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1. 发明申请

US20100249233A1 COMPOUND AND USE THEREOF IN THE TREATMENT OF AMYLOIDOSIS 失效
标题翻译：化合物及其在治疗淀粉样变性中的应用
公开(公告)号：US20100249233A1
公开(公告)日：2010-09-30
申请号：US12728361
申请日：2010-03-22
申请人： Mark Brian PEPYS , Steven Victor Ley , Angus John Morrison , Vittorio Bellotti , Stephen Wood , Simon Kolstoe , Martin Smith
发明人： Mark Brian PEPYS , Steven Victor Ley , Angus John Morrison , Vittorio Bellotti , Stephen Wood , Simon Kolstoe , Martin Smith
IPC分类号： A61K31/196 , C07C229/58 , A61P43/00
CPC分类号： A61K31/194
摘要： The present invention relates to compounds of formula (I) for stabilizing the tetrameric form of transthyretin, compounds for use in the treatment or prevention of amyloidosis, and agents and medicaments comprising such compounds. wherein X, Y, R1, R2, R3, R4, m, n, p, q, and the linker are as defined herein.
摘要翻译：本发明涉及用于稳定转甲状腺素蛋白的四聚体形式的式（I）化合物，用于治疗或预防淀粉样变性的化合物，以及包含这些化合物的药剂和药物。其中X，Y，R 1，R 2，R 3，R 4，m，n，p，q和连接体如本文所定义。

2. 发明授权

US08236984B2 Compound and use thereof in the treatment of amyloidosis 失效
标题翻译：化合物及其在治疗淀粉样变性中的应用
公开(公告)号：US08236984B2
公开(公告)日：2012-08-07
申请号：US12728361
申请日：2010-03-22
申请人： Mark Brian Pepys , Steven Victor Ley , Angus John Morrison , Vittorio Bellotti , Simon Kolstoe , Martin Smith
发明人： Mark Brian Pepys , Steven Victor Ley , Angus John Morrison , Vittorio Bellotti , Simon Kolstoe , Martin Smith
IPC分类号： C07C63/33 , A01N37/30
CPC分类号： A61K31/194
摘要： The present invention relates to compounds of formula (I) for stabilizing the tetrameric form of transthyretin, compounds for use in the treatment or prevention of amyloidosis, and agents and medicaments comprising such compounds. wherein X, Y, R1, R2, R3, R4, m, n, p, q, and the linker are as defined herein.
摘要翻译：本发明涉及用于稳定转甲状腺素蛋白的四聚体形式的式（I）化合物，用于治疗或预防淀粉样变性的化合物，以及包含这些化合物的药剂和药物。其中X，Y，R 1，R 2，R 3，R 4，m，n，p，q和连接体如本文所定义。

3. 发明申请

US20070188804A1 Module 有权
公开(公告)号：US20070188804A1
公开(公告)日：2007-08-16
申请号：US11788088
申请日：2007-04-19
申请人： Jim Henderson , Mel Walter , Martin Smith , Wolf Rossmann , Paul Nielsen
发明人： Jim Henderson , Mel Walter , Martin Smith , Wolf Rossmann , Paul Nielsen
IPC分类号： G06F3/12
CPC分类号： G07G5/00 , G06Q20/20 , G06Q20/202 , G06Q20/206 , G06Q20/209 , G06Q20/32 , G06Q20/401 , G06Q30/0236 , G07F17/42 , G07F19/20 , G07F19/201
摘要： A module (38), a terminal (12) including the module, and a system (10) including the terminal (12), are described. The module may be a printer module (38) comprising a print engine (60), a microcontroller (62), and a wireless receiver (66), such as a wireless modem, so that the module (38) is operable to receive data from a remote server (18) and to print the received data. The module (38) also includes a coupler (70 or 270) for directing data received from the wireless modem (66) to the microcontroller (62) and for directing data from the terminal (12) to the microcontroller (62). A method of printing tickets at a terminal (12) and a method of retro-fitting a self-service terminal (12) are also described.

