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1. 发明授权

US08482723B2 Optical information analyzer and optical information analysis method 有权
标题翻译：光信息分析仪和光信息分析方法
公开(公告)号：US08482723B2
公开(公告)日：2013-07-09
申请号：US13337848
申请日：2011-12-27
申请人： Ken Tsukii , Kenichi Kimura , Toru Takahashi , Jie Xu
发明人： Ken Tsukii , Kenichi Kimura , Toru Takahashi , Jie Xu
IPC分类号： G01N21/00
CPC分类号： G01N15/1434 , G01N2015/1452
摘要： An optical information analyzer (10) includes a light emitting unit (30) that emits light (excitation light) (L0) to a sample (S), a transmission light receiving unit (50) that receives transmission light (L1), which is the excitation light passing through the sample (S), and detects the received transmission light as a transmission light signal (SG1), scattered light/fluorescence receiving units (60) and (70) that are provided at a plurality of positions, receive side scattered light/fluorescence components (L2) and (L3) from the sample (S), and detect the received side scattered light/fluorescence components as scattered light/fluorescence signals (SG2) and (SG3), and an analyzing unit (90) that measures the optical information of the sample (S) on the basis of the detected scattered light/fluorescence signals (SG2) and (SG3) and the detected transmission light signal (SG1) and analyzes the sample (S) on the basis of the measured optical information.
摘要翻译：光信息分析装置（10）包括对样本（S）发光（激发光）（L0）的发光单元（30），接收透射光（L1）的透射光接收单元（50）通过样品（S）的激发光，并且检测作为透射光信号（SG1）的接收的透射光，设置在多个位置的散射光/荧光接收单元（60）和（70），接收侧检测来自样品（S）的散射光/荧光成分（L2）和（L3），并检测作为散射光/荧光信号（SG2）和（SG3）的接收侧散射光/荧光成分，以及分析单元（90）根据检测到的散射光/荧光信号（SG2）和（SG3）和检测到的透射光信号（SG1）来测量样品（S）的光学信息，并基于样品（S）测量光信息。

2. 发明授权

US09435728B2 Sample identification/sorting apparatus and sample identification/sorting method 有权
标题翻译：样品识别/分选设备和样品鉴定/分选方法
公开(公告)号：US09435728B2
公开(公告)日：2016-09-06
申请号：US13342233
申请日：2012-01-03
申请人： Ken Tsukii , Kenichi Kimura , Toru Takahashi , Jie Xu
发明人： Ken Tsukii , Kenichi Kimura , Toru Takahashi , Jie Xu
IPC分类号： B07C5/342 , G01N15/14
CPC分类号： G01N15/1459 , B01L2300/0832 , B07C5/342 , G01N15/1404 , G01N2015/1438 , G01N2015/149
摘要： A sample identification/sorting apparatus includes a sample storage portion that stores samples dispersed in a liquid, a flow cell having a flow path through which the liquid flows, and a sorting nozzle that has a flow path communicating with the flow path of the flow cell and dispenses a sorting solution including the sample, which is a target sample, to a culture plate. A difference between a flow direction of the liquid at an outlet of the sample storage portion and a flow direction of the liquid at a leading end of the sorting nozzle is less than 90 degrees.
摘要翻译：样品识别/分选装置包括存储分散在液体中的样品的样品存储部分，具有液体流过的流路的流通池，以及具有与流通池的流路连通的流路的分选喷嘴并将包含作为目标样品的样品的分选溶液分配到培养板。样品储存部分的出口处的液体的流动方向与分拣喷嘴前端的液体的流动方向之间的差小于90度。

3. 发明授权

US08345237B2 Optical information analyzing device and optical information analyzing method 有权
标题翻译：光信息分析装置及光信息分析方法
公开(公告)号：US08345237B2
公开(公告)日：2013-01-01
申请号：US13335997
申请日：2011-12-23
申请人： Ken Tsukii , Kenichi Kimura , Toru Takahashi , Jie Xu
发明人： Ken Tsukii , Kenichi Kimura , Toru Takahashi , Jie Xu
IPC分类号： G01N21/00
CPC分类号： G01N15/1434 , G01N2015/1452
摘要： An optical information analyzing device includes an irradiating unit that irradiates irradiation light to specimens, a transmitted light receiving unit that receives transmitted light and detects the transmitted light as a transmitted light signal, a scattering/fluorescent light receiving unit that receives lateral scattering light and fluorescent light and detects the lateral scattering light and the fluorescent light as a scattering/fluorescent light signal, a nozzle position adjusting mechanism, and an analyzing unit that measures the optical information on the specimen on the basis of the detected transmitted light signal and the detected scattering/fluorescent light signal and analyzes the specimen.
摘要翻译：光学信息分析装置包括：照射照射光的照射单元，接收透射光的透射光接收单元，并将透射光作为透射光信号进行检测;散射/荧光受光单元，其接收横向散射光和荧光光并且检测作为散射/荧光信号的横向散射光和荧光，喷嘴位置调整机构和分析单元，其基于检测到的透射光信号和检测到的散射来测量样品上的光学信息 /荧光灯信号并分析样品。

