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1. 发明申请

US20110183964A1 HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B 有权
标题翻译：脱乙酰壳多糖基抑制剂B
公开(公告)号：US20110183964A1
公开(公告)日：2011-07-28
申请号：US13082956
申请日：2011-04-08
申请人： Michael SHULTZ , Christine Hiu-Tung CHEN , Young Shin CHO , Lei JIANG , Jianmei FAN , Gang LIU , Dyuti MAJUMDAR , Jianke LI
发明人： Michael SHULTZ , Christine Hiu-Tung CHEN , Young Shin CHO , Lei JIANG , Jianmei FAN , Gang LIU , Dyuti MAJUMDAR , Jianke LI
IPC分类号： A61K31/55 , A61P35/00 , A61P35/02 , A61K31/404 , A61K31/4155 , A61K31/437 , A61K31/40 , A61K31/4025 , A61K31/497 , A61K31/422 , A61K31/41 , A61K31/496
CPC分类号： C07D207/08 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D471/04
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and are as defined herein.The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R 1，R 2，R 3，Y，Z如本文所定义。本教导还提供制备式I化合物的方法和使用式I化合物治疗，抑制或预防全部或部分由脱乙酰酶介导的病理状况或病症的方法。

2. 发明申请

US20110053925A1 Hydroxamate-Based Inhibitors of Deacetylases 审中-公开
标题翻译：基于羟基甲酸酯的去乙酰化酶抑制剂
公开(公告)号：US20110053925A1
公开(公告)日：2011-03-03
申请号：US12870123
申请日：2010-08-27
申请人： Young Shin CHO , Lei JIANG , Michael SHULTZ , Christine Hiu-Tung CHEN , Gang LIU , Jianke LI
发明人： Young Shin CHO , Lei JIANG , Michael SHULTZ , Christine Hiu-Tung CHEN , Gang LIU , Jianke LI
IPC分类号： A61K31/537 , C12N5/00 , A61K31/5377 , A61K31/495 , A61K31/438 , A61K31/437 , A61K31/454 , C07D498/10 , C07D413/14 , C07D413/02 , C07D295/205 , C07D471/10 , C07D471/04 , C07D401/02 , A61P25/16 , A61P25/28 , A61P9/04 , A61P7/02 , A61P19/02 , A61P9/10 , A61P35/00
CPC分类号： C07D295/205 , C07D213/74 , C07D217/22 , C07D235/30 , C07D241/42 , C07D241/50 , C07D295/155 , C07D295/185 , C07D295/26 , C07D401/04 , C07D401/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D491/107 , C07D491/113 , C07D498/10
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, ring A, and are as defined herein.The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R1，R2，R3，环A，如本文所定义。本教导还提供制备式I化合物的方法和使用式I化合物治疗，抑制或预防全部或部分由脱乙酰酶介导的病理状况或病症的方法。

3. 发明申请

US20110060009A1 Hydroxamate-Based Inhibitors of Deacetylases 审中-公开
标题翻译：基于羟基甲酸酯的去乙酰化酶抑制剂
公开(公告)号：US20110060009A1
公开(公告)日：2011-03-10
申请号：US12870186
申请日：2010-08-27
申请人： Clinton A. BROOKS , Christine Hiu-Tung CHEN , Young Shin CHO , Lei JIANG , Gang LIU , Michael SHULTZ
发明人： Clinton A. BROOKS , Christine Hiu-Tung CHEN , Young Shin CHO , Lei JIANG , Gang LIU , Michael SHULTZ
IPC分类号： A61K31/4439 , C07D403/06 , A61K31/4045 , C07D401/06 , C07D401/14 , A61K31/4155 , A61K31/4192 , A61P35/00 , A61P25/28 , A61P25/16 , A61P9/00 , A61P19/02 , C12N9/99
CPC分类号： C07D403/06 , C07D401/14 , C07D403/04 , C07D498/06
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, R4, R5, ring A, and Z are as defined herein.The present teachings also provide methods of preparing compounds of Formula I and methods of use compounds of Formula I in treating pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R 1，R 2，R 3，R 4，R 5，环A和Z如本文所定义。本教导还提供制备式I化合物的方法和使用式I化合物治疗全部或部分由脱乙酰酶介导的病理状况或病症的方法。

4. 发明申请

US20160039802A1 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH 审中-公开
标题翻译： 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES作为突变体IDH的抑制剂
公开(公告)号：US20160039802A1
公开(公告)日：2016-02-11
申请号：US14774741
申请日：2014-03-13
申请人： Young Shin CHO , Julian Roy LEVELL , Gang LIU , Michael David SHULTZ , Simon Cornelis VAN DER PLAS , NOVARTIS AG
发明人： Young Shin CHO , Julian Roy LEVELL , Gang LIU , Michael David SHULTZ , Simon Cornelis VAN DER PLAS
IPC分类号： C07D413/04 , C07D487/08 , C07D417/14 , A61K31/5377 , A61K31/506 , C07D413/14
CPC分类号： C07D413/04 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/14 , C07D417/14 , C07D487/08 , A61K2300/00
摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are described herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant I DH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
摘要翻译：本发明涉及式（I）：或其药学上可接受的盐，其中R1，R2a，R2b和R3-R7如本文所述。本发明还涉及含有式（I）化合物的组合物以及这些化合物在抑制具有新形态活性的突变体IDH蛋白质中的用途。本发明还涉及式（I）化合物在治疗与这种突变体I DH蛋白相关的疾病或病症中的应用，包括但不限于细胞增殖病症如癌症。