4. 发明申请

US20070167632A1 Method for synthesizing compound and catalyst for synthesis reaction 失效
标题翻译：合成化合物的方法和合成反应的催化剂
公开(公告)号：US20070167632A1
公开(公告)日：2007-07-19
申请号：US11587340
申请日：2006-04-25
申请人： Steven Ley , Martin Smith , Sophie Lohmann , Steven Andrews , J. Attfield , Hirohisa Tanaka , Kimiyoshi Kaneko
发明人： Steven Ley , Martin Smith , Sophie Lohmann , Steven Andrews , J. Attfield , Hirohisa Tanaka , Kimiyoshi Kaneko
IPC分类号： C07D213/06 , B01J23/00 , C07C6/12
CPC分类号： B01J23/002 , B01J23/63 , B01J23/6562 , B01J23/894 , B01J23/8986 , B01J2523/00 , C07C2/861 , C07C17/266 , C07C49/78 , C07C201/12 , C07C2523/10 , C07C2523/44 , C07C2523/72 , C07C2523/745 , C07D333/10 , C07C15/54 , C07C25/24 , B01J2523/17 , B01J2523/3706 , B01J2523/824 , B01J2523/842 , B01J2523/36 , B01J2523/3725 , B01J2523/24 , B01J2523/3718 , B01J2523/72 , B01J2523/845 , C07C205/35
摘要： To provide a catalyst for synthesis reaction which can achieve good yield in the Sonogashira reaction and also can be recovered after the reaction, and a method for synthesizing a compound in which the catalyst for synthesis reaction is used, a perovskite-type composite oxide containing palladium is used as the catalyst for synthesis reaction in the Sonogashira reaction represented by the following reaction scheme (1): R1—X+HC≡CR2→R1C≡CR2 (1)
摘要翻译：为了提供合成反应的催化剂，其能够在Sonogashira反应中获得良好的产率，并且也可以在反应后回收，以及合成其中使用合成反应的催化剂的化合物的方法，含有钯的钙钛矿型复合氧化物用作由以下反应方案（1）表示的Sonogashira反应中的合成反应的催化剂：<？in-line-formula description =“In-line formula”end =“lead”？> R＆lt; 1＆ / SUB + -X +HC≡CR2 - > R 1C≡CR2（1）<β在线公式描述 =“内联公式”end =“tail”？>

5. 发明申请

US20060094015A1 Methods and materials for using chemical compounds as a tool for nucleic acid storage on media of nucleic acid purification systems 审中-公开
标题翻译：使用化学化合物作为核酸在核酸净化系统介质上储存的工具的方法和材料
公开(公告)号：US20060094015A1
公开(公告)日：2006-05-04
申请号：US10530146
申请日：2003-10-03
申请人： Martin Smith , Galina Fomovskaia , Mikhail Fomovsky
发明人： Martin Smith , Galina Fomovskaia , Mikhail Fomovsky
IPC分类号： C12Q1/68 , C07H21/04 , C12N1/08
CPC分类号： C12Q1/6806 , C12N15/1006 , C12N15/1017 , C12Q2523/308
摘要： The present invention relates to methods for isolating and storing, nucleic acid from a sample containing nucleic acid, such as a cell sample or cell lysate. The nucleic acid is isolated on a solid phase medium, which is then dried, and which can be stored efficiently, such as at room temperature, in columns, tubes, and microwell plates having a wide variety of filters and other solid phase media, for extended periods of time, including days, weeks, and months. The invention provides methods for isolating and storing nucleic acid from a sample by applying the sample to a solid phase medium, retaining the cells, lysing the cellular retentate, drying the medium and retaining the nucleic acid, storing the nucleic acid for extended periods of time at room temperature and humidity, and optionally eluting the nucleic acid. The invention provides methods for storing nucleic acid-containing samples on a wide range of solid phase media in many types of tubes, columns, or multiwell plates, many of which are commercial available.
摘要翻译：本发明涉及从含有核酸例如细胞样品或细胞裂解液的样品中分离和储存核酸的方法。核酸在固相培养基上分离，然后将其干燥，并且可以有效地存储，例如室温下，具有各种过滤器和其它固相培养基的柱，管和微孔板中，用于延长的时间，包括天，周和月。本发明提供了通过将样品应用于固相培养基，保留细胞，裂解细胞滞留物，干燥培养基和保留核酸，将核酸延长时间来分离和储存来自样品的核酸的方法在室温和湿度下，并任选地洗脱核酸。本发明提供了在许多类型的管，柱或多孔板中在宽范围的固相培养基上储存含有核酸的样品的方法，其中许多是商业可得的。

