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1. 发明授权

KR840001569B1 PROCESS FOR THE PREPARATION OF PROSTAGLANDINE DERIVATIVES OF 2-PGE2 2-PGF2 SERIES 失效
公开(公告)号：KR840001569B1
公开(公告)日：1984-10-06
申请号：KR790002632
申请日：1979-08-02
申请人： HOECHST AG
发明人： BARTMANN WILHELM , BECK GERHARD , KONZ ELMAR , LERCH ULRICH
IPC分类号： C07C405/00 , C07C177/00
摘要： Title compd.(I; X1,Y1 = O, H, OH; R2 = C3-7 alkyl), were prepd. by hydrolysis of Ib obtained from Ia (R3 = protecting group). Compd. Ia was obtained by reaction of XVII and (R4)3P=CH-COOCh3 (R4=C1-4 alkyl, Ph). Thus, 190mg 1-[4-(1-formyl-3-hydroxy)-butyl-2-(3-hydroxy-1-octenyl-3, 5-dihydroxy-cyclopentane and 20mg carbomethoxymethylene-triphenylphosphorane were stirred at room temp for 16hr in 10ml anhyd. benzene to give 6,9,11,15-tetrahydroxy-(E)-2, (E)-13-prostadienic methyl ester.

2. 发明授权

KR790001361B1 PROCESS FOR PREPARATION OF CYCLOPENANE DERIVATIVES 失效
公开(公告)号：KR790001361B1
公开(公告)日：1979-09-28
申请号：KR740002787
申请日：1974-06-15
申请人： HOECHST AG
发明人： BECK GERHARD , MILOS BABEJ , LERCH ULRICH , BARTMANN WILHELM
摘要： Title compds. (I; R1,R2 = O; R3,R4 = C1-5 alkyl ; R5 = tetrahydropyranyl, H ; U = (CH2)0-5, cis- or trans-alkyl = c-alkyl; V = simple bond, O, furan, benzyl ; W = alkyl-C-alkyl; X = (CH2)0-4), similar in structure to natural prostaglandine, having strong antiprostaglandine activity were prepd. by reaction of II and in aprotic solvent. Thus, 3.66g (5RS,3'RS)-2-oxo-5 3'-(2"-tetrahydropyranyloxy) -trans-1'-octenyl -cyclopentane-carboxylic ester in C6H5CH3 were stirred with 1.35g potassium-t-butylate followed by reaction with 4g 7-iodo-heptanophosphoric ethyl ester to give I.

3. 发明授权

KR840000928B1 PROCESS FOR THE PREPARATION PROSTAGLANDIN 6-KETOPGE1 SERIES 失效
公开(公告)号：KR840000928B1
公开(公告)日：1984-06-29
申请号：KR790004479
申请日：1979-12-17
申请人： HOECHST AG
发明人： BECK GERHARD , SCHOELKENS BERNWARD , RAPP RICHARD H , LERCH ULRICH
IPC分类号： C07C177/00
摘要： Title compds. (I; R1 = H, C1-8 alkyl radical, C1-6 unsaturated aliphatic radical, C3-7 ring aliphatic radical, metal ion, NH4+ ion, ammonium ion, tetraalkylammonium ion; R2 = C3-7 cycloalkyl radical, C1-8 alkyl radical) sere prepd. by elimination of R3 from V(R3 = protecting group) obtained from IV. Compd. IV was prepd. by the acid hydrolysis of III obtained from II(X = halogen).

4. 发明授权

US3914236A 1-(Imidazole-1-yl)-isoquinolines and process for preparing them 失效
标题翻译： 1-（咪唑-1-基） - 异喹啉及其制备方法
公开(公告)号：US3914236A
公开(公告)日：1975-10-21
申请号：US45471374
申请日：1974-03-25
申请人： HOECHST AG
发明人： LERCH ULRICH , GRANZER ERNOLD
IPC分类号： A61K31/47 , A61K31/472 , A61P3/06 , A61P3/08 , A61P9/10 , C07D217/22 , C07D217/24 , C07D227/06 , C07D401/04 , C07D521/00
CPC分类号： C07D231/12 , C07D217/22 , C07D217/24 , C07D233/56 , C07D249/08
摘要： 1-(1-Imidazolyl)-isoquinolines of the general formula I and their physiologically tolerated salts,

IN WHICH R1, R2 and R3 represent hydrogen, alkyl of 1 to 4 carbon atoms or phenyl, R1, R2 and R3 may be identical or different, R4 represents hydrogen, alkyl of 1 to 4 carbon atoms, phenyl or chlorine, and R5 represents hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, phenyl or chlorine, a process for preparing them and pharmaceutical preparations containing them as active ingredient.
摘要翻译：通式I的1-（1-咪唑基） - 异喹啉及其生理上耐受的盐，其中R 1，R 2和R 3表示氢，1至4个碳原子的烷基或苯基，R 1，R 2和R 3可以相同或不同，R4表示氢，1-4个碳原子的烷基，苯基或氯，R5表示氢，1-6个碳原子的烷基，5-8个碳原子的环烷基，苯基或氯，它们的制备方法和药物制剂含有它们作为活性成分。

5. 发明专利

CA1341064C COMPOUNDS HAVING A COGNITION ADJUVANT ACTION, AGENTS CONTAINING THEM, AND THE USE THEREOF FOR THE TREATMENT AND PROPHYLAXIS OF COGNITIVE DYSFUNCTIONS 未知
公开(公告)号：CA1341064C
公开(公告)日：2000-08-01
申请号：CA533092
申请日：1987-03-26
申请人： HOECHST AG
发明人： SCHOLTHOLT JOSEF , HOCK FRANZ , LERCH ULRICH , NICKEL WOLF-ULRICH , RUGER WOLFGANG , HENNING RAINER , URBACH HANSJORG
IPC分类号： C07K14/81 , A61K38/00 , A61P9/12 , A61P25/28 , C07C235/02 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/06 , A61K31/40
摘要： Compounds having a coginition adjuvant action, agents containing them and the use thereof in the treatment and prophylaxis of cognitive dysfunctions The invention relates to new compounds having a cognition adjuvant action, to the use of ACE inhibitors as medicaments having a cognition adjuvant action, to agents containing them, and to the use thereof for the treatment and prophylaxis of cognitive dysfunctions.

