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1. 发明申请

US20050250105A1 Multiple viral replicon culture systems 审中-公开
标题翻译：多重病毒复制子培养系统
公开(公告)号：US20050250105A1
公开(公告)日：2005-11-10
申请号：US10809226
申请日：2004-03-25
申请人： Julie Dyall , Charles Romano , Paul Olivo , Robert Roth
发明人： Julie Dyall , Charles Romano , Paul Olivo , Robert Roth
IPC分类号： A01N43/04 , A61K20060101 , A61K31/70 , C12N5/06 , C12N5/08 , C12N5/10 , C12N5/16 , C12N7/00 , C12N7/01 , C12N15/09 , C12P19/34 , C12P21/06 , C12Q1/02 , C12Q1/25 , C12Q1/68 , C12Q1/70 , C12R1/93 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： G01N33/502 , G01N33/5008 , G01N2500/10
摘要： Methods and compositions are provided for screening candidate antiviral agents using cells containing subgenomic viral replication systems such as replicons and minigenomes. The methods involve the simultaneous assay of more than one subgenomic viral replication system. Compositions useful for these methods are also provided.
摘要翻译：提供了使用含有亚基因组病毒复制系统（例如复制子和小基因组）的细胞筛选候选抗病毒剂的方法和组合物。该方法涉及同时测定多于一个亚基因组病毒复制系统。还提供了对这些方法有用的组合物。

2. 发明申请

US20050164167A1 Method of discovery and development of broad-spectrum antiviral drugs 审中-公开
标题翻译：发现和开发广谱抗病毒药物的方法
公开(公告)号：US20050164167A1
公开(公告)日：2005-07-28
申请号：US10766226
申请日：2004-01-28
申请人： Benjamin Buscher , Julie Dyall , Jennifer Jockel-Balsarotti , Andrew O'Guin , Paul Olivo , Robert Roth , Yi Zhou
发明人： Benjamin Buscher , Julie Dyall , Jennifer Jockel-Balsarotti , Andrew O'Guin , Paul Olivo , Robert Roth , Yi Zhou
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/6897
摘要： Method for identifying a broad-spectrum antiviral lead compound. Also methods for marketing and delivering a broad-spectrum antiviral compound and methods for treating patients with antiviral infections with a broad-spectrum antiviral drug are disclosed.
摘要翻译：识别广谱抗病毒铅化合物的方法。还公开了广谱抗病毒化合物的销售和递送方法以及用广谱抗病毒药物治疗患有抗病毒感染的患者的方法。

3. 发明授权

US08809344B2 Compounds, compositions, and methods for control of hepatitis C viral infections 有权
标题翻译：用于控制丙型肝炎病毒感染的化合物，组合物和方法
公开(公告)号：US08809344B2
公开(公告)日：2014-08-19
申请号：US13126619
申请日：2009-10-29
申请人： Urszula Slomczynska , Paul Olivo , Jodi Beattie , Gale Starkey , Amine Noueiry , Robert Roth
发明人： Urszula Slomczynska , Paul Olivo , Jodi Beattie , Gale Starkey , Amine Noueiry , Robert Roth
IPC分类号： A61K31/519
CPC分类号： C07D487/04
摘要： Various tetrahydropyrazolo[1,5-a]pyrimidine compounds, compositions, methods of making, and methods for the prevention and treatment of HCV infections and associated diseases are disclosed. The invention further relates to biomarkers for identification of HCV strains which are resistant to the tetrahydropyrazolo[1,5-a]pyrimidine compounds.
摘要翻译：公开了各种四氢吡唑并[1,5-a]嘧啶化合物，组合物，制备方法和预防和治疗HCV感染及相关疾病的方法。本发明还涉及用于鉴定对四氢吡唑并[1,5-a]嘧啶化合物具有抗性的HCV毒株的生物标志物。

4. 发明申请

US20110262397A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR CONTROL OF HEPATITIS C VIRAL INFECTIONS 有权
标题翻译：化合物，组合物和控制HEPATITIS C病毒感染的方法
公开(公告)号：US20110262397A1
公开(公告)日：2011-10-27
申请号：US13126619
申请日：2009-10-29
申请人： Urszula Slomczynska , Paul Olivo , Jodi Beattie , Gale Starkey , Amine Noueiry , Robert Roth
发明人： Urszula Slomczynska , Paul Olivo , Jodi Beattie , Gale Starkey , Amine Noueiry , Robert Roth
IPC分类号： A61K38/21 , A61K31/519 , A61K31/7056 , A61P31/14 , A61K31/7088 , A61K39/395 , C07H21/00 , C12Q1/70 , C07D487/04 , A61K31/713
CPC分类号： C07D487/04
摘要： Various tetrahydropyrazolo[1,5-a]pyrimidine compounds, compositions, methods of making, and methods for the prevention and treatment of HCV infections and associated diseases are disclosed. The invention further relates to biomarkers for identification of HCV strains which are resistant to the tetrahydropyrazolo[1,5-a]pyrimidine compounds.
摘要翻译：公开了各种四氢吡唑并[1,5-a]嘧啶化合物，组合物，制备方法和预防和治疗HCV感染及相关疾病的方法。本发明还涉及用于鉴定对四氢吡唑并[1,5-a]嘧啶化合物具有抗性的HCV毒株的生物标志物。