4. 发明授权

US08942458B2 Method for distinguishing and sorting of cells and device therefor 有权
标题翻译：用于区分和分类细胞的方法及其装置
公开(公告)号：US08942458B2
公开(公告)日：2015-01-27
申请号：US13001128
申请日：2009-06-19
申请人： Toru Takahashi , Ken Tsukii , Jie Xu
发明人： Toru Takahashi , Ken Tsukii , Jie Xu
IPC分类号： G06K9/00 , G01N15/14
CPC分类号： G01N15/147 , G01N2015/1438 , G01N2015/1493 , G01N2015/1497
摘要： A method for distinguishing and sorting cells characterized by comprising distinguishing and sorting a specific cell mass or a part of the cells in the cell mass with the use of transmitted light data reflecting the morphological characteristics of the cells such as size and shape optionally together with side-scattering light data reflecting the characteristics of the internal structure of the cells. The part of the cells in the specific cell mass as described above are at the G1 stage or at a part of the M stage in the cell cycle. A part of the cells at the G1 stage are referred to as the left bottom line in an analytical dispersion diagram of the cells wherein the abscissa indicates the transmitted light data, while a part of the cells at the M stage are referred to as the right bottom line in the analytical dispersion diagram of the cells wherein the abscissa indicates the transmitted light data.
摘要翻译：一种用于区分和分选细胞的方法，其特征在于包括使用反映细胞形态学特征的透射光数据（例如尺寸和形状）来选择性地与侧面区分和分选细胞块中的特定细胞块或细胞的一部分反映细胞内部结构特征的散射光数据。如上所述的特定细胞团中的细胞的部分在细胞周期中处于G1阶段或M阶段的一部分。在G1阶段的细胞的一部分在细胞的分析色散图中被称为左下底线，其中横坐标表示透射光数据，而M阶段的一部分细胞被称为右细胞的分析色散图中的底线，其中横坐标表示透射的光数据。

5. 发明授权

US08300225B2 Method for optical measurement and optical measurement apparatus 有权
标题翻译：光学测量方法和光学测量装置
公开(公告)号：US08300225B2
公开(公告)日：2012-10-30
申请号：US13092740
申请日：2011-04-22
申请人： Ken Tsukii , Jie Xu , Kenichi Kimura
发明人： Ken Tsukii , Jie Xu , Kenichi Kimura
IPC分类号： G01N21/00
CPC分类号： G01N21/645 , G01N15/1434 , G01N15/1459
摘要： An optical measurement apparatus can be provided, in which the sample is optically measured without loss of the illuminating light with high sensitivity. A glass plate as the transparent member 50 is placed in the interface between the end face 43 of the optical waveguide 40 guiding the illuminating light L generated by the laser light source 20 and the wall face of the capillary 30. According to the above feature, the air layer is prevented from existing in the interface between the end face 43 of the optical fiber 40 and the wall face of the capillary 30, thus the sample S can be optically measured with high sensitivity and few variability without causing the loss of the illuminating light L.
摘要翻译：可以提供光学测量装置，其中在没有损失高灵敏度的照明光的情况下光学测量样品。作为透明构件50的玻璃板被放置在引导由激光光源20产生的照明光L和毛细管30的壁面的光波导40的端面43之间的界面中。根据上述特征，防止空气层存在于光纤40的端面43与毛细管30的壁面之间的界面中，因此可以以高灵敏度和少量的变化光学测量样品S，而不会导致照射损失光L.

