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1. 发明申请

WO2007126799A3 COMPOSITIONS AND METHODS OF USE FOR ANTIBODIES OF C-MET 审中-公开
标题翻译：用于C-MET抗体的组合物和方法
公开(公告)号：WO2007126799A3
公开(公告)日：2008-04-03
申请号：PCT/US2007007543
申请日：2007-03-29
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , STOVER DAVID RAYMOND , PRASSLER JOSEF , BERGER CATRIN , BROCKS BODO
发明人： STOVER DAVID RAYMOND , PRASSLER JOSEF , BERGER CATRIN , BROCKS BODO
IPC分类号： C07K16/28 , A61K31/00 , A61K38/00 , A61K39/395 , A61K47/48 , A61P29/00 , A61P35/00 , C12N15/13 , C12N15/85 , G01N33/00
CPC分类号： C07K16/2863 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要： Antibodies and fragments that bind to the protein target c Met, particularly to epitopes located in the c Met extracellular domain, are provided, as are methods of use of the antibodies and kits, for treating an unwanted cell, in particular, a cell associated with a c Met-related condition such as a cancer, a metastasis, or an inflammatory condition.
摘要翻译：提供了结合蛋白质靶标c Met的抗体和片段，特别是位于c Met细胞外结构域中的表位，以及使用抗体和试剂盒的方法，用于治疗不想要的细胞，特别是与 ac Met相关病症如癌症，转移或炎性病症。

2. 发明申请

WO2010130824A2 COLLECTIONS AND USES THEREOF 审中-公开
标题翻译：收集和使用
公开(公告)号：WO2010130824A2
公开(公告)日：2010-11-18
申请号：PCT/EP2010056637
申请日：2010-05-14
申请人： MORPHOSYS AG , ENZELBERGER MARKUS , PRASSLER JOSEF , URLINGER STEFANIE
发明人： ENZELBERGER MARKUS , PRASSLER JOSEF , URLINGER STEFANIE
IPC分类号： C07K16/00
CPC分类号： C07K16/00
摘要： The present disclosure relates to synthetic collections of candidate proteinaceous binding molecules, for example, antibodies, wherein one or more candidate proteinaceous binding molecules comprise an optimized property as compared to a parental proteinaceous binding molecule. In particular, the collections of candidate proteinaceous binding molecules are made by gene synthesis, and are based upon the sequence of the parental proteinaceous binding molecule, for example, antibody, therefore a custom collection of candidate proteinaceous binding molecules can be made specifically for one parental proteinaceous binding molecules. The present disclosure also relates to methods of making and using such collections for optimizing parental proteinaceous binding molecules, for example, antibodies. The present disclosure also relates to the candidate proteinaceous binding molecules of the synthetic collections comprising optimized properties.
摘要翻译：本公开涉及候选蛋白质结合分子的合成收集，例如抗体，其中与亲本蛋白质结合分子相比，一种或多种候选蛋白质结合分子包含优化的性质。特别地，通过基因合成制备候选蛋白质结合分子的集合，并且基于亲本蛋白质结合分子的序列，例如抗体，因此候选蛋白质结合分子的定制收集可以专门为一个亲本蛋白质结合分子。本公开还涉及制备和使用这些收集物以优化亲本蛋白质结合分子例如抗体的方法。本公开还涉及包含优化性质的合成收集物的候选蛋白质结合分子。

3. 发明申请

WO2004013276A3 NOVEL TRICISTRONIC VECTORS AND USES THEREFOR 审中-公开
标题翻译：新颖的TRICISTRONIC矢量及其用途
公开(公告)号：WO2004013276A3
公开(公告)日：2004-12-29
申请号：PCT/IB0303681
申请日：2003-07-30
申请人： MORPHOSYS IP GMBH , PRASSLER JOSEF , STARK YVONNE
发明人： PRASSLER JOSEF , STARK YVONNE
IPC分类号： C07K16/00 , C07K16/28 , C12N15/10 , C40B40/02
CPC分类号： C40B40/02 , C07K16/00 , C07K16/005 , C07K16/2845 , C07K2317/55 , C07K2317/622 , C12N15/1037 , C12N15/70
摘要： A tricistronic vector (i.e., a vector capable of expressing three exogenous genes, which are not fused together, under the control of one promoter) effectively can encode an immunoglobulin-presenting polypeptide and two immunoglobulin (Ig) polypeptides. The encoded Ig-presenting polypeptide is able to associate with at least one of the Ig polypeptides via co-expressed associating agents. A vector according to the present invention particularly is suited for phage display technology, e.g., when the Ig-presenting polypeptide is a phage coat protein and the Ig polypeptides associate to form a Fab.