6. 发明授权

US06870515B2 MIMO wireless communication system 有权
标题翻译： MIMO无线通信系统
公开(公告)号：US06870515B2
公开(公告)日：2005-03-22
申请号：US09975653
申请日：2001-10-11
申请人： Dean Kitchener , Martin Smith , Chris Ward
发明人： Dean Kitchener , Martin Smith , Chris Ward
IPC分类号： H04B7/04 , H04B7/06 , H04B7/08 , H04B7/10 , H04L1/02 , H01Q21/24
CPC分类号： H04B7/0417 , H04B7/0469 , H04B7/0626 , H04B7/0673 , H04B7/0891 , H04B7/10 , H04L1/0625
摘要： Previous MIMO systems have used spatially diverse antenna elements in order not to reduce the number of orthogonal channels that can be realized. The present invention recognizes that this leads to large antenna sizes, as compared to multiple beam antenna systems which use closely spaced antenna elements. In order to provide a compact antenna unit, while still allowing a MIMO system to be exploited, the present invention recognizes that polarization diversity only can be used in a MIMO system without the need for spatially diverse antenna elements. Closely spaced antenna elements are used and this enables a compact MIMO antenna unit to be provided. In addition, such MIMO systems with polarization diversity but no spatial diversity can advantageously be used in line of sight situations and also combined with multi-beam antenna systems to further increase capacity.
摘要翻译：先前的MIMO系统已经使用空间多样的天线元件，以便不减少可以实现的正交信道的数量。与使用紧密间隔的天线元件的多个波束天线系统相比，本发明认识到这导致大的天线尺寸。为了提供紧凑的天线单元，在仍然允许利用MIMO系统的情况下，本发明认识到仅在MIMO系统中可以使用极化分集，而不需要空间多样的天线元件。使用紧密间隔的天线元件，这使得能够提供紧凑的MIMO天线单元。此外，具有极化分集但没有空间分集的这种MIMO系统可以有利地用于视线情况，并且还可与多波束天线系统组合以进一步增加容量。

7. 发明授权

US06627226B2 Dry solid medium for storage and analysis of genetic material 失效
公开(公告)号：US06627226B2
公开(公告)日：2003-09-30
申请号：US09805326
申请日：2001-03-13
申请人： Leigh Alexander Burgoyne , Martin Smith , Neil Butt
发明人： Leigh Alexander Burgoyne , Martin Smith , Neil Butt
IPC分类号： A61K914
CPC分类号： C12N15/1006 , B01L2200/14 , B01L2300/0838 , G01N2035/00564
摘要： The present invention provides for device for obtaining and storing genetic material. The device has a support and a head portion. The head portion is composed of a solid matrix for sorbing genetic material and a preserving mechanism for the protection of genetic material from degradation. Additionally, the present invention provides for a method of storing a sample of genetic material onto the swab device. In the preferred embodiment, the present invention utilizes polyester material as the solid matrix.

