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1. 发明专利

JP2005289951A Lipase inhibitor comprising component of eucommia ulmoides leaf 有权
标题翻译：脂肪酶抑制剂包含欧洲乳杆菌叶子的组分
公开(公告)号：JP2005289951A
公开(公告)日：2005-10-20
申请号：JP2004130474
申请日：2004-03-31
申请人： Kobayashi Pharmaceut Co Ltd , 小林製薬株式会社
发明人： TANABE KAZUYO , HIRATA TETSUYA
IPC分类号： A23L2/52 , A23L1/30 , A61K36/18 , A61K36/46 , A61P3/06 , A61P43/00 , C12N9/99 , A61K35/78
CPC分类号： A61K36/46 , A23L33/105
摘要： PROBLEM TO BE SOLVED: To provide an effective means for preventing and treating diseases caused by lipase activity and to obtain a lipase inhibitor, fat absorption inhibitor, fat accumulation inhibitor, medicine composition, food, beverage and cosmetic to be the treatment means. SOLUTION: This lipase inhibitor comprises crushed Eucommia ulmoides leaves or their water extract. The medicine composition, the food, the beverage, the cosmetic, and the like, have lipase inhibitory effect. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供预防和治疗由脂肪酶活性引起的疾病的有效手段，并获得作为治疗手段的脂肪酶抑制剂，脂肪吸收抑制剂，脂肪蓄积抑制剂，药物组合物，食品，饮料和化妆品。
解决方案：该脂肪酶抑制剂包括粉碎的杜仲叶或其水提取物。药物组合物，食品，饮料，化妆品等具有脂肪酶抑制作用。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2007238456A Fractionated material of water extract of leaf of eucommia ulmoides oliver and antiobestic agent containing the same 审中-公开
标题翻译： EUCOMMIA ULMOIDES OLIVER和含有其的抗菌剂水分提取物的分离物质
公开(公告)号：JP2007238456A
公开(公告)日：2007-09-20
申请号：JP2006058734
申请日：2006-03-03
申请人： Kobayashi Pharmaceut Co Ltd , 小林製薬株式会社
发明人： HIRATA TETSUYA
IPC分类号： A61K36/18 , A23F3/18 , A23F3/22 , A23F3/32 , A23L1/30 , A23L2/38 , A23L2/52 , A61K9/20 , A61K31/7048 , A61K36/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P43/00 , C07H17/08
CPC分类号： A61K36/46 , A23L33/105 , A61K31/7048
摘要： PROBLEM TO BE SOLVED: To provide a fractionation method for efficiently taking out a component of leaf of Eucommia ulmoides Oliver, particularly a pharmaceutical component such as an iridoid compound and to provide a fractionated material of leaf of Eucommia ulmoides Oliver containing a specific component in high concentration and to provide a composition for oral ingestion, a medicinal composition, a food composition, a medicine and a food, each using a natural material as a raw material, which are safe also when taken in the human body over a long period because of little adverse effect. SOLUTION: The fractionated material of water extract of leaf of Eucommia ulmoides Oliver is obtained by a production method comprising steps for producing a component obtained by adsorbing a water extract of leaf of Eucommia ulmoides Oliver obtained from dried Eucommia ulmoides Oliver into a reverse phase synthetic adsorbing agent and eluting the adsorbed material with water. A medicine and a food each contains the fractionated material of water extract of leaf of Eucommia ulmoides Oliver. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种有效地取出杜仲叶片的成分的分馏方法，特别是诸如环烯醚萜类化合物的药物成分，并提供含有特异性的杜仲叶的分级分离物并且提供用于口服摄取的组合物，药物组合物，食物组合物，药物和食品，每种都使用天然材料作为原料，其在长时间摄入人体时也是安全的期间因为不利影响小。解决方案：杜仲叶片水分提取物的分馏物通过包括以下步骤的制备方法获得：制备通过将从杜仲杜仲杜仲得到的杜仲叶的水提取物吸收到反向并用水洗脱吸附的材料。药物和食物各自含有杜仲叶提取物的分级物质。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2005287469A Method for producing green eucommia ulmoides tea leaf and green powder of eucommia ulmoides leaf 有权
标题翻译：生产绿色超氧化物歧化酶的绿茶叶和绿豆粉的方法
公开(公告)号：JP2005287469A
公开(公告)日：2005-10-20
申请号：JP2004130472
申请日：2004-03-31
申请人： Kobayashi Pharmaceut Co Ltd , 小林製薬株式会社
发明人： HIRATA TETSUYA
IPC分类号： A23L2/38 , A23F3/00 , A23F3/34 , A23L19/00
CPC分类号： A23F3/00 , A23F3/34
摘要： PROBLEM TO BE SOLVED: To obtain green Eucommia ulmoides tea leaves having favorable essential qualities agreeable with taste of more consumers with respect to color and/or fragrance, green powder of Eucommia ulmoides leaves that is dispersed into water to give a dispersion as a beverage and an extracted solution of green Eucommia ulmoides tea leaves with water and a water dispersion of green powder of Eucommia ulmoides leaves having favorable essential qualities as a beverage with respect to color and/or fragrance. SOLUTION: The method for producing green Eucommia ulmoides tea leaves comprises a process for steaming raw Eucommia ulmoides leaves, a process for drying the Eucommia ulmoides leaves while stirring and/or rolling, a process for crushing the Eucommia ulmoides leaves and a process for drying the Eucommia ulmoides leaves by irradiating the Eucommia ulmoides leaves with far-infrared radiation. The method for producing green powder of Eucommia ulmoides leaves comprises making Eucommia ulmoides tea leaves into powder having 3-14 μm average diameter by a jet mill. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了获得与颜色和/或香味相关的更多消费者的味道具有良好基本质量的绿色杜仲叶茶，分散在水中的杜仲绿色粉末分散成水分散体将杜仲绿茶的饮料和提取液与水和杜仲叶绿色粉末的水分散体作为饮料相对于颜色和/或香味具有有利的基本品质。解决方案：生产杜仲杜鹃叶茶的方法包括蒸煮杜仲杜仲叶的方法，搅拌和/或滚动干燥杜仲叶的方法，破碎杜仲叶的方法和方法通过用远红外线照射杜仲叶来干燥杜仲叶。杜仲叶绿色粉末的生产方法包括使杜仲叶茶叶通过喷射磨机平均粒径为3〜14μm的粉末。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2008106008A Geniposidic acid derivative 有权
标题翻译：基因酸衍生物
公开(公告)号：JP2008106008A
公开(公告)日：2008-05-08
申请号：JP2006291553
申请日：2006-10-26
申请人： Kobayashi Pharmaceut Co Ltd , 小林製薬株式会社
发明人： HIRATA TETSUYA , KOBAYASHI TAKEO , NOHARA TOSHIHIRO , IKEDA TAKESHI , TAKAMURA CHIKA
IPC分类号： C07H17/04 , A23L1/30 , A61K31/7048 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12
摘要： PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for therapy or prophylaxis of diseases such as obesity comprising a new compound contained in a leaf of Eucommia ulmoides oliver. SOLUTION: The pharmaceutical composition comprises a compound represented by formula (I) (wherein, R 1 to R 4 and R 11 to R 14 represent each a specific substituent) or a salt thereof. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种用于治疗或预防包括杜仲叶的叶中的新化合物的肥胖症等疾病的药物组合物。解决方案：药物组合物包含由式（I）表示的化合物（其中R 1，R 2，R 3，R 4，R 11，其中R 14为每个特定取代基）或其盐。版权所有（C）2008，JPO＆INPIT