5. 发明申请

US20160318915A1 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH 有权
标题翻译： 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES作为突变体IDH的抑制剂
公开(公告)号：US20160318915A1
公开(公告)日：2016-11-03
申请号：US15209731
申请日：2016-07-13
申请人： Thomas Raymond CAFERRO , Zhuoliang CHEN , Young Shin CHO , Abran Q. COSTALES , Julian Roy LEVELL , Gang LIU , James R. MANNING , Martin SENDZIK , Cynthia SHAFER , Michael David SHULTZ , James Clifford SUTTON , Yaping WANG , Qian ZHAO
发明人： Thomas Raymond CAFERRO , Zhuoliang CHEN , Young Shin CHO , Abran Q. COSTALES , Julian Roy LEVELL , Gang LIU , James R. MANNING , Martin SENDZIK , Cynthia SHAFER , Michael David SHULTZ , James Clifford SUTTON , Yaping WANG , Qian ZHAO
IPC分类号： C07D413/14 , C07D413/04 , C07D417/14
CPC分类号： C07D413/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/04 , C07D417/14
摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
摘要翻译：或其药学上可接受的盐，其中R1，R2a，R2b和R3-R7为本文。本发明还涉及含有式（I）化合物的组合物以及这些化合物在抑制具有新形态活性的突变体IDH蛋白质中的用途。本发明还涉及式（I）化合物在治疗与这种突变体IDH蛋白相关的疾病或病症中的用途，包括但不限于细胞增殖病症如癌症。

6. 发明申请

US20140275083A1 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH 审中-公开
标题翻译： 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES作为突变体IDH的抑制剂
公开(公告)号：US20140275083A1
公开(公告)日：2014-09-18
申请号：US14208015
申请日：2014-03-13
申请人： Thomas Raymond CAFERRO , Zhuoliang CHEN , Young Shin CHO , Abran Q. COSTALES , Julian Roy LEVELL , Gang LIU , James R. MANNING , Martin SENDZIK , Cynthia SHAFER , Michael David SHULTZ , James SUTTON , Yaping WANG , Qian ZHAO
发明人： Thomas Raymond CAFERRO , Zhuoliang CHEN , Young Shin CHO , Abran Q. COSTALES , Julian Roy LEVELL , Gang LIU , James R. MANNING , Martin SENDZIK , Cynthia SHAFER , Michael David SHULTZ , James SUTTON , Yaping WANG , Qian ZHAO
IPC分类号： C07D413/04 , A61K31/5377 , C07D417/14 , C07D413/14 , A61K31/506
CPC分类号： C07D413/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/04 , C07D417/14
摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
摘要翻译：本发明涉及式（I）：或其药学上可接受的盐，其中R1，R2a，R2b和R3-R7为本文。本发明还涉及含有式（I）化合物的组合物以及这些化合物在抑制具有新形态活性的突变体IDH蛋白质中的用途。本发明还涉及式（I）化合物在治疗与这种突变体IDH蛋白相关的疾病或病症中的用途，包括但不限于细胞增殖病症如癌症。

7. 发明申请

US20180216732A1 MOTOR 审中-公开
公开(公告)号：US20180216732A1
公开(公告)日：2018-08-02
申请号：US15939342
申请日：2018-03-29
申请人： Gang LIU
发明人： Gang LIU
IPC分类号： F16H61/662 , H02K21/16 , F16H61/14 , F16H1/32
摘要： A motor with a variable-speed torque converter is disclosed. A rotor of the motor has a common permanent magnet structure. Permanent magnets are disposed on the rotor. The variable-speed torque converter includes a wheel disc, a wheel ring, a roller, a transmission gear II, a transmission gear III, a round wheel, an annular gear, a driving gear, turning discs, a transmission shaft, and an output shaft. The driving gear fixedly connected to the transmission shaft of the motor drives the transmission gear. The transmission gear is in contact with the annular gear. The transmission gear rotates around the driving gear to drive the wheel disc to rotate together. The wheel disc is fixedly connected to the output shaft to drive a driving wheel to rotate. Therefore, a working capability of the motor is enhanced. The converter can be applied to an electromotor, a generator, or any other power device.

