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1. 发明申请

WO2007026725A2 DRUG, DRUG GUDANCE SYSTEM, MAGNETIC DETECTION SYSTEM, AND DRUG DESIGN METHOD 审中-公开
标题翻译：药物，药物系统，磁性检测系统和药物设计方法
公开(公告)号：WO2007026725A2
公开(公告)日：2007-03-08
申请号：PCT/JP2006/317027
申请日：2006-08-23
申请人： ISHIKAWAJIMA-HARIMA HEAVY INDUSTRIES CO., LTD. , ISHIKAWA, Yoshihiro , EGUCHI, Haruki
发明人： ISHIKAWA, Yoshihiro , EGUCHI, Haruki
IPC分类号： A61K41/00
CPC分类号： A61K41/0004 , A61K31/35 , A61K33/24 , G06F19/701 , G06F19/706
摘要： A drug comprises an organic or inorganic compound, and is made magnetic by modification of side chains and/or crosslinking between side chains.
摘要翻译：药物包括有机或无机化合物，并且通过侧链的改性和/或侧链之间的交联而制成磁性。

2. 发明授权

EP2557155B1 METAL SALEN COMPLEX DERIVATIVE AND PROCESS FOR PRODUCTION THEREOF 有权
公开(公告)号：EP2557155B1
公开(公告)日：2018-06-13
申请号：EP11765233.9
申请日：2011-04-06
申请人： IHI Corporation , Ishikawa, Yoshihiro
发明人： ISHIKAWA, Yoshihiro , EGUCHI, Haruki , SATO, Hiroshi
IPC分类号： C12N9/50 , A61K31/7088 , A61K38/00 , A61P35/00 , C07F15/02 , A61K38/43 , A61K39/00 , A61K39/395 , A61K45/00
CPC分类号： A61K47/547 , A61K9/0009 , A61K41/00
摘要： A metal-salen complex derivative with an excellent yield and stability is provided and a method for producing such a metal-salen complex derivative is provided. The present invention provides: metal-salen complex derivative obtained by allowing a target component composed of at least one of an enzyme, an antibody, an antigen, a peptide, an amino acid, an oligonucleotide, a protein, a nucleic acid, and a medical molecule to bind to a metal-salen complex via an amide bond or a disulfide bond; a method for producing such a metal-salen complex derivative.

3. 发明公开

EP2933802A1 MAGNETIC BODY, AND METHOD FOR MANUFACTURING MAGNETIC BODY 审中-公开
标题翻译： MAGNETKÖRPERUND VERFAHREN ZUR HERSTELLUNG EINES MAGNETISCHENKÖRPERS
公开(公告)号：EP2933802A1
公开(公告)日：2015-10-21
申请号：EP13862772.4
申请日：2013-12-13
申请人： IHI Corporation , Ishikawa, Yoshihiro
发明人： ISHIKAWA, Yoshihiro , EGUCHI, Haruki
IPC分类号： H01F1/00 , H01F1/34
CPC分类号： H01F1/42
摘要： [Object] A magnetization technique that enhances magnetic properties of an organic compound is provided without damaging properties of the organic compound or while maintaining the structure of the organic compound.
[Solution] The present invention is a method for manufacturing a magnetic substance composed of crystals of a magnetization target compound and an electron acceptor by combining the magnetization target compound with the electron acceptor; forming a solution by dissolving a mixture of the magnetization target compound and the electron acceptor in a solvent; maintaining the solution in a very low temperature state and allowing the solution to deposit the crystals of the magnetic target compound and the electron acceptor; and separating the crystals from the solvent.
摘要翻译：提供了增强有机化合物的磁性能的磁化技术，而不损害有机化合物的性质或同时保持有机化合物的结构。解决方案本发明是通过将磁化目标化合物与电子受体组合来制造由磁化目标化合物和电子受体的晶体构成的磁性物质的方法; 通过将磁化目标化合物和电子受体的混合物溶解在溶剂中形成溶液; 将溶液保持在非常低的温度状态，并使溶液沉积磁性目标化合物和电子受体的晶体; 并从溶剂中分离晶体。