5. 发明专利

JP2008044885A Composition for oral administration for fatigue prevention and preparation for oral administration for fatigue prevention 有权
标题翻译：用于疲劳预防的口服管理组合物和用于疲劳预防的口服管理的准备
公开(公告)号：JP2008044885A
公开(公告)日：2008-02-28
申请号：JP2006221825
申请日：2006-08-16
申请人： Kobayashi Pharmaceut Co Ltd , 小林製薬株式会社
发明人： TSUKAMOTO SHINYA , HIRATA TETSUYA
IPC分类号： A61K36/896 , A61K35/74 , A61K36/25 , A61P3/02
摘要： PROBLEM TO BE SOLVED: To obtain a composition for an oral administration for fatigue prevention, having realization of sufficient fatigue prevention effect (nutritional fortification effect) on human and a preparation for an oral administration for fatigue prevention comprising the same.
SOLUTION: The composition for an oral administration for fatigue prevention synergistically increases fatigue prevention effects (nutritional fortification effects) of both black garlic and Ginseng radix by using black garlic produced by fermenting raw garlic and Ginseng radix.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：为了获得具有足够的疲劳预防效果（营养强化作用）对人体的疲劳预防的口服给药组合物和包含该组合物的用于预防疲劳的口服给药的制剂。解决方案：通过使用通过发酵生蒜和人参根产生的黑蒜，用于疲劳预防的口服给药组合物协同地增加了黑蒜和人参根的疲劳预防效果（营养强化效果）。版权所有（C）2008，JPO＆INPIT

