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1. 发明授权

US09238150B2 Optical tissue interface method and apparatus for stimulating cells 有权
标题翻译：用于刺激细胞的光学组织界面方法和装置
公开(公告)号：US09238150B2
公开(公告)日：2016-01-19
申请号：US12185624
申请日：2008-08-04
申请人： Karl Deisseroth , Alexander Aravanis , Feng Zhang , M. Bret Schneider , Jaimie M. Henderson
发明人： Karl Deisseroth , Alexander Aravanis , Feng Zhang , M. Bret Schneider , Jaimie M. Henderson
IPC分类号： A61K50/00 , A61N5/06 , A61K48/00
CPC分类号： A61N5/0622 , A61K36/05 , A61K38/16 , A61K41/0057 , A61K48/005 , A61K48/0058 , A61K48/0083 , A61N5/0601 , A61N5/062 , A61N2005/063 , A61N2005/0651 , C12N7/00 , C12N2710/10043 , C12N2710/16643 , G06F19/00
摘要： In one example, a system electrically stimulates target cells of a living animal using an elongated structure, a modulation circuit and a light pathway such as provided by an optical fiber arrangement. The elongated structure is for insertion into a narrow passageway in the animal such that an end of the elongated structure is sufficiently near the target cells to deliver stimulation thereto. The modulation circuit is for modulating the target cells while the elongated structure is in the narrow passageway, where the modulation circuit is adapted to deliver viral vectors through the elongated structure for expressing light responsive proteins in the target cells. The light pathway is used for stimulating the target cells by delivering light to the light-responsive proteins in the target cells.
摘要翻译：在一个实例中，系统使用由光纤布置提供的细长结构，调制电路和光通路电刺激活动物体的靶细胞。细长结构用于插入到动物中的狭窄通道中，使得细长结构的端部足够靠近靶细胞以向其施加刺激。调制电路用于在细长结构处于窄通道中时调制靶细胞，其中调制电路适于通过细长结构递送病毒载体，用于在靶细胞中表达光响应蛋白。光通路用于通过将光传递到靶细胞中的光响应蛋白来刺激靶细胞。

2. 发明申请

US20090099038A1 CELL LINE, SYSTEM AND METHOD FOR OPTICAL-BASED SCREENING OF ION-CHANNEL MODULATORS 有权
标题翻译：细胞线，系统和方法用于离子通道调制器的光学筛选
公开(公告)号：US20090099038A1
公开(公告)日：2009-04-16
申请号：US12187927
申请日：2008-08-07
申请人： Karl Deisseroth , Feng Zhang , Viviana Gradinaru , M. Bret Schneider
发明人： Karl Deisseroth , Feng Zhang , Viviana Gradinaru , M. Bret Schneider
IPC分类号： C40B30/10 , C12N5/06 , C12M1/00 , C40B60/12 , C12Q1/02
CPC分类号： G01N33/502 , A61N5/0622 , B01J2219/00315 , B01J2219/00495 , B01J2219/00702 , C40B60/12 , G01N33/5008 , G01N33/6872
摘要： A variety of applications, systems, methods and constructs are implemented for use in connection with screening of ion-channel modulators. Consistent with one such system, drug candidates are screened to identify their effects on cell membrane ion channels and pumps. The system includes screening cells having light responsive membrane ion switches, voltage-gated ion switches and fluorescence producing voltage sensors. A chemical delivery device introduces the drug candidates to be screened. An optical delivery device activates the light responsive ion switches. An optical sensor monitors fluorescence produced by the voltage sensors. A processor processes data received from the optical sensor. A memory stores the data received from the optical sensor.
摘要翻译：实现了各种应用，系统，方法和结构，用于与离子通道调制器的筛选相结合。与一个这样的系统一致，筛选候选药物以鉴定其对细胞膜离子通道和泵的影响。该系统包括筛选具有光响应性膜离子开关，电压门控离子开关和荧光产生电压传感器的电池。化学品输送装置引入待筛选的候选药物。光学传递装置激活光响应离子开关。光学传感器监测由电压传感器产生的荧光。处理器处理从光学传感器接收的数据。存储器存储从光学传感器接收的数据。

