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1. 发明申请

US20120157667A1 Methods Of Producing Humanized Non-Human Mammals 审中-公开
标题翻译：生产人类非人类哺乳动物的方法
公开(公告)号：US20120157667A1
公开(公告)日：2012-06-21
申请号：US13381313
申请日：2010-06-28
申请人： Qingfeng Chen , Jianzhu Chen
发明人： Qingfeng Chen , Jianzhu Chen
IPC分类号： C07K16/24 , C12P21/08 , C12N5/18 , A01K67/027
CPC分类号： A61K39/3955 , A01K67/027 , A01K67/0271 , A01K2207/12 , A01K2227/105 , A01K2267/0331 , A01K2267/0381 , A61K2039/505 , C07K16/2893 , C07K2317/24 , A61K2300/00
摘要： Provided herein are methods of reconstituting functional human blood cell lineages in a non-human mammal comprising introducing human hematopoietic stem cells (HSCs) and nucleic acid encoding one or more human cytokines into an immunodeficient non-human mammal. The non-human mammal is maintained under conditions in which the nucleic acid is expressed and the human HSCs differentiate into functional human blood cell lineages in the non-human mammal, thereby reconstituting functional human blood cell lineages in the non-human mammal. Also provided are methods of producing human antibodies directed against an immunogen in a non-human mammal, hybridomas that secrete the monoclonal antibodies as well as antibodies (e.g., polyclonal antibodies; monoclonal antibodies) produced by the B cells and non-human mammals produced by the methods.
摘要翻译：本文提供了在非人哺乳动物中重建功能性人类血细胞谱系的方法，包括将人造血干细胞（HSC）和编码一种或多种人细胞因子的核酸引入免疫缺陷型非人哺乳动物。将非人哺乳动物保持在其中表达核酸的条件下，并且人类HSCs在非人哺乳动物中分化为功能性人类血细胞谱系，从而重建非人哺乳动物中的功能性人类血细胞谱系。还提供了在非人哺乳动物中产生针对免疫原的人抗体的方法，分泌单克隆抗体的杂交瘤以及由B细胞和非人哺乳动物产生的抗体（例如，多克隆抗体;单克隆抗体）方法。

2. 发明申请

US20140147413A1 Therapies That Target Autoimmunity For Treating Glaucoma And Optic Neuropathy 审中-公开
标题翻译：靶向自身免疫治疗青光眼和视神经病变的疗法
公开(公告)号：US20140147413A1
公开(公告)日：2014-05-29
申请号：US14002036
申请日：2012-02-28
申请人： Dong Feng Chen , Jianzhu Chen , Huihui Chen
发明人： Dong Feng Chen , Jianzhu Chen , Huihui Chen
IPC分类号： G01N33/68 , G01N33/569 , A61K45/06 , A61K39/395 , A61K31/436
CPC分类号： G01N33/6854 , A61K9/0048 , A61K9/0051 , A61K31/382 , A61K31/4168 , A61K31/4178 , A61K31/433 , A61K31/436 , A61K31/4704 , A61K31/5377 , A61K31/5575 , A61K31/683 , A61K38/13 , A61K38/1793 , A61K38/21 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2809 , G01N33/56972 , G01N33/6893 , G01N2800/164 , A61K2300/00
摘要： The present invention comprises a composition with means to inhibit an autoimmune response and methods for using this composition to treat glaucoma and optic neuropathy.
摘要翻译：本发明包括具有抑制自身免疫应答的方法的组合物和使用该组合物治疗青光眼和视神经病变的方法。

