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1. 发明申请

US20100016443A1 METHOD FOR PREPARING PARTICLES COMPRISING METAL OXIDE COATING AND PARTICLES WITH METAL OXIDE COATING 审中-公开
标题翻译：用于制备包含金属氧化物涂层和颗粒与金属氧化物涂层的颗粒的方法
公开(公告)号：US20100016443A1
公开(公告)日：2010-01-21
申请号：US12525331
申请日：2008-02-03
申请人： Ofer Toledano , Haim Bar-Simantov , Nissim Bilman , Leora Shapiro , Raed Abu-Reziq , Srikanth Sriadibhatla , William T. Sommer
发明人： Ofer Toledano , Haim Bar-Simantov , Nissim Bilman , Leora Shapiro , Raed Abu-Reziq , Srikanth Sriadibhatla , William T. Sommer
IPC分类号： A61K31/327 , B05D7/00 , B32B5/16 , A61K47/02 , A01N25/26 , A61K31/11 , A01N31/04 , A01N35/02 , A61K31/07 , A01P7/04 , A61P17/00 , A61P17/10 , A61P17/04 , A61P17/06
CPC分类号： A61K9/5073 , A01N25/26 , A01N53/00 , A61K8/11 , A61K8/25 , A61K8/38 , A61K8/671 , A61K9/501 , A61K9/5021 , A61K9/5026 , A61K2800/412 , A61Q19/00 , B01J13/02 , B01J13/22 , C09C3/063 , Y10T428/2991 , A01N2300/00
摘要： The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer. The invention further relates to particles comprising a particulate matter coated by a metal oxide layer, to a use of the particles for topical administration, and to a method for preventing, reducing, or eliminating pests at a locus, using the particles.
摘要翻译：本发明涉及一种用金属氧化物涂覆固体，不溶于水的颗粒物质的方法，包括：（a）使固体，水不溶性颗粒物质与离子添加剂和水性介质接触，以获得所述颗粒的分散体表面上有正面指控的事情; （b）对颗粒状物质进行包括在金属氧化物表面上析出金属氧化物盐以形成金属氧化物层的涂覆方法，从而获得由金属氧化物涂层涂覆的颗粒状物质; （c）重复步骤（b）至少4次以上; 和（d）老化所述涂层。本发明还涉及包含由金属氧化物层涂覆的颗粒物质，使用该颗粒用于局部给药的颗粒，以及使用该颗粒来防止，减少或消除某些场所的害虫的方法。

2. 发明申请

US20100047357A1 COMPOSITIONS FOR TOPICAL APPLICATION COMPRISING A PEROXIDE AND RETINOID 审中-公开
标题翻译：用于包含过氧化物和再生物的局部应用的组合物
公开(公告)号：US20100047357A1
公开(公告)日：2010-02-25
申请号：US12525329
申请日：2008-02-03
申请人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov , Leora Shapiro , Raed Abu-Reziq
发明人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov , Leora Shapiro , Raed Abu-Reziq
IPC分类号： A61K9/14 , A61K31/327 , A61K31/202 , A61K31/192 , A61K31/4436 , A61P17/00 , A61P17/06 , A61P17/10
CPC分类号： A61K9/0014 , A61K9/28 , A61K47/34
摘要： The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.
摘要翻译：本发明涉及用于局部应用的组合物，其包含作为活性成分的过氧化物和类视色素，其中所述过氧化物和类视色素之一为第一微粒的形式，其包含由金属氧化物层包被的活性成分的固体颗粒物质，所述过氧化物和类视色素中的另一种以未包衣的游离形式或活性成分的包衣形式存在。本发明还涉及使用所述组合物治疗受试者的表面状况的方法，制备显示出改善的稳定性的组合物的方法，以及试剂盒，其包含：（a）第一组合物，其包含作为第一活性成分的过氧化物; 和（b）第二组合物，其包含类视黄醇作为第二活性成分; 所述第一和第二活性成分中的至少一个被金属氧化物层包覆。

3. 发明授权

US10525433B2 Formation of nanometric core-shell particles having a metal oxide shell 有权
公开(公告)号：US10525433B2
公开(公告)日：2020-01-07
申请号：US12518743
申请日：2007-12-12
申请人： Ofer Toledano , Hanan Sertchook , Raed Abu-Reziq , Haim Bar-Simantov , Leora Shapiro
发明人： Ofer Toledano , Hanan Sertchook , Raed Abu-Reziq , Haim Bar-Simantov , Leora Shapiro
IPC分类号： A61K9/66 , A61K8/06 , A61K8/18 , A61Q11/00 , A61Q17/04 , B01J13/14
摘要： A process for preparing nanocapsules having a core-shell structure, comprising:(a) preparing an oil-in-water emulsion by emulsification of an oily phase that comprises a core material, in an aqueous phase, under high shear forces, wherein one or both of the oily phase, and the aqueous phase comprises a sol-gel precursor; (b) subjecting the emulsion obtained in (a) to a high pressure homogenization to obtain a nano-emulsion; and (c) applying conditions for hydrolyzing and polycondensing the sol-gel precursor to obtain nanocapsules having a metal oxide shell encapsulating the core material, said nanocapsules have a particle size distribution of: d10=10-80 nm, d50=30-200 nm, and d90=70-500 nm, in diameter. The invention also relate to nanocapsules having the above particle size distribution and to composition comprising the nanocapsules.

