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1. 发明授权

US08349883B2 Hydroxamate-based inhibitors of deacetylases B 有权
标题翻译：脱乙酰酶的羟基甲酸酯抑制剂B
公开(公告)号：US08349883B2
公开(公告)日：2013-01-08
申请号：US13082956
申请日：2011-04-08
申请人： Michael D. Shultz , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar , Jianke Li
发明人： Michael D. Shultz , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar , Jianke Li
IPC分类号： A61K31/4162 , A61K31/4155
CPC分类号： C07D207/08 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D471/04
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and are as defined herein. The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R 1，R 2，R 3，Y，Z如本文所定义。本教导还提供制备式I化合物的方法和使用式I化合物治疗，抑制或预防全部或部分由脱乙酰酶介导的病理状况或病症的方法。

2. 发明授权

US07943652B2 Hydroxamate-based inhibitors of deacetylases B 有权
标题翻译：脱乙酰酶的羟基甲酸酯抑制剂B
公开(公告)号：US07943652B2
公开(公告)日：2011-05-17
申请号：US12411715
申请日：2009-03-26
申请人： Michael D. Shultz , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar , Jianke Li
发明人： Michael D. Shultz , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar , Jianke Li
IPC分类号： A61K31/4162 , A61K31/4155 , C07D487/04 , C07D231/10
CPC分类号： C07D207/08 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D471/04
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and are as defined herein. The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R 1，R 2，R 3，Y，Z如本文所定义。本教导还提供制备式I化合物的方法和使用式I化合物治疗，抑制或预防全部或部分由脱乙酰酶介导的病理状况或病症的方法。

3. 发明申请

US20090247547A1 HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B 有权
标题翻译：脱乙酰壳多糖基抑制剂B
公开(公告)号：US20090247547A1
公开(公告)日：2009-10-01
申请号：US12411715
申请日：2009-03-26
申请人： Michael SHULTZ , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar
发明人： Michael SHULTZ , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar
IPC分类号： A61K31/496 , C07D209/04 , A61K31/404 , C12N5/00 , C07D261/06 , A61K31/42 , C07D231/10 , A61K31/415 , C07D471/02 , A61K31/437 , C07D207/00 , A61K31/40 , C07D401/02 , A61K31/4439 , C07D403/14 , A61K31/497 , A61P35/00 , A61P25/00 , A61P37/06 , A61P29/00 , A61P31/10
CPC分类号： C07D207/08 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D471/04
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and are as defined herein.The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R1，R2，R3，Y，Z和如本文所定义。本教导还提供制备式I化合物的方法和使用式I化合物治疗，抑制或预防全部或部分由脱乙酰酶介导的病理状况或病症的方法。

4. 发明申请

US20130231373A1 HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES 审中-公开
标题翻译：基于羟基甲酸酯的脱乙酰基抑制剂
公开(公告)号：US20130231373A1
公开(公告)日：2013-09-05
申请号：US13818779
申请日：2010-08-27
申请人： Clinton Alan Brooks , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Gang Liu , Michael David Schultz
发明人： Clinton Alan Brooks , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Gang Liu , Michael David Schultz
IPC分类号： C07D413/06 , C07D403/06 , C07D401/14
CPC分类号： C07D413/06 , A61K31/4015 , A61K31/4025 , A61K31/4155 , A61K31/416 , A61K31/4192 , A61K31/4245 , A61K31/4427 , A61K31/4439 , C07D207/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D407/14
摘要： The present teachings relate to compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, R4, R5, ring A, and Z are as defined herein. The present teachings also provide methods of preparing compounds of Formula (I) and methods of use compounds of Formula (I) in treating pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译：本发明涉及式（I）的化合物及其药学上可接受的盐，水合物，酯和前药，其中R 1，R 2，R 3，R 4，R 5，环A和Z如本文所定义。本教导还提供制备式（I）化合物的方法和使用式（I）化合物治疗全部或部分由脱乙酰酶介导的病理状况或病症的方法。

