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1. 发明授权

US06395479B1 Androgen-metabolic gene mutations and prostate cancer risk 有权
标题翻译：雄激素代谢基因突变和前列腺癌风险
公开(公告)号：US06395479B1
公开(公告)日：2002-05-28
申请号：US09235538
申请日：1999-01-22
申请人： Juergen K. V. Reichardt , Gerhard A. Coetzee , Brian E. Henderson , Nick Makridakis , Ronald Ross
发明人： Juergen K. V. Reichardt , Gerhard A. Coetzee , Brian E. Henderson , Nick Makridakis , Ronald Ross
IPC分类号： C12Q168
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/156
摘要： This present invention identifies mutations in several androgen-metabolic genes (SRD5A2, CYP17, HSD3B2, and HSD17B3) and methods of using such mutations in the diagnosis and treatment of inheritable prostate cancer susceptibility. Isolation of genomic DNA of various racial/ethnic populations followed by SSCP scanning and direct PCR sequencing of the aberrant SSCP (single-strand conformation dependent DNA polymorphism) patterns allows for identification of the disclosed polymorphisms. Screening for the disclosed mutations establishes a differential distribution among various racial/ethnic groups as well as altered in vivo enzyme activity that parallels prostate cancer risk.
摘要翻译：本发明鉴定了几种雄激素代谢基因（SRD5A2，CYP17，HSD3B2和HSD17B3）中的突变以及在遗传性前列腺癌易感性的诊断和治疗中使用这种突变的方法。各种种族/种族群体的基因组DNA的分离，随后SSCP扫描和异常SSCP（单链构象依赖性DNA多态性）模式的直接PCR测序允许鉴定所公开的多态性。筛选所公开的突变，确定各种族/民族之间的差异分布以及与前列腺癌风险相似的体内酶活性的变化。

2. 发明授权

US06335367B1 Fungicidal and insecticidal benzyloxy cyclopropyl substituted aromatic compounds 失效
标题翻译：杀真菌和杀虫的苄氧基环丙基取代芳香族化合物
公开(公告)号：US06335367B1
公开(公告)日：2002-01-01
申请号：US09558314
申请日：2000-04-25
申请人： Ronald Ross , Ted Tsutomu Fujimoto , Duyan Vuong Nguyen , Steven Howard Shaber
发明人： Ronald Ross , Ted Tsutomu Fujimoto , Duyan Vuong Nguyen , Steven Howard Shaber
IPC分类号： A01N3744
CPC分类号： C07C251/42 , A01N37/38 , A01N37/50 , A01N37/52 , C07C251/82 , C07C2601/02 , C07C2601/16
摘要： Compounds with fungicidal and insecticidal properties having the following formula: wherein A is N or CH; V is O or NH; m and n are the integers 0 and 1, and m+n is 1; X is independently selected from hydrogen, halo, (C1-C4)alkyl, and (C1-C4)alkoxy; Z is NR5R6, OR5 or CR7R8R9; and R, R1, R2, R3, R4, R5, R6, R7, R8 and R9 vary.
摘要翻译：具有杀真菌性和杀虫性的化合物具有下式：其中A是N或CH; V是O或NH; m和n是整数0和1，并且m + n是1; X独立地选自氢，卤素，（C 1 -C 4）烷基和（C 1 -C 4）烷氧基; Z为NR5R6，OR5或CR7R8R9; R，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9各不相同。

