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1. 发明申请

WO2022258724A1 SYSTEM FOR PROVIDING STIMULATION 审中-公开
公开(公告)号：WO2022258724A1
公开(公告)日：2022-12-15
申请号：PCT/EP2022/065615
申请日：2022-06-09
申请人： KONINKLIJKE PHILIPS N.V.
发明人： VAN EE, Raymond , MENA BENITO, Maria Estrella , WESTERINK, Joanne Henriette Desiree Monique , VAN DOOREN, Marieke , LEUFKENS, Timmy Robertus Maria , HUIJBERS, Willem , DENISSEN, Adrianus Johannes Maria
IPC分类号： A61N1/36 , A61B5/055 , A61B5/00
摘要： :A system and method for controlling rhythmic sensory stimulation provided to a subject with post-stroke depression, PSD, during an MRI scan. A control unit is configured to control a rhythmic sensory stimulation signal such that the signal is rhythmically synchronous to a scanning rhythm of an MRI scanner performing the MRI scan.

2. 发明申请

WO2022152710A1 MRI WAKEFULNESS MONITORING 审中-公开
公开(公告)号：WO2022152710A1
公开(公告)日：2022-07-21
申请号：PCT/EP2022/050470
申请日：2022-01-12
申请人： KONINKLIJKE PHILIPS N.V.
发明人： VAN EE, Raymond , WESTERINK, Joanne Henriëtte Desirée Monique , LEUFKENS, Timmy Robertus Maria , HUIJBERS, Willem , MENA BENITO, Maria Estrella , DENISSEN, Adrianus Johannes Maria
IPC分类号： A61B5/055 , A61B5/00 , A61B5/0205
摘要： The present invention relates to a method (10) for monitoring the wakefulness of an imaged subject dining an MRI examination. The method comprises acquiring (11) at least one magnetic resonance image of the subject using an MRI system (100), and determining (13) a wakefulness measure based on at least a part (I) of the acquired image or images and/or on EEG data obtained from the imaged subject during the acquisition. The method also comprises generating (14) at least one signal if the determined wakefulness measure indicates that the subject has fallen asleep, has woken up and/or is predicted to transition from an wake to a sleep state and/or vice versa. The signal is generated during the acquisition (11) and/or before removing the subject from the MRI system. Further aspects of the invention relate to computer program products, computer systems and MRI systems.

3. 发明申请

WO2022078837A1 SYSTEM AND METHOD FOR PERSONALIZATION OF SLEEP RESTRICTION THERAPY 审中-公开
公开(公告)号：WO2022078837A1
公开(公告)日：2022-04-21
申请号：PCT/EP2021/077552
申请日：2021-10-06
申请人： KONINKLIJKE PHILIPS N.V.
发明人： WESTERINK, Joanne, Henriëtte, Desirée, Monique , MENA BENITO, Maria, Estrella , LEUFKENS, Timmy, Robertus, Maria , VAN EE, Raymond , PFUNDTNER, Stefan , WEIJSEN, Tim, Elisabeth, Joseph
IPC分类号： G16H20/10 , G16H20/70
摘要： A system for guiding sleep restriction therapy is based on sleep data as well as medication data for a subject for a plurality of nightly sleep sessions. The sleep data and the medication data are processed to derive a target in-bed duration and to derive a target medication dose. A sleep restriction and medication recommendation are then output based on the target in-bed duration and the target medication dose. This system implements an 5 improved sleep restriction therapy method that not only promotes the usual gradual increase of the allowed sleeping window, but also enables implementation of a gradual decrease of sleeping medication, which is beneficial for therapy adherence.

4. 发明申请

WO2021156488A1 A BREATHING GUIDANCE SYSTEM AND A MAGNETIC RESONANCE IMAGING SYSTEM USING THE BREATHING GUIDANCE SYSTEM 审中-公开
公开(公告)号：WO2021156488A1
公开(公告)日：2021-08-12
申请号：PCT/EP2021/052882
申请日：2021-02-05
申请人： KONINKLIJKE PHILIPS N.V.
发明人： VAN EE, Raymond , LEUFKENS, Timmy, Robertus, Maria , WESTERINK, Joanne, Henriëtte, Desirée, Monique , MATTERS, Marco , DENISSEN, Adrianus, Johannes, Maria , HUIJBERS, Willem
IPC分类号： A61B5/055 , A61B5/08 , G01R33/28 , G01R33/385 , G01R33/567
摘要： A breathing guidance system is provided for guiding the breathing of a user during a magnetic resonance imaging procedure. A target breathing rate is determined for the user which is in synchronism with the sounds, such as clicking sounds, generated by the MRI scanner. In this way, an improved signal to noise ratio is obtained for the scanned image by controlling the breathing of the user to be regular.

