专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08801922B2 Dialysis system 有权
标题翻译：透析系统
公开(公告)号：US08801922B2
公开(公告)日：2014-08-12
申请号：US12795444
申请日：2010-06-07
申请人： Julie S. Wrazel , James R. Curtis , Ladislaus Nonn , Richard B. Peterson , Hailei Wang , Robbie Ingram-Goble , Luke W. Fisher , Anna E. Garrison , M. Kevin Drost , Goran Jovanovic , Richard Todd Miller , Bruce W. Johnson , Alana Warner-Tuhy , Eric K. Anderson
发明人： Julie S. Wrazel , James R. Curtis , Ladislaus Nonn , Richard B. Peterson , Hailei Wang , Robbie Ingram-Goble , Luke W. Fisher , Anna E. Garrison , M. Kevin Drost , Goran Jovanovic , Richard Todd Miller , Bruce W. Johnson , Alana Warner-Tuhy , Eric K. Anderson
IPC分类号： B01D61/32 , B01D61/28 , B01D61/30 , A61M1/16 , A61M1/14 , C02F1/02 , C02F1/44 , C02F103/02 , F28D21/00
CPC分类号： A61M1/1686 , A61M1/14 , A61M1/16 , A61M1/1656 , A61M1/1662 , A61M1/1666 , A61M2205/0244 , B01D63/085 , B01D2313/08 , C02F1/02 , C02F1/20 , C02F1/283 , C02F1/44 , C02F1/441 , C02F1/444 , C02F9/005 , C02F2103/026 , C02F2209/03 , C02F2209/05 , C02F2303/04 , F24H1/121 , F24H9/0021 , F28D7/12 , F28D2021/005 , F28F3/08 , F28F2260/02 , Y10T29/494
摘要： A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream.
摘要翻译：透析系统包括能够过滤水流的过滤系统，能够以非分批方法净化所述水流的水净化系统，能够通过将一种或多种透析液组分与非批次过程中的水流，以及透析器系统。透析器可以是能够流体耦合到透析液流和血流的微流体透析器。

2. 发明申请

US20100326916A1 DIALYSIS SYSTEM 有权
标题翻译： DIALYSIS系统
公开(公告)号：US20100326916A1
公开(公告)日：2010-12-30
申请号：US12795444
申请日：2010-06-07
申请人： Julie Wrazel , James R. Curtis , Ladislaus Nonn , Richard B. Peterson , Hailei Wang , Robbie Ingram-Goble , Luke W. Fisher , Anna E. Garrison , M. Kevin Drost , Goran Jovanovic , Richard Todd Miller , Bruce W. Johnson , Alana Warner-Tuhy , Eric K. Anderson
发明人： Julie Wrazel , James R. Curtis , Ladislaus Nonn , Richard B. Peterson , Hailei Wang , Robbie Ingram-Goble , Luke W. Fisher , Anna E. Garrison , M. Kevin Drost , Goran Jovanovic , Richard Todd Miller , Bruce W. Johnson , Alana Warner-Tuhy , Eric K. Anderson
IPC分类号： B01D61/26 , B01D61/32 , B01D61/28
CPC分类号： A61M1/1686 , A61M1/14 , A61M1/16 , A61M1/1656 , A61M1/1662 , A61M1/1666 , A61M2205/0244 , B01D63/085 , B01D2313/08 , C02F1/02 , C02F1/20 , C02F1/283 , C02F1/44 , C02F1/441 , C02F1/444 , C02F9/005 , C02F2103/026 , C02F2209/03 , C02F2209/05 , C02F2303/04 , F24H1/121 , F24H9/0021 , F28D7/12 , F28D2021/005 , F28F3/08 , F28F2260/02 , Y10T29/494
摘要： A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream.
摘要翻译：透析系统包括能够过滤水流的过滤系统，能够以非分批方法净化所述水流的水净化系统，能够通过将一种或多种透析液组分与非批次过程中的水流，以及透析器系统。透析器可以是能够流体耦合到透析液流和血流的微流体透析器。