3. 发明授权

US09274099B2 Screening test drugs to identify their effects on cell membrane voltage-gated ion channel 有权
标题翻译：筛选试验药物，以鉴别其对细胞膜电压门控离子通道的影响
公开(公告)号：US09274099B2
公开(公告)日：2016-03-01
申请号：US12187927
申请日：2008-08-07
申请人： Karl Deisseroth , Feng Zhang , Viviana Gradinaru , M. Bret Schneider
发明人： Karl Deisseroth , Feng Zhang , Viviana Gradinaru , M. Bret Schneider
IPC分类号： A61N5/06 , G01N33/50 , C40B60/12 , G01N33/68
CPC分类号： G01N33/502 , A61N5/0622 , B01J2219/00315 , B01J2219/00495 , B01J2219/00702 , C40B60/12 , G01N33/5008 , G01N33/6872
摘要： A variety of applications, systems, methods and constructs are implemented for use in connection with screening of ion-channel modulators. Consistent with one such system, drug candidates are screened to identify their effects on cell membrane ion channels and pumps. The system includes screening cells having light responsive membrane ion switches, voltage-gated ion switches and fluorescence producing voltage sensors. A chemical delivery device introduces the drug candidates to be screened. An optical delivery device activates the light responsive ion switches. An optical sensor monitors fluorescence produced by the voltage sensors. A processor processes data received from the optical sensor. A memory stores the data received from the optical sensor.
摘要翻译：实现了各种应用，系统，方法和结构，用于与离子通道调制器的筛选相结合。与一个这样的系统一致，筛选候选药物以鉴定其对细胞膜离子通道和泵的影响。该系统包括筛选具有光响应性膜离子开关，电压门控离子开关和荧光产生电压传感器的电池。化学品输送装置引入待筛选的候选药物。光学传递装置激活光响应离子开关。光学传感器监测由电压传感器产生的荧光。处理器处理从光学传感器接收的数据。存储器存储从光学传感器接收的数据。

4. 发明申请

US20100190229A1 SYSTEM FOR OPTICAL STIMULATION OF TARGET CELLS 审中-公开
标题翻译：目标细胞光刺激系统
公开(公告)号：US20100190229A1
公开(公告)日：2010-07-29
申请号：US12522528
申请日：2008-01-09
申请人： Feng Zhang , Karl Deisseroth , David J. Mishelevich , M. Bret Schneider
发明人： Feng Zhang , Karl Deisseroth , David J. Mishelevich , M. Bret Schneider
IPC分类号： C12N13/00 , C12N5/079
CPC分类号： A61N5/0622 , A61K41/0019 , A61K48/005 , A61K48/0058 , A61K48/0083 , A61N5/0601 , A61N5/062 , A61N2005/0651
摘要： Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one example, embodiments involve methods for stimulating target cells using a photosensitive protein that allows the target cells to be stimulated in response to light. In another specific example embodiment, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo. Other aspects and embodiments are directed to systems and methods for screening chemicals based screening chemicals to identify their effects on cell membrane ion channels and pumps, and to systems and methods for controlling an action potential of neuron (e.g., in vivo and in vitro environments).
摘要翻译：使用光（例如，体内）使用各种方法和装置来实现靶细胞的刺激。在一个实例中，实施方案涉及使用允许靶细胞响应于光而被刺激的光敏蛋白刺激靶细胞的方法。在另一具体示例性实施方案中，使用可植入装置刺激靶细胞。该装置包括用于产生光和生物部分的电光产生装置。生物部分具有通过在体内刺激靶细胞来响应所产生的光的感光生物分子结构。其他方面和实施方案涉及用于筛选基于化学品的筛选化学品以识别其对细胞膜离子通道和泵的影响的系统和方法，以及用于控制神经元的动作电位（例如，体内和体外环境）的系统和方法，。