3. 发明授权

US5883125A Benzyloxy substituted aromatics and their use as fungicides and insecticides 失效
标题翻译：苄氧基取代的芳族化合物及其作为杀真菌剂和杀虫剂的用途
公开(公告)号：US5883125A
公开(公告)日：1999-03-16
申请号：US857375
申请日：1997-06-02
申请人： Ronald Ross , Ted Tsutomu Fujimoto , Steven Howard Shaber
发明人： Ronald Ross , Ted Tsutomu Fujimoto , Steven Howard Shaber
IPC分类号： C07D239/26 , A01N37/38 , A01N37/50 , A01N43/08 , A01N43/10 , A01N43/40 , A01N43/48 , A01N43/60 , C07C69/734 , C07C69/736 , C07C69/738 , C07C235/34 , C07C251/48 , C07D207/33 , C07D213/38 , C07D213/50 , C07D215/12 , C07D217/02 , C07D237/08 , C07D241/12 , C07D261/10 , C07D271/02 , C07D307/38 , C07D333/12 , C07D333/22 , A01N37/10
CPC分类号： A01N43/40 , A01N37/38 , A01N37/50 , A01N43/10 , C07C251/48 , C07C69/736 , C07D213/50 , C07D333/22 , C07C2101/02 , C07C2101/08 , C07C2101/14
摘要： Compounds with fungicidal and insecticidal properties having formula I ##STR1## wherein A is N or CH; V is O or NH; m and n are integers 0 and 1 provided that m+n is 1;X is independently selected from hydrogen, halo, (C.sub.1 -C.sub.4)alkyl, and (C.sub.1 -C.sub.4) alkoxy;R is independently selected from, (C.sub.1 -C.sub.12)alkyl, halo(C.sub.1 -C.sub.12)alkyl, (C.sub.2 -C.sub.8) alkenyl, (C.sub.2 -C.sub.8)alkynyl, (C.sub.1 -C.sub.12)alkoxy(C.sub.1 -C.sub.12)alkyl, (C.sub.3 -C.sub.7) cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.1 -C.sub.4)alkyl, aryl, aralkyl, and heterocyclic moieties;R is independently selected from (C.sub.1 -C.sub.12)alkyl, halo(C.sub.1 -C.sub.12)alkyl, (C.sub.2 -C.sub.8) alkenyl, (C.sub.2 -C.sub.8)alkynyl, (C.sub.1 -C.sub.12)alkoxy(C.sub.1 -C.sub.12)alkyl, (C.sub.3 -C.sub.7) cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.1 -C.sub.4)alkyl, aryl, aralkyl, and heterocyclic;R.sub.1 and R.sub.2 are independently selected from hydrogen, (C.sub.1 -C.sub.6)alkyl, halo(C.sub.1 -C.sub.12) alkyl, (C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.1 -C.sub.4)alkyl, cyano, carboxy(C.sub.1 -C.sub.4)alkyl, and aryl; provided at least one of R.sub.1 and R.sub.2 is H.
摘要翻译：具有式I的具有杀真菌性和杀虫性的化合物其中A为N或CH; V为O或NH; m和n为整数0和1，条件是m + n为1; X独立地选自氢，卤代（C1-C4）烷基和（C1-C4）烷氧基; R独立地选自（C1-C12）烷基，卤代（C1-C12）烷基，（C2-C8）烯基，（C2-C8）（C 1 -C 12）烷基，（C 3 -C 7）环烷基，（C 3 -C 7）环烷基（C 1 -C 4）烷基，芳基，芳烷基和杂环部分; R独立地选自（C 1 -C 12） -C 1 -C 12）烷基，（C 1 -C 12）烷基，（C 2 -C 8）烯基，（C 2 -C 8）炔基，（C 1 -C 12）烷氧基（C 1 -C 12）烷基，（C 3 -C 7） C 1 -C 6烷基，（C 1 -C 12）烷基，（C 3 -C 7）环烷基，（C 3 -C 7）环烷基， -C 7）环烷基（C 1 -C 4）烷基，氰基，羧基（C 1 -C 4）烷基和芳基;提供R 1和R 2中的至少一个为H.

4. 发明申请

US20100168436A1 PROCESS FOR THE PREPARATION OF 2-SUBSTITUTED-5- (1-ALKYLTHIO)ALKYLPYRIDINES 有权
标题翻译：制备2-取代的5-（1-烷基硫代）烷基吡啶的方法
公开(公告)号：US20100168436A1
公开(公告)日：2010-07-01
申请号：US12722978
申请日：2010-03-12
申请人： James M. Renga , Ronald Ross , Timothy P. Martin , Kim E. Arndt , Nicholas M. Irvine
发明人： James M. Renga , Ronald Ross , Timothy P. Martin , Kim E. Arndt , Nicholas M. Irvine
IPC分类号： C07D213/32
CPC分类号： C07D213/32
摘要： 2-Substituted-5-(1-alkylthio)alkylpyridines are produced efficiently and in high yield from a non-pyridine source by cyclization.
摘要翻译： 2-取代的5-（1-烷硫基）烷基吡啶通过环化从非吡啶源有效且高产率地制备。