3. 发明申请

US20100204297A1 INFLUENZA THERAPEUTIC 审中-公开
标题翻译：流感治疗
公开(公告)号：US20100204297A1
公开(公告)日：2010-08-12
申请号：US11909413
申请日：2006-03-22
申请人： Jianzhu Chen , Qing Ge , Herman N. Eisen
发明人： Jianzhu Chen , Qing Ge , Herman N. Eisen
IPC分类号： A61K31/713 , C07K7/08 , C07K14/00 , A61P31/16 , C12N15/63
CPC分类号： A61K9/5146 , A61K9/5153 , A61K38/00 , C12N15/111 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/321 , C12N2310/53 , C12N2320/11 , C12N2320/32 , C12N2799/021 , C12N2310/3521
摘要： The present invention provides compositions comprising an RNAi-inducing entity targeted to an influenza virus transcript and any of a variety of delivery agents. The invention further includes methods of use of the compositions for inhibiting a biological activity of an influenza virus and/or for treatment or prevention of influenza. The invention provides target portion sequences that are favorably conserved for RNAi across a plurality of influenza virus A strains isolated from human hosts and/or avian hosts and RNAi-inducing entities, e.g., siRNAs and shRNAs, targeted to such favorably conserved target portions. The invention provides a variety of nucleic acids comprising sequences identical or complementary to at least a portion of one or more of these favorably conserved target portion sequences. The invention further provides methods and compositions for delivering RNAi-inducing agents to an organ or tissue of a mammalian subject, e.g., to the lung. Methods of diagnosing influenza and determining the susceptibility of an influenza virus to inhibition by an RNAi-inducing agent are also provided. Transgenic animals that express an RNAi-inducing agent targeted to an influenza gene are another aspect of the invention.
摘要翻译：本发明提供了包含针对流感病毒转录物的RNAi诱导实体和各种递送试剂中的任一种的组合物。本发明还包括使用该组合物抑制流感病毒的生物学活性和/或用于治疗或预防流感的方法。本发明提供了针对分离自人宿主和/或禽类宿主和RNAi诱导实体（例如siRNA和shRNA）的多个流感病毒A菌株的RNAi有利地保守的靶标部分序列，靶向这些有利的保守靶部分。本发明提供了多种核酸，其包含与这些有利保守的靶部分序列中的一种或多种的至少一部分相同或互补的序列。本发明进一步提供了将哺乳动物受试者的器官或组织例如向肺部递送RNAi诱导剂的方法和组合物。还提供了诊断流感和确定流感病毒对RNAi诱导剂抑制的易感性的方法。表达靶向流感基因的RNAi诱导剂的转基因动物是本发明的另一方面。

4. 发明申请

US20090106852A1 Influenza Therapeutic 审中-公开
公开(公告)号：US20090106852A1
公开(公告)日：2009-04-23
申请号：US11952056
申请日：2007-12-06
申请人： Jianzhu Chen , Herman N. Eisen , Qing Ge
发明人： Jianzhu Chen , Herman N. Eisen , Qing Ge
IPC分类号： A01K67/027 , C07H21/02 , A61K31/7105 , A61K9/12 , A61P31/16 , C12N15/63 , C12N5/10
CPC分类号： C12N15/1131 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/32 , C12N2799/021
摘要： The present invention provides methods and compositions for inhibiting influenza infection and/or replication based on the phenomenon of RNA interference (RNAi) well as systems for identifying effective siRNAs and shRNAs for inhibiting influenza virus and systems for studying influenza virus infective mechanisms. The invention also provides methods and compositions for inhibiting infection, pathogenicity and/or replication of other infectious agents, particularly those that infect cells that are directly accessible from outside the body, e.g., skin cells or mucosal cells. In addition, the invention provides compositions comprising an RNAi-inducing entity, e.g., an siRNA, shRNA, or RNAi-inducing vector targeted to an influenza virus transcript and any of a variety of delivery agents. The invention further includes methods of use of the compositions for treatment of influenza.