5. 发明申请

WO2020069948A1 BREATHING ADAPTATION SYSTEM AND METHOD FOR INFLUENCING A BREATHING PARAMETER 审中-公开
公开(公告)号：WO2020069948A1
公开(公告)日：2020-04-09
申请号：PCT/EP2019/075958
申请日：2019-09-26
申请人： KONINKLIJKE PHILIPS N.V.
发明人： HOUBRAKEN, Mara , VAN EE, Raymond , LASCHET, Cliff, Johannes, Robert, Hubertina , TIMMERS, Iris , COPPOLA, Giuseppe , BERGEVOET, Bas, Arnold, Jan
IPC分类号： A61B5/00 , A61B5/055 , A63B23/18
摘要： It is an object of the invention to improve a user's breathing for a specific application (e.g. diagnostic imaging, falling asleep improvement (shortening sleep onset), delivery, tinnitus control therapy, CORD, blood pressure control). This object is achieved by a breathing adaptation system configured for influencing a breathing parameter of a user's breathing pattern in order to meet a goal of decreasing or increasing the influenced breathing parameter to a certain extent in a user specific manner. The breathing adaptation system comprises a sensor, configured for monitoring a current value of the influenced breathing parameter of the user. The breathing adaptation system further comprises a feedback unit configured for providing feedback to the user about a preferred value of the influenced breathing parameter, wherein the preferred value is different from the current value of the influenced breathing parameter (310). The breathing adaptation system further comprises a control unit, comprising program code means for determining the preferred value of the influenced breathing parameter in a user specific manner by means of an intelligent agent, wherein the control unit is implemented such that the intelligent agent is rewarded (330) by means of a reward function after performing the determination of the preferred value (320) of the influenced breathing parameter, wherein the reward function is such that it balances the reward for obtaining the goal and the ability of the user to breathe according to a breathing pattern having the preferred value for the influenced breathing parameter.

6. 发明申请

WO2015028479A1 STIMULATING SYSTEM WITH VESTIBULAR-TACTILE AND AUDITORY STIMULATION 审中-公开
标题翻译：刺激系统与VESTIBULAR-TACTILE和审计刺激
公开(公告)号：WO2015028479A1
公开(公告)日：2015-03-05
申请号：PCT/EP2014/068109
申请日：2014-08-27
申请人： KONINKLIJKE PHILIPS N.V.
发明人： VAN EE, Raymond , AARTS, Ronaldus Maria , MENA BENITO, Maria Estrella , VOSSEN, Franciscus Jacobus
IPC分类号： H04R25/00 , A61M21/02 , H04R1/02
CPC分类号： H04R25/75 , H04R1/028 , H04R2201/023
摘要： A stimulation system with a stimulator device, e.g. comprising an inflatable/deflatable pillow, arranged to engage with a person's head in order to generate rocking movements of the person's head in a manner stimulating the person's vestibular system, e.g. side-to-side rolls of the person's head. A control system controls the stimulator device in accordance with an auditory input to the person. Preferably, the control system serves to rhythmically synchronize the auditory input and the rocking head movements, e.g. to have the same repetition frequency of between 1/30 Hz and 2 Hz, e.g. 1/10 Hz. The combined synchronous audio and vestibular-tactile stimulation has been shown effective in reducing blood pressure,distracting tinnitus patients form their discomfort, and to help them to fall asleep. The auditory input may be a repeated sound signal provided by headphones to the person, e.g. a recording of breaking sea waves, singing birds etc., with a dominating audible feature having a perioditicy aligned with the head movements.
摘要翻译：具有刺激器装置的刺激系统，例如。包括充气/可放气的枕头，其布置成与人的头部接合，以便以刺激人的前庭系统的方式产生人的头部的摇摆运动，例如，人的头部的侧面卷。控制系统根据对人的听觉输入来控制刺激器装置。优选地，控制系统用于有节奏地同步听觉输入和摇头动作，例如，具有在1/30Hz和2Hz之间的相同重复频率，例如。 1/10 Hz。已经显示组合的同步音频和前庭触觉刺激有效降低血压，分心耳鸣患者形成不适，并帮助他们入睡。听觉输入可以是由耳机向人提供的重复声音信号，例如，以海浪，唱歌鸟等为主题的录音，具有与头部动作一致的周期性声音特征。

7. 发明申请

WO2023041593A1 ADAPTIVE TESTING FOR IMPULSE CONTROL 审中-公开
公开(公告)号：WO2023041593A1
公开(公告)日：2023-03-23
申请号：PCT/EP2022/075547
申请日：2022-09-14
申请人： KONINKLIJKE PHILIPS N.V.
发明人： VAN DOOREN, Marieke , HUIJBERS, Willem , VAN EE, Raymond , DENISSEN, Adrianus Johannes Maria , MENA BENITO, Maria Estrella , LAMERICHS, Rudolf Mathias Johannes Nicolaas
IPC分类号： A61B5/16 , A61B5/00 , A61B5/055 , G16H20/70 , A61B5/291 , A61B5/369
摘要： A device for adapting testing parameters of a test, wherein the test comprises presenting congruent stimuli and incongruent stimuli to a subject. The device comprises a processor configured to obtain brain activity data corresponding to the brain activity of the subject responding to stimuli and adapt at least one testing parameter of the test based on the brain activity data.

