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1. 发明申请

US20210315984A1 COMPOSITIONS COMPRISING HERPES SIMPLEX VIRUS-I FOR USE IN METHODS OF TREATING AND PREVENTING CANCER 有权
公开(公告)号：US20210315984A1
公开(公告)日：2021-10-14
申请号：US17264420
申请日：2019-08-01
申请人： Konstantin G. Kousoulas , Vladimir N. Chouljenko , James Michael Mathis
发明人： Konstantin G. Kousoulas , Vladimir N. Chouljenko , James Michael Mathis
IPC分类号： A61K39/00 , C12N7/00
摘要： The present invention provides compositions for treating or preventing cancer and methods of using and making the compositions. The compositions comprise herpes simplex viruses comprising recombinant herpes simplex virus genomes. Further provided are recombinant herpes simplex virus genomes, viruses comprising the recombinant herpes simplex virus genomes, and cancer vaccines and other compositions comprising the viruses.

2. 发明授权

US06605287B2 Vaccines for Chlamydia psittaci infections 有权
标题翻译：鹦鹉热衣原体感染疫苗
公开(公告)号：US06605287B2
公开(公告)日：2003-08-12
申请号：US09143127
申请日：1998-08-28
申请人： Konstantin G. Kousoulas , Vladimir N. Chouljenko , Abolgasem Baghian , Thomas N. Tully, Jr.
发明人： Konstantin G. Kousoulas , Vladimir N. Chouljenko , Abolgasem Baghian , Thomas N. Tully, Jr.
IPC分类号： A61K39118
CPC分类号： C07K14/295 , A61K39/00 , A61K2039/51 , A61K2039/53 , C07K2319/00 , Y10S530/825
摘要： Vaccine compositions protective against Chlamydia psittaci infections in animals, including but not limited to humans and avian species, comprising an immunogenic amount of a C. psittaci major outer membrane protein (MOMP) polypeptide lacking regions VD1 and VD2 are provided. Nucleic acid vectors for the expression of MOMP polypeptides and MOMP polypeptide fusion proteins are disclosed. Nucleic acid vectors encoding a C. psittaci major outer membrane protein (MOMP) polypeptide lacking regions VD1 and VD2 useful for genetic, or “naked nucleic acid” vaccination are disclosed. Methods for preventing a Chlamydia psittaci infection in a subject using MOMP polypeptides, MOMP polypeptide-fusion proteins, or nucleic acid expression vectors are also provided.
摘要翻译：提供了保护动物（包括但不限于人类和禽类物种）的鹦鹉热衣原体感染的疫苗组合物，其包含免疫原性量的缺乏区域VD1和VD2的鹦鹉
鹦鹉主要外膜蛋白（MOMP）多肽。公开了用于表达MOMP多肽和MOMP多肽融合蛋白的核酸载体。公开了编码可用于遗传或“裸核酸”疫苗接种的缺乏区域VD1和VD2的鹦鹉
鹦鹉主要外膜蛋白（MOMP）多肽的核酸载体。还提供了使用MOMP多肽，MOMP多肽融合蛋白或核酸表达载体来预防鹦鹉刺精衣病感染的方法。

3. 发明授权

US07279171B2 Vaccines for Chlamydia psittaci infections 有权
标题翻译：鹦鹉热衣原体感染疫苗
公开(公告)号：US07279171B2
公开(公告)日：2007-10-09
申请号：US10638950
申请日：2003-08-11
申请人： Konstantin G. Kousoulas , Vladimir N. Chouljenko , Abolgasem Baghian , Thomas N. Tully, Jr.
发明人： Konstantin G. Kousoulas , Vladimir N. Chouljenko , Abolgasem Baghian , Thomas N. Tully, Jr.
IPC分类号： A61K39/118 , C07K14/295 , C12N15/09 , C07H21/04
CPC分类号： C07K14/295 , A61K39/00 , A61K2039/51 , A61K2039/53 , C07K2319/00 , Y10S530/825
摘要： Vaccine compositions protective against Chlamydia psittaci infections in animals, including but not limited to humans and avian species, comprising an immunogenic amount of a C. psittaci major outer membrane protein (MOMP) polypeptide lacking regions VD1 and VD2 are provided. Nucleic acid vectors for the expression of MOMP polypeptides and MOMP polypeptide fusion proteins are disclosed. Nucleic acid vectors encoding a C. psittaci major outer membrane protein (MOMP) polypeptide lacking regions VD1 and VD2 useful for genetic, or “naked nucleic acid” vaccination are disclosed. Methods for preventing a Chlamydia psittaci infection in a subject using MOMP polypeptides, MOMP polypeptide-fusion proteins, or nucleic acid expression vectors are also provided.
摘要翻译：提供了保护动物（包括但不限于人类和禽类物种）的鹦鹉热衣原体感染的疫苗组合物，其包含免疫原性量的缺乏区域VD1和VD2的鹦鹉
鹦鹉主要外膜蛋白（MOMP）多肽。公开了用于表达MOMP多肽和MOMP多肽融合蛋白的核酸载体。公开了编码可用于遗传或“裸核酸”疫苗接种的缺乏区域VD1和VD2的鹦鹉
鹦鹉主要外膜蛋白（MOMP）多肽的核酸载体。还提供了使用MOMP多肽，MOMP多肽融合蛋白或核酸表达载体来预防鹦鹉刺精衣病感染的方法。