5. 发明授权

US08357664B2 Antisense antiviral compound and method for treating influenza viral infection 有权
标题翻译：反义抗病毒化合物及治疗流感病毒感染的方法
公开(公告)号：US08357664B2
公开(公告)日：2013-01-22
申请号：US11259434
申请日：2005-10-25
申请人： David A. Stein , Qing Ge , Jianzhu Chen , Patrick L. Iversen , Hong M. Moulton
发明人： David A. Stein , Qing Ge , Jianzhu Chen , Patrick L. Iversen , Hong M. Moulton
IPC分类号： A61K48/00
CPC分类号： C12N15/1131 , C12N2310/3145 , C12N2310/3233 , C12N2310/3513
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having 1) a nuclease resistant backbone, 2) 12-40 nucleotide bases, and 3) a targeting sequence of at least 12 bases in length that hybridizes to a target region selected from the following: a) the 5′ or 3′ terminal 25 bases of the negative sense viral RNA segment of Influenzavirus A, Influenzavirus B and Influenzavirus C; b) the terminal 25 bases of the 3′ terminus of the positive sense cRNA and; and c) the 50 bases surrounding the AUG start codon of an influenza viral mRNA.
摘要翻译：本发明提供反义抗病毒化合物及其在抑制正粘病毒科的病毒生长和用于病毒感染治疗中的用途和生产方法。该化合物特别可用于治疗哺乳动物的流感病毒感染。反义抗病毒化合物是具有1）核酸酶抗性主链，2）12-40个核苷酸碱基的基本上不带电荷的吗啉代寡核苷酸，和3）长度为至少12个碱基的靶向序列与选自以下的靶区域杂交：）流感病毒A，流感病毒B和流感病毒C的负义病毒RNA片段的5'或3'末端25个碱基; b）正义cRNA的3'末端的末端25个碱基; 和c）围绕流感病毒mRNA的AUG起始密码子的50个碱基。

6. 发明申请

US20070004661A1 Antisense antiviral compound and method for treating influenza viral infection 审中-公开
标题翻译：反义抗病毒化合物及治疗流感病毒感染的方法
公开(公告)号：US20070004661A1
公开(公告)日：2007-01-04
申请号：US11433213
申请日：2006-05-11
申请人： David Stein , Qing Ge , Jianzhu Chen , Patrick Iversen , Dwight Weller
发明人： David Stein , Qing Ge , Jianzhu Chen , Patrick Iversen , Dwight Weller
IPC分类号： A61K48/00 , C07H21/02 , C07F9/6533
CPC分类号： C12N15/1131 , C12N2310/3145 , C12N2310/3233 , C12N2310/3513
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal. The antisense antiviral compounds are substantially uncharged, including partially positively charged, morpholino oligonucleotides having 1) a nuclease resistant backbone, 2) 12-40 nucleotide bases, and 3) a targeting sequence of at least 12 bases in length that hybridizes to a target region selected from the following: a) the 5′ or 3′ terminal 25 bases of the negative sense viral RNA segment of Influenzavirus A, Influenzavirus B and Influenzavirus C; b) the terminal 25 bases of the 3′ terminus of the positive sense cRNA and; and c) the 50 bases surrounding the AUG start codon of an influenza viral mRNA.
摘要翻译：本发明提供反义抗病毒化合物及其在抑制正粘病毒科的病毒生长和用于病毒感染治疗中的用途和生产方法。该化合物特别可用于治疗哺乳动物的流感病毒感染。反义抗病毒化合物基本上不带电，包括部分带正电荷的吗啉代寡核苷酸，其具有1）核酸酶抗性主链，2）12-40个核苷酸碱基，和3）与目标区域杂交的至少12个碱基长度的靶向序列选自以下：a）流感病毒A，流感病毒B和流感病毒C的阴性病毒RNA片段的5'或3'末端25个碱基; b）正义cRNA的3'末端的末端25个碱基; 和c）围绕流感病毒mRNA的AUG起始密码子的50个碱基。

7. 发明申请

US20050008617A1 Compositions and methods for delivery of short interfering RNA and short hairpin RNA 审中-公开
标题翻译：用于递送短干扰RNA和短发夹RNA的组合物和方法
公开(公告)号：US20050008617A1
公开(公告)日：2005-01-13
申请号：US10674087
申请日：2003-09-29
申请人： Jianzhu Chen , Herman Eisen , Qing Ge
发明人： Jianzhu Chen , Herman Eisen , Qing Ge
IPC分类号： A61K38/00 , A61K48/00 , C12N15/11 , C12N15/113
CPC分类号： C12N15/1131 , A61K9/5146 , A61K9/5153 , A61K38/00 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/32 , C12N2799/021
摘要： The present invention provides compositions comprising an RNAi-inducing entity any of a variety of different delivery agents. Preferred RNAi-inducing agents include siRNA, shRNA, and RNAi-inducing vectors. Preferred delivery agents include cationic polymers, modified cationic polymers, lipids, and surfactants suitable for introduction into the lung. The invention further provides methods of inhibiting expression of a target transcript in a mammal and methods of treating or preventing a disease or condition in a mammal by administration of the compositions.
摘要翻译：本发明提供包含多种不同递送剂的RNAi诱导实体的组合物。优选的RNAi诱导剂包括siRNA，shRNA和RNAi诱导载体。优选的递送剂包括阳离子聚合物，改性阳离子聚合物，脂质和适用于引入肺的表面活性剂。本发明还提供抑制哺乳动物中靶转录物表达的方法以及通过施用组合物治疗或预防哺乳动物疾病或病症的方法。

