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1. 发明申请

WO2014145983A1 SHEATH FLUID SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BLOOD SAMPLES 审中-公开
标题翻译： SHEATH流体系统及其在血液样品中的粒子分析方法
公开(公告)号：WO2014145983A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/030850
申请日：2014-03-17
申请人： IRIS INTERNATIONAL, INC.
发明人： FARRELL, Gregory, A. , WANDERS, Bart J. , ADAMS, Thomas H. , GRONER, Warren , ZHAO, Xiaodong
IPC分类号： G01N15/14 , G01N15/00
CPC分类号： G01N33/4915 , G01N15/1404 , G01N15/1434 , G01N15/1436 , G01N15/1459 , G01N15/1463 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/05 , G01N33/5091 , G01N2015/0065 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G01N2015/1037 , G01N2015/1409 , G01N2015/1411 , G01N2015/1413 , G01N2015/1452 , G01N2015/1486 , G01N2021/058 , G01N2201/12
摘要： Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer.
摘要翻译：本公开的方面和实施方案提供用于分析样品中包含的颗粒的颗粒分析仪的颗粒和/或细胞内细胞器取向剂。示例性的颗粒和/或细胞内细胞器取向剂包括水溶液，粘度调节剂和/或缓冲液。

2. 发明申请

WO2018067770A1 DYNAMIC FOCUS SYSTEM AND METHODS 审中-公开
标题翻译：动态聚焦系统和方法
公开(公告)号：WO2018067770A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/055245
申请日：2017-10-05
申请人： IRIS INTERNATIONAL, INC.
发明人： LU, Jiuliu , QIAN, Bian , WANDERS, Bart J. , GOOD, Ken , RILEY, John
IPC分类号： G01N15/14 , G02B21/24 , G02B27/36 , G01N15/10
摘要： A method for dynamic focusing is presented that can be performed by a dynamic focusing controller that can receive images from the image capture device, and for each image, determine a border of the particle within the image, and calculate a pixel intensity ratio of the image based on the border of the particle. The dynamic focusing controller can also calculate a median pixel intensity ratio from the pixel intensity ratios for each image, determine a focal distance direction based on the median pixel intensity ratio, calculate a focal distance based on the median pixel intensity ratio when the focal distance direction is positive, and calculate the focal distance based on a median border width when the focal distance direction is negative. The autofocusing controller can then send an instruction to the focusing mechanism to adjust the image capture device by the focal distance in the focal distance direction.
摘要翻译：提出了一种用于动态聚焦的方法，其可以由动态聚焦控制器执行，该动态聚焦控制器可以从图像捕获设备接收图像，并且对于每个图像确定图像内的粒子的边界，以及基于粒子的边界计算图像的像素强度比。动态聚焦控制器还可以根据每个图像的像素强度比计算中值像素强度比，基于中值像素强度比确定焦距方向，基于中值像素强度比计算焦距，是正的，并且在焦距方向为负时基于中值边界宽度来计算焦距。自动对焦控制器然后可以向聚焦机构发送指令以通过焦距方向上的焦距调整图像捕捉设备。

3. 发明申请

WO2016060691A1 SYSTEMS AND METHODS FOR IMAGING FLUID SAMPLES 审中-公开
标题翻译：用于成像流体样品的系统和方法
公开(公告)号：WO2016060691A1
公开(公告)日：2016-04-21
申请号：PCT/US2014/061221
申请日：2014-10-17
申请人： IRIS INTERNATIONAL, INC.
发明人： WANDERS, Bart J.
IPC分类号： G01N15/14 , G01N15/00
CPC分类号： G01N15/1463 , A61B5/0059 , G01N15/1404 , G01N15/1425 , G01N15/1459 , G01N21/05 , G01N21/85 , G01N2015/0065 , G01N2015/1409 , G01N2015/144
摘要： Systems and methods for imaging a plurality of blood fluid samples or other types of samples include processing at least a portion of a sample to enhance imageability of certain particles in that portion and subsequently imaging the sample portion. In some instances, processing and imaging of various samples may be staged in a manner to optimize throughput of the system or method.
摘要翻译：用于对多个血液样品或其他类型的样品进行成像的系统和方法包括处理样品的至少一部分以增强该部分中某些颗粒的成像能力，并随后对样品部分进行成像。在一些情况下，可以以优化系统或方法的吞吐量的方式分级各种样品的处理和成像。