5. 发明申请

US20080132705A1 Process for the preparation of 2-substituted-5-(1-alkylthio)alkylpyridines 有权
标题翻译： 2-取代-5-（1-烷硫基）烷基吡啶的制备方法
公开(公告)号：US20080132705A1
公开(公告)日：2008-06-05
申请号：US11704759
申请日：2007-02-09
申请人： Stephen T. Heller , Ronald Ross , Nicholas M. Irvine , James M. Renga , Mark M. Zettler , Kim E. Erndt
发明人： Stephen T. Heller , Ronald Ross , Nicholas M. Irvine , James M. Renga , Mark M. Zettler , Kim E. Erndt
IPC分类号： C07D211/02
CPC分类号： C07D213/32 , C07D213/12 , C07D213/26
摘要： 2-Substituted-5-(1-alkylthio)alkylpyridines are produced efficiently and in high yield by cyclization and thioalkylation.
摘要翻译：通过环化和硫代烷基化有效产生2-取代的5-（1-烷硫基）烷基吡啶。

6. 发明授权

US07124183B2 Method and apparatus for secure distributed managed network information services with redundancy 有权
公开(公告)号：US07124183B2
公开(公告)日：2006-10-17
申请号：US10145793
申请日：2002-05-16
申请人： Dave Pekary , Chris Sibbitt , Michael Kelland , Arthur Vardanyan , Ronald Ross
发明人： Dave Pekary , Chris Sibbitt , Michael Kelland , Arthur Vardanyan , Ronald Ross
IPC分类号： G06F15/16
CPC分类号： H04L41/18 , H04L41/0253 , H04L63/20 , H04L69/40
摘要： Provided is a managed network service delivery system and method. The managed network service delivery system includes an IOC (Internetworking Operating Center) and a SCA (SAM (Security Activity Manager) Collector Agent) at at least one of a plurality of customer sites of a customer. The customer sites are connected to the IOC through a VPN (Virtual Private Network) or directly from a respective one of the SCAs to the IOC. The SCAs collect log and statistical information from equipment at a respective one of the customer sites and provide summary information to the IOC. The SCAs also perform queries regarding status of equipment and report to the IOC. The customer accesses reports from a web server at the IOC or through a PSTN (Public Switched Telephone Network) connection at the SCAs. A redundant connection, through the PSTN, between a SCA and the IOC provides a robust system for management, monitoring and security of the customer sites.

