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1. 发明授权

KR840002087B1 설포닐 우레아의 제조방법 失效
公开(公告)号：KR840002087B1
公开(公告)日：1984-11-14
申请号：KR840005313
申请日：1984-08-30
申请人： HOECHST AG
发明人： WEYER RUDI , HITZEL VOLKER , REGITZ GUNTER , GEISEN KARL
IPC分类号： C07D209/46

2. 发明授权

KR840001970B1 설포닐 우레아의 제조방법 失效
公开(公告)号：KR840001970B1
公开(公告)日：1984-10-26
申请号：KR840005311
申请日：1984-08-30
申请人： HOECHST AG
发明人： WEYER RUDI , HITZEL VOLKER , REGITZ GUENTER , GEISEN KARL
IPC分类号： C07D209/46

3. 发明授权

KR840001984B1 설포닐 우레아의 제조방법 失效
公开(公告)号：KR840001984B1
公开(公告)日：1984-10-26
申请号：KR840005310
申请日：1984-08-30
申请人： HOECHST AG
发明人： WEYER RUDI , HITZEL VOLKER , REGITZ GUENTER , GEISEN KARL
IPC分类号： C07D209/46

4. 发明授权

US3927088A Sulfonyl ureas and process for preparing them 失效
标题翻译：磺酰脲及其制备方法
公开(公告)号：US3927088A
公开(公告)日：1975-12-16
申请号：US30800272
申请日：1972-11-20
申请人： HOECHST AG
发明人： WEBER HELMUT , AUMULLER WALTER , WEYER RUDI , MUTH KARL , HITZEL VOLKER
IPC分类号： C07C67/00 , C07C301/00 , C07C303/36 , C07C311/58 , C07C311/59 , C07D215/16 , C07D215/48 , C07D333/38 , C07C127/16
CPC分类号： C07D215/16 , C07D215/48 , C07D333/38 , Y10S514/866
摘要： Sulfonyl-ureas of the formula X-CO-NH-A-SO2-NH-CO-NH-R1, in which R1 represents cyclopentylmethyl, alkyl-cyclopentylmethyl or dialkyl-cyclopentylmethyl, having up to 2 carbon atoms in the alkyl rest, or cyclopentylethyl, X represents a)
AND THEIR PHYSIOLOGICALLY TOLERATED SALTS, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.

in which R4 represents hydrogen, Cl or Br, A represents one of the groupings

in which R3 represents hydrogen, Cl or CH3,

IN WHICH R2 represents hydrogen, F, Cl, Br, CF3, CH3 or OCH3,
摘要翻译：式X-CO-NH-A-SO2-NH-CO-NH-R1的磺酰脲，其中R1表示烷基休止中具有至多2个碳原子的环戊基甲基，烷基 - 环戊基甲基或二烷基 - 环戊基甲基，或环戊基乙基，X代表a）其中R 2表示氢，F，Cl，Br，CF 3，CH 3或OCH 3，其中R 3表示氢，Cl或CH 3，其中R 4表示氢，Cl或Br，A表示其中一个及其生理学上的容忍性盐，其制备方法及其含有的药物制剂。

5. 发明授权

US3919245A Benzenesulfonyl ureas 失效
标题翻译：苯磺酰脲
公开(公告)号：US3919245A
公开(公告)日：1975-11-11
申请号：US38532373
申请日：1973-08-03
申请人： HOECHST AG
发明人： WEYER RUDI , AUMULLER WALTER , HITZEL VOLKER , SCHMIDT FELIX HELMUT
IPC分类号： C07D239/26 , C07C311/58 , C07C311/59 , C07C311/60 , C07D213/75 , C07D215/38 , C07D239/42 , C07D263/58 , C07D277/82 , C07D213/36
CPC分类号： C07D213/75 , C07D215/38 , C07D239/42 , C07D263/58 , C07D277/82 , Y10S514/866
摘要： Sulfonyl-ureas of the formula

wherein X represents a heteroaromatic 5- or 6- ring substituted, if desired, by one or two methyl groups and/or annellated with benzene, which ring may contain in addition to a nitrogen atom a further nitrogen, oxygen or sulfur atom and which, in vicinal position to the nitrogen atom, is linked to the rest of the molecule portion, R is alkyl having 1 to 3 carbon atoms, R1 is alkyl having 3 to 6 carbon atoms, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkenyl, alkylcycloalkenyl having each 5 to 9 carbon atoms, cyclohexenylmethyl, chlorocyclohexyl, bicycloheptenylmethyl, bicycloheptylmethyl, bicycloheptenyl, bicycloheptyl, nortricyclyl, adamantyl, benzyl, which as substance or in form of the salts thereof have hypoglycemic properties and are distinguished by a strong and continuous lowering of the blood sugar level, process for preparing them as well as pharmaceutical preparations containing the sulfonyl-ureas as an active substance.
摘要翻译：式XN-CO-NH-CH2-CH2-SO2-NH-CO-NH-R1的磺酰脲，| R其中X表示杂芳基5-或6-环，如果需要，通过一个或两个甲基基团和/或与环环烷基，该环除了氮原子之外还可以含有另外的氮，氧或硫原子，并且在与氮原子相邻的位置连接到分子部分的其余部分，R是烷基具有1至3个碳原子，R 1是具有3至6个碳原子的烷基，环烷基，烷基环烷基，环烷基烷基，环烯基，具有5至9个碳原子的烷基环烯基，环己烯基甲基，氯代环己基，双环庚烯基甲基，双环庚基甲基，双环庚烯基，双环庚基，苄基，其作为物质或其盐的形式具有降血糖特性，并且通过强烈和持续降低血糖水平，其制备方法以及含有磺酰脲的药物制剂来区分作为活性物质。

