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1. 发明授权

US09580437B2 Triazolopyrimidine compounds and uses thereof 有权
标题翻译：三唑并嘧啶化合物及其用途
公开(公告)号：US09580437B2
公开(公告)日：2017-02-28
申请号：US14977273
申请日：2015-12-21
申请人： Ho Man Chan , Xiang-Ju Justin Gu , Ying Huang , Ling Li , Yuan Mi , Wei Qi , Martin Sendzik , Yongfeng Sun , Long Wang , Zhengtian Yu , Hailong Zhang , Ji Yue (Jeff) Zhang , Man Zhang , Qiong Zhang , Kehao Zhao
发明人： Ho Man Chan , Xiang-Ju Justin Gu , Ying Huang , Ling Li , Yuan Mi , Wei Qi , Martin Sendzik , Yongfeng Sun , Long Wang , Zhengtian Yu , Hailong Zhang , Ji Yue (Jeff) Zhang , Man Zhang , Qiong Zhang , Kehao Zhao
IPC分类号： C07D487/04 , A61K31/519 , A61K31/541 , A61K31/551 , A61K45/06 , A61K31/5377
CPC分类号： A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , C07D487/04
摘要： A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.
摘要翻译：提供式（I）化合物或其药学上可接受的盐，其已被证明可用于治疗PRC2介导的疾病或病症：其中R1，R2，R3，R4，R5和n如所定义这里。

2. 发明申请

US20150354006A1 MARKERS FOR ACUTE LYMPHOBLASTIC LEUKEMIA 审中-公开
标题翻译：急性淋巴细胞白血病标志物
公开(公告)号：US20150354006A1
公开(公告)日：2015-12-10
申请号：US14434063
申请日：2013-10-15
申请人： Ho Man CHAN , Nathan P. ENGLUND , Levi GARRAWAY , Min HU , Jacob JAFFE , Gregory KRYUKOV , Jun LIU , Xianghui LIU , Rob MCDONALD , Frank Peter STEGMEIER , Zhaofu WANG , Yan WANG , Haiping WU , Feng YAN
发明人： Ho Man Chan , Nathan P. Englund , Levi Garraway , Min Hu , Jacob Jaffe , Gregory Kryukov , Jun Liu , Xianghui Liu , Rob McDonald , Frank Peter Stegmeier , Zhaofu Wang , Yan Wang , Haiping Wu , Feng Yan
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , G01N33/5011 , G01N33/57426 , G01N2333/91017 , G01N2440/12 , G01N2500/04 , G01N2500/10
摘要： The invention provides methods of detecting a NSD2 mutation in a cancer cell, methods cancer diagnosis and methods of screening for NSD2 inhibitors.
摘要翻译：本发明提供检测癌细胞NSD2突变的方法，方法癌症诊断和筛选NSD2抑制剂的方法。

3. 发明授权

US07238493B2 Acetylation of pRb by p300 assay method for compounds which modulate this process 失效
标题翻译：通过p300测定方法对调节此过程的化合物进行pRb的乙酰化
公开(公告)号：US07238493B2
公开(公告)日：2007-07-03
申请号：US10344243
申请日：2001-08-09
申请人： Nicholas Barrie la Thangue , Ho Man Chan
发明人： Nicholas Barrie la Thangue , Ho Man Chan
IPC分类号： C12Q1/00 , C12C1/02 , C12C1/04 , G01N33/573
CPC分类号： G01N33/5011
摘要： The present invention is based upon the finding that the protein p300 has acetylation activity which is directed to the retinoblastoma tumour suppressor protein pRb by the presence in the cell of the adenovirus E1A protein. This represents a target for modulators of the cell cycle, to which end the invention provides an assay for a modulator of acetylation of pRb by p300, which comprises: a) bringing into contact a p300 protein a pRb protein and a putative modulator compound under conditions where the p300 protein, in the absence of said modulator is capable of acetylating the pRb protein; b) providing conditions for acetylation of said pRb protein; and c) measuring the degree of inhibition of acetylation caused by said modulator compound.
摘要翻译：本发明基于蛋白质p300具有通过在腺病毒E1A蛋白质的细胞中的存在而导向视网膜母细胞瘤肿瘤抑制蛋白质pRb的乙酰化活性的发现。这表示细胞周期的调节剂的靶标，本发明的最后本发明提供了p300对pRb的乙酰化调节剂的测定法，其包括：a）在条件下使p300蛋白与推定的调节剂化合物接触其中p300蛋白在没有所述调节剂的情况下能够乙酰化pRb蛋白; b）提供所述pRb蛋白的乙酰化条件; 和c）测量由所述调节剂化合物引起的乙酰化抑制程度。

4. 外观设计

USD436145S1 Toy vehicle 失效
公开(公告)号：USD436145S1
公开(公告)日：2001-01-09
申请号：US29116858
申请日：2000-01-11
申请人： Ho Man Chan
设计人： Ho Man Chan

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