7. 发明授权

US6121251A Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides 失效
标题翻译：二氢哒嗪酮和哒嗪酮及其作为杀真菌剂和杀虫剂的用途
公开(公告)号：US6121251A
公开(公告)日：2000-09-19
申请号：US938552
申请日：1997-09-26
申请人： Steven Howard Shaber , Edward Michael Szapacs , Ronald Ross
发明人： Steven Howard Shaber , Edward Michael Szapacs , Ronald Ross
IPC分类号： A01N43/58 , A01N47/24 , A01N55/10 , C07D237/04 , C07D237/14 , C07F9/6509 , C07D237/16
CPC分类号： C07D237/04 , A01N47/24 , C07D237/14 , C07F9/650911
摘要： Compounds with fungicidal and insecticidal properties having formula I ##STR1## wherein W is ##STR2## n is 0 or 1; Y is O, S, NR.sub.1, or R.sub.6 ;the ring bond containing R.sub.4 and R.sub.5 is a single or double bond;X is independently selected from hydrogen, halo, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy and --HC.dbd.CH--CH.dbd.CH-- thereby forming a napthyl ring;R is independently selected from (C.sub.1 -C.sub.12)alkyl and halo(C.sub.1 -C.sub.12)alkyl;R.sub.1 is independently selected from (C.sub.1 -C.sub.12)alkyl, (C.sub.2 -C.sub.8)alkenyl and aryl;R.sub.2 is independently selected from hydrogen, (C.sub.1 -C.sub.12)alkyl (C.sub.1 -C.sub.12)alkoxy, halo(C.sub.1 -C.sub.12)alkyl, halo(C.sub.1 -C.sub.12)alkoxy, hydroxy(C.sub.1 -C.sub.12)alkyl, (C.sub.1 -C.sub.12)alkoxy(C.sub.1 -C.sub.12)alkyl, (C.sub.1 -C.sub.12)alkoxycarbonyl(C.sub.1 -C.sub.12)alkyl, (C.sub.2 -C.sub.8)alkenyl, halo(C.sub.2 -C.sub.8)alkenyl, (C.sub.3 -C.sub.10)alkynyl, halo(C.sub.3 -C.sub.10)alkynyl, (C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkyl(C.sub.1 -C.sub.4)alkyl, epoxy(C.sub.1 -C.sub.12)alkyl, PO(OR.sub.1).sub.2 (C.sub.1 -C.sub.12)alkyl, R.sub.1 S(O).sub.2 (C.sub.1 -C.sub.12)alkyl, (R.sub.1).sub.3 Si(C.sub.1 -C.sub.12)alkyl, aryl, aryloxy(C.sub.1 -C.sub.12)alkyl, arylcarbonyl(C.sub.1 -C.sub.12)alkyl, aralkyl, arylalkenyl, heterocyclic, heterocyclic (C.sub.1 -C.sub.12)alkyl, N-morpholino(C.sub.1 -C.sub.12)alkyl, N-piperidinyl(C.sub.1 -C.sub.12)alkyl;R.sub.4, and R.sub.5 are independently selected from hydrogen, halo, (C.sub.1 -C.sub.8)alkyl, (C.sub.1 -C.sub.8)alkoxy, cyano, halo(C.sub.1 -C.sub.12)alkyl, (C.sub.2 -C.sub.8)alkenyl, (C.sub.3 -C.sub.10)alkynyl, aryl and aralkyl; andR.sub.6 is (C.sub.1 -C.sub.12) alkylenyl and (C.sub.2 -C.sub.12)alkenylenyl.
摘要翻译：具有式I的具有杀真菌性和杀虫性的化合物，其中W是n是0或1; Y是O，S，NR1或R6; 含有R 4和R 5的环键是单键或双键; X独立地选自氢，卤素，（C 1 -C 4）烷基，（C 1 -C 4）烷氧基和-HC = CH-CH = CH-，从而形成萘基环; R独立地选自（C 1 -C 12）烷基和卤代（C 1 -C 12）烷基; R 1独立地选自（C 1 -C 12）烷基，（C 2 -C 8）烯基和芳基; R2是独立选自氢，（C1-C12）烷基（C1-C12）烷氧基，卤代（C1-C12）烷基，卤代（C1-C12）烷氧基，羟基（C1-C12）烷基，（C1-C12）烷氧基（C1-C12）烷基，（C1-C12）烷氧基羰基（C1-C12）烷基，（C2-C8）烯基，卤代（C2-C8）烯基，（C3-C10）炔基，卤代（C3-C10）炔基，（C 3 -C 7）环烷基，（C 3 -C 7）环烷基（C 1 -C 4）烷基，环氧（C 1 -C 12）烷基，PO（OR 1）2（C 1 -C 12）烷基，烷基，（R1）3Si（C1-C12）烷基，芳基，芳氧基（C1-C12）烷基，芳基羰基（C1-C12）烷基，芳烷基，芳基烯基，杂环，杂环（C1-C12）烷基，N-吗啉代 -C 12）烷基，N-哌啶基（C 1 -C 12）烷基; （C 1 -C 8）烷氧基，氰基，卤代（C 1 -C 12）烷基，（C 2 -C 8）烯基，（C 3 -C 10）炔基，芳基和芳烷基; 并且R 6是（C 1 -C 12）亚烷基和（C 2 -C 12）烯基。