4. 发明授权

US08617580B2 Compositions for topical application comprising a peroxide and retinoid 有权
标题翻译：用于局部应用的组合物，其包含过氧化物和类视色素
公开(公告)号：US08617580B2
公开(公告)日：2013-12-31
申请号：US13495701
申请日：2012-06-13
申请人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov , Leora Shapiro , Raed Abu-Reziq
发明人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov , Leora Shapiro , Raed Abu-Reziq
IPC分类号： A61Q19/02 , A61P17/10
CPC分类号： A61K9/0014 , A61K9/28 , A61K47/34
摘要： The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.
摘要翻译：本发明涉及用于局部应用的组合物，其包含作为活性成分的过氧化物和类视色素，其中所述过氧化物和类视色素之一为第一微粒的形式，其包含由金属氧化物层包被的活性成分的固体颗粒物质，所述过氧化物和类视色素中的另一种以未包衣的游离形式或活性成分的包衣形式存在。本发明还涉及使用所述组合物治疗受试者的表面状况的方法，制备显示出改善的稳定性的组合物的方法，以及试剂盒，其包含：（a）第一组合物，其包含作为第一活性成分的过氧化物; 和（b）第二组合物，其包含类视黄醇作为第二活性成分; 所述第一和第二活性成分中的至少一个被金属氧化物层包覆。

5. 发明申请

US20100203121A1 FORMATION OF NANOMETRIC CORE-SHELL PARTICLES HAVING A METAL OXIDE SHELL 审中-公开
标题翻译：形成具有金属氧化物壳的纳米核壳体颗粒
公开(公告)号：US20100203121A1
公开(公告)日：2010-08-12
申请号：US12518743
申请日：2007-12-12
申请人： Ofer Toledano , Hanan Sertchook , Raed Abu-Reziq , Haim Bar-Simantov , Leora Shapiro
发明人： Ofer Toledano , Hanan Sertchook , Raed Abu-Reziq , Haim Bar-Simantov , Leora Shapiro
IPC分类号： A61K9/66 , A61K8/06 , A61K8/18 , A61Q11/00 , A61Q17/04
CPC分类号： B01J13/14
摘要： A process for preparing nanocapsules having a core-shell structure, comprising:(a) preparing an oil-in-water emulsion by emulsification of an oily phase that comprises a core material, in an aqueous phase, under high shear forces, wherein one or both of the oily phase, and the aqueous phase comprises a sol-gel precursor; (b) subjecting the emulsion obtained in (a) to a high pressure homogenization to obtain a nano-emulsion; and (c) applying conditions for hydrolyzing and polycondensing the sol-gel precursor to obtain nanocapsules having a metal oxide shell encapsulating the core material, said nanocapsules have a particle size distribution of: d10=10-80 nm, d50=30-200 nm, and d90=70-500 nm, in diameter. The invention also relate to nanocapsules having the above particle size distribution and to composition comprising the nanocapsules.
摘要翻译：一种制备具有核 - 壳结构的纳米胶囊的方法，包括：（a）通过在高剪切力下在水相中乳化包含核心材料的油相的水包油乳液制备，其中一个或油相和水相都包含溶胶 - 凝胶前体; （b）将（a）中得到的乳液进行高压均化，得到纳米乳液; 并且（c）施加水解和缩聚溶胶 - 凝胶前体的条件以获得具有包封核心材料的金属氧化物壳的纳米胶囊，所述纳米胶囊的粒度分布为：d10 = 10-80nm，d50 = 30-200nm ，d90 = 70-500nm。本发明还涉及具有上述粒度分布的纳米胶囊和包含纳米胶囊的组合物。