5. 发明授权

US10052497B2 System for optical stimulation of target cells 有权
公开(公告)号：US10052497B2
公开(公告)日：2018-08-21
申请号：US12522528
申请日：2008-01-09
申请人： Karl Deisseroth , Feng Zhang , David J. Mishelevich , M. Bret Schneider
发明人： Karl Deisseroth , Feng Zhang , David J. Mishelevich , M. Bret Schneider
IPC分类号： C07K14/00 , A61K48/00 , C12N15/86 , C07K4/04 , C07K14/215 , C07K14/195 , A61N5/06 , A61K41/00
CPC分类号： A61N5/0622 , A61K41/0019 , A61K48/005 , A61K48/0058 , A61K48/0083 , A61N5/0601 , A61N5/062 , A61N2005/0651
摘要： Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one example, embodiments involve methods for stimulating target cells using a photosensitive protein that allows the target cells to be stimulated in response to light. In another specific example embodiment, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo. Other aspects and embodiments are directed to systems and methods for screening chemicals based screening chemicals to identify their effects on cell membrane ion channels and pumps, and to systems and methods for controlling an action potential of neuron (e.g., in in vivo and in vitro environments).

6. 发明授权

US10711242B2 Apparatus and methods for controlling cellular development 有权
公开(公告)号：US10711242B2
公开(公告)日：2020-07-14
申请号：US12997140
申请日：2009-06-17
申请人： Karl Deisseroth , Albrecht Stroh , M. Bret Schneider , Raag D. Airan
发明人： Karl Deisseroth , Albrecht Stroh , M. Bret Schneider , Raag D. Airan
IPC分类号： C12N13/00 , C12N5/0735 , C12N5/0793 , A61N5/06 , C12M1/00 , C12N15/86
摘要： According to one aspect and example, a method for facilitating cellular interactions in biological tissue provides controllable activation of a selected type of stem cell among a plurality of cell types present in the tissue. The method includes various steps including the introduction of a microbial opsin into a region of the tissue that includes a selected type of stem cell, by expressing the microbial opsin in the stem cell. A light source is then introduced near the stem cell, and the light source is used to controllably activate the light source to direct pulses of illumination from the light source to the selected type of stem cell, for selectively controlling the growth and development of the stem cell in a manner that is independent of the growth and development of the other types of cells.

7. 发明授权

US08956363B2 Methods, systems and devices for optical stimulation of target cells using an optical transmission element 有权
公开(公告)号：US08956363B2
公开(公告)日：2015-02-17
申请号：US12997158
申请日：2009-06-17
申请人： M. Bret Schneider , Karl Deisseroth
发明人： M. Bret Schneider , Karl Deisseroth
IPC分类号： A61N5/06 , A61B18/18 , A61B17/00
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2018/00005 , A61B2018/00107 , A61B2018/00273 , A61B2018/00708 , A61B2018/00791 , A61B2018/2266 , A61B2018/2272 , A61B2018/2288 , A61K38/1767 , A61K48/00 , A61N5/0616 , A61N5/062 , A61N5/0622 , A61N2005/0626 , A61N2005/063 , A61N2005/0643 , A61N2005/0644 , A61N2005/0652 , A61N2005/067
摘要： Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one such device, target cells are stimulated using an implantable device. The device includes a light source for producing light from electrical power. An optical transmission element is made from a material that is substantially transparent to the light from the light source. This transmission element substantially encases the light source at a proximal end. The transmission element delivers light from the light source to a distal end. The shape and size of the transmission element facilitates implanting of the element within a patient. A fixation portion physically couples to the optical transmission element and secures the device to the patient. A heat dissipation portion removes heat from the near optical transmission element and the light source and dissipates the removed heat through the fixation portion.

