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1. 发明授权

US6074816A NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus 失效
标题翻译： NANBV诊断：用于筛选丙型肝炎病毒的多核苷酸
公开(公告)号：US6074816A
公开(公告)日：2000-06-13
申请号：US307273
申请日：1994-09-16
申请人： Michael Houghton , Qui-Lim Choo , George Kuo
发明人： Michael Houghton , Qui-Lim Choo , George Kuo
IPC分类号： A61K39/00 , C07K14/18 , C07K16/10 , C12N5/08 , C12N15/40 , C12Q1/68 , C12Q1/70 , G01N33/53
CPC分类号： C12Q1/707 , C07K14/005 , C07K16/109 , C12Q1/6853 , C12Q1/6858 , C12Q1/701 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2770/24222 , Y10S436/82
摘要： A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBH), but which are absent from individuals infected with hepatitis A virus, or hepatitis B virus, and also are absent in control individuals. The HCV cDNA sequences lack substantial homology to the sequences of hepatitis delta virus (HDV) and HBV. A comparison of the sequences of amino acids encoded in the HCV cDNA with the sequences of Flaviviruses indicates that HCV may be related to the Flaviviruses. The HCV cDNA sequences and the polypeptides encoded therein are useful as reagents for the detection and therapy of HCV. The reagents provided in the invention are also useful for the isolation of NANBH agent(s), for the propagation of these agents in tissue culture, and for the screening of antiviral agents for HCV.
摘要翻译：提供了源自丙型肝炎病毒（HCV）的cDNA序列家族。这些序列编码与存在于非A非乙型肝炎（NANBH）的个体中存在的抗体进行免疫反应但是在感染甲型肝炎病毒或乙型肝炎病毒的个体中不存在的抗原，并且在对照个体中也不存在。 HCV cDNA序列与乙型肝炎病毒（HDV）和HBV的序列缺乏实质同源性。 HCV cDNA编码的氨基酸序列与黄病毒序列的比较表明，HCV可能与黄病毒有关。 HCV cDNA序列及其中编码的多肽可用作检测和治疗HCV的试剂。本发明中提供的试剂也可用于分离NANBH剂，用于组织培养中这些试剂的繁殖，以及筛选用于HCV的抗病毒剂。

2. 发明授权

US5863719A Methods for detecting hepatitis C virus using polynucleotides specific for same 失效
标题翻译：用相同特异性的多核苷酸检测丙型肝炎病毒的方法
公开(公告)号：US5863719A
公开(公告)日：1999-01-26
申请号：US472821
申请日：1995-06-07
申请人： Michael Houghton , Qui-Lim Choo , George Kuo
发明人： Michael Houghton , Qui-Lim Choo , George Kuo
IPC分类号： C07K14/18 , C07K16/10 , C12Q1/68 , C12Q1/70 , C07H21/04 , C12N15/00
CPC分类号： C07K14/005 , C07K16/109 , C12Q1/6853 , C12Q1/6858 , C12Q1/701 , C12Q1/707 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2770/24222
摘要： A new virus, Hepatitis C virus (HCV), which has proven to be the major etiologic agent of blood-borne NANBH, was discovered by Applicant. Reagents for isolating, amplifying, and detecting HCV polynucleotides are provided. These reagents are oligomers containing polynucleotide sequences which are capable of forming hybrid structures with HCV target polynucleotide sequences.
摘要翻译：被证明是血液传播的NANBH的主要病原体的新型病毒丙型肝炎病毒（HCV）被申请人发现。提供了用于分离，扩增和检测HCV多核苷酸的试剂。这些试剂是含有能够与HCV靶多核苷酸序列形成杂交结构的多核苷酸序列的寡聚物。

3. 发明授权

US5350671A HCV immunoassays employing C domain antigens 失效
标题翻译： HCV免疫测定采用C结构域抗原
公开(公告)号：US5350671A
公开(公告)日：1994-09-27
申请号：US103961
申请日：1993-08-09
申请人： Michael Houghton , Qui-Lim Choo , George Kuo
发明人： Michael Houghton , Qui-Lim Choo , George Kuo
IPC分类号： A61K39/00 , C07K14/18 , C07K16/10 , C12Q1/68 , C12Q1/70 , G01N33/576 , C12G1/70 , A61K37/02 , G01N33/543 , C12G1/68
CPC分类号： G01N33/5767 , C07K14/005 , C07K16/109 , C12Q1/701 , C12Q1/707 , A61K39/00 , C07K2319/02 , C07K2319/40 , C12N2770/24222 , Y10S435/975 , Y10S530/812 , Y10S530/826 , Y10S930/223
摘要： Immunoassays for the detection of antibodies to HCV are provided which employ "C" domain antigens. Immunoassay kits comprising such antigens are also provided.
摘要翻译：提供用于检测HCV抗体的免疫测定法，其使用“C”结构域抗原。还提供了包含这种抗原的免疫测定试剂盒。