6. 发明申请

US20120202695A1 CORE STABILIZED MICROCAPSULES, METHOD OF THEIR PREPARATION AND USES THEREOF 审中-公开
标题翻译：核心稳定化微球，其制备方法及其用途
公开(公告)号：US20120202695A1
公开(公告)日：2012-08-09
申请号：US13500937
申请日：2010-12-30
申请人： Ofer Toledano , Haim Bar-Simantov , Hanan Sertchook , Sharon Fireman-Shoresh , Dorit Marco-Dagan
发明人： Ofer Toledano , Haim Bar-Simantov , Hanan Sertchook , Sharon Fireman-Shoresh , Dorit Marco-Dagan
IPC分类号： A01N25/28 , A61K8/11 , A61K31/327 , A61K31/19 , A61P31/10 , A61P31/04 , A61P29/00 , A61P17/04 , A61P17/06 , A61P17/10 , A61P17/00 , A61P17/08 , A01P13/00 , A01P1/00 , A01P7/04 , A61K9/50
CPC分类号： A61Q19/00 , A61K8/11 , A61K8/25 , A61K8/26 , A61K8/38 , A61K8/671 , A61K9/0014 , A61K9/5115 , A61K9/5192 , A61K2800/412 , B01J13/14
摘要： The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.
摘要翻译：本发明提供核心稳定的微胶囊，其中所述核包含包封在金属氧化物壳内的至少一种活性剂，其制备方法，包含它们的比较及其用途。

7. 发明申请

US20080254082A1 Methods for Crop Protection 审中-公开
标题翻译：作物保护方法
公开(公告)号：US20080254082A1
公开(公告)日：2008-10-16
申请号：US12088297
申请日：2006-09-27
申请人： Ofer Toledano , Iris Binyamin , Haim Bar-Simantov , Alon Seri-Levy
发明人： Ofer Toledano , Iris Binyamin , Haim Bar-Simantov , Alon Seri-Levy
IPC分类号： A01N25/28 , A01N57/16 , A01N53/06 , A01N43/653 , A01P15/00
CPC分类号： A01N25/28 , A01N2300/00
摘要： The invention relates to a method for crop protection comprising administering to one or both of the crop and its environment a composition comprising a carrier; and microcapsules having a core material comprising a pesticide encapsulated by a silica shell, wherein the silica shell constitutes up to 10% w/w out of the total weight of the microcapsules, and wherein said administration gives rise to pesticide activity with immediate onset and prolonged effect. The invention further relates to a method for acute treatment of a pest-infested crop.
摘要翻译：本发明涉及一种用于作物保护的方法，其包括向作物及其环境中的一种或两种施用包含载体的组合物; 和具有包含由二氧化硅壳包封的农药的核心材料的微胶囊，其中所述二氧化硅壳构成所述微胶囊总重量的至多10％w / w，并且其中所述给药导致立即起始和延长的农药活性影响。本发明还涉及用于害虫侵染作物的急性处理的方法。

8. 发明授权

US10512796B2 Core stabilized microcapsules, method of their preparation and uses thereof 有权
公开(公告)号：US10512796B2
公开(公告)日：2019-12-24
申请号：US13500937
申请日：2010-12-30
申请人： Ofer Toledano , Haim Bar-Simantov , Hanan Sertchook , Sharon Fireman-Shoresh , Dorit Marco-Dagan
发明人： Ofer Toledano , Haim Bar-Simantov , Hanan Sertchook , Sharon Fireman-Shoresh , Dorit Marco-Dagan
IPC分类号： A01N25/28 , A61Q19/00 , A61K8/11 , A61K8/25 , A61K8/26 , A61K8/38 , A61K8/67 , A61K9/00 , A61K9/51 , B01J13/14
摘要： The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

9. 发明授权

US09868103B2 Metal oxide coating of water insoluble ingredients 有权
公开(公告)号：US09868103B2
公开(公告)日：2018-01-16
申请号：US11997823
申请日：2006-08-02
申请人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov
发明人： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov
IPC分类号： A01N25/28 , A01N31/00 , A01N47/10 , A01N53/02 , A01N57/00 , A01P13/00 , A01P3/00 , A01P7/00 , A61K31/12 , A61K31/203 , A61K31/66 , A61K8/02 , A61K9/50 , B01J13/22 , A01N25/26 , A61K8/11 , A61K9/16 , A61Q19/00 , B01J13/02
CPC分类号： B01J13/22 , A01N25/26 , A61K8/11 , A61K9/1676 , A61K9/5078 , A61K2800/412 , A61K2800/434 , A61K2800/57 , A61Q19/00 , B01J13/02 , A01N51/00 , A01N53/00
摘要： The invention relates to process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid water-insoluble particulate matter with a cationic additive in an aqueous medium to obtain a dispersion of said particulate matter having a positive zeta potential; (b) coating the solid water-insoluble particulate matter by precipitation of a metal oxide salt onto the surface of the particulate matter, forming a metal oxide layer thereon; and (c) aging said coating layer. The invention further relates to coated particulate matter obtained by the process and to compositions comprising solid, water-insoluble particulate matter, coated by a metal oxide layer, the particulate matter being a dermatological active agent or a pesticide. The invention additionally relates to methods of treating a surface condition in a subject using compositions comprising solid, water insoluble dermatologically active agent, coated by a metal oxide layer.

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