8. 发明申请

WO2022128574A1 NEURAL ACTIVITY CONTROLLED VIRTUAL REALITY SYSTEM 审中-公开
公开(公告)号：WO2022128574A1
公开(公告)日：2022-06-23
申请号：PCT/EP2021/084417
申请日：2021-12-06
申请人： KONINKLIJKE PHILIPS N.V.
发明人： VAN DOOREN, Marieke , LEUFKENS, Timmy, Robertus, Maria , VAN EE, Raymond , JOHNSON, Mark, Thomas , MENA BENITO, Maria, Estrella , HUIJBERS, Willem
IPC分类号： G16H20/70 , A61B5/16 , G16H40/20
摘要： Disclosed herein is a medical instrument (100, 300) comprising an activity measurement system (110, 301, 302) configured for measuring brain activity data (136) from a subject (102), a memory (120) storing machine executable instructions (130) and storing a simulation model (132), wherein the simulation model is configured to generating simulation data (134), wherein the simulation model is configured for modifying the simulation data using a model parameter (140), a virtual reality system (106, 106', 106'', 106''', 106'''') configured for rendering the simulation data; and a computational system (114) for controlling the medical instrument. Execution of the machine executable instructions causes the computational system to set (200) the model parameter to an initial value (142). Execution of the machine executable instructions further causes the computational system to repeatedly: generate (202) the simulation data using the simulation model; render (204) the simulation data using the virtual reality system; measure (206) the brain activity data using the activity measurement system; calculate (208) a neural activity metric (138) descriptive of neural activity of the subject from the brain activity data; increase (210) the model parameter to adjust the simulation model if the neural activity metric is below a first predetermined value (144); and decrease (212) the model parameter to adjust the simulation model if the neural activity metric is above a second predetermined value (146).

9. 发明申请

WO2022117395A1 METHOD AND SYSTEM FOR PERSONALIZED ATTENTION BIAS MODIFICATION TREATMENT BY MEANS OF NEUROFEEDBACK MONITORING 审中-公开
公开(公告)号：WO2022117395A1
公开(公告)日：2022-06-09
申请号：PCT/EP2021/082587
申请日：2021-11-23
申请人： KONINKLIJKE PHILIPS N.V.
发明人： VAN DOOREN, Marieke , LEUFKENS, Timmy, Robertus, Maria , VAN EE, Raymond , LAMERICHS, Rudolf, Mathias, Johannes, Nicolaas , MATTERS, Marco , MENA BENITO, Maria, Estrella , HUIJBERS, Willem , WESTERINK, Joanne, Henriëtte, Desirée, Monique , DENISSEN, Adrianus, Johannes, Maria
IPC分类号： G16H20/70 , A61B5/377
摘要： The present invention relates to attention bias modification treatment. In order to improve the treatment effect, an ABM system is proposed with a neural brain response monitoring device, such as functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), and/or electroencephalography (EEG), to provide real-time information regarding neural brain responses in order to personalize and optimize the ABM treatment.

10. 发明申请

WO2022096540A1 DEEP BRAIN PATH PLANNING USING AUGMENTED REALITY 审中-公开
公开(公告)号：WO2022096540A1
公开(公告)日：2022-05-12
申请号：PCT/EP2021/080568
申请日：2021-11-04
申请人： KONINKLIJKE PHILIPS N.V.
发明人： DENISSEN, Adrianus, Johannes, Maria , VAN EE, Raymond , LAMERICHS, Rudolf, Mathias, Johannes, Nicolaas , HUIJSKENS, Jean-Marc , LEUFKENS, Timmy, Robertus, Maria
IPC分类号： A61B34/10 , G02B27/01 , A61B34/20 , A61N5/10
摘要： Disclosed herein is a medical system (200, 300) comprising an augmented reality system (204) configured for rendering virtual objects within a visual three-dimensional field of view of an operator (214). Execution of machine executable instructions (230) causes the computational system to: receive (400) segmented medical imaging data (100, 232) descriptive of a continuous volume of a subject (210) comprising at least a portion of a brain (102) of the subject and a cranial surface (106) of the subject; control (402) the augmented reality system to determine a registration (234) between the subject and the segmented medical imaging data; receive (404) a target location (104) within the at least a portion of the brain; discretize (406) the cranial surface to define multiple entry locations (108); determine (408) a straight path (110) for each of the multiple entry locations that extends to the target location; assign (410) a path score (238) to the straight path for each of the multiple entry locations using the segmented medical imaging data; calculate (412) a three-dimensional path score surface defined by the cranial surface and is descriptive of the path score of each of the multiple entry locations; and render (414) the three-dimensional path score surface using the augmented reality system, wherein the rendered three-dimensional path score surface is positioned in the visual three-dimensional field of view of the operator using the registration.

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