6. 发明申请

US20130026180A1 METHODS OF SEPARATING, IDENTIFYING AND DISPENSING SPECIMEN AND DEVICE THEREFOR, AND ANALYZING DEVICE METHOD 有权
标题翻译：分离，鉴定和分配样本及其设备的方法和分析设备方法
公开(公告)号：US20130026180A1
公开(公告)日：2013-01-31
申请号：US13561941
申请日：2012-07-30
申请人： Toru TAKAHASHI , Ken Tsukii , Jie Xu
发明人： Toru TAKAHASHI , Ken Tsukii , Jie Xu
IPC分类号： B67D7/06
CPC分类号： G01N15/1459 , B01F5/0057 , B01F11/0074 , B07C5/00 , G01N1/286 , G01N15/1427 , G01N15/1436 , G01N2015/1075 , G01N2035/1062
摘要： A specimen sorter includes a separating device to remove a specimen from a container, a detection device to identify the specimen as a target specimen or a non-target specimen, and a dispensing device to dispense the specimen. The dispensing device includes a dispensing nozzle to contact a vibration member to form liquid droplets at a front end of the dispensing nozzle and to dispense the liquid droplets, a first container to collect the liquid droplets dispensed from the dispensing nozzle that contain the target specimen, and a second container to collect the liquid droplets dispensed from the dispensing nozzle that contain the non-target specimen.
摘要翻译：样品分选机包括从容器中取出试样的分离装置，将样品识别为目标试样或非目标试样的检测装置以及分配试样的分注装置。分配装置包括分配喷嘴，其接触振动构件以在分配喷嘴的前端处形成液滴并分配液滴;第一容器，用于收集从包含目标样本的分配喷嘴分配的液滴; 以及用于收集从分配喷嘴分配的含有非目标样品的液滴的第二容器。

7. 发明授权

US07957002B2 Method for optical measurement and optical measurement apparatus 有权
标题翻译：光学测量方法和光学测量装置
公开(公告)号：US07957002B2
公开(公告)日：2011-06-07
申请号：US12403772
申请日：2009-03-13
申请人： Ken Tsukii , Jie Xu , Kenichi Kimura
发明人： Ken Tsukii , Jie Xu , Kenichi Kimura
IPC分类号： G01N21/00
CPC分类号： G01N21/645 , G01N15/1434 , G01N15/1459
摘要： An optical measurement apparatus can be provided, in which the sample is optically measured without loss of the illuminating light with high sensitivity. A glass plate as the transparent member 50 is placed in the interface between the end face 43 of the optical waveguide 40 guiding the illuminating light L generated by the laser light source 20 and the wall face of the capillary 30. According to the above feature, the air layer is prevented from existing in the interface between the end face 43 of the optical fiber 40 and the wall face of the capillary 30, thus the sample S can be optically measured with high sensitivity and few variability without causing the loss of the illuminating light L.
摘要翻译：可以提供光学测量装置，其中在没有损失高灵敏度的照明光的情况下光学测量样品。作为透明构件50的玻璃板被放置在引导由激光光源20产生的照明光L和毛细管30的壁面的光波导40的端面43之间的界面中。根据上述特征，防止空气层存在于光纤40的端面43与毛细管30的壁面之间的界面中，因此可以以高灵敏度和少量的变化光学测量样品S，而不会导致照射损失光L.

8. 发明申请

US20090021722A1 Specimen optical information recognizing device and its recognizing method 有权
标题翻译：标本光信息识别装置及其识别方法
公开(公告)号：US20090021722A1
公开(公告)日：2009-01-22
申请号：US11659132
申请日：2005-08-01
申请人： Ken Tsukii , Jie Xu , Kenichi Kimura , Satoshi Sugiyama
发明人： Ken Tsukii , Jie Xu , Kenichi Kimura , Satoshi Sugiyama
IPC分类号： G01N21/00 , G01M7/00 , G01F23/00 , A61N5/00
CPC分类号： G01N21/6452 , G01N21/253 , G01N2201/08
摘要： A specimen optical information recognizing device comprises a specimen containing section (14) containing a specimen (12) to be measured, a specimen measuring section (20) having a light source (16) for outputting light for observing the specimen (12) and a photodetecting section (18) for collecting optical information from the specimen (12), and an optical waveguide (22) for propagating light between the specimen containing section (14) and the specimen measuring section (20). The optical information on the specimen is recognized by using the measurement values acquired under at least two measurement conditions. The specimen optical information recognizing device may further comprises a measurement auxiliary liquid interposed between the end of the optical waveguide and the specimen. Further, the specimen containing section may have a feature that the longitudinal cross section is of a recessed shape, and the aperture depth of the recessed portion is greater than the aperture diameter. The specimen containing section may further have a feature that a through hole is provided at least in a part near the bottom of the specimen containing section.
摘要翻译：样本光学信息识别装置包括：样本容纳部（14），其包含待测试样本（12）;样本测量部（20），具有用于输出用于观察样本（12）的光的光源（16）;以及用于从样本（12）收集光学信息的光电检测部分（18）和用于在样本容纳部分（14）和样本测量部分（20）之间传播光的光波导（22）。通过使用在至少两个测量条件下获取的测量值来识别样品上的光学信息。样本光学信息识别装置还可以包括插入在光波导的端部和样本之间的测量辅助液体。此外，试样容纳部可以具有纵向截面为凹状的特征，凹部的开口深度大于孔径。样品容纳部还可以具有至少在样本容纳部的底部附近的部分设置通孔的特征。