4. 发明申请

WO2014146051A1 AUTOFOCUS SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BLOOD SAMPLES 审中-公开
标题翻译：自动分析系统及其在血液样品中的分析方法
公开(公告)号：WO2014146051A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/030928
申请日：2014-03-17
申请人： IRIS INTERNATIONAL, INC.
发明人： WANDERS, Bart J. , JORDAN, Brett , FARRELL, Gregory A. , ADAMS, Thomas H. , GRONER, Warren
IPC分类号： G01N15/14 , G01N21/05
CPC分类号： G01N15/1404 , G01N1/30 , G01N15/1434 , G01N15/1463 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/53 , G01N33/49 , G01N33/4915 , G01N33/5091 , G01N33/5094 , G01N33/80 , G01N2015/0065 , G01N2015/1037 , G01N2015/1411 , G01N2015/1413 , G01N2015/1452 , G01N2015/1486 , G01N2021/058
摘要： Particles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. A contrast pattern for autofocusing is provided on the flowcell, for example at an edge of a rear illumination opening. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and/or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Blood cell images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.
摘要翻译：可以通过数字图像处理器对诸如血细胞的颗粒进行分类和计数。数字显微镜照相机可以被引导到限定对称变窄的流动路径的流动池中，其中样品流在由鞘液层之间的流动和粘度参数平坦化的带中流动。在流动池上提供用于自动聚焦的对比度图案，例如在后部照明开口的边缘。图像处理器从像素数据对比度评估焦点精度。定位电机沿着光轴移动显微镜和/或流动池，用于自动聚焦在对比度图案目标上。然后，处理器将显微镜和流动池移位在对比度图案和样品流之间已知的距离，从而聚焦于样品流。从该位置收集血细胞图像，直到通过输入信号周期性重新开始自动聚焦，或当检测图像数据中的温度变化或聚焦不准确时。

5. 发明申请

WO2014146062A3 FLOWCELL, SHEATH FLUID, AND AUTOFOCUS SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN URINE SAMPLES 审中-公开
公开(公告)号：WO2014146062A3
公开(公告)日：2014-09-18
申请号：PCT/US2014/030940
申请日：2014-03-18
申请人： IRIS INTERNATIONAL, INC.
发明人： WANDERS, Bart J. , CHAPOULAUD, Eric , JORDAN, Brett
IPC分类号： G01N15/14 , G01N21/05 , G01N15/00
摘要： The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. A particle imaging system or analyzer can include a flowcell through which a urine sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis. A contrast pattern for autofocusing is provided on the flowcell. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and/or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Cell or particle images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.

6. 发明申请

WO2014146061A1 DYNAMIC RANGE EXTENSION SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BLOOD SAMPLES 审中-公开
标题翻译：动态范围扩展系统及其在血液样品中的粒度分析方法
公开(公告)号：WO2014146061A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/030939
申请日：2014-03-18
申请人： IRIS INTERNATIONAL, INC.
发明人： ADAMS, Thomas H. , WANDERS, Bart J. , ROCHE, John , KASDAN, Harvey L.
IPC分类号： G01N15/14 , G01N15/10
CPC分类号： G01N15/1404 , G01N1/30 , G01N15/1434 , G01N15/1463 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/53 , G01N33/49 , G01N33/4915 , G01N33/5091 , G01N33/5094 , G01N33/80 , G01N2015/0065 , G01N2015/1037 , G01N2015/1411 , G01N2015/1413 , G01N2015/1452 , G01N2015/1486 , G01N2021/058
摘要： For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.
摘要翻译：为了分析含有至少两个类别的颗粒的样品，例如含有血细胞的样品，具有检测极限的颗粒计数器与能够鉴别颗粒数比例的分析仪（例如视觉分析仪和处理器）相结合。第一类颗粒可以存在超出检测范围限度，而第二类颗粒存在于相应的检测范围限度内。第二类粒子的浓度由粒子计数器确定。在分析器上确定第一类别与第二类别的计数比。基于第二类颗粒的比例和计数或浓度，在处理器上计算第一类中颗粒的浓度。