4. 发明申请

US20100297085A1 Synthetic Herpes Simplex Viruses Type-1 for Treatment of Cancers 有权
标题翻译：合成单纯疱疹病毒1型治疗癌症
公开(公告)号：US20100297085A1
公开(公告)日：2010-11-25
申请号：US12598937
申请日：2008-05-09
申请人： Konstantin G. Kousoulas
发明人： Konstantin G. Kousoulas
IPC分类号： A61K35/76 , C12N7/00 , C12N15/63 , A61P35/00
CPC分类号： C07K14/005 , A61K35/763 , C12N7/00 , C12N2710/16622 , C12N2710/16632 , C12N2710/16662
摘要： A recombinant herpes simplex virus type-1 (HSV-1) has been constructed that carries a deletion of one of the two viral γ1 34.5 genes and other immediate early genes, which render the virus able to selectively replicate in cancer cells but not efficiently replicate in normal cells, and in which specific mutations have been introduced to enable the virus to spread among cancer cells by virus-induced fusion. Specifically, syncytial mutations have been introduced in the genes coding for glycoprotein B and glycoprotein K of the virus, enabling high replication and spread of the virus in cancer cells in the presence of substantially lower amounts of γ1 34.5 protein, which is required for optimum infectious virus produced and virus-induced cell fusion. Other known syncytial mutations could also be introduced that would render the virus able to cause extensive virus-induced cell fusion. In addition, other known mutations can be introduced to limit the spread of the virus to the nervous system. These altered viruses or the isolated bacterial chromosomes could be used to treat various cancers including breast, liver, colon, and other tissues.
摘要翻译：已经构建了重组的单纯疱疹病毒1型（HSV-1），其携带两种病毒γ134.5基因和其他立即早期基因之一的缺失，这使得该病毒能够在癌细胞中选择性复制但不能有效复制在正常细胞中，并且其中引入了特异性突变以使病毒能够通过病毒诱导的融合在癌细胞中扩散。具体来说，在编码病毒的糖蛋白B和糖蛋白K的基因中引入了合胞体突变，使得在存在显着更低量的γ134.5蛋白质的情况下能够在癌细胞中高度复制和扩散，这是最佳感染性病毒产生和病毒诱导的细胞融合。还可以引入其他已知的合胞体突变，这将使病毒能够引起广泛的病毒诱导的细胞融合。此外，可以引入其他已知的突变以限制病毒传播到神经系统。这些改变的病毒或分离的细菌染色体可用于治疗各种癌症，包括乳腺癌，肝癌，结肠癌和其他组织。