3. 发明申请

US20100326914A1 MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流体装置
公开(公告)号：US20100326914A1
公开(公告)日：2010-12-30
申请号：US12795371
申请日：2010-06-07
申请人： M. Kevin Drost , Goran Jovanovic , Richard Todd Miller , James R. Curtis , Bruce W. Johnson , Alana Warner-Tuhy , Eric K. Anderson , Julie S. Wrazel
发明人： M. Kevin Drost , Goran Jovanovic , Richard Todd Miller , James R. Curtis , Bruce W. Johnson , Alana Warner-Tuhy , Eric K. Anderson , Julie S. Wrazel
IPC分类号： B01D61/26 , B01D61/28
CPC分类号： B01D63/082 , A61M1/1629 , B01D63/084 , B01D2313/08 , B01D2313/10 , B01D2313/14 , B01D2313/38
摘要： The present disclosure concerns embodiments of a microfluidic transfer device. The device mitigates risk of cross contamination between working fluids and is amenable to high-volume, low-cost manufacturing techniques. The device may be configured for mass transfer, heat transfer, or both. For instance, certain disclosed embodiments incorporate semi-permeable membranes to transfer target substances from one fluid to another. Moreover, the device may incorporate both heat and mass transfer components.
摘要翻译：本公开涉及微流控转移装置的实施方案。该装置可减轻工作流体之间交叉污染的风险，并且适合大批量，低成本的制造技术。该装置可以被配置用于传质，传热或两者。例如，某些公开的实施例包括将目标物质从一种流体转移到另一种流体的半透膜。此外，该装置可以并入热传质和传质组件。

4. 发明申请

US20050074834A1 Method and system for classifying a scenario 审中-公开
标题翻译：分类场景的方法和系统
公开(公告)号：US20050074834A1
公开(公告)日：2005-04-07
申请号：US10801389
申请日：2004-03-12
申请人： Frank Chaplen , William Gerwick , Goran Jovanovic , Wojtek Kolodziej , Jim Liburdy , Phil McFadden , Brian Paul , Thomas Plant , Janine Trempy , Nicolas Roussel , Corwin Willard , Rosalyn Upson , Andrzej Pacut
发明人： Frank Chaplen , William Gerwick , Goran Jovanovic , Wojtek Kolodziej , Jim Liburdy , Phil McFadden , Brian Paul , Thomas Plant , Janine Trempy , Nicolas Roussel , Corwin Willard , Rosalyn Upson , Andrzej Pacut
IPC分类号： C12Q1/04 , G01N15/14 , G01N33/48 , G01N33/50 , G06F19/00 , G06K9/00 , G06K9/62 , G06K9/68
CPC分类号： G06K9/6292 , G01N15/1475 , G01N2015/1472 , G06K9/00127
摘要： Living cells can be used to identify or quantify bioactive conditions, including without limitation, chemicals, biological pathogens, and environmental conditions, such as pH, in samples based on changes in, for example, cell color, morphology and/or physiology. Such changes can be directly detected or detected with the aid of instrumentation. One embodiment of the method comprises exposing a system to a bioactive condition, such as a chemical agent, a biological pathogen, an environmental condition, such as pH, etc., and combinations of such conditions. The system then exhibits a response to the bioactive condition. The response of the system, or a portion thereof, to the bioactive condition is then represented, such as by digital images. The method then involves attempting to classify a scenario by database comparison. Classification can be in terms of numeric or non-numerical classifiers. Typically, the system comprises living cells. Living cells useful for practicing the method experience a detectable change in response to an interaction with a bioactive condition. A likely living cell for use with the method and apparatus of the present invention is a chromatophore. The present method has a number of uses, including classifying unknown drug candidates, classifying unknown toxins, classifying chemical warfare agents, etc. The method a can be implemented using a computer program encoding the method. Moreover, a computer-readable medium is described on which is stored a computer program having instructions for executing the method. A cytosensor apparatus also is described.
摘要翻译：活体细胞可以用于基于例如细胞颜色，形态和/或生理学的变化来鉴定或定量生物活性条件，包括但不限于化学品，生物病原体和样品中的环境条件，例如pH。可以借助于仪器直接检测或检测到这种变化。该方法的一个实施方案包括将系统暴露于生物活性状况，例如化学试剂，生物病原体，环境条件如pH等，以及这些条件的组合。然后，该系统对生物活性状况作出响应。然后，例如通过数字图像来表示系统或其一部分对生物活性状况的响应。该方法然后涉及尝试通过数据库比较对场景进行分类。分类可以是数字或非数字分类器。通常，该系统包括活细胞。可用于实践该方法的活细胞经历对与生物活性条件相互作用的响应的可检测变化。与本发明的方法和装置一起使用的可能的活细胞是染色质。本方法具有多种用途，包括分类未知药物候选物，分类未知毒素，分类化学战剂等。方法a可以使用编码该方法的计算机程序来实现。此外，描述了一种计算机可读介质，其上存储有具有用于执行该方法的指令的计算机程序。还描述了细胞传感器装置。

5. 发明授权

US07955504B1 Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use 有权
标题翻译：微流体装置，特别是包括聚合物膜的过滤装置及其制造和使用的方法
公开(公告)号：US07955504B1
公开(公告)日：2011-06-07
申请号：US11243937
申请日：2005-10-04
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
IPC分类号： B01D63/00 , B01D61/00 , C02F1/44
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis devices. Generally, such devices comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters; etc. Particular materials had to be developed for use with certain embodiments of the device disclosed herein. For example, a new composite material was made comprising nanocrystalline cellulose filler and a polysulfone polymeric material. A dialyzer comprising the composite membrane also is disclosed.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成装置的装置。通常，这样的装置包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，所述装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微加热器结合; 必须开发特定的材料以用于本文公开的装置的某些实施例。例如，制备了包含纳米晶纤维素填料和聚砜聚合物材料的新型复合材料。还公开了包含复合膜的透析器。