4. 发明申请

WO2004013276A9 NOVEL TRICISTRONIC VECTORS AND USES THEREFOR 审中-公开
标题翻译：新型三相矢量并用于此
公开(公告)号：WO2004013276A9
公开(公告)日：2004-04-01
申请号：PCT/IB0303681
申请日：2003-07-30
申请人： MORPHOSYS IP GMBH , PRASSLER JOSEF , STARK YVONNE
发明人： PRASSLER JOSEF , STARK YVONNE
IPC分类号： C07K16/00 , C07K16/28 , C12N15/10 , C40B40/02 , C12N
CPC分类号： C40B40/02 , C07K16/00 , C07K16/005 , C07K16/2845 , C07K2317/55 , C07K2317/622 , C12N15/1037 , C12N15/70
摘要： A tricistronic vector (i.e., a vector capable of expressing three exogenous genes, which are not fused together, under the control of one promoter) effectively can encode an immunoglobulin-presenting polypeptide and two immunoglobulin (Ig) polypeptides. The encoded Ig-presenting polypeptide is able to associate with at least one of the Ig polypeptides via co-expressed associating agents. A vector according to the present invention particularly is suited for phage display technology, e.g., when the Ig-presenting polypeptide is a phage coat protein and the Ig polypeptides associate to form a Fab.
摘要翻译：三顺反子载体（即，能够表达三种外源基因的载体，其在一种启动子的控制下不融合在一起）有效地可以编码免疫球蛋白呈递多肽和两种免疫球蛋白（Ig）多肽。编码的Ig-呈递多肽能够通过共表达的缔合剂与至少一种Ig多肽缔合。根据本发明的载体特别适用于噬菌体展示技术，例如，当Ig-呈递多肽是噬菌体外壳蛋白并且Ig多肽结合形成Fab时。

5. 发明专利

ES2386738T3 Composiciones y métodos de uso para anticuerpos de C-MET 未知
公开(公告)号：ES2386738T3
公开(公告)日：2012-08-28
申请号：ES07754114
申请日：2007-03-29
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH
发明人： STOVER DAVID RAYMOND , PRASSLER JOSEF , BERGER CATRIN , BROCKS BODO
IPC分类号： C07K16/28 , A61K31/00 , A61K38/00 , A61K39/395 , A61K47/48 , A61P29/00 , A61P35/00 , C12N15/13 , C12N15/85 , G01N33/00
摘要： Un antígeno humano humanizado o una porción de enlazamiento a antígeno de los mismos que comprende unaregión en enlazamiento antígeno que es específico para una proteína diana c-Met, en donde el anticuerpo o la porciónde enlazamiento a anticuerpo del mismo comprende los CDRs del VL y los dominios de:(a) anticuerpo 5091 de SEQ ID NOs. 34 y 66(b) anticuerpo 5097 de EQ ID NOs. 37 y 67;(c) Anticuerpo 5098 de SEQ ID NOs. 38 y 68; o(d) Anticuerpo 5185 de SEQ ID NOs. 53 y 71.

6. 发明申请

WO2007134876A8 HIGH AFFINITY HUMAN AND HUMANIZED ANTI-a5ß1 INTEGRIN FUNCTION BLOCKING ANTIBODIES WITH REDUCED IMMUNOGENICITY 审中-公开
标题翻译：具有降低免疫原性的高亲和力和人类抗α5β1整合功能阻断抗体
公开(公告)号：WO2007134876A8
公开(公告)日：2009-07-02
申请号：PCT/EP2007004648
申请日：2007-05-21
申请人： BAYER SCHERING PHARMA AG , MORPHOSYS AG , MENRAD ANDREAS , WILLUDA JOERG , BOSSLET KLAUS , ZOPF DIETER , PETRUL HEIKE , STEIDL STEFAN , PRASSLER JOSEF , PETIT-FRERE CORINNE
发明人： MENRAD ANDREAS , WILLUDA JOERG , BOSSLET KLAUS , ZOPF DIETER , PETRUL HEIKE , STEIDL STEFAN , PRASSLER JOSEF , PETIT-FRERE CORINNE
IPC分类号： C07K16/28 , A01K67/027 , A61K39/395 , A61P35/00 , C12N15/63
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/21
摘要： The present invention relates to recombinant human or humanized polypeptides which bind to a5ß1 integrin with high affinity and blocking function. Further, diagnostic and pharmaceutic applications of the polypeptides are disclosed.
摘要翻译：本发明涉及以高亲和性和阻断功能结合α5整合素的重组人或人源化多肽。此外，公开了多肽的诊断和药物应用。

7. 发明申请

WO2009015908A2 ANTI EPHB4 ANTIBODIES AND ANTIBODY FRAGMENTS 审中-公开
标题翻译：抗EPHB4抗体和抗体片段
公开(公告)号：WO2009015908A2
公开(公告)日：2009-02-05
申请号：PCT/EP2008006451
申请日：2008-07-25
申请人： BAYER SCHERING PHARMA AG , MORPHOSYS AG , PETRUL HEIKE , MENRAD ANDREASE , WILLUDA JOERG , ZOPF DIETER , GLIENKE JENS , PRASSLER JOSEF , POPP ANDREAS , STEIDL STEFAN , PRACHT CATRIN
发明人： PETRUL HEIKE , MENRAD ANDREASE , WILLUDA JOERG , ZOPF DIETER , GLIENKE JENS , PRASSLER JOSEF , POPP ANDREAS , STEIDL STEFAN , PRACHT CATRIN
IPC分类号： C07K16/28 , A61K39/395 , C07K16/30
CPC分类号： C07K16/2866 , C07K16/30 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The invention concerns antibodies and antibody fragments, specifically recognising the EphB4 receptor comprising heavy chains and light chain, comprising light and heavy CDR's, and their use as medicament for the treatment of pathological angiogenesis, in particular cancer therapy.
摘要翻译：本发明涉及特异性识别包含重链和轻链的EphB4受体的抗体和抗体片段，其包含轻链和重链CDR，以及它们作为用于治疗病理性血管生成，特别是癌症治疗的药物的用途。