4. 发明授权

EP2564852B1 ANTI-BRAIN-TUMOR DRUG 有权
标题翻译：有效对抗脑瘤
公开(公告)号：EP2564852B1
公开(公告)日：2015-02-25
申请号：EP11774575.2
申请日：2011-04-11
申请人： IHI Corporation , Ishikawa, Yoshihiro
发明人： ISHIKAWA, Yoshihiro , EGUCHI, Haruki
IPC分类号： A61K31/555 , A61P35/00 , C07C251/24 , C07F15/02 , C07F13/00 , C07F15/00
CPC分类号： C07F15/025 , C07C251/24 , C07F13/005 , C07F15/0013

5. 发明公开

EP2517752A1 MAGNET BODY AND DRUG DELIVERY CONTROL DEVICE USING MAGNET BODY 有权
标题翻译： MAGNETKÖRPERUND VORRICHTUNG ZUR STEUERUNG DER WIRKSTOFFFREISETZUNG UNTER VERWENDUNG DESMAGNETKÖRPERS
公开(公告)号：EP2517752A1
公开(公告)日：2012-10-31
申请号：EP10838988.3
申请日：2010-12-24
申请人： IHI Corporation , Ishikawa, Yoshihiro
发明人： ISHIKAWA, Yoshihiro , EGUCHI, Haruki , HARA, Masakazu
IPC分类号： A61M37/00 , A61K33/26 , H01F7/02
CPC分类号： A61M37/00 , A61B2034/731 , A61B2090/064 , A61M31/002 , H01F7/0205
摘要： A magnetic body that may be suitably applied to a drug delivery system using magnetism, may be provided. Furthermore, a drug delivery control device that allows the magnetic body to be suitably applied to drug delivery, is provided. The magnetic body includes a magnet; and a cover part attached to an edge of the magnet. The cover part is composed of a material with high magnetic permeability, and a ratio of a length to a radius of the cover part is 10:1 to 7: 3. The drug delivery control device includes the magnetic body including the magnet; and the cover part attached to the edge of the magnet, a head for supporting the magnetic body; and a drive mechanism of the head that causes the head to operate along a projected region formed by the affected area with respect to a surface of a tissue. A magnetic field is applied from the magnetic body to the affected area where a magnetic drug is administered.
摘要翻译：可以提供可以适用于使用磁性的药物输送系统的磁性体。此外，提供了允许磁性体适合用于药物输送的药物输送控制装置。磁体包括磁体; 以及附接到磁体边缘的盖部分。盖部由具有高磁导率的材料构成，盖部的长度与半径的比例为10：1〜7：3。药物输送控制装置包括具有磁体的磁性体; 并且所述盖部附接到所述磁体的边缘，用于支撑所述磁性体的头部; 以及头部的驱动机构，其使头部相对于组织的表面沿着由受影响区域形成的突出区域进行操作。磁体从磁体施加到施用磁性药物的受影响区域。

6. 发明授权

EP2357166B1 AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND 有权
公开(公告)号：EP2357166B1
公开(公告)日：2020-01-15
申请号：EP09827243.8
申请日：2009-11-20
申请人： IHI Corporation , Ishikawa, Yoshihiro
发明人： ISHIKAWA, Yoshihiro , EGUCHI, Haruki
IPC分类号： C07C251/24 , A61K31/135 , A61K31/167 , A61K31/295 , A61K31/337 , A61P35/00 , C07D305/14

7. 发明授权

EP2657223B1 METAL-SALEN COMPLEX COMPOUND AND PRODUCTION METHOD FOR SAME 有权
标题翻译：金属 - 盐络合物及其生产方法
公开(公告)号：EP2657223B1
公开(公告)日：2017-06-28
申请号：EP11850943.9
申请日：2011-12-21
申请人： IHI Corporation , Ishikawa, Yoshihiro
发明人： ISHIKAWA, Yoshihiro , EGUCHI, Haruki
IPC分类号： A61K31/28 , A61K9/00 , A61K9/50 , C07F15/02 , C07C251/24
CPC分类号： A61K31/28 , A61K9/0009 , A61K9/0019 , A61K9/5094 , C07C251/24 , C07F15/025 , Y10T428/2982