8. 发明授权

US08668141B2 Digital receipt reading device, software and method of digital receipt reading 有权
标题翻译：数字收据阅读设备，数字收据阅读软件和方法
公开(公告)号：US08668141B2
公开(公告)日：2014-03-11
申请号：US12977178
申请日：2010-12-23
申请人： Martin Smith , Nathaniel Christopher Herwig
发明人： Martin Smith , Nathaniel Christopher Herwig
IPC分类号： G06Q40/00
CPC分类号： G06Q20/32 , G06Q20/3276
摘要： A customer's mobile device comprises a camera and a processor. The camera is used to scan a two-dimensional barcode which has encoded within it transaction details and ancillary information relating to purchases made by a customer in their receipted transaction.
摘要翻译：客户的移动设备包括相机和处理器。相机用于扫描在其交易详细信息中编码的二维条形码和与客户在其接收交易中进行的购买有关的辅助信息。

9. 发明申请

US20080110621A1 Managing lost returns in a wellbore 有权
标题翻译：管理井筒中的失去的回报
公开(公告)号：US20080110621A1
公开(公告)日：2008-05-15
申请号：US11983061
申请日：2007-11-06
申请人： John Montgomery , Stuart Keller , Nancy Krahel , Martin Smith , Robert Williamson
发明人： John Montgomery , Stuart Keller , Nancy Krahel , Martin Smith , Robert Williamson
IPC分类号： E21B43/267 , E21B37/00
CPC分类号： E21B21/003 , C09K8/5045 , C09K8/528 , C09K8/80 , E21B33/138
摘要： A method of managing lost returns in a wellbore is disclosed. The method includes contacting a filter cake with a treating fluid to remove metallic weighting agents from the filter cake, wherein the filter cake is disposed on a face of a formation fracture in the wellbore. The method also includes contacting the filter cake with a proppant slurry, wherein the proppant slurry contacts the filter cake concurrently with the treating fluid or after the treating fluid contacts the filter cake. This method may include increasing the filter cake permeability and may utilize a barite removal agent, such as a chelation agent. At least one related wellbore management method is disclosed, which provides for creating a fracture in the wellbore and propping open the fracture to increase wellbore integrity to utilize higher weight drilling fluids and prevent fractures from forming further down the wellbore.
摘要翻译：公开了一种在井眼中管理丢失回报的方法。该方法包括使滤饼与处理流体接触以从滤饼中除去金属加重剂，其中滤饼设置在井眼中的地层断裂面上。该方法还包括使滤饼与支撑剂浆料接触，其中支撑剂浆料与处理流体同时接触滤饼，或处理流体接触滤饼之后。该方法可以包括增加滤饼渗透性，并且可以使用重晶石去除剂，例如螯合剂。公开了至少一个相关的井筒管理方法，其提供在井眼中产生断裂并支撑打开裂缝以增加井筒完整性以利用更高重量的钻井液并防止裂缝进一步向下形成井筒。

10. 发明授权

US07372832B2 Channel selection 有权
标题翻译：频道选择
公开(公告)号：US07372832B2
公开(公告)日：2008-05-13
申请号：US10683413
申请日：2003-10-10
申请人： David Bevan , Steven Baines , Martin Smith
发明人： David Bevan , Steven Baines , Martin Smith
IPC分类号： H04Q7/00
CPC分类号： H04L45/00 , H04W40/12 , H04W40/248 , H04W72/02
摘要： The invention is directed to methods and apparatus for transmitting data between a first node and a second node in a communications network, for example a wireless network. The method comprises the steps of selecting a transmission channel from a predetermined set of transmission channels according to probability information and transmitting data using the selected channel. The probability information is based on a determination of a characteristic of previous transmissions using each of said set of channels. The invention is also directed to a method of selecting a channel at a node in a communications network for communication with a second node.
摘要翻译：本发明涉及用于在通信网络（例如无线网络）中的第一节点和第二节点之间传输数据的方法和装置。该方法包括以下步骤：根据概率信息从预定传输信道集合中选择传输信道，并使用所选择的信道发送数据。概率信息基于使用所述一组信道中的每一个的先前传输的特性的确定。本发明还涉及一种在通信网络中的节点处选择信道以与第二节点进行通信的方法。

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