7. 发明公开

EP3467472A1 SHEATH FLUID SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BLOOD SAMPLES 审中-公开
公开(公告)号：EP3467472A1
公开(公告)日：2019-04-10
申请号：EP18202980.1
申请日：2014-03-17
申请人： Iris International, Inc.
发明人： FARRELL, Gregory, A. , WANDERS, Bart J. , ADAMS, Thomas H. , GRONER, Warren , ZHAO, Xiaodong
IPC分类号： G01N15/14 , G01N15/00 , G01N15/10 , G01N1/30 , G01N33/49 , G01N21/53 , G01N33/50 , G01N33/80 , G01N21/05
摘要： Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer.

8. 发明公开

EP3489656A1 FLOWCELL SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BIOLOGICAL FLUID SAMPLES 审中-公开
公开(公告)号：EP3489656A1
公开(公告)日：2019-05-29
申请号：EP18213038.5
申请日：2014-03-17
申请人： Iris International, Inc.
发明人： WANDERS, Bart J.
IPC分类号： G01N15/14 , G01N15/00 , G01N15/10 , G01N1/30 , G01N33/49 , G01N21/53 , G01N33/50 , G01N33/80 , G01N21/05
摘要： The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. In some aspects the system comprises an analyzer which may be a visual analyzer. In one aspect, this disclosure relates to a particle imaging system comprising a flowcell through which a sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis of samples. Other compositions, methods and features of this disclosure are disclosed herein.

9. 发明公开

EP2972215A2 FLOWCELL, SHEATH FLUID, AND AUTOFOCUS SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN URINE SAMPLES 审中-公开
标题翻译：流通池壳体流和自动对焦系统和粒子分析方法在尿液样本
公开(公告)号：EP2972215A2
公开(公告)日：2016-01-20
申请号：EP14729508.3
申请日：2014-03-18
申请人： Iris International, Inc.
发明人： WANDERS, Bart J. , CHAPOULAUD, Eric , JORDAN, Brett
IPC分类号： G01N15/14 , G01N21/05 , G01N15/00
CPC分类号： G01N33/5091 , G01N15/1404 , G01N15/1468 , G01N15/147 , G01N2015/0065 , G01N2015/1452 , G01N2021/8557
摘要： The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. A particle imaging system or analyzer can include a flowcell through which a urine sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis. A contrast pattern for autofocusing is provided on the flowcell. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and/or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Cell or particle images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.

10. 发明公开

EP2972214A1 SHEATH FLUID SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BLOOD SAMPLES 有权
标题翻译：在卢布罗本的VERFAHREN ZUR PARTIKELANALSE的HÜLLFLÜSSIGKEITSSYSTEME
公开(公告)号：EP2972214A1
公开(公告)日：2016-01-20
申请号：EP14723592.3
申请日：2014-03-17
申请人： Iris International, Inc.
发明人： FARRELL, Gregory, A. , WANDERS, Bart J. , ADAMS, Thomas H. , GRONER, Warren , ZHAO, Xiaodong
IPC分类号： G01N15/14 , G01N15/00
CPC分类号： G01N15/1404 , G01N1/30 , G01N15/1434 , G01N15/1463 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/53 , G01N33/49 , G01N33/4915 , G01N33/5091 , G01N33/5094 , G01N33/80 , G01N2015/0065 , G01N2015/1037 , G01N2015/1411 , G01N2015/1413 , G01N2015/1452 , G01N2015/1486 , G01N2021/058
摘要： The present disclosure relates to a staining methodology employing a particle contrast agent composition capable of rapidly staining cells in a single step. The particle contrast agent composition can be comprised of a combination of one or more particle contrast agents, one or more permeabilizing agents, and one or more fixing agents. The particle contrast agent composition can include Crystal Violet, New Methylene Blue, Saponin, and Gluteraldehyde.
摘要翻译：本公开涉及使用能够在单一步骤中快速染色细胞的颗粒造影剂组合物的染色方法。颗粒造影剂组合物可以由一种或多种颗粒造影剂，一种或多种渗透剂和一种或多种固定剂的组合组成。颗粒造影剂组合物可以包括结晶紫，新亚甲基蓝，皂苷和戊二醛。

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