5. 发明授权

US09434719B2 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH 有权
标题翻译： 3-嘧啶-4-基 - 恶唑烷-2-酮作为突变体IDH的抑制剂
公开(公告)号：US09434719B2
公开(公告)日：2016-09-06
申请号：US14408418
申请日：2014-03-12
申请人： Thomas Raymond Caferro , Zhuoliang Chen , Young Shin Cho , Abran Q. Costales , Julian Roy Levell , Gang Liu , James R. Manning , Martin Sendzik , Cynthia Shafer , Michael David Shultz , James Sutton , Yaping Wang , Qian Zhao
发明人： Thomas Raymond Caferro , Zhuoliang Chen , Young Shin Cho , Abran Q. Costales , Julian Roy Levell , Gang Liu , James R. Manning , Martin Sendzik , Cynthia Shafer , Michael David Shultz , James Sutton , Yaping Wang , Qian Zhao
IPC分类号： C07D413/04 , A61K31/506 , C07D413/14 , C07D417/14 , A61K31/5377
CPC分类号： C07D413/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/04 , C07D417/14
摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

6. 发明授权

US08957068B2 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH 有权
标题翻译： 3-嘧啶-4-基 - 恶唑烷-2-酮作为突变体IDH的抑制剂
公开(公告)号：US08957068B2
公开(公告)日：2015-02-17
申请号：US14347481
申请日：2012-09-26
申请人： Thomas Raymond Caferro , Young Shin Cho , Abran Q. Costales , Huangshu Lei , Francois Lenoir , Julian Roy Levell , Gang Liu , Mark G. Palermo , Keith Bruce Pfister , Martin Sendzik , Cynthia Shafer , Michael David Shultz , Troy Smith , James Clifford Sutton , Bakary-Barry Toure , Fan Yang , Qian Zhao
发明人： Thomas Raymond Caferro , Young Shin Cho , Abran Q. Costales , Huangshu Lei , Francois Lenoir , Julian Roy Levell , Gang Liu , Mark G. Palermo , Keith Bruce Pfister , Martin Sendzik , Cynthia Shafer , Michael David Shultz , Troy Smith , James Clifford Sutton , Bakary-Barry Toure , Fan Yang , Qian Zhao
IPC分类号： C07D413/04 , C07D413/14 , A61K31/506 , C07D487/04 , C07D471/04 , C07D487/08 , C07D417/14 , C07D498/10
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D498/10 , C07D513/04
摘要： The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1 -R 6在本文中定义。本发明还涉及含有式（I）化合物的组合物以及这些化合物在抑制具有新形态活性的突变体IDH蛋白质中的用途。本发明还涉及式（I）化合物在治疗与这种突变体IDH蛋白相关的疾病或病症中的用途，包括但不限于细胞增殖病症如癌症。

7. 发明授权

US10914361B2 Multi-gear torquer 有权
公开(公告)号：US10914361B2
公开(公告)日：2021-02-09
申请号：US16201979
申请日：2018-11-27
申请人： Gang Liu
发明人： Gang Liu
IPC分类号： F16H1/28 , F16H57/04 , F16H3/44 , F16H57/031 , F16H57/038
摘要： Disclosed is a multi-gear torquer with end covers on both sides of the casing. An input shaft and an output shaft are respectively arranged at the center of the two end covers. A sun gear is fixed on the input shaft and moves along a planet gear engaged in the transmission mechanism. The planet gear meshes with a gear ring and moves around the sun gear, then the planet gear drives the turntable centrally fixed with the output shaft connected to the load end. The multi-gear torquer disclosed herein has the following advantages: large output torque and high mechanical efficiency, and it can be used as power transmission equipment for a car or a train and used as other mechanical transmission equipment.