6. 发明专利

JP2007230969A Ameliorant for metabolic syndrome 审中-公开
标题翻译：代谢代谢综合征
公开(公告)号：JP2007230969A
公开(公告)日：2007-09-13
申请号：JP2006057825
申请日：2006-03-03
申请人： Kobayashi Pharmaceut Co Ltd , 小林製薬株式会社
发明人： HIRATA TETSUYA , ANDO CHIHO
IPC分类号： A61K36/18 , A23L1/30 , A61K31/718 , A61K36/00 , A61K36/60 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12
CPC分类号： A61K36/46 , A23L33/105 , A61K31/718
摘要： PROBLEM TO BE SOLVED: To provide an ameliorant for metabolic syndrome with reduced adverse reaction and safe in daily intake over long period, having ameliorating efficacy on accumulation of visceral fat together with other risk factors, and to provide a prophylactic agent for arteriosclerosis, and to provide pharmaceuticals and foods comprising the same. SOLUTION: The invention relates to the ameliorant for metabolic syndrome and the prophylactic agent for arteriosclerosis comprising a processed product of leaves of Eucommia ulmoides oliver and a processed product of a vegetable having blood sugar reducing action. The invention relates to the pharmaceuticals and foods comprising the same. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种减少不良反应和长期摄入安全的代谢综合征的改善剂，具有改善内脏脂肪积累与其他危险因素的功效，并提供用于动脉硬化的预防剂，并提供包含其的药物和食品。解决方案：本发明涉及代谢综合征改善剂和动脉硬化预防剂，其包含杜仲叶的加工产物和具有降血糖作用的植物的加工产品。本发明涉及包含其的药物和食品。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2005289952A Deodorizer comprising eucommia ulmoides 有权
标题翻译：包含EUCOMMIA ULMOIDES的除臭剂
公开(公告)号：JP2005289952A
公开(公告)日：2005-10-20
申请号：JP2004130482
申请日：2004-03-31
申请人： Kobayashi Pharmaceut Co Ltd , 小林製薬株式会社
发明人： OKUNO YUKIKO , HIRATA TETSUYA
IPC分类号： A01K1/015 , A61K8/00 , A61K8/96 , A61K8/97 , A61L9/01 , A61Q11/00 , A61Q15/00 , B01D11/02 , A61K7/26 , A61K7/32
CPC分类号： A61Q11/00 , A61K8/97 , A61L9/01 , A61Q15/00
摘要： PROBLEM TO BE SOLVED: To obtain a deodorizer that is highly safe and has excellent deodorizing effect. SOLUTION: This deodorizer contains Eucommia ulmoides. Powder or an extract of Eucommia ulmoides is useful as a deodorizer. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：获得高度安全且具有优异除臭效果的除臭剂。
解决方案：该除臭剂含有杜仲杜仲。杜仲粉或杜仲提取物可用作除臭剂。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2005289950A Lipase inhibitor comprising water extraction component of eucommia ulmoides leaf 有权
标题翻译：包含EUCOMMIA ULMOIDES LEAF的水提取成分的脂肪酶抑制剂
公开(公告)号：JP2005289950A
公开(公告)日：2005-10-20
申请号：JP2004130473
申请日：2004-03-31
申请人： Kobayashi Pharmaceut Co Ltd , 小林製薬株式会社
发明人： TANABE KAZUYO , HIRATA TETSUYA
IPC分类号： A23L2/38 , A23L1/30 , A23L2/52 , A61K8/96 , A61K8/97 , A61K36/18 , A61K36/46 , A61P3/04 , A61P3/06 , A61P17/10 , A61P43/00 , A61Q5/02 , A61Q19/06 , C12N9/99 , A61K35/78 , A61K7/00
CPC分类号： A61K36/46 , A23L33/105 , A61K8/97 , A61K2800/782 , A61Q19/06
摘要： PROBLEM TO BE SOLVED: To provide an effective means for preventing and treating diseases caused by lipase activity and to obtain a lipase inhibitor, fat absorption inhibitor, fat accumulation inhibitor, medicine composition, food, beverage and cosmetic to be the treatment means. SOLUTION: This lipase inhibitor comprises crushed Eucommia ulmoides leaves or their water extract. The medicine composition, the food, the beverage, the cosmetic, and the like, have lipase inhibitory effect. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供预防和治疗由脂肪酶活性引起的疾病的有效手段，并获得作为治疗手段的脂肪酶抑制剂，脂肪吸收抑制剂，脂肪蓄积抑制剂，药物组合物，食品，饮料和化妆品。
解决方案：该脂肪酶抑制剂包括粉碎的杜仲叶或其水提取物。药物组合物，食品，饮料，化妆品等具有脂肪酶抑制作用。版权所有（C）2006，JPO＆NCIPI