5. 发明授权

US07813288B2 Transaction detection in link based computing system 有权
标题翻译：基于链接的计算系统中的事务检测
公开(公告)号：US07813288B2
公开(公告)日：2010-10-12
申请号：US11284459
申请日：2005-11-21
申请人： Robert Roth , Bharadwaj Pudipeddi , Richard Glass , Madhu Athreya
发明人： Robert Roth , Bharadwaj Pudipeddi , Richard Glass , Madhu Athreya
IPC分类号： G01R31/08
CPC分类号： G06F11/2236
摘要： A transaction detection device is described having inputs to couple to communication lines. Each communication line to transport notification of a packet observed by a link probe within a computing system containing point-to-point links between nodes. Each of said nodes having at least one processing core. The transaction detection device also comprises logic circuitry to determine from said notifications whether a looked for transaction has occurred within said computing system.
摘要翻译：描述具有用于耦合到通信线路的输入的交易检测装置。每个通信线路在包含节点之间的点对点链路的计算系统内传送由链路探测器观察到的分组的通知。每个所述节点具有至少一个处理核。事务检测设备还包括逻辑电路，用于从所述通知确定在所述计算系统内是否发生了寻找的事务。

6. 发明授权

US07003456B2 Methods and systems of routing utterances based on confidence estimates 有权
标题翻译：基于置信估计路由话语的方法和系统
公开(公告)号：US07003456B2
公开(公告)日：2006-02-21
申请号：US09878173
申请日：2001-06-12
申请人： Laurence S. Gillick , Robert Roth , Linda Manganaro , Barbara R. Peskin , David C. Petty , Ashwin Rao
发明人： Laurence S. Gillick , Robert Roth , Linda Manganaro , Barbara R. Peskin , David C. Petty , Ashwin Rao
IPC分类号： G10L15/26
CPC分类号： G10L15/32 , G10L15/10
摘要： A computer-based method of routing a message to a system includes receiving a message, and processing the message using large-vocabulary continuous speech recognition to generate a string of text corresponding to the message. The method includes generating a confidence estimate of the string of text corresponding to the message and comparing the confidence estimate to a predetermined threshold. If the confidence estimate satisfies the predetermined threshold, the string of text is forwarded to the system. If the confidence estimate does not satisfy the predetermined threshold, the information relating to the message is forwarded to a transcriptionist. The message may include one or more utterances. Each utterance in the message may be separately or jointly processed. In this way, a confidence estimate may be generated and evaluated for each utterance or for the whole message. Information relating to each utterance may be separately or jointly forwarded based on the results of the generation and evaluation.
摘要翻译：将消息路由到系统的基于计算机的方法包括接收消息，以及使用大词汇连续语音识别处理消息以生成与消息对应的文本串。该方法包括生成对应于消息的文本串的置信估计，并将置信度估计与预定阈值进行比较。如果置信度估计满足预定阈值，那么文本串将被转发给系统。如果置信度估计不满足预定阈值，与消息相关的信息被转发给记录者。消息可以包括一个或多个话语。消息中的每个话语可以单独或联合处理。以这种方式，可以为每个话语或整个消息产生和评估置信估计。与每个话语有关的信息可以根据生成和评估的结果单独或共同转发。

