专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08975258B2 Heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders 有权
标题翻译：用于治疗糖尿病和代谢紊乱的杂环受体激动剂
公开(公告)号：US08975258B2
公开(公告)日：2015-03-10
申请号：US13612451
申请日：2012-09-12
申请人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
发明人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
IPC分类号： A61K31/50 , C07D413/04 , C07D401/04 , C07D401/14 , C07D417/14 , C07D413/14 , C07D417/04
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。本发明的化合物是口服活性的。

2. 发明申请

US20140024830A1 HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权
标题翻译：用于治疗糖尿病和代谢障碍的异位受体激动剂
公开(公告)号：US20140024830A1
公开(公告)日：2014-01-23
申请号：US13612451
申请日：2012-09-12
申请人： Xin Chen , Peng Cheng , L. Edwards Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jaingao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
发明人： Xin Chen , Peng Cheng , L. Edwards Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jaingao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
IPC分类号： C07D413/04 , C07D413/14
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。本发明的化合物是口服活性的。

3. 发明授权

US08183381B2 N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders 有权
标题翻译：用于治疗糖尿病和代谢紊乱的N-连接的杂环受体激动剂
公开(公告)号：US08183381B2
公开(公告)日：2012-05-22
申请号：US12171209
申请日：2008-07-10
申请人： Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
发明人： Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
IPC分类号： C07D401/00
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。

4. 发明申请

US20070072858A1 Process for the stereoselective preparation of (-)-halofenate and derivatives thereof 失效
标题翻译：（ - ） - 卤代苯甲酸酯及其衍生物的立体选择性制备方法
公开(公告)号：US20070072858A1
公开(公告)日：2007-03-29
申请号：US11525200
申请日：2006-09-20
申请人： Yan Zhu , Peng Cheng , Xin Chen , Jingyuan Ma , Zuchun Zhao
发明人： Yan Zhu , Peng Cheng , Xin Chen , Jingyuan Ma , Zuchun Zhao
IPC分类号： A61K31/5375 , A61K31/495 , A61K31/4025 , A61K31/401
CPC分类号： C07D295/185
摘要： The present invention provides a compounds the formula (IV): and methods for producing an α-(phenoxy)phenylacetic acid compound of the formula: wherein R1 is a member selected from the group consisting of: each R2 is a member independently selected from the group consisting of (C1-C4)alkyl, halo, (C1-C4)haloalkyl, amino, (C1-C4)aminoalkyl, amido, (C1-C4)amidoalkyl, (C1-C4)sulfonylalkyl, (C1-C4)sulfamylalkyl, (C1-C4)alkoxy, (C1-C4)heteroalkyl, carboxy and nitro; the subscript n is 1 when R1 has the formula (a) or (b) and 2 when R1 has the formula (c) or (d); the subscript m is an integer of from 0 to 3; * indicates a carbon which is enriched in one stereoisomeric configuration; and the wavy line indicates the point of attachment of R1; and compounds
摘要翻译：本发明提供式（IV）化合物及其制备下式的α-（苯氧基）苯乙酸化合物的方法：其中R 1是选自以下的成员：各 R 2是独立地选自（C 1 -C 4 -C 4）烷基，卤素，（C 1 -C 4）烷基的成员， C 1 -C 4卤代烷基，氨基，（C 1 -C 4）氨基烷基，酰氨基，（C 1 H 4）（C 1 -C 4）磺酰基烷基，（C 1 -C 4）磺酰基烷基，（C 1 -C 4 - C 1 -C 4亚磺酰基烷基，（C 1 -C 4 -C 4）烷氧基，（C 1 -C 3 - 亚磺酰基烷基） > 4个）杂烷基，羧基和硝基; 当R 1具有式（a）或（b）时，下标n为1，当R 1具有式（c）或（d））时，下标n为1。下标m为0〜3的整数; *表示富含一种立体异构构型的碳; 波浪线表示R 1的连接点; 和化合物

5. 发明授权

US08846675B2 N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders 有权
标题翻译：用于治疗糖尿病和代谢紊乱的N-连接的杂环受体激动剂
公开(公告)号：US08846675B2
公开(公告)日：2014-09-30
申请号：US13463617
申请日：2012-05-03
申请人： Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
发明人： Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
IPC分类号： A61K31/535 , C07D401/14 , C07D413/14 , C07D401/04 , C07D417/14
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。

6. 发明申请

US20120322804A1 N-LINKED HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权
标题翻译：用于治疗糖尿病和代谢障碍的N-连锁异位受体激动剂
公开(公告)号：US20120322804A1
公开(公告)日：2012-12-20
申请号：US13463617
申请日：2012-05-03
申请人： Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
发明人： Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
IPC分类号： A61K31/454 , C07D401/14 , A61K31/506 , C07D413/14 , A61K31/4545 , C12N5/0783 , A61K31/5377 , A61K31/4709 , C07D451/02 , A61K31/46 , A61P3/10 , C12N5/071 , C07D401/04 , C07D417/14
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。

7. 发明授权

US08288384B2 Heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders 有权
标题翻译：用于治疗糖尿病和代谢紊乱的杂环受体激动剂
公开(公告)号：US08288384B2
公开(公告)日：2012-10-16
申请号：US12619577
申请日：2009-11-16
申请人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christoper J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
发明人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christoper J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
IPC分类号： A61K31/50
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。本发明的化合物是口服活性的。

8. 发明申请

US20090137590A1 N-LINKED HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权
标题翻译：用于治疗糖尿病和代谢障碍的N-连锁异位受体激动剂
公开(公告)号：US20090137590A1
公开(公告)日：2009-05-28
申请号：US12171209
申请日：2008-07-10
申请人： Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
发明人： Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
IPC分类号： A61K31/5377 , C07D401/04 , A61K31/454 , A61K31/506 , C12N5/06 , C07D401/14 , C07D413/14
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。

9. 发明授权

US08227495B2 2,4-disubsituted thiazoles and pharmaceutical compositions thereof 有权
标题翻译： 2,4-二取代噻唑及其药物组合物
公开(公告)号：US08227495B2
公开(公告)日：2012-07-24
申请号：US12541865
申请日：2009-08-14
申请人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
发明人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
IPC分类号： A61K31/425
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present disclosure provides 2,4-disubstituted thiazoles of the general structure shown below that are agonists of G-protein coupled receptor (IC-GPCR2). Also, provided are compositions comprising these compounds as well as methods for using these compounds in a variety of applications including diabetes and metabolic disorders.
摘要翻译：本公开提供了下列通式结构的2,4-二取代噻唑，它是G-蛋白偶联受体（IC-GPCR2）的激动剂。此外，提供了包含这些化合物的组合物以及在各种应用中使用这些化合物的方法，包括糖尿病和代谢紊乱。

10. 发明申请

US20100087465A1 HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权
标题翻译：用于治疗糖尿病和代谢障碍的异位受体激动剂
公开(公告)号：US20100087465A1
公开(公告)日：2010-04-08
申请号：US12541865
申请日：2009-08-14
申请人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
发明人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
IPC分类号： A61K31/506 , C07D401/04 , C07D401/14 , C07D211/68 , A61K31/454 , A61K31/4545 , A61P3/10
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。本发明的化合物是口服活性的。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式