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1. 外观设计

USD953573S1 Flow cell cartridge 有权
公开(公告)号：USD953573S1
公开(公告)日：2022-05-31
申请号：US29714660
申请日：2019-11-25
申请人： Illumina, Inc.
设计人： Jay Taylor , James Osmus , Philip Paik , Jack Godfrey Wood , Carlos Dominguez

2. 外观设计

USD913518S1 Reagent cartridge 有权
公开(公告)号：USD913518S1
公开(公告)日：2021-03-16
申请号：US29714705
申请日：2019-11-25
申请人： Illumina, Inc.
设计人： James Osmus , Erik Allegoren , James Blake , Philip Paik , Jay Taylor

3. 发明申请

US20170016060A1 DISPOSABLE, INTEGRATED MICROFLUIDIC CARTRIDGE AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：一体化的微流控盒及其制造和使用方法
公开(公告)号：US20170016060A1
公开(公告)日：2017-01-19
申请号：US15125124
申请日：2015-03-11
申请人： ILLUMINA, INC.
发明人： Poorya Sabounchi , Behnam Javanmardi , Tarun Khurana , Philip Paik , Yan-You Lin
IPC分类号： C12Q1/68 , B01L7/00 , B01L3/00
摘要： The disclosed embodiments concern microfluidic cartridges for detecting biological reactions. In some embodiments, the microfluidic cartridges are configured to perform sequencing operations on a nucleic acid sample. In one aspect, a microfluidic cartridge includes a stack of fluidics layers defining channels and valves for processing the nucleic acid sample to be sequenced, and a solid state CMOS biosensor integrated in the stack. The biosensor has an active area configured to detect signals of biological reactions, wherein substantially all of the active area is available for reagent delivery and illumination during operation. In another aspect, a microfluidic cartridge includes: (a) a flow cell including a reaction site area encompassing one or more reaction sites; (b) fluidics channels for delivering reactants to and/or removing reactants from the reaction site area; (c) a biosensor having an active area configured to detect signals of biological reactions in the reaction site area. The reaction site area is proximal to the active area of the biosensor and the reaction site area spans substantially all of the active area of the biosensor. In some embodiments, the fluidics channels do not substantially overlap with the active area of the biosensor. Methods for manufacturing and operating the microfluidic cartridges are also disclosed.
摘要翻译：所公开的实施例涉及用于检测生物反应的微流体盒。在一些实施方案中，微流控盒被配置为对核酸样品进行测序操作。在一个方面，微流控筒包括限定用于处理要测序的核酸样品的通道和阀的流体层叠层，以及集成在堆中的固态CMOS生物传感器。生物传感器具有被配置为检测生物反应的信号的有源区域，其中在操作期间基本上所有的有效区域可用于试剂递送和照明。在另一方面，微流控盒包括：（a）流动池，包括包含一个或多个反应位点的反应位点区域; （b）用于将反应物输送到和/或从反应部位区域除去反应物的流体通道; （c）生物传感器，其具有被配置为检测反应部位区域中的生物反应信号的有源区域。反应部位区域靠近生物传感器的有效区域，反应部位区域基本上跨越生物传感器的所有活性区域。在一些实施例中，流体通道基本上与生物传感器的有效区域重叠。还公开了用于制造和操作微流控盒的方法。

4. 外观设计

USD952892S1 Sequencing cartridge assembly 有权
公开(公告)号：USD952892S1
公开(公告)日：2022-05-24
申请号：US29714661
申请日：2019-11-25
申请人： Illumina, Inc.
设计人： James Osmus , Erik Allegoren , James Blake , Philip Paik , Jay Taylor , Jack Godfrey-Wood , Carlos Dominguez