4. 发明申请

US20060292556A1 Method of detecting antibodies to HCV 审中-公开
公开(公告)号：US20060292556A1
公开(公告)日：2006-12-28
申请号：US11269906
申请日：2005-11-09
申请人： Michael Houghton , Qui-Lim Choo , George Kuo
发明人： Michael Houghton , Qui-Lim Choo , George Kuo
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C07K16/109 , C07K2317/21 , C07K2319/00 , C12N2770/24222 , C12Q1/6853 , C12Q1/6858 , C12Q1/701 , C12Q1/707 , G01N33/5767 , Y02A50/451
摘要： A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBV), but which are absent from individuals infected with hepatitis A virus, or hepatitis B virus, and also are absent in control individuals. The HCV cDNA sequences lack substantial homology to the sequences of hepatitis delta virus (HDV) and HBV. A comparison of the sequences of amino acids encoded in the HCV cDNA with the sequences of Flaviviruses indicated that HCV may be related to the Flaviviruses. The HCV cDNA sequences and the polypeptides encoded therein are useful as reagents for the detection and therapy of HCV. The reagents provided in the invention are also useful for the isolation of NANBV agent(s), for the propagation of these agents in tissue culture, and for the screening of antiviral agents for HCV.

5. 发明授权

US06861212B1 NANBV diagnostics and vaccines 失效
标题翻译： NANBV诊断和疫苗
公开(公告)号：US06861212B1
公开(公告)日：2005-03-01
申请号：US08441355
申请日：1995-05-15
申请人： Michael Houghton , Qui-Lim Choo , George Kuo
发明人： Michael Houghton , Qui-Lim Choo , George Kuo
IPC分类号： A61K39/00 , C07K14/18 , C07K16/10 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/00 , G01N33/566 , G01N33/537
CPC分类号： C12Q1/6853 , A61K39/00 , C07K14/005 , C07K16/109 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2770/24222 , C12Q1/6858 , C12Q1/701 , C12Q1/707 , Y02A50/451 , Y10S435/948 , Y10S435/96 , Y10S436/811 , Y10S436/82 , C12Q2521/107 , C12Q2521/101
摘要： A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBH), but which are absent from individuals infected with hepatitis A virus, or hepatitis B virus, and also are absent in control individuals. The HCV cDNA sequences lack substantial homology to the sequences of hepatitis delta virus (HDV) and HBV. A comparison of the sequences of amino acids encoded in the HCV cDNA with the sequences of Flaviviruses indicates that HCV may be related to the Flaviviruses.The HCV cDNA sequences and the polypeptides encoded therein are useful as reagents for the detection and therapy of HCV. The reagents provided in the invention are also useful for the isolation of NANBH agent(s), for the propagation of these agents in tissue culture, and for the screening of antiviral agents for HCV.
摘要翻译：提供了源自丙型肝炎病毒（HCV）的cDNA序列家族。这些序列编码与存在于非A非乙型肝炎（NANBH）的个体中存在的抗体进行免疫反应但是在感染甲型肝炎病毒或乙型肝炎病毒的个体中不存在的抗原，并且在对照个体中也不存在。 HCV cDNA序列与乙型肝炎病毒（HDV）和HBV的序列缺乏实质同源性。 HCV cDNA编码的氨基酸序列与黄病毒序列的比较表明，HCV可能与黄病毒有关。HCV cDNA序列及其中编码的多肽可用作检测和治疗HCV的试剂。本发明中提供的试剂也可用于分离NANBH剂，用于组织培养中这些试剂的繁殖，以及筛选用于HCV的抗病毒剂。