6. 发明申请

US20080093298A1 Mecs Diayzer 有权
公开(公告)号：US20080093298A1
公开(公告)日：2008-04-24
申请号：US11576804
申请日：2005-10-06
申请人： David Browning , James Curtis , Goran Jovanovic , Brian Paul , Sundar Atre
发明人： David Browning , James Curtis , Goran Jovanovic , Brian Paul , Sundar Atre
IPC分类号： A61M1/22 , B01D61/28
CPC分类号： A61M1/16 , A61M2205/0244 , B01D61/28 , B01D63/081 , B01D63/082 , B01D2313/08 , B01D2313/14
摘要： The present invention is related to hemodialysis, and more particularly, to a dialyser with improved efficiency of mass transfer across a dialysis membrane utilizing microchannel separation provided in accordance with embodiments of the present invention. In accordance with an embodiment, a dialyzer is provided comprising a plurality of semipermeable membrane sheets and a plurality of flow separators. The membrane sheets and flow are arranged in alternating configuration and coupled into a laminae stack defining a plurality of parallel microchannel layers. Each microchannel layer comprises a plurality of first microchannels and a plurality of second microchannels. The first and second microchannels of each microchannel layer are in fluid communication with each other via one of the plurality of membrane sheets therebetween. The MECS dialyzer is characterized as having a high surface to volume ratio and a high mass transfer coefficient.
摘要翻译：本发明涉及血液透析，更具体地说，涉及使用根据本发明的实施方案提供的利用微通道分离的透析膜的传质效率提高的透析器。根据一个实施例，提供一种透析器，其包括多个半透膜和多个分流器。膜片和流动被布置成交替配置并且耦合到限定多个平行微通道层的薄片叠层中。每个微通道层包括多个第一微通道和多个第二微通道。每个微通道层的第一和第二微通道之间通过多个膜片之一彼此流体连通。 MECS透析器的特征在于具有高的表面与体积比和高的传质系数。

7. 发明申请

US20070125489A1 Microfluidic welded devices or components thereof and method for their manufacture 审中-公开
标题翻译：微流控焊接装置或其组件及其制造方法
公开(公告)号：US20070125489A1
公开(公告)日：2007-06-07
申请号：US11517731
申请日：2006-09-08
申请人： Brian Paul , Goran Jovanovic
发明人： Brian Paul , Goran Jovanovic
IPC分类号： B32B37/00
CPC分类号： B29C66/54 , B29C65/1403 , B29C65/1412 , B29C65/1416 , B29C65/1419 , B29C65/1425 , B29C65/1635 , B29C65/1654 , B29C65/3456 , B29C65/346 , B29C65/3476 , B29C65/3488 , B29C65/3492 , B29C65/3612 , B29C65/366 , B29C65/3676 , B29C65/3684 , B29C65/48 , B29C65/524 , B29C65/526 , B29C65/8246 , B29C65/8253 , B29C66/1122 , B29C66/242 , B29C66/5412 , B29C66/71 , B29C66/727 , B29C66/73118 , B29C66/73921 , B29C66/9141 , B29C66/91631 , B29C66/919 , B29C66/934 , B29C66/93431 , B29C66/93441 , B29C66/93451 , B29K2001/00 , B29K2001/12 , B29K2069/00 , B29K2081/06 , B29L2031/14 , B29L2031/756
摘要： One embodiment of the disclosed welding process comprises providing plural heterogeneous materials, such as plural polymeric laminae, that form at least a part of a microfluidic device. Electromagnetic energy, such as laser or microwave energy, is applied to the materials for a period of time sufficient to effectively bond the heterogeneous materials together. For certain embodiments such method comprises providing plural laminae made from a first material, such as a substantially rigid material, positioned to substantially encompass at least one additional lamina made from a second, less rigid material.
摘要翻译：所公开的焊接方法的一个实施方案包括提供形成微流体装置的至少一部分的多种异质材料，例如多个聚合物层。将电磁能量，例如激光或微波能量施加到材料一段足以有效地将异质材料粘合在一起的时间段。对于某些实施例，这种方法包括提供由第一材料制成的多个层，例如基本上刚性的材料，其被定位成基本上包围由第二较不刚性的材料制成的至少一个附加层。