5. 发明授权

US06933286B2 Therapeutic delivery compositions and methods of use thereof 失效
标题翻译：治疗递送组合物及其使用方法
公开(公告)号：US06933286B2
公开(公告)日：2005-08-23
申请号：US09929819
申请日：2001-08-14
申请人： R. Martin Emanuele , Mark Newman , Konstantin G. Kousoulas , Hameedsulthan S. Allaudeen
发明人： R. Martin Emanuele , Mark Newman , Konstantin G. Kousoulas , Hameedsulthan S. Allaudeen
IPC分类号： A61K9/00 , A61K31/765 , A61K31/77 , A61K38/50 , A61K39/245 , A61K45/06 , A61K47/10 , A61K47/48 , A61K48/00 , C08G65/08 , C08G65/26 , C08G65/30 , A61K31/70 , C07C43/20
CPC分类号： C08G65/30 , A61K9/0019 , A61K31/765 , A61K31/77 , A61K38/50 , A61K39/12 , A61K39/245 , A61K45/06 , A61K47/10 , A61K47/56 , A61K47/60 , A61K48/00 , A61K2039/53 , A61K2039/55555 , A61K2039/6093 , C08G65/08 , C08G65/2624 , C12N2710/16634
摘要： The present invention relates to compositions and methods for treating infectious diseases and genetic disorders through gene therapy and intracellular delivery of antisense oligonucleotides or other nucleic acid sequences. In particular, compositions and methods using biologically active nononic reverse block copolymers are described. The reverse copolymers have an inner core of polyoxyethylene (POE) that is flanked on either end by polyoxpropylene (POP). The reverse block copolymers have the following formula: wherein “b” represents a number such that the molecular weight of the hydrophobe (C3H6O)b is between approximately 750 and 20,000 Daltons and “a” represents a number such that the percentage of hydrophile (C2H4O)a is between approximately 1% and 90% of the weight of the block copolymer.
摘要翻译：本发明涉及通过基因治疗和反义寡核苷酸或其他核酸序列的细胞内递送来治疗感染性疾病和遗传疾病的组合物和方法。特别地，描述了使用生物活性非诺卡氏反相嵌段共聚物的组合物和方法。反相共聚物具有聚氧乙烯（POE）的内核，其两端在聚丙烯（POP）两端。反向嵌段共聚物具有下式：其中“b”表示使疏水基（C 3 H 6 O）的分子量b < / SUB>在约750和20,000道尔顿之间，“a”表示一个数字，使得亲水性（C 2 H 3 H 4 O） SUB>占嵌段共聚物重量的约1％至90％。

6. 发明申请

US20200345836A1 VACCINES AGAINST GENITAL HERPES SIMPLEX INFECTIONS 审中-公开
公开(公告)号：US20200345836A1
公开(公告)日：2020-11-05
申请号：US16784665
申请日：2020-02-07
申请人： Konstantin G. Kousoulas
发明人： Konstantin G. Kousoulas
IPC分类号： A61K39/245 , A61K39/12 , C12N7/00
摘要： The present invention provides vaccines for treating or preventing a herpes simplex virus infection and methods of using and making the vaccine. Further provided are recombinant herpes simplex virus genomes, recombinant viruses, and immunogenic compositions.

7. 发明授权

US08586028B2 Synthetic herpes simplex viruses type-1 for treatment of cancers 有权
标题翻译： 1型合成单纯疱疹病毒治疗癌症
公开(公告)号：US08586028B2
公开(公告)日：2013-11-19
申请号：US12598937
申请日：2008-05-09
申请人： Konstantin G. Kousoulas
发明人： Konstantin G. Kousoulas
IPC分类号： A01N63/00 , C12N15/00 , C12N15/09 , C12N15/33
CPC分类号： C07K14/005 , A61K35/763 , C12N7/00 , C12N2710/16622 , C12N2710/16632 , C12N2710/16662
摘要： A recombinant herpes simplex virus type-1 (HSV-1) has been constructed that carries a deletion of one of the two viral γ1 34.5 genes and other immediate early genes, which render the virus able to selectively replicate in cancer cells but not efficiently replicate in normal cells, and in which specific mutations have been introduced to enable the virus to spread among cancer cells by virus-induced fusion. Specifically, syncytial mutations have been introduced in the genes coding for glycoprotein B and glycoprotein K of the virus, enabling high replication and spread of the virus in cancer cells in the presence of substantially lower amounts of γ1 34.5 protein, which is required for optimum infectious virus produced and virus-induced cell fusion. These altered viruses or the isolated bacterial chromosomes could be used to treat various cancers including breast, liver, colon, and other tissues.
摘要翻译：已经构建了重组型单纯疱疹病毒1型（HSV-1），其携带两种病毒γ134.5基因之一和其他即时早期基因之一的缺失，这使得该病毒能够在癌细胞中选择性复制但不能有效地复制在正常细胞中，并且其中引入了特异性突变以使病毒能够通过病毒诱导的融合在癌细胞中扩散。具体来说，在编码病毒的糖蛋白B和糖蛋白K的基因中引入合胞体突变，使得在存在显着较低量的γ134.5蛋白质的情况下能够在癌细胞中高度复制和扩散，这是最佳感染性病毒产生和病毒诱导的细胞融合。这些改变的病毒或分离的细菌染色体可用于治疗各种癌症，包括乳腺癌，肝癌，结肠癌和其他组织。