6. 发明授权

US06096541A Cell culture systems for HCV 失效
标题翻译： HCV细胞培养系统
公开(公告)号：US06096541A
公开(公告)日：2000-08-01
申请号：US441026
申请日：1995-05-15
申请人： Michael Houghton , Qui-Lim Choo , George Kuo
发明人： Michael Houghton , Qui-Lim Choo , George Kuo
IPC分类号： A61K39/00 , C07K14/18 , C07K16/10 , C12N5/08 , C12N15/40 , C12Q1/68 , C12Q1/70 , G01N33/53
CPC分类号： C12Q1/707 , C07K14/005 , C07K16/109 , C12Q1/6853 , C12Q1/6858 , C12Q1/701 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2770/24222 , Y10S436/82
摘要： A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBH), but which are absent from individuals infected with hepatitis A virus, or hepatitis B virus, and also are absent in control individuals. The HCV cDNA sequences lack substantial homology to the sequences of hepatitis delta virus (HDV) and HBV. A comparison of the sequences of amino acids encoded in the HCV cDNA with the sequences of Flaviviruses indicates that HCV may be related to the Flaviviruses.The HCV cDNA sequences and the polypeptides encoded therein are useful as reagents for the detection and therapy of HCV. The reagents provided in the invention are also useful for the isolation of NANBH agent(s), for the propagation of these agents in tissue culture, and for the screening of antiviral agents for HCV.
摘要翻译：提供了源自丙型肝炎病毒（HCV）的cDNA序列家族。这些序列编码与存在于非A非乙型肝炎（NANBH）的个体中存在的抗体进行免疫反应但是在感染甲型肝炎病毒或乙型肝炎病毒的个体中不存在的抗原，并且在对照个体中也不存在。 HCV cDNA序列与乙型肝炎病毒（HDV）和HBV的序列缺乏实质同源性。 HCV cDNA编码的氨基酸序列与黄病毒序列的比较表明，HCV可能与黄病毒有关。 HCV cDNA序列及其中编码的多肽可用作检测和治疗HCV的试剂。本发明中提供的试剂也可用于分离NANBH剂，用于组织培养中这些试剂的繁殖，以及筛选用于HCV的抗病毒剂。

7. 发明授权

US6027729A NANBV Diagnostics and vaccines 失效
标题翻译： NANBV诊断和疫苗
公开(公告)号：US6027729A
公开(公告)日：2000-02-22
申请号：US440755
申请日：1995-05-15
申请人： Michael Houghton , Qui-Lim Choo , George Kuo
发明人： Michael Houghton , Qui-Lim Choo , George Kuo
IPC分类号： A61K39/00 , C07K14/18 , C07K16/10 , C12Q1/68 , C12Q1/70 , A61K39/12 , A61K39/29
CPC分类号： C07K14/005 , C07K16/109 , C12Q1/6853 , C12Q1/6858 , C12Q1/701 , C12Q1/707 , G01N33/5767 , A61K39/00 , C07K2317/21 , C07K2319/00 , C12N2770/24222
摘要： A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBH), but which are absent from individuals infected with hepatitis A virus, or hepatitis B virus, and also are absent in control individuals. The HCV cDNA sequences lack substantial homology to the sequences of hepatitis delta virus (HDV) and HBV. A comparison of the sequences of amino acids encoded in the HCV cDNA with the sequences of Flaviviruses indicates that HCV may be related to the Flaviviruses.The HCV cDNA sequences and the polypeptides encoded therein are useful as reagents for the detection and therapy of HCV. The reagents provided in the invention are also useful for the isolation of NANBH agent(s), for the propagation of these agents in tissue culture, and for the screening of antiviral agents for HCV.
摘要翻译：提供了源自丙型肝炎病毒（HCV）的cDNA序列家族。这些序列编码与存在于非A非乙型肝炎（NANBH）的个体中存在的抗体进行免疫反应但是在感染甲型肝炎病毒或乙型肝炎病毒的个体中不存在的抗原，并且在对照个体中也不存在。 HCV cDNA序列与乙型肝炎病毒（HDV）和HBV的序列缺乏实质同源性。 HCV cDNA编码的氨基酸序列与黄病毒序列的比较表明，HCV可能与黄病毒有关。 HCV cDNA序列及其中编码的多肽可用作检测和治疗HCV的试剂。本发明中提供的试剂也可用于分离NANBH剂，用于组织培养中这些试剂的繁殖，以及筛选用于HCV的抗病毒剂。