6. 发明授权

KR840001971B1 설포닐 우레아의 제조방법 失效
公开(公告)号：KR840001971B1
公开(公告)日：1984-10-26
申请号：KR840005312
申请日：1984-08-30
申请人： HOECHST AG
发明人： WEYER RUDI , HITZEL VOLKER , REGITZ GUENTER , GEISEN KARL
IPC分类号： C07D209/46

7. 发明授权

KR840001969B1 설포닐 우레아의 제조방법 失效
公开(公告)号：KR840001969B1
公开(公告)日：1984-10-26
申请号：KR800004902
申请日：1980-12-23
申请人： HOECHST AG
发明人： WEYER RUDI , HITZEL VOLKER , REGITZ GUENTER , GEISEN KARL
IPC分类号： C07D209/46

8. 发明授权

KR820000367B1 PROCESS FOR PREPARING BENZOIC ACID DERIVATIVES 失效
公开(公告)号：KR820000367B1
公开(公告)日：1982-03-25
申请号：KR770001677
申请日：1977-09-24
申请人： HOECHST AG
发明人： GEISON KARL , HITZEL VOLKER , PFAFF WERNER , WEYER RUDI
IPC分类号： C07D213/28
摘要： Benzoates[I; T = H, Cl, Br; W = carboxy; X = III (R1 = C2-8 alkyl, aralkyl, phenyl, C5-8 cycloalkyl; R2 =H, Cl, Br), IV(R3 = C5-8 alkyl, aralkyl, phenyl, C5-8 cycloalkyl); Y = C1-3 hydrocarbon; Z = H, halogen, alkyl, alkoxy, alkenyloxy useful as flood suger concentration lowering agent, were prepd. by reaction of II and XCOOH followed by removing formyl group. Thus, 2-butoxynicotinic acid was treated with ClCO2Me and 4-H2NCH2CH2C6H4CO2Et.HCl to give I[X = III(R1 = H; R2 = Bu); Y = Me; T,Z = H; W = CO2H, which was hydrolyzed to II(R2 = Et).

9. 发明专利

DK163242C 未知
公开(公告)号：DK163242C
公开(公告)日：1992-06-29
申请号：DK269679
申请日：1979-06-26
申请人： HOECHST AG
发明人： HITZEL VOLKER , LATTRELL RUDOLF , BORMANN DIETER
IPC分类号： C07D20060101 , C07D501/06 , C07D501/34 , C07D501/36

10. 发明专利

CA1247621A SUBSTITUTED PYRIDO(1,2-C)IMIDAZO(1,2-A)BENZIMIDAZOLES, PROCESSES FOR THEIR PREPARATION, THEIR USE, AND PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS 未知
公开(公告)号：CA1247621A
公开(公告)日：1988-12-28
申请号：CA463077
申请日：1984-09-13
申请人： HOECHST AG
发明人： HITZEL VOLKER , RACKUR GERHARD , BICKEL MARTIN
IPC分类号： C07D471/10 , A61K31/435 , A61K31/44 , A61P1/04 , C07D213/38 , C07D213/53 , C07D401/06 , C07D471/14 , A61K31/47
摘要： of the disclosure: The invention relates to compounds of the formula I (I) in which R1 and R2 are identical or different and are hydrogen, alkyl, trifluoromethyl, halogen, alkoxycarbonyl, alkoxy or alkanoyl, R3, R4 and R5 are identical or different and are hydrogen, methyl, alkoxy or alkoxyethoxy, and R is hydrogen or a group SR6, in which R6 is the lone, unpaired electron of the 12-sulfenyl radical, hydrogen, optionally substituted alkyl, alkenyl, alkynyl, alkanoyl, optionally mono- or poly-substituted benzoyl, fuoryl, phenacyl, phenoxyacetyl, phenylacetyl or another conventional thiol-protective group, and to physiologically acceptable salts thereof, and to processes for their preparation, to their use and to pharmaceutical preparations based on these compounds. Due to their excellent properties, the substituted pyrido(1,2-c)imidazo(1,2-a)benzimidazoles and their pharmacologically acceptable salts are outstandingly suitable for use in human and veterinary medicine, and they are used especially for the treatment and prophylaxis of gastro-intestinal diseases and those diseases which are caused by excessive gastric acid secretion.

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