8. 发明授权

US5959982A Method and apparatus for adapting a time division duplex timing device for propagation delay 失效
标题翻译：用于适应传播延迟的时分双工定时装置的方法和装置
公开(公告)号：US5959982A
公开(公告)日：1999-09-28
申请号：US920756
申请日：1997-08-29
申请人： John C Federkins , Namvar Kiaie , Ronald Ross , Karl K Yick
发明人： John C Federkins , Namvar Kiaie , Ronald Ross , Karl K Yick
IPC分类号： H04J3/06 , H04J3/16
CPC分类号： H04J3/0685
摘要： A Time Division Duplex (TDD) wireless system utilizes an identical TDD IC engine in both base station and remote stations. In the base station the clock input to the TDD IC is halted once in the middle of each time slice to provide a central guard band between transmit and receive portions that determines the maximum range of the system. At the remote stations clock halts are programmed and utilized to provide guard bands to position transmit and receive portions in each time slice to accommodate propagation delay based on separation of a remote station from the base station. In a preferred embodiment the remote stations determine range to the base and a controller programs clock halts based on the range finding. In one aspect a TDD IC engine is used with a minimum fixed central guard band and a time slice of a first duration at a first clock frequency. Clock frequency is increased and the clock halted to provide increased range at the same time slice duration. The same IC engine at the remote stations is operated at the higher frequency and clock halts used to provide the same time slice duration of the base station and to space the transmit and receive portions of the time slice properly to accommodate propagation delay.
摘要翻译：时分双工（TDD）无线系统在基站和远程站中都使用相同的TDD IC引擎。在基站中，在每个时间片的中间停止向TDD IC输入的时钟一次，以在确定系统的最大范围的发送和接收部分之间提供中央保护带。在远程站处，时钟暂停被编程并用于提供保护频带以在每个时间片中定位发射和接收部分，以适应基于远程站与基站的分离的传播延迟。在优选实施例中，远程站确定到基站的范围，并且控制器程序基于距离寻找停止时钟。在一个方面，TDD IC引擎在第一时钟频率下具有最小固定中心保护频带和第一持续时间的时间片。时钟频率增加，时钟停止，以在相同时间片段持续时间提供增加的范围。在远程站处的相同的IC引擎在用于提供基站的相同时间片持续时间的较高频率和时钟暂停下操作，并适当地对时间片的发射和接收部分进行空间以适应传播延迟。

9. 发明申请

US20100168437A1 PROCESS FOR THE PREPARATION OF 2-SUBSTITUTED-5-(1-ALKYLTHIO)ALKYLPYRIDINES 审中-公开
标题翻译：制备2-取代的5-（1-烷基硫代）烷基吡啶的方法
公开(公告)号：US20100168437A1
公开(公告)日：2010-07-01
申请号：US12723042
申请日：2010-03-12
申请人： Stephen T. Heller , Ronald Ross , Nicholas M. Irvine , James M. Renga , Mark W. Zettler , Kim E. Arndt
发明人： Stephen T. Heller , Ronald Ross , Nicholas M. Irvine , James M. Renga , Mark W. Zettler , Kim E. Arndt
IPC分类号： C07D213/32
CPC分类号： C07D213/32 , C07D213/12 , C07D213/26
摘要： 2-Substituted-5-(1-alkylthio)alkylpyridines are produced efficiently and in high yield by cyclization and thioalkylation.
摘要翻译：通过环化和硫代烷基化有效产生2-取代的5-（1-烷硫基）烷基吡啶。

10. 发明申请

US20080207910A1 Process for the preparation of certain substituted sulfilimines 有权
标题翻译：制备某些取代的亚硫酰亚胺的方法
公开(公告)号：US20080207910A1
公开(公告)日：2008-08-28
申请号：US12069627
申请日：2008-02-12
申请人： David E. Podhorez , Ronald Ross , James R. McConnell
发明人： David E. Podhorez , Ronald Ross , James R. McConnell
IPC分类号： C07D211/04
CPC分类号： C07D213/34
摘要： Cyano-substituted sulfilimines are produced efficiently and in high yield from the corresponding sulfides by reaction with cyanamide and hypochlorite.
摘要翻译：氰基取代的亚硫酰亚胺通过与氰酰胺和次氯酸盐反应而从相应的硫化物中高效地产生。

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