8. 发明授权

US5712088A Methods for detecting Hepatitis C virus using polynucleotides specific for same 失效
标题翻译：使用特异性的多核苷酸检测丙型肝炎病毒的方法
公开(公告)号：US5712088A
公开(公告)日：1998-01-27
申请号：US440769
申请日：1995-05-15
申请人： Michael Houghton , Qui-Lim Choo , George Kuo , Amy J. Weiner , Jang Han , Michael Steven Urdea , Bruce Duncan Irvine , Janice A. Kolberg
发明人： Michael Houghton , Qui-Lim Choo , George Kuo , Amy J. Weiner , Jang Han , Michael Steven Urdea , Bruce Duncan Irvine , Janice A. Kolberg
IPC分类号： C07K14/18 , C07K16/10 , C12Q1/68 , C12Q1/70 , C07H21/02 , C12N15/00 , C12P19/34
CPC分类号： C07K14/005 , C07K16/109 , C12Q1/6853 , C12Q1/6858 , C12Q1/701 , C12Q1/707 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2770/24222
摘要： A new virus, Hepatitis C virus (HCV), which has proven to be the major etiologic agent of blood-borne NANBH, was discovered by Applicant. Reagents for isolating, amplifying, and detecting HCV polynucleotides are provided. These reagents are oligomers containing polynucleotide sequences which are capable of forming hybrid structures with HCV target polynucleotide sequences.
摘要翻译：被证明是血液传播的NANBH的主要病原体的新型病毒丙型肝炎病毒（HCV）被申请人发现。提供了用于分离，扩增和检测HCV多核苷酸的试剂。这些试剂是含有能够与HCV靶多核苷酸序列形成杂交结构的多核苷酸序列的寡聚物。

9. 发明授权

US5371017A Hepatitis C virus protease 失效
标题翻译：丙型肝炎病毒蛋白酶
公开(公告)号：US5371017A
公开(公告)日：1994-12-06
申请号：US680296
申请日：1991-04-04
申请人： Michael Houghton , Qui-Lim Choo , George Kuo
发明人： Michael Houghton , Qui-Lim Choo , George Kuo
IPC分类号： C12N15/09 , A61K38/00 , C07K14/00 , C07K14/18 , C12N9/02 , C12N9/50 , C12N9/90 , C12N15/57 , C12Q1/18 , C12Q1/37 , C12R1/93 , C12N15/00
CPC分类号： C12N9/0089 , C07K14/00 , C07K14/005 , C12N9/506 , C12N9/90 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/95 , C12N2770/24222
摘要： The protease necessary for polyprotein processing in Hepatitis C virus is identified, cloned, and expressed. Proteases, truncated protease, and altered proteases are disclosed which are useful for cleavage of specific polypeptides, and for assay and design of antiviral agents specific for HCV.
摘要翻译：鉴定，克隆和表达丙型肝炎病毒中多蛋白加工所需的蛋白酶。公开了蛋白酶，截短的蛋白酶和改变的蛋白酶，其可用于特异性多肽的切割，以及用于HCV特异性的抗病毒剂的测定和设计。

10. 发明申请

US20050202418A1 HCV peptide compositions 审中-公开
标题翻译： HCV肽组合物
公开(公告)号：US20050202418A1
公开(公告)日：2005-09-15
申请号：US11023183
申请日：2004-12-28
申请人： Michael Houghton , Qui-Lim Choo , George Kuo
发明人： Michael Houghton , Qui-Lim Choo , George Kuo
IPC分类号： A61K39/00 , C07K14/18 , C07K16/10 , C12Q1/68 , C12Q1/70 , C07K14/02 , C07K16/08
CPC分类号： C07K14/005 , A61K39/00 , C07K16/109 , C07K2317/21 , C07K2319/00 , C12N2770/24222 , C12Q1/6853 , C12Q1/6858 , C12Q1/701 , C12Q1/707 , G01N33/5767 , Y02A50/451
摘要： A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBV), but which are absent from individuals infected with hepatitis A virus, or hepatitis B virus, and also are absent in control individuals. The HCV cDNA sequences lack substantial homology to the sequences of hepatitis delta virus (HDV) and HBV. A comparison of the sequences of amino acids encoded in the HCV cDNA with the sequences of Flaviviruses indicated that HCV may be related to the Flaviviruses. The HCV cDNA sequences and the polypeptides encoded therein are useful as reagents for the detection and therapy of HCV. The reagents provided in the invention are also useful for the isolation of NANBV agent(s), for the propagation of these agents in tissue culture, and for the screening of antiviral agents for HCV.
摘要翻译：提供了源自丙型肝炎病毒（HCV）的cDNA序列家族。这些序列编码与存在于非A非乙型肝炎（NANBV）的个体中存在的抗体免疫反应的抗原，但是在感染甲型肝炎病毒或乙型肝炎病毒的个体中不存在，并且在对照个体中也不存在。 HCV cDNA序列与乙型肝炎病毒（HDV）和HBV的序列缺乏实质同源性。 HCV cDNA编码的氨基酸序列与黄病毒序列的比较表明，HCV可能与黄病毒有关。 HCV cDNA序列及其中编码的多肽可用作检测和治疗HCV的试剂。本发明中提供的试剂也可用于分离NANBV试剂，用于在组织培养物中繁殖这些试剂，以及筛选用于HCV的抗病毒剂。

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