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1. 发明申请

WO2010129752A1 COMPOSITIONS AND METHODS OF USE FOR BINDING MOLECULES TO DICKKOPF-1 OR DICKKOPF-4 OR BOTH 审中-公开
标题翻译：用于将分子结合到DICKKOPF-1或DICKKOPF-4或两者的组合物和方法
公开(公告)号：WO2010129752A1
公开(公告)日：2010-11-11
申请号：PCT/US2010/033845
申请日：2010-05-06
申请人： NOVARTIS AG , BRAENDLE, Edgar , RAE, Patricia , RANGWALA, Shamina M. , STOVER, David Raymond , TAYLOR, Ann
发明人： BRAENDLE, Edgar , RAE, Patricia , RANGWALA, Shamina M. , STOVER, David Raymond , TAYLOR, Ann
IPC分类号： C07K16/18 , A61P35/00 , A61P3/10
CPC分类号： C07K16/18 , A61K38/19 , A61K39/39533 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/70 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Methods of using binding molecules and fragments thereof that bind to the protein target Dickkopf -1 (DKK1), Dickkopf-4 (DKK4) or both (wherein specificity to DKK1 or DKK4 or both is herein denoted as "DKK1/4") are provided.
摘要翻译：提供结合蛋白质目标Dickkopf -1（DKK1），Dickkopf-4（DKK4）或两者的结合分子及其片段的方法（其中DKK1或DKK4或两者的特异性在本文中表示为“DKK1 / 4”）。

2. 发明申请

WO2004098651A2 BONE LOCALISING RADIOPHARMACEUTICAL AND TUBULIN-INTERACTING COMPOUND COMBINATORIAL RADIOTHERAPY 审中-公开
标题翻译：骨骼局部放射治疗与管腔相互作用化合物组合放射治疗
公开(公告)号：WO2004098651A2
公开(公告)日：2004-11-18
申请号：PCT/EP2004/004434
申请日：2004-04-27
申请人： SCHERING AG , BRAENDLE, Edgar , HAUSMAN, Diana
发明人： BRAENDLE, Edgar , HAUSMAN, Diana
IPC分类号： A61K51/04
CPC分类号： A61K31/337 , A61K51/0476 , A61K51/0489
摘要： The present invention relates to a method for the improved treatment of a cancerous disease in a patient and/or for the palliation of pain associated with cancer diseases, comprising the administration of a tubulin interacting compound in combination with a bone-localising radiopharmaceutical to said patient in an effective amount that will not cause any substantial ablation of the bone marrow of said patent. In particular, the cancerous disease is selected from the group of cancer diseases, comprising multiple myeloma, leukaemia, lymphoma, breast cancer, prostate cancer, gynecologic cancer, gastric cancer ovarian cancer, lung cancer and/or renal cell carcinoma. In a preferred embodiment, the bone-localising radiopharmaceutical is samarium Sm 153 lexidronam and the tubulin interacting compound is docetaxel.
摘要翻译：本发明涉及一种用于改善患者癌症和/或用于缓解与癌症疾病相关的疼痛的治疗方法，包括将微管蛋白相互作用化合物与骨定位放射性药物组合给所述患者有效量不会导致所述专利的骨髓的任何实质性消融。特别地，癌性疾病选自包括多发性骨髓瘤，白血病，淋巴瘤，乳腺癌，前列腺癌，妇科癌症，胃癌卵巢癌，肺癌和/或肾细胞癌的癌症疾病。在优选的实施方案中，骨定位放射性药物是钐Sm 153 lexidronam，微管蛋白相互作用化合物是多西紫杉醇。

3. 发明公开

EP2427490A1 COMPOSITIONS AND METHODS OF USE FOR BINDING MOLECULES TO DICKKOPF-1 OR DICKKOPF-4 OR BOTH 审中-公开
标题翻译：组合物和方法FOR USE ON DICK HEAD 1 OR DICK HEAD 4 OR两种结合分子
公开(公告)号：EP2427490A1
公开(公告)日：2012-03-14
申请号：EP10719858.2
申请日：2010-05-06
申请人： Novartis AG
发明人： BRAENDLE, Edgar , RAE, Patricia , RANGWALA, Shamina M. , STOVER, David Raymond , TAYLOR, Ann
IPC分类号： C07K16/18 , A61P35/00 , A61P3/10
CPC分类号： C07K16/18 , A61K38/19 , A61K39/39533 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/70 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Methods of using binding molecules and fragments thereof that bind to the protein target Dickkopf -1 (DKK1), Dickkopf-4 (DKK4) or both (wherein specificity to DKK1 or DKK4 or both is herein denoted as "DKK1/4") are provided.

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