8. 发明授权

US08137554B2 Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use 有权
标题翻译：微流体装置，特别是包括聚合物膜的过滤装置及其制造和使用的方法
公开(公告)号：US08137554B2
公开(公告)日：2012-03-20
申请号：US13068037
申请日：2011-04-29
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
IPC分类号： B01D63/00 , B01D61/00 , C02F1/44
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis devices. Generally, such devices comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. The fluids can both be liquids, gases, or a liquid and a gas, such as may be used for gas absorption into a liquid. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters; etc. Examples of devices made according to the present invention included an oxygenator, a dialzyer, microheat exchangers, etc. Particular materials had to be developed for use with certain embodiments of the device disclosed herein. For example, a new composite material was made comprising nanocrystalline cellulose filler and a polysulfone polymeric material. A dialyzer comprising the composite membrane also is disclosed. In order to make the nanocrystalline cellulose-polymer composite, a new method was devised for making an organic dispersion of nanocrystalline cellulose. The method comprised first forming an aqueous dispersion of nanocrystalline cellulose. A mixture was then formed comprising the aqueous dispersion and an organic liquid having a boiling point higher than water. The water was then selectively removed to form a second mixture comprising the nanocrystalline cellulose and the organic liquid.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成装置的装置。通常，这样的装置包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。流体可以是液体，气体或液体和气体，例如可以用于气体吸收到液体中。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，所述装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微加热器结合; 根据本发明制造的装置的实例包括氧合器，拨动器，微热交换器等。必须开发特定的材料以用于本文公开的装置的某些实施例。例如，制备了包含纳米晶纤维素填料和聚砜聚合物材料的新型复合材料。还公开了包含复合膜的透析器。为了制备纳米晶纤维素 - 聚合物复合材料，设计了一种制备纳米晶纤维素有机分散体的新方法。该方法首先形成纳米晶体纤维素的水性分散体。然后形成包含水分散体和沸点高于水的有机液体的混合物。然后选择性地除去水以形成包含纳米晶体纤维素和有机液体的第二混合物。

9. 发明授权

US06913877B1 Methods for detecting bioactive compounds 失效
标题翻译：检测生物活性化合物的方法
公开(公告)号：US06913877B1
公开(公告)日：2005-07-05
申请号：US10024654
申请日：2001-12-17
申请人： Frank W. R. Chaplen , William H. Gerwick , Goran Jovanovic , Wojtek Kolodziej , Jim Liburdy , Phil McFadden , Brian Kevin Paul , Thomas K. Plant , Janine E. Trempy , Corwin Willard
发明人： Frank W. R. Chaplen , William H. Gerwick , Goran Jovanovic , Wojtek Kolodziej , Jim Liburdy , Phil McFadden , Brian Kevin Paul , Thomas K. Plant , Janine E. Trempy , Corwin Willard
IPC分类号： A61K9/14 , A61K35/60 , C12Q1/00 , C12Q1/02 , C12Q1/04 , G01N33/542
CPC分类号： G01N33/542 , C12Q1/04
摘要： Methods of detecting bioactive compounds include exposing compounds to one or more classes of chromatophores and measuring or sensing associated changes in one or more of the chromatophores. Representative methods permit identification and quantification of neurotransmitters, toxins, hormones, and chemical warfare agents with or without prior knowledge of the content of a sample. In some examples, chromatophores based on Betta fish are used. Cytosensor apparatus using such chromatophores include means for exposing chromatophores to a sample and optical detection systems for assessing changes in chromatophore optical properties. Compounds can be identified or quantified based on a red-green-blue or hue saturation-value representations of transmitted or reflected light or based on other characterizations of transmitted or reflected light.
摘要翻译：检测生物活性化合物的方法包括将化合物暴露于一类或多种色素，并测量或检测一种或多种色素中的相关变化。代表性的方法允许在有或没有样品内容的知识的情况下鉴定和定量神经递质，毒素，激素和化学战剂。在一些实例中，使用基于Betta鱼的色素。使用这种色素的细胞传感器装置包括用于将染色体暴露于样品的装置和用于评估染色质光学性质变化的光学检测系统。可以基于透射或反射光的红 - 绿 - 蓝或色相饱和度值表示或基于透射或反射光的其它表征来鉴定或量化化合物。

10. 发明申请

US20120074062A1 MICROFLUIDIC DEVICES, PARTICULARLY FILTRATION DEVICES COMPRISING POLYMERIC MEMBRANES, AND METHODS FOR THEIR MANUFACTURE AND USE 有权
标题翻译：微流体装置，包含聚合膜的特别过滤装置及其制造和使用方法
公开(公告)号：US20120074062A1
公开(公告)日：2012-03-29
申请号：US13292903
申请日：2011-11-09
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
IPC分类号： B01D61/00 , B01D63/00
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis. Such devices generally comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters, etc. Examples of devices made according to the present invention included an oxygenator, a dialyzer, microheat exchangers, etc.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成的装置。这种装置通常包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，这些装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微量加热器等连接。根据本发明制造的装置的实例包括氧合器，透析器，微热交换器等。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式