8. 发明申请

US20130017724A1 EMI-PREVENTING SOCKET AND MANUFACTURING METHOD THEREOF 有权
标题翻译：防EMI插座及其制造方法
公开(公告)号：US20130017724A1
公开(公告)日：2013-01-17
申请号：US13355305
申请日：2012-01-20
申请人： Gang LIU
发明人： Gang LIU
IPC分类号： H01R13/648 , B29C45/14
CPC分类号： H01R43/24 , H01R13/6581 , Y10T29/49117 , Y10T29/49169
摘要： A manufacturing method for an EMI-preventing socket comprises the following steps of: providing an EMI-preventing element and a plurality of pins that include a ground pin; connecting a connecting portion of the EMI-preventing element to the ground pin; providing a mold; placing the EMI-preventing element, the ground pin and the other pins in the mold in such a manner that the EMI-preventing element surrounds the pins; and providing a molding material into the mold to wrap the pins, and a joint of the connection portion of the EMI-preventing element and the ground pin to form a socket body of the EMI-preventing socket. Parts of the EMI-preventing element and one ends of the pins are exposed out of the socket body of the EMI-preventing socket. An EMI-preventing socket made by the manufacturing method is also disclosed.
摘要翻译：防EMI插座的制造方法包括以下步骤：提供防EMI元件和包括接地引脚的多个引脚; 将防EMI元件的连接部分连接到接地引脚; 提供模具; 将防EMI元件，接地销和其他销放置在模具中，使得防EMI元件围绕销; 以及将模制材料提供到模具中以包裹销，以及防EMI元件的连接部分和接地销的接头，以形成防EMI插座的插座主体。防EMI元件的一部分和销的一端从防EMI插座的插座主体露出。还公开了一种通过制造方法制造的防EMI插座。

9. 发明申请

US20140044131A1 METHOD AND APPARATUS FOR FORWARDING PACKETS IN IPV6 ACCESS NODE 有权
标题翻译：用于在IPV6访问节点中转发分组的方法和装置
公开(公告)号：US20140044131A1
公开(公告)日：2014-02-13
申请号：US13950815
申请日：2013-07-25
申请人： Haibo WEN , Gang LIU
发明人： Haibo WEN , Gang LIU
IPC分类号： H04L12/741
CPC分类号： H04L45/745 , H04L12/2858 , H04L69/16 , H04L69/167 , H04W8/26 , H04W80/04 , H04W88/16
摘要： In view of the technical problems that exist during implementing IP address anti-spoofing in an access node device in an IPv6 access network, the present invention proposes a packet forwarding method and apparatus in an IPv6 Access Node, for forwarding a packet from a Residential Gateway. In the method, the access node device first receives a packet from the Residential Gateway, then obtains a network prefix in a source UPv6 address of the packet, judges whether the network prefix in the source IPv6 address of the packet is a valid network prefix of a CPN corresponding to the Residential Gateway, and if yes, forwards the packet finally. Particularly, in the present invention the access node device can automatically obtain valid network prefix using technical means such as snooping a network prefix allocation reply message. Therefore, the present invention greatly increases operation efficiency and security of the IPv6 access network and simplifies network management of the IPv6 access network.
摘要翻译：鉴于在IPv6接入网中的接入节点设备中实现IP地址反欺骗时存在的技术问题，本发明提出了IPv6接入节点中的分组转发方法和装置，用于从住宅网关。在该方法中，接入节点设备首先从住宅网关接收分组，然后获取分组的源UPv6地址中的网络前缀，判断分组的源IPv6地址中的网络前缀是否为有效的网络前缀对应于住宅网关的CPN，如果是，则转发该分组。特别地，在本发明中，接入节点设备可以使用诸如窥探网络前缀分配回复消息的技术手段自动获得有效的网络前缀。因此，本发明大大提高了IPv6接入网的运行效率和安全性，简化了IPv6接入网的网络管理。

10. 发明申请

US20110157352A1 INFRARED DIRECT ILLUMINATION MACHINE VISION TECHNIQUE FOR SEMICONDUCTOR PROCESSING EQUIPMENT 有权
标题翻译：半导体加工设备的红外直接照明机器视觉技术
公开(公告)号：US20110157352A1
公开(公告)日：2011-06-30
申请号：US12977229
申请日：2010-12-23
申请人： Gang LIU , Lei Wang
发明人： Gang LIU , Lei Wang
IPC分类号： H04N7/18
CPC分类号： G03F9/00 , G03F9/7065 , G03F9/7084 , G03F9/7088
摘要： A vision system is provided to determine a positional relationship between a semiconductor wafer on a platen and an element on a processing machine, such as a printing screen, on a remote side of the semiconductor wafer from the platen. A source directs infrared light through an aperture in the platen to illuminate the semiconductor wafer and cast a shadow onto the element adjacent an edge of the semiconductor wafer. A video camera produces an image using light received from the platen aperture, wherein some of that received light was reflected by the wafer. The edge of the semiconductor wafer in the image is well defined by a dark/light transition.
摘要翻译：提供了一种视觉系统，用于确定压板上的半导体晶片与半导体晶片的远离压纸台的诸如印刷屏幕的处理机器上的元件之间的位置关系。源将红外光引导通过压板中的孔以照亮半导体晶片并将阴影投射到与半导体晶片的边缘相邻的元件上。摄像机使用从压板孔接收的光产生图像，其中一些所接收的光被晶片反射。图像中的半导体晶片的边缘由暗/光转变很好地限定。

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