5. 发明授权

US11174513B2 Disposable, integrated microfluidic cartridge and methods of making and using same 有权
公开(公告)号：US11174513B2
公开(公告)日：2021-11-16
申请号：US16405547
申请日：2019-05-07
申请人： ILLUMINA, INC.
发明人： Poorya Sabounchi , Behnam Javanmardi , Tarun Khurana , Philip Paik , Yan-You Lin
IPC分类号： B01L3/00 , B01L7/00 , C12Q1/6869 , C12Q1/6806 , C12Q1/68
摘要： A stack of fluidics layers of a microfluidic cartridge for sequencing nucleic acid molecules includes a sequencing chamber layer having a sequencing chamber area configured for carrying out clustering and sequencing reactions, and a sequencing chamber bottom layer disposed under the sequencing chamber layer. The sequencing chamber bottom layer has an opening configured to hold an image sensor with the image sensor having an active area disposed under the sequencing chamber area. The sequencing chamber area spans substantially all of the active area of the image sensor. The stack of fluidics layers includes a flexible printed circuit board (PCB) layer under the sequencing chamber bottom layer, and a fluidics channels layer disposed under the flexible PCB layer. The fluidics channels layer includes fluidics channels that are configured to deliver reactants to the sequencing chamber area. The fluidics channels do not substantially overlap with the active area of the image sensor.

6. 发明申请

US20190264276A1 DISPOSABLE, INTEGRATED MICROFLUIDIC CARTRIDGE AND METHODS OF MAKING AND USING SAME 审中-公开
公开(公告)号：US20190264276A1
公开(公告)日：2019-08-29
申请号：US16405547
申请日：2019-05-07
申请人： ILLUMINA, INC.
发明人： Poorya Sabounchi , Behnam Javanmardi , Tarun Khurana , Philip Paik , Yan-You Lin
IPC分类号： C12Q1/6869 , B01L3/00 , B01L7/00 , C12Q1/6806
摘要： A stack of fluidics layers of a microfluidic cartridge for sequencing nucleic acid molecules includes a sequencing chamber layer having a sequencing chamber area configured for carrying out clustering and sequencing reactions, and a sequencing chamber bottom layer disposed under the sequencing chamber layer. The sequencing chamber bottom layer has an opening configured to hold an image sensor with the image sensor having an active area disposed under the sequencing chamber area. The sequencing chamber area spans substantially all of the active area of the image sensor. The stack of fluidics layers includes a flexible printed circuit board (PCB) layer under the sequencing chamber bottom layer, and a fluidics channels layer disposed under the flexible PCB layer. The fluidics channels layer includes fluidics channels that are configured to deliver reactants to the sequencing chamber area. The fluidics channels do not substantially overlap with the active area of the image sensor.

7. 外观设计

USD942034S1 Reagent cartridge 有权
公开(公告)号：USD942034S1
公开(公告)日：2022-01-25
申请号：US29745314
申请日：2020-08-05
申请人： Illumina, Inc.
设计人： James Osmus , Erik Allegoren , James Blake , Philip Paik , Jay Taylor , Jack Godfrey Wood

8. 外观设计

USD962467S1 Flow cell device 有权
公开(公告)号：USD962467S1
公开(公告)日：2022-08-30
申请号：US29714672
申请日：2019-11-25
申请人： Illumina, Inc.
设计人： Jay Taylor , Bradley Drews , James Osmus , Philip Paik , Tsukasa Takahashi , Brandon Westerberg , Jack Godfrey Wood , Carlos Dominguez

9. 外观设计

USD953575S1 Flow cell cartridge 有权
公开(公告)号：USD953575S1
公开(公告)日：2022-05-31
申请号：US29714671
申请日：2019-11-25
申请人： Illumina, Inc.
设计人： Jay Taylor , James Osmus , Philip Paik , Jack Godfrey-Wood , Carlos Dominguez

10. 外观设计

USD953574S1 Flow cell cartridge 有权
公开(公告)号：USD953574S1
公开(公告)日：2022-05-31
申请号：US29714665
申请日：2019-11-25
申请人： Illumina, Inc.
设计人： Jay Taylor , James Osmus , Philip Paik , Jack Godfrey Wood , Carlos Dominguez , Max Pollock

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