症。

10. 发明申请

US20070020635A1 Nucleotides for prevention and treatment of bacterial and fungal pathologies 有权
标题翻译：用于预防和治疗细菌和真菌病理学的核苷酸
公开(公告)号：US20070020635A1
公开(公告)日：2007-01-25
申请号：US10574254
申请日：2004-06-03
申请人： Yin Chen , Xin Tan
发明人： Yin Chen , Xin Tan
IPC分类号： C12Q1/68 , C40B40/02 , C40B40/08 , C07H21/04 , A61K48/00 , C12N15/74
CPC分类号： C12N15/113 , C07H21/04 , C12N15/1034 , C12N15/111 , C12N15/74 , C12N2310/11 , C12N2310/111 , C12N2310/127 , C12N2320/11 , C12N2330/31 , C12Q1/6837 , C12Q2565/531
摘要： A selectively inducible, single-stranded DNA (ssDNA) expression library, a method for constructing a ssDNA expression library, a method for screening ssDNA using the expression library, and a method for identifying ssDNA molecules that alter expression of bacterial and fungal gene(s) related to cell growth and toxin production and secretion. The screening library is used to, among other things, identify ODNs effective in stopping cell growth, killing bacteria or fungi, or preventing bacteria and/or fungi from synthesizing and secreting their toxins, and/or to discover ODNs effective in eukaryotic (e.g., mammalian) cells for targeted alteration of gene function. The library is also useful for identifying ssDNAs or ODNs that are used as therapeutic agents for, for instance, providing a method for treatment of bacterial infections such as sepsis.
摘要翻译：选择性诱导型单链DNA（ssDNA）表达文库，构建ssDNA表达文库的方法，使用表达文库筛选ssDNA的方法以及鉴定改变细菌和真菌基因表达的ssDNA分子的方法）与细胞生长和毒素生成和分泌有关。除了别的以外，筛选文库用于鉴别有效阻止细胞生长，杀死细菌或真菌，或阻止细菌和/或真菌合成和分泌其毒素的ODN，和/或发现在真核生物中有效的ODN（例如，哺乳动物）细胞用于靶向改变基因功能。该文库也可用于鉴定用作治疗剂的ssDNA或ODN，例如提供治疗细菌感染如败血症的方法。

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