9. 发明授权

US08685710B2 Photodetector and measurement object reader 有权
标题翻译：光电检测器和测量对象读取器
公开(公告)号：US08685710B2
公开(公告)日：2014-04-01
申请号：US12187872
申请日：2008-08-07
申请人： Kenichi Kimura , Ken Tsukii , Shinichi Taguchi , Jie Xu , Motosuke Kiyohara
发明人： Kenichi Kimura , Ken Tsukii , Shinichi Taguchi , Jie Xu , Motosuke Kiyohara
IPC分类号： C12M1/34 , C12M3/00 , G02B6/00 , G01N21/00 , G01N21/01 , G01N21/64 , G01N21/66
CPC分类号： G01N21/6452 , G01N21/6428 , G01N2021/6484
摘要： A photodetector detects fluorescence emitted from a sample placed on a substrate of a DNA chip. There is an irradiation optical system for guiding irradiation light by a first optical waveguide, gathering the irradiation light by a first lens and irradiating the sample. A reception optical system gathers fluorescence at an input-side end surface of a second optical waveguide by a second lens and guides the fluorescence to a measuring unit. The irradiation optical system and the reception optical system are separate light guiding paths. The reception optical system is of a confocal optical system in which a focal point on the sample is identical to a focal point at the input-side end surface of the second optical waveguide of the reception optical system.
摘要翻译：光电检测器检测从放置在DNA芯片的基底上的样品发出的荧光。存在用于通过第一光波导引导照射光的照射光学系统，通过第一透镜聚集照射光并照射样品。接收光学系统通过第二透镜在第二光波导的输入侧端面收集荧光，并将荧光引导到测量单元。照射光学系统和接收光学系统是分开的光导路径。接收光学系统是共焦光学系统，其中样本上的焦点与接收光学系统的第二光波导的输入侧端面处的焦点相同。

10. 发明授权

US07999929B2 Specimen optical information recognizing device and its recognizing method 有权
标题翻译：标本光信息识别装置及其识别方法
公开(公告)号：US07999929B2
公开(公告)日：2011-08-16
申请号：US11659132
申请日：2005-08-01
申请人： Ken Tsukii , Jie Xu , Kenichi Kimura , Satoshi Sugiyama
发明人： Ken Tsukii , Jie Xu , Kenichi Kimura , Satoshi Sugiyama
IPC分类号： G01N21/00
CPC分类号： G01N21/6452 , G01N21/253 , G01N2201/08
摘要： A specimen optical information recognizing device includes a specimen containing section containing a specimen to be measured, a specimen measuring section having a light source for outputting light for observing the specimen, a photodetecting section for collecting optical information from the specimen, and an optical waveguide for propagating light between the specimen containing and the specimen measuring sections. The optical information on the specimen may be recognized by measuring values under at least two measurement conditions. The specimen optical information recognizing device includes a measurement auxiliary liquid interposed between the end of the optical waveguide and the specimen. A longitudinal cross section of the specimen containing section may be of a recessed shape, and the aperture depth of the recessed portion may be greater than the aperture diameter. A through hole may be provided at least in a part near the bottom of the specimen containing section.
摘要翻译：样本光学信息识别装置包括：包含待测试样本的检体容纳部，具有用于输出用于观察样本的光的光源的检体测定部;检体的光信息的光检测部;光检测部在载体和样品测量部分之间传播光。可以通过在至少两个测量条件下测量值来识别样品上的光学信息。样本光学信息识别装置包括介于光波导的端部和样本之间的测量辅助液体。试样容纳部的纵截面可以是凹形，凹部的开口深度可以大于孔直径。至少在样本容纳部的底部附近的部分设置通孔。

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