8. 发明申请

US20110159562A1 APPARATUS AND METHODS FOR CONTROLLING CELLULAR DEVELOPMENT 审中-公开
标题翻译：用于控制细胞发育的装置和方法
公开(公告)号：US20110159562A1
公开(公告)日：2011-06-30
申请号：US12997140
申请日：2009-06-17
申请人： Karl Deisseroth , Albrecht Stroh , M. Bret Schneider , Raag D. Airan
发明人： Karl Deisseroth , Albrecht Stroh , M. Bret Schneider , Raag D. Airan
IPC分类号： C12N13/00
CPC分类号： C12N5/0606 , A61N5/0601 , C12M21/02 , C12N5/0619 , C12N15/86 , C12N2500/38 , C12N2501/115 , C12N2501/119 , C12N2501/385 , C12N2501/41 , C12N2501/998 , C12N2506/02 , C12N2510/00 , C12N2529/10 , C12N2535/00 , C12N2740/00043
摘要： According to one aspect and example, a method for facilitating cellular interactions in biological tissue provides controllable activation of a selected type of stem cell among a plurality of cell types present in the tissue. The method includes various steps including the introduction of a microbial opsin into a region of the tissue that includes a selected type of stem cell, by expressing the microbial opsin in the stem cell. A light source is then introduced near the stem cell, and the light source is used to controllably activate the light source to direct pulses of illumination from the light source to the selected type of stem cell, for selectively controlling the growth and development of the stem cell in a manner that is independent of the growth and development of the other types of cells.
摘要翻译：根据一个方面和实施例，促进生物组织中的细胞相互作用的方法提供组织中存在的多种细胞类型中所选类型的干细胞的可控活化。该方法包括通过在干细胞中表达微生物视蛋白来将微生物视蛋白引入到包括选定类型的干细胞的组织的区域中的各种步骤。然后在干细胞附近引入光源，并且光源用于可控制地激活光源以将来自光源的照明脉冲引导到选定类型的干细胞，用于选择性地控制茎的生长和发育细胞以独立于其他类型细胞的生长和发育的方式。

9. 发明授权

US10434327B2 Implantable optical stimulators 有权
公开(公告)号：US10434327B2
公开(公告)日：2019-10-08
申请号：US12263044
申请日：2008-10-31
申请人： Karl Deisseroth , M. Bret Schneider
发明人： Karl Deisseroth , M. Bret Schneider
IPC分类号： A61N5/06
摘要： Various systems and methods are implemented for in vivo use in a living animal. One such method involves stimulating target cells having light-responsive proteins and includes providing an elongated light-delivery structure in a narrow passageway in the animal, the elongated light-delivery structure having separately-activatable light sources located along the length of the elongated light-delivery structure. The method also includes activating less than all the light sources to deliver light to light-responsive proteins adjacent to the activated light sources along the length of the elongated light-delivery structure, thereby stimulating target cells in vivo.

10. 发明授权

US10035027B2 Device and method for ultrasonic neuromodulation via stereotactic frame based technique 有权
公开(公告)号：US10035027B2
公开(公告)日：2018-07-31
申请号：US12263026
申请日：2008-10-31
申请人： Karl Deisseroth , M. Bret Schneider
发明人： Karl Deisseroth , M. Bret Schneider
IPC分类号： A61N7/02 , A61N7/00
CPC分类号： A61N7/00 , A61N2007/0026 , A61N2007/0078 , A61N2007/0095 , A61N2007/027
摘要： One embodiment involves modifying neural transmission patterns between neural structures and/or neural regions in a noninvasive manner. In a related exemplary method, sound waves are directed toward a first targeted neural structure and characteristics of the sound waves are controlled at the first target neural structure with respect to characteristics of sound waves at the second target neural structure. In response, neural transmission patterns modified to produce the intended effect (e.g., long-term potentiation and long-term depression of the neural transmission patterns). In a related embodiment, a transducer produces the sound for stimulating the first neural structure and the second neural structure, and an electronically-based control circuit is used to control characteristics of the sound waves as described above to modify the neural transmission patterns between the first and second neural structures.

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