7. 发明申请

US20050061372A1 Pressure regulator assembly 审中-公开
标题翻译：压力调节器总成
公开(公告)号：US20050061372A1
公开(公告)日：2005-03-24
申请号：US10932763
申请日：2004-09-02
申请人： Dennis McGrath , Partab Jeswani , Robert Roth , Philip Anderson
发明人： Dennis McGrath , Partab Jeswani , Robert Roth , Philip Anderson
IPC分类号： F16K15/04 , F16K17/04 , G05D16/10
CPC分类号： F02M69/465 , F02M69/54 , F16K15/044 , F16K17/0406 , Y10T137/7928
摘要： A pressure regulator assembly for a fluid system includes a housing having at least one cavity therein and a valve seat disposed in the at least one cavity and having an aperture extending therethrough. The pressure regulator assembly also includes a movable valve member disposed in the at least one cavity of the housing. The valve member has a closed position to engage the valve seat to prevent fluid from flowing into the at least one cavity and an open position to disengage the valve seat to allow fluid to flow into the at least one cavity. The pressure regulator assembly further includes a biasing mechanism disposed in the at least one cavity to bias the valve member toward the valve seat to close the aperture. The valve seat and the valve member and the biasing mechanism are aligned linearly along an axis of the valve housing.
摘要翻译：用于流体系统的压力调节器组件包括其中具有至少一个空腔的壳体和设置在所述至少一个空腔中并具有延伸穿过其中的孔的阀座。压力调节器组件还包括设置在壳体的至少一个空腔中的可移动阀构件。阀构件具有闭合位置以接合阀座以防止流体流入至少一个空腔中，并且打开位置以使阀座脱离以允许流体流入至少一个空腔。压力调节器组件还包括设置在至少一个空腔中的偏置机构，以将阀构件偏压到阀座以关闭孔。阀座和阀构件以及偏压机构沿着阀壳体的轴线线性对准。

8. 发明授权

US07315818B2 Error correction in speech recognition 有权
标题翻译：语音识别中的纠错
公开(公告)号：US07315818B2
公开(公告)日：2008-01-01
申请号：US11126271
申请日：2005-05-11
申请人： Daniell Stevens , Robert Roth , Joel M. Gould , Michael J. Newman , Dean Sturtevant , Charles E. Ingold , David Abrahams , Allan Gold
发明人： Daniell Stevens , Robert Roth , Joel M. Gould , Michael J. Newman , Dean Sturtevant , Charles E. Ingold , David Abrahams , Allan Gold
IPC分类号： G10L15/26
CPC分类号： G10L15/22 , G10L2015/0631
摘要： New techniques and systems may be implemented to improve error correction in speech recognition. These new techniques and systems may be implemented to correct errors in speech recognition systems may be used in a standard desktop environment, in a mobile environment, or in any other type of environment that can receive and/or present recognized speech.
摘要翻译：可以实现新的技术和系统以改善语音识别中的纠错。这些新技术和系统可以被实现以纠正语音识别系统中的错误，可以在标准桌面环境，移动环境中或可以接收和/或呈现识别语音的任何其它类型的环境中使用。

9. 发明申请

US20070168752A1 Method for detecting hang or dead lock conditions 有权
标题翻译：检测挂锁或死锁条件的方法
公开(公告)号：US20070168752A1
公开(公告)日：2007-07-19
申请号：US11284524
申请日：2005-11-21
申请人： Robert Roth
发明人： Robert Roth
IPC分类号： G06F11/00
CPC分类号： G06F11/3672
摘要： A scheme for monitoring links in a point-to-point architecture computer system is discussed. The scheme monitors labels for transactions to determine if they have been reissued within a user selected time window. A corresponding position in a register is updated to reflect the value of the transaction identifier. Subsequently, after the expiration of a counter, the corresponding position in the registers is compared to other predetermined positions in other registers to determine if the transaction identifier has been used (reissued). Otherwise, a possible hang condition might have occurred.
摘要翻译：讨论了一种用于监视点对点架构计算机系统中的链路的方案。该方案监视交易的标签，以确定它们是否已在用户选定的时间窗口内重新发行。更新寄存器中的相应位置以反映事务标识符的值。随后，在计数器到期之后，将寄存器中的相应位置与其他寄存器中的其他预定位置进行比较，以确定事务标识符是否已被使用（重新发行）。否则，可能出现挂起状况。

10. 发明申请

US20050203751A1 Error correction in speech recognition 有权
标题翻译：语音识别中的纠错
公开(公告)号：US20050203751A1
公开(公告)日：2005-09-15
申请号：US11126271
申请日：2005-05-11
申请人： Daniell Stevens , Robert Roth , Joel Gould , Michael Newman , Dean Sturtevant , Charles Ingold , David Abrahams , Allan Gold
发明人： Daniell Stevens , Robert Roth , Joel Gould , Michael Newman , Dean Sturtevant , Charles Ingold , David Abrahams , Allan Gold
IPC分类号： G10L15/22 , G10L15/00
CPC分类号： G10L15/22 , G10L2015/0631
摘要： New techniques and systems may be implemented to improve error correction in speech recognition. These new techniques and systems may be implemented to correct errors in speech recognition systems may be used in a standard desktop environment, in a mobile environment, or in any other type of environment that can receive and/or present recognized speech.
摘要翻译：可以实现新的技术和系统以改善语音识别中的纠错。这些新技术和系统可以被实现以纠正语音识别系统中的错误，可以在标准桌面环境，移动环境中或可以接收和/或呈现识别语音的任何其它类型的环境中使用。

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