8. 发明申请

US20130202639A1 Synthetic Herpes Simplex Viruses for Treatment of Cancers 审中-公开
标题翻译：合成单纯疱疹病毒治疗癌症
公开(公告)号：US20130202639A1
公开(公告)日：2013-08-08
申请号：US13634611
申请日：2011-03-25
申请人： Konstantin G. Kousoulas , Jason D. Walker
发明人： Konstantin G. Kousoulas , Jason D. Walker
IPC分类号： C12N7/00 , A61K45/06 , A61K35/76
CPC分类号： C12N7/00 , A61K35/763 , A61K45/06 , C12N2710/16632 , C12N2710/16643 , C12N2710/16662 , A61K2300/00
摘要： New recombinant oncolytic viral vectors have been constructed based on a known herpes simplex virus-1 with a single 34.5 gene and a synctial mutation (called OncSyn (OS) virus), which was designed to be more immunogenic than the parental OS virus largely due to deletion of the viral gene viral host shutoff (vhs) gene (the “OSV” virus). In another embodiment, the OSV virus was constructed to constitutively express 15-PGDH (the “OSVP” virus), the principal enzyme responsible for degradation of PGE2. OSVP was shown to decrease both breast tumors and prostate cancer tumors in mice models. In addition, OSVP was shown to trigger substantial inflammatory cytokine production and pro mote anti-tumor immune responsiveness. These altered viruses, OSV and OSVP, can be used to treat various cancers including breast, prostate, liver, colon, and other tissues. Other exogenous genes can be added to either OSV or OSVP to improve the therapeutic response.
摘要翻译：已经基于具有单一34.5基因和合成突变（称为OncSyn（OS）病毒）的已知单纯疱疹病毒-1构建了新的重组溶瘤病毒载体，其被设计为比亲本OS病毒更具免疫原性，主要是由于病毒基因病毒宿主关闭（vhs）基因（“OSV”病毒）的删除。在另一个实施方案中，构建OSV病毒以组成型表达负责PGE2降解的主要酶的15-PGDH（“OSVP”病毒）。 OSVP显示在小鼠模型中降低乳腺肿瘤和前列腺癌肿瘤。此外，OSVP被证明可以引发大量的炎性细胞因子产生和促进抗肿瘤免疫反应。这些改变的病毒，OSV和OSVP可用于治疗各种癌症，包括乳腺癌，前列腺癌，肝癌，结肠癌和其他组织。可以将其他外源基因加入到OSV或OSVP中以改善治疗反应。

9. 发明授权

US07202225B1 Therapeutic delivery compositions and methods of use thereof 失效
标题翻译：治疗递送组合物及其使用方法
公开(公告)号：US07202225B1
公开(公告)日：2007-04-10
申请号：US09457771
申请日：1999-12-09
申请人： R. Martin Emanuele , Konstantin G. Kousoulas , Hameedsulthan S. Allaudeen
发明人： R. Martin Emanuele , Konstantin G. Kousoulas , Hameedsulthan S. Allaudeen
IPC分类号： A61K31/715 , A61K31/08 , A61K47/32 , C07C43/00
CPC分类号： A61K48/00 , A61K9/0019 , A61K9/1075 , A61K31/08 , A61K31/715 , A61K2039/53 , C12N15/87 , C12N15/88 , C12N2710/16611 , C12N2740/15011 , C12N2770/20011
摘要： The present invention relates to compositions and methods for delivery of antisense oligonucleotides or other nucleic acid sequences. The present invention comprises a delivery composition comprising an administerable admixture of an effective amount of a nucleic acid sequence and an effective amount of a surface active nonionic block copolymer having the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight between approximately 750 and approximately 15,000, preferably between approximately 2250 and approximately 15,000, more preferably between approximately 3250 and approximately 15,000, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 1% to approximately 50% by weight of the compound, preferably approximately 5% to approximately 25%.
摘要翻译：本发明涉及递送反义寡核苷酸或其他核酸序列的组合物和方法。本发明包括一种递送组合物，其包含有效量的核酸序列和有效量的具有以下一般形式的表面活性非离子嵌段共聚物的可施用的混合物

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