6. 发明专利

HU213273B PROCESS FOR PRODUCING RACEM AND OPTICALLY ACTIVE 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID 未知
公开(公告)号：HU213273B
公开(公告)日：1997-04-28
申请号：HU9200231
申请日：1992-01-24
申请人： HOECHST AG
发明人： KAMMERMEIER BERNHARD , LERCH ULRICH
IPC分类号： C07D217/26
摘要： A process for the preparation of racemic and optically active 1,2.3,4-tetrahydroisoquinoline-3-carboxylic acid is described, in which dihalo-o-xylylenes are cyclized to dicarboxylic acid esters in basic medium using dialkyl N-acylamidomalonates of the formula (CO2R1)2CHNHCOR2, in which R1 is (C1-C4)-alkyl and R2 is H, (C1-C4)-alkyl or (C6-C12)-aryl, decarboxylated by basic hydrolysis and subsequent acid work-up and then reacted in acid medium to give (D,L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, or dihalo-o-xylylenes are cyclized in basic medium to give the dicarboxylic acid esters and these are reacted directly without isolation in a one-pot process to give (D,L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, if desired the racemic 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is reacted with (-)menthol and p-toluenesulfonic acid to give (-)menthyl (D)- or (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate, then the diastereomers are separated by column chromatography and subjected to basic hydrolysis to give (D)-or (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, or (D,L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is esterified by means of benzyl alcohol and p-toluenesulfonic acid, reacted with D(-)mandelic acid to give benzyl (D)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (D)-mandelate and benzyl (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (D)-mandelate or with L(+)mandelic acid to give benzyl (D)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (L)-mandelate and benzyl (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (L)-mandelate and then the compounds obtained are separated into the optical antipodes by fractional crystallization in an inert solvent and the enantiomers (D)- or (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid are liberated by basic hydrolysis, the chiral auxiliary reagent being recovered.

7. 发明专利

HU9503598D0 PROCESS FOR PRODUCE AROMATIC METHYLSULPHONYL DERIVATIVES DURING METHYLIZATION OF ARYL-SULPHINACIDS 未知
公开(公告)号：HU9503598D0
公开(公告)日：1996-02-28
申请号：HU9503598
申请日：1995-12-15
申请人： HOECHST AG
发明人： WORM MANFRED , FUELLING GERD , HOERLEIN ROLF , LERCH ULRICH
IPC分类号： C07C313/02 , C07C315/00 , C07C315/02 , C07C317/44

8. 发明专利

IE62456B1 Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfunctions 未知
公开(公告)号：IE62456B1
公开(公告)日：1995-02-08
申请号：IE78487
申请日：1987-03-26
申请人： HOECHST AG
发明人： HOCK FRANZ , SCHOLTHOLT JOSEF , URBACH HANSJORG , HENNING RAINER , LERCH ULRICH , NICKEL WOLF-ULRICH , RUGER WOLFGANG
IPC分类号： C07K14/81 , A61K38/00 , A61P9/12 , A61P25/28 , C07C235/02 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/06 , A61K37/02 , A61K37/64
摘要： The invention relates to novel compounds having a nootropic activity, the use of ACE inhibitors as medicaments having nootropic activity, agents containing them, and their use in the treatment and prophylaxis of cognitive malfunctions.

9. 发明专利

FI91876B 未知
公开(公告)号：FI91876B
公开(公告)日：1994-05-13
申请号：FI871304
申请日：1987-03-25
申请人： HOECHST AG
发明人： HOCK FRANZ , SCHOLTHOLT JOSEF , URBACH HANSJOERG , HENNING RAINER , LERCH ULRICH , NICKEL WOLF-ULRICH , RUEGER WOLFGANG
IPC分类号： C07K14/81 , A61K38/00 , A61P9/12 , A61P25/28 , C07C235/02 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/06 , C07D209/52
摘要： The invention relates to novel compounds having a nootropic activity, the use of ACE inhibitors as medicaments having nootropic activity, agents containing them, and their use in the treatment and prophylaxis of cognitive malfunctions.

10. 发明专利

DK162092B 未知
公开(公告)号：DK162092B
公开(公告)日：1991-09-16
申请号：DK343486
申请日：1986-07-18
申请人： HOECHST AG
发明人： HENNING RAINER , LERCH ULRICH , KAISER JOACHIM
IPC分类号： A61K31/47 , A61K31/495 , A61K31/535 , A61P3/00 , A61P3/14 , A61P9/00 , C07D215/22 , C07D215/227 , C07D401/12 , C07D491/056
摘要： Compounds of the formula I (I) where R(1), R(2), R(3), R(4) and R(5) are, inter alia, hydrogen and alkyl, m is 1-4, n is 0 or 1, p is 0-4 and R(6) is identical or different dialkylamine derivatives, and salts thereof, have a calcium-antagonistic action. They are obtained by reacting corresponding amines with a compound II which carries, on the side chain, a leaving group which can be displaced nucleophilically, or from a hydroxyphenyl-dihydroquinolin-2-one compound by reaction with a corresponding side chain compound which has a leaving group which can be displaced nucleophilically.

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