8. 发明公开

EP2738158A1 METAL SALEN COMPLEX COMPOUND, LOCAL ANESTHETIC, AND ANTI-MALIGNANT TUMOR AGENT 审中-公开
标题翻译：金属盐复合物，局部麻醉剂和抗恶性肿瘤剂
公开(公告)号：EP2738158A1
公开(公告)日：2014-06-04
申请号：EP12800466.0
申请日：2012-05-10
申请人： IHI Corporation , Ishikawa, Yoshihiro
发明人： ISHIKAWA, Yoshihiro , EGUCHI, Haruki
IPC分类号： C07C251/24 , A61K47/48 , C07F11/00 , C07F13/00 , C07F15/02
CPC分类号： A61K31/295 , A61F2007/009 , A61K9/0014 , A61K9/06 , A61K31/28 , A61K31/555 , A61K31/566 , A61K31/661 , A61K31/7135 , A61K38/12 , A61K47/54 , A61K47/542 , A61K47/545 , A61K47/547 , A61K47/551 , A61K47/554 , A61K47/558 , A61K47/61 , A61K47/62 , A61K47/64 , A61M19/00 , A61M35/00 , C07F15/025
摘要： A metal-salen complex compound, which exhibits excellent noninvasiveness and can be efficiently transferred to an affected site, a local anesthetic containing this metal-salen complex compound, and an antineoplastic drug containing this metal-salen complex compound are provided. Regarding the metal-salen complex compound, a metal atom part in each of two molecules of a metal-salen complex or a derivative of the metal-salen complex is dimerized via water, and the metal-salen complex compound is mixed with a base to produce an ointment.
摘要翻译：提供具有优异的非侵入性且可以有效地转移至患部的金属沙仑配合物化合物，含有该金属沙仑配合物化合物的局部麻醉剂以及含有该金属沙仑配合物化合物的抗肿瘤药物。关于金属salen络合物化合物，金属salen络合物的两个分子或金属salen络合物的衍生物的每一个中的金属原子部分通过水而二聚化，并且金属salen络合物化合物与碱混合生产一种药膏。

9. 发明公开

EP2682384A1 AUTO-MAGNETIC METAL SALEN COMPLEX COMPOUND 审中-公开
标题翻译： AUTOMAGNETISCHE METALL-SALEN-KOMPLEXVERBINDUNG
公开(公告)号：EP2682384A1
公开(公告)日：2014-01-08
申请号：EP12747598.6
申请日：2012-01-19
申请人： IHI Corporation , Ishikawa, Yoshihiro
发明人： ISHIKAWA, Yoshihiro , EGUCHI, Haruki
IPC分类号： C07C251/24 , A61K31/135 , A61K31/28 , A61K31/295 , A61K31/315 , A61P23/02 , A61P35/00 , C07F11/00 , C07F13/00 , C07F15/02 , C07F15/06
CPC分类号： A61K47/48023 , A61K47/52 , C07C251/24 , C07F11/005 , C07F13/005 , C07F15/025
摘要： The molecular structures of metal-salen complexes which exerts pharmacological effects are clarified and the metal-salen complexes having such molecular structures and their derivatives are provided. A metal-salen complex compound is characterized in that a metal atom part in each of multiple molecules of the metal-salen complex or its derivative is multimerized via water.
摘要翻译：阐明发挥药理作用的金属 - 盐配合物的分子结构，提供具有这样的分子结构及其衍生物的金属 - 盐配合物。金属盐配合物的特征在于金属 - 盐配合物或其衍生物的多个分子中的每一个中的金属原子部分通过水多聚化。

10. 发明授权

EP2933802B1 MAGNETIC BODY, AND METHOD FOR MANUFACTURING MAGNETIC BODY 有权
公开(公告)号：EP2933802B1
公开(公告)日：2020-08-19
申请号：EP13862772.4
申请日：2013-12-13
申请人： IHI Corporation , Ishikawa, Yoshihiro
发明人： ISHIKAWA, Yoshihiro , EGUCHI, Haruki
IPC分类号： H01F1/42

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