8. 发明授权

US10670143B2 Motor 审中-公开
公开(公告)号：US10670143B2
公开(公告)日：2020-06-02
申请号：US15939342
申请日：2018-03-29
申请人： Gang Liu
发明人： Gang Liu
IPC分类号： F16H1/32 , F16H61/662 , H02K7/116 , H02K1/27 , F16H61/14 , H02K21/16 , F16H57/02
摘要： A motor with a variable-speed torque converter is disclosed. A rotor of the motor has a common permanent magnet structure. Permanent magnets are disposed on the rotor. The variable-speed torque converter includes a wheel disc, a wheel ring, a roller, a transmission gear II, a transmission gear III, a round wheel, an annular gear, a driving gear, turning discs, a transmission shaft, and an output shaft. The driving gear fixedly connected to the transmission shaft of the motor drives the transmission gear. The transmission gear is in contact with the annular gear. The transmission gear rotates around the driving gear to drive the wheel disc to rotate together. The wheel disc is fixedly connected to the output shaft to drive a driving wheel to rotate. Therefore, a working capability of the motor is enhanced. The converter can be applied to an electromotor, a generator, or any other power device.

9. 发明授权

US09883797B1 System and method for automatically tracking a contact lens in a wearer's eye 有权
公开(公告)号：US09883797B1
公开(公告)日：2018-02-06
申请号：US14277139
申请日：2014-05-14
申请人： Gang Liu , Lei Wang , Lowell D. Jacobson
发明人： Gang Liu , Lei Wang , Lowell D. Jacobson
IPC分类号： A61B3/14 , A61B3/10 , A61B3/00 , A61B3/113
CPC分类号： A61B3/113 , A61B3/0041 , A61B3/14 , G06K9/0061
摘要： A system and method for automated determination of position and movement of a contact lens with respect to a subject wearer's eye based upon a complimentary pair of images, acquired in rapid succession, in which one image of the pair is acquired using light that allows viewing of the pupil and/or limbus through the lens and the other image is acquired using light that is absorbed by the lens to generate an opaque image with a defined edge relative to the surrounding sclera. The images of the pair are acquired in close enough temporal proximity to ensure that eye movement in the interval therebetween is insignificant and both images are in the same approximate reference frame. Thus, the location of the pupil and limbus in one image can be accurately compared with the location of the contact lens edge in the other image.

10. 发明授权

US09301248B2 Methods and apparatuses for communication in a personal area network 有权
标题翻译：用于个人区域网络通信的方法和装置
公开(公告)号：US09301248B2
公开(公告)日：2016-03-29
申请号：US13996059
申请日：2010-12-20
申请人： Zheng Liang , Gang Liu , Jun Zheng , Haibo Wen , Fanxiang Bin , Chunyan Yao
发明人： Zheng Liang , Gang Liu , Jun Zheng , Haibo Wen , Fanxiang Bin , Chunyan Yao
IPC分类号： H04W52/02 , H04W28/16 , H04W84/18 , H04W76/04
CPC分类号： H04W52/0203 , H04W28/16 , H04W52/0216 , H04W52/0219 , H04W52/0229 , H04W52/0258 , H04W76/28 , H04W84/18 , Y02D70/144
摘要： An exemplary technique is provided for communication in a personal area network. The technique includes transmitting, to a personal area network coordinator, joint information of a sensor device indicated by reserved bits and includes a type, a channel access rate, and a latest node buffer occupation rate of the sensor device; receiving, from the personal area network coordinator, information regarding adjusted active duration and duty cycle of the communication of the sensor device; and performing further communication based upon the adjusted active duration and duty cycle. Also, the technique includes receiving, from a sensor device, joint information indicated by reserved bits and includes a type, a channel access rate, and a latest node buffer occupation rate of the sensor device; adjusting an active duration and a duty cycle of the communication of the sensor device; and transmitting information regarding the adjusted active duration and duty cycle to the sensor device.
摘要翻译：提供了一种用于个人区域网络中的通信的示例性技术。该技术包括向个人区域网络协调器发送由保留位指示的传感器设备的联合信息，并且包括传感器设备的类型，信道访问速率和最新节点缓冲器占用率; 从个人区域网络协调器接收关于传感器设备的通信的调整的有效持续时间和占空比的信息; 并且基于调整的有效持续时间和占空比执行进一步的通信。此外，该技术包括从传感器设备接收由保留位指示的联合信息，并且包括传感器设备的类型，信道访问速率和最新节点缓冲器占用率; 调整传感器装置的通信的有效持续时间和占空比; 以及将关于经调节的有效持续时间和占空比的信息发送到传感器装置。

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