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    • 6. 发明申请
    • Pneumatic seating system for use with a motorcycle
    • 用于摩托车的气动座椅系统
    • US20050168018A1
    • 2005-08-04
    • US11049317
    • 2005-02-02
    • George Cox
    • George Cox
    • B60N2/52B62J1/02B62J1/26
    • B62J1/26
    • An pneumatic seating system for use with a motorcycle including a mount for pivotally mounting a motorcycle seat to the frame of a motorcycle. The system includes an air spring mountable between an end portion of the motorcycle seat and the frame. The air spring being adjustable between inflated and deflated positions, the inflated position wherein pressurized air is retained in the cavity such that a length of the air spring is extended so that the seat is spaced from the frame, the deflated position wherein the air spring is in a retracted position. An air compressor is provided for inflating the air spring. An air release valve is coupled to the opening of the air spring for releasing pressurized air from the air spring. The system providing adjustable cushioning between the seat and the frame of the motorcycle for improving the comfort of a rider on the motorcycle.
    • 一种与摩托车一起使用的气动座椅系统,其包括用于将摩托车座椅枢转地安装到摩托车的车架上的安装座。 该系统包括可安装在摩托车座椅的端部与框架之间的空气弹簧。 空气弹簧可在充气位置和放气位置之间调节,膨胀位置,其中加压空气保持在空腔中,使得空气弹簧的长度延伸,使得座椅与框架间隔开,其中空气弹簧为 处于缩回位置。 空气压缩机设置用于使空气弹簧膨胀。 空气释放阀联接到空气弹簧的开口,用于从空气弹簧释放加压空气。 该系统在座椅和摩托车的框架之间提供可调节的缓冲,以提高摩托车上的骑手的舒适度。
    • 8. 发明申请
    • DERIVATIVES OF GROWTH HORMONE AND RELATED PROTEINS, AND METHODS OF USE THEREOF
    • 生长激素和相关蛋白的衍生物及其使用方法
    • US20070253929A1
    • 2007-11-01
    • US11612373
    • 2006-12-18
    • George CoxDaniel Doherty
    • George CoxDaniel Doherty
    • A61K45/00A61P31/18A61P35/02A61P7/00C12N5/06
    • A61K38/193A61K47/60C07K14/475C07K14/505C07K14/52C07K14/535C07K14/5431C07K14/61
    • The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby. Also disclosed are therapeutic methods for using the cysteine variants of the invention.
    • 生长激素超基因家族包含大于20个结构相关的细胞因子和生长因子。 提供了一种用于产生这些蛋白质的位点特异性,生物活性缀合物的通用方法。 该方法包括将半胱氨酸残基添加到蛋白质的非必需区域中,或者使用定点突变将蛋白质中的非必需氨基酸取代半胱氨酸残基,然后将半胱氨酸反应性聚合物或其它类型的半胱氨酸反应性部分共价偶联到 通过添加的半胱氨酸残基的蛋白质。 本文公开了用于添加半胱氨酸残基或将半胱氨酸取代引入蛋白质的优选位点,以及由此产生的蛋白质和蛋白质衍生物。 还公开了使用本发明的半胱氨酸变体的治疗方法。