8. 发明专利

AU2003253193B2 Novel tricistronic vectors and uses therefor 未知
公开(公告)号：AU2003253193B2
公开(公告)日：2009-07-02
申请号：AU2003253193
申请日：2003-07-30
申请人： MORPHOSYS AG , PRASSLER JOSEF , STARK YVONNE
发明人： PRASSLER JOSEF , STARK YVONNE
IPC分类号： C12N15/10 , C07K16/00 , C07K16/28 , C40B40/02
摘要： A tricistronic vector (i.e., a vector capable of expressing three exogenous genes, which are not fused together, under the control of one promoter) effectively can encode an immunoglobulin-presenting polypeptide and two immunoglobulin (Ig) polypeptides. The encoded Ig-presenting polypeptide is able to associate with at least one of the Ig polypeptides via co-expressed associating agents. A vector according to the present invention particularly is suited for phage display technology, e.g., when the Ig-presenting polypeptide is a phage coat protein and the Ig polypeptides associate to form a Fab.

9. 发明专利

AU2003253193A1 NOVEL TRICISTRONIC VECTORS AND USES THEREFOR 未知
公开(公告)号：AU2003253193A1
公开(公告)日：2004-02-23
申请号：AU2003253193
申请日：2003-07-30
申请人： MORPHOSYS AG , PRASSLER JOSEF , STARK YVONNE
发明人： PRASSLER JOSEF , STARK YVONNE
IPC分类号： C07K16/00 , C07K16/28 , C12N15/10 , C40B40/02
摘要： A tricistronic vector (i.e., a vector capable of expressing three exogenous genes, which are not fused together, under the control of one promoter) effectively can encode an immunoglobulin-presenting polypeptide and two immunoglobulin (Ig) polypeptides. The encoded Ig-presenting polypeptide is able to associate with at least one of the Ig polypeptides via co-expressed associating agents. A vector according to the present invention particularly is suited for phage display technology, e.g., when the Ig-presenting polypeptide is a phage coat protein and the Ig polypeptides associate to form a Fab.

10. 发明专利

JP2013056888A Lingo binding molecule and pharmaceutical use thereof 审中-公开
标题翻译：林O ING。。。。。。。。。。。。。。。。。
公开(公告)号：JP2013056888A
公开(公告)日：2013-03-28
申请号：JP2012222370
申请日：2012-10-04
申请人： Novartis Ag , ノバルティスアーゲー
发明人： WALMSLEY ADRIAN , WISHART WILLIAM LEONARD , CORTES-CROS MARTA , PRASSLER JOSEF , KLAGGE INGO
IPC分类号： C07K16/28 , A61K39/395 , A61P25/00 , C12N15/09
CPC分类号： C07K16/28 , A61K39/39533 , A61K2039/505 , C07K16/18 , C07K16/2803 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
摘要： PROBLEM TO BE SOLVED: To provide binding molecules capable of binding to rat, cynomolgus monkey and human LINGO polypeptide, a polynucleotide encoding such binding molecule; an expression vector comprising the polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell comprising the expression system as defined above; use of such binding molecule as a pharmaceutical, especially in treatment to promote axonal regeneration/plasticity; a pharmaceutical composition comprising the binding molecule; and a method of treatment of diseases associated with axonal degeneration and demyelination.SOLUTION: The binding molecule to a particular region or epitope of LINGO-1 is provided. The binding molecule binds to the mature ectodomain (residues 34-550) of rat LINGO-1, cynomolgus monkey LINGO-1 and human LINGO-1 with a dissociation constant (K)
摘要翻译：要解决的问题：提供能够结合大鼠，食蟹猴和人LINGO多肽的结合分子，编码这种结合分子的多核苷酸; 包含该多核苷酸的表达载体; 包含能够产生结合分子的多核苷酸的表达系统; 包含如上定义的表达系统的分离的宿主细胞; 使用这种结合分子作为药物，特别是在治疗中促进轴突再生/可塑性; 包含所述结合分子的药物组合物; 以及治疗与轴索变性和脱髓鞘相关的疾病的方法。解决方案：提供了与LINGO-1的特定区域或表位的结合分子。结合分子以解离常数（K D ）结合大鼠LINGO-1，食蟹猴LINGO-1和人LINGO-1的成熟胞外域（残基34-550） <1000nM，更优选的是用K D <100nM，最优选的是K D <10nM。版权所有（C）2013，JPO＆INPIT

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