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1. 发明申请

US20080205833A1 Imaging System 失效
标题翻译：成像系统
公开(公告)号：US20080205833A1
公开(公告)日：2008-08-28
申请号：US11917553
申请日：2006-06-16
申请人： Ling Fu , Min Gu , Xiaosong Gan
发明人： Ling Fu , Min Gu , Xiaosong Gan
IPC分类号： G02B6/06 , G02B6/036
CPC分类号： A61B1/043 , A61B1/00096 , A61B1/0017 , A61B1/00172 , A61B1/07 , A61B5/0062 , A61B5/0068 , A61B5/0071 , A61B5/0086 , A61B5/4523 , G02B6/32 , G02B23/24 , G02B26/0833
摘要： An imaging system including a multi-mode fiber and a gradient index (GRIN) lens. The invention also relates to a system including a multi-mode fibre, such as a double-clad photonic crystal fibre, for transmitting an excitation signal to a sample for the purpose of imaging, and a scanning mechanism, which preferably includes a microelectromechanical system (MEMS) mirror, for reflecting the excitation signal in varying directions in order to scan the sample.
摘要翻译：一种包括多模光纤和梯度折射率（GRIN）透镜的成像系统。本发明还涉及一种包括诸如双包层光子晶体光纤的多模光纤用于将激发信号传输到用于成像的样品的系统，以及扫描机构，其优选地包括微机电系统（ MEMS）反射镜，用于在变化的方向上反射激励信号，以扫描样品。

2. 发明授权

US07715673B2 Imaging system 失效
标题翻译：成像系统
公开(公告)号：US07715673B2
公开(公告)日：2010-05-11
申请号：US11917553
申请日：2006-06-16
申请人： Ling Fu , Min Gu , Xiaosong Gan
发明人： Ling Fu , Min Gu , Xiaosong Gan
IPC分类号： G02B6/02
CPC分类号： A61B1/043 , A61B1/00096 , A61B1/0017 , A61B1/00172 , A61B1/07 , A61B5/0062 , A61B5/0068 , A61B5/0071 , A61B5/0086 , A61B5/4523 , G02B6/32 , G02B23/24 , G02B26/0833
摘要： An imaging system including a multi-mode fiber and a gradient index (GRIN) lens. The invention also relates to a system including a multi-mode fiber, such as a double-clad photonic crystal fiber, for transmitting an excitation signal to a sample for the purpose of imaging, and a scanning mechanism, which preferably includes a microelectromechanical system (MEMS) mirror, for reflecting the excitation signal in varying directions in order to scan the sample.
摘要翻译：一种包括多模光纤和梯度折射率（GRIN）透镜的成像系统。本发明还涉及一种包括诸如双包层光子晶体光纤的多模光纤用于将激发信号传输到用于成像的样品的系统，以及扫描机构，其优选地包括微机电系统（ MEMS）反射镜，用于在变化的方向上反射激励信号，以扫描样品。

3. 发明授权

US08168393B2 Compositions and methods for diagnosing tumors using LEDGF/p75 有权
标题翻译：使用LEDGF / p75诊断肿瘤的组成和方法
公开(公告)号：US08168393B2
公开(公告)日：2012-05-01
申请号：US12070039
申请日：2008-02-13
申请人： Lee E. Goldstein , Ling Fu
发明人： Lee E. Goldstein , Ling Fu
IPC分类号： G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/136
摘要： The invention provides methods for diagnosing tumors in mammals using a reagent that bind to LEDGF/p75 or to a nucleic acid encoding LEDGF/p75. For example, the tumor may be located in the CNS, the prostate, the skin, the bone marrow, or the gut of the mammal. Also provided are methods for diagnosing brain tumors such as medulloblastomas, meningiomas, astrocytomas, glioblastomas multiforme, and ependymomas by examining LEDGF/p75 or a nucleic acid encoding LEDGF/p75 localization. The invention also involves methods for diagnosing cancers involving cancerous epithelial cells such as colon cancer. The instant invention also provides methods for isolating stem cells from a heterogeneous population of cells, as well as methods for identifying neuroepithelial stem cells, newly differentiated neurons, and astrocytes in a subject. Also provided are methods for inducing the differentiation of neuroepithelial stem cells into astrocytes or neurons and methods for screening candidate compounds that regulate the differentiation of neuroepithelial stem cells.
摘要翻译：本发明提供使用结合LEDGF / p75的试剂或编码LEDGF / p75的核酸来诊断哺乳动物肿瘤的方法。例如，肿瘤可以位于CNS，前列腺，皮肤，骨髓或哺乳动物的肠道中。还提供了通过检查LEDGF / p75或编码LEDGF / p75定位的核酸来诊断脑肿瘤如神经母细胞瘤，脑膜瘤，星形细胞瘤，多形性成胶质细胞瘤和室管膜瘤的方法。本发明还涉及用于诊断涉及癌性上皮细胞如结肠癌的癌症的方法。本发明还提供从异质细胞群体中分离干细胞的方法，以及用于鉴定受试者中的神经上皮干细胞，新分化的神经元和星形胶质细胞的方法。还提供了诱导神经上皮干细胞分化成星形胶质细胞或神经元的方法以及用于筛选调节神经上皮干细胞分化的候选化合物的方法。

4. 发明申请

US20090053712A1 Methods of using LEDGF/p75 有权
标题翻译：使用LEDGF / p75的方法
公开(公告)号：US20090053712A1
公开(公告)日：2009-02-26
申请号：US12070039
申请日：2008-02-13
申请人： Lee E. Goldstein , Ling Fu
发明人： Lee E. Goldstein , Ling Fu
IPC分类号： C12Q1/68 , G01N33/53 , C12Q1/02 , C12N5/06
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/136
摘要： The invention provides methods for diagnosing tumors in mammals using a reagent that bind to LEDGF/p75 or to a nucleic acid encoding LEDGF/p75. For example, the tumor may be located in the CNS, the prostate, the skin, the bone marrow, or the gut of the mammal. Also provided are methods for diagnosing brain tumors such as medulloblastomas, meningiomas, astrocytomas, glioblastomas multiforme, and ependymomas by examining LEDGF/p75 or a nucleic acid encoding LEDGF/p75 localization. The invention also involves methods for diagnosing cancers involving cancerous epithelial cells such as colon cancer. The instant invention also provides methods for isolating stem cells from a heterogeneous population of cells, as well as methods for identifying neuroepithelial stem cells, newly differentiated neurons, and astrocytes in a subject. Also provided are methods for inducing the differentiation of neuroepithelial stem cells into astrocytes or neurons and methods for screening candidate compounds that regulate the differentiation of neuroepithelial stem cells.
摘要翻译：本发明提供使用结合LEDGF / p75的试剂或编码LEDGF / p75的核酸来诊断哺乳动物肿瘤的方法。例如，肿瘤可以位于CNS，前列腺，皮肤，骨髓或哺乳动物的肠道中。还提供了通过检查LEDGF / p75或编码LEDGF / p75定位的核酸来诊断脑肿瘤如神经母细胞瘤，脑膜瘤，星形细胞瘤，多形性成胶质细胞瘤和室管膜瘤的方法。本发明还涉及用于诊断涉及癌性上皮细胞如结肠癌的癌症的方法。本发明还提供从异质细胞群体中分离干细胞的方法，以及用于鉴定受试者中的神经上皮干细胞，新分化的神经元和星形胶质细胞的方法。还提供了诱导神经上皮干细胞分化成星形胶质细胞或神经元的方法以及用于筛选调节神经上皮干细胞分化的候选化合物的方法。

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