9. 发明专利

JP2007238449A Fractionated material of water extract of leaf of eucommia ulmoides oliver and antiobestic agent containing the fractionated material 有权
$Fractionated material of water extract of leaf of eucommia ulmoides oliver and antiobestic agent containing the fractionated material$
标题翻译： EUCOMMIA ULMOIDES OLIVER和含有分解材料的抗菌剂水分提取物的分离材料
公开(公告)号：JP2007238449A
公开(公告)日：2007-09-20
申请号：JP2006058657
申请日：2006-03-03
申请人： Kobayashi Pharmaceut Co Ltd , 小林製薬株式会社
发明人： HIRATA TETSUYA , ANDO CHIHO , KOBAYASHI TAKEO , NOHARA TOSHIHIRO , IKEDA TAKESHI , TAKAMURA CHIKA
IPC分类号： A61K36/18 , A23L1/30 , A61P3/04
CPC分类号： A61K31/7048 , A23L33/105 , A23V2002/00 , A23V2200/30 , A23V2200/332 , A23V2200/328 , A23V2250/21
摘要： PROBLEM TO BE SOLVED: To provide a fractionation method for efficiently taking out a component of leaf of Eucommia ulmoides Oliver, particularly a pharmaceutical component such as an iridoid compound and to provide a fractionated material of leaf of Eucommia ulmoides Oliver containing a specific component in high concentration and to provide an antiobestic agent, a composition for oral ingestion, a medicinal composition, a food composition, a medicine and a food, each using a natural material as a raw material, which are safe also when taken into the human body over a long period because of little adverse effect. SOLUTION: The fractionated material of water extract of leaf of Eucommia ulmoides Oliver is obtained by adsorbing a water extract of leaf of Eucommia ulmoides Oliver obtained from dried Eucommia ulmoides Oliver into a reverse phase synthetic adsorbing agent, washing the adsorbed material with water and carrying out elution from the adsorbed material by using 5-80 vol.% methanol aqueous solution. The medicine and food having antiobestic action each contain the fractionated material of water extract of leaf of Eucommia ulmoides Oliver. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种有效地取出杜仲叶片的成分的分馏方法，特别是诸如环烯醚萜类化合物的药物成分，并提供含有特异性的杜仲叶的分级分离物高浓度成分，提供抗生物剂，口服摄取用组合物，药物组合物，食品组合物，药物和食品，每种都使用天然材料作为原料，当被摄入人体时也是安全的身体长时间因为不利影响。解决方案：杜仲杜鹃叶提取物的分馏物通过将从杜仲杜仲杜仲得到的杜仲叶提取物吸收到反相合成吸附剂中，用水洗涤吸附材料，并用5-80体积％的甲醇水溶液进行吸附材料的洗脱。具有抗生物作用的药物和食物均含有杜仲叶提取物的分级物质。版权所有（C）2007，JPO＆INPIT

10. 发明专利

JP2012077012A Bone density increasing agent and agent for anti-menopausal syndrome 有权
标题翻译：骨密度增加抗体男性综合征的代理和代理
公开(公告)号：JP2012077012A
公开(公告)日：2012-04-19
申请号：JP2010221779
申请日：2010-09-30
申请人： Kobayashi Pharmaceutical Co Ltd , 小林製薬株式会社
发明人： FUJIKAWA TAKAHIKO , ISHIDA TORAO , CHO BUNPEI , HIRATA TETSUYA
IPC分类号： A61K36/18 , A61P5/30 , A61P9/10 , A61P9/12 , A61P13/10 , A61P15/08 , A61P15/10 , A61P15/12 , A61P19/00 , A61P19/10 , A61P25/00 , A61P25/22 , A61P25/28 , A61P27/16
摘要： PROBLEM TO BE SOLVED: To provide a new bone density increasing agent and an agent for anti-menopausal syndrome.SOLUTION: The bone density increasing agent and the agent for anti-menopausal syndrome contain dried leaves of Eucommia ulmoides oliver, and/or a leaf extract of Eucommia ulmoides oliver.

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