8. 发明申请

US20110112169A1 RNAi-BASED THERAPEUTICS FOR ALLERGIC RHINITIS AND ASTHMA 审中-公开
标题翻译：用于过敏性RHINITIS和ASTHMA的基于RNAi的治疗方法
公开(公告)号：US20110112169A1
公开(公告)日：2011-05-12
申请号：US12891626
申请日：2010-09-27
申请人： Jianzhu Chen , Herman N. Eisen , Qing Ge
发明人： Jianzhu Chen , Herman N. Eisen , Qing Ge
IPC分类号： A61K31/713 , C07H21/02 , A61K31/7105 , A61P11/00 , A61P11/06 , C12N15/63
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/32
摘要： The present invention provides compositions comprising one or more RNAi agents (e.g., siRNAs, shRNAs, or RNAi vectors) for the treatment of conditions and diseases mediated by (e.g., featuring IgE-mediated hypersensitivity), as well as systems for identifying RNAi agents effective for this purpose. The compositions are suitable for the treatment of allergic rhinitis and/or asthma. In certain embodiments of the invention the RNAi agent is targeted to a transcript that encodes a protein selected from the group consisting of the FCεRIα chain, the FCεRIβ chain, c-Kit, Lyn, Syk, ICOS, OX40L, CD40, CD80, CD86, Re1A, Re1B, 4-1BB ligand, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, CD83, SLAM, common γ chain, and COX-2. In addition, the invention provides RNAi agent/delivery agent compositions and methods of use. In certain embodiments of the invention compositions comprising an RNAi agent are delivered by the respiratory route.
摘要翻译：本发明提供包含用于治疗由（例如，特征为IgE介导的超敏反应）介导的病症和疾病的一种或多种RNAi剂（例如siRNA，shRNA或RNAi载体）的组合物，以及用于鉴定有效的RNAi剂的系统以此目的。该组合物适用于治疗过敏性鼻炎和/或哮喘。在本发明的某些实施方案中，所述RNAi试剂靶向编码选自下组的蛋白质的转录物：FC＆amp;RIα链，FC＆amp; RI＆bgr; 链，c-Kit，Lyn，Syk，ICOS，OX40L，CD40，CD80，CD86，Re1A，Re1B，4-1BB配体，TLR1，TLR2，TLR3，TLR4，TLR5，TLR6，TLR7，TLR8，TLR9，CD83，SLAM ，普通γ链和COX-2。此外，本发明提供RNAi剂/递送剂组合物和使用方法。在本发明的某些实施方案中，包含RNAi试剂的组合物通过呼吸途径递送。

9. 发明申请

US20100298214A1 TREATMENT OF AUTOIMMUNE DISEASE 审中-公开
标题翻译：治疗自发性疾病
公开(公告)号：US20100298214A1
公开(公告)日：2010-11-25
申请号：US12672436
申请日：2008-08-29
申请人： Qibin Leng , Jianzhu Chen
发明人： Qibin Leng , Jianzhu Chen
IPC分类号： A61K38/16 , C12Q1/04 , A61K38/22 , C40B40/00 , A61K31/7105 , A61K31/711 , A61K38/02 , A61P37/02 , A61P3/10
CPC分类号： A61K31/395 , A61K38/10 , A61K38/16 , Y02A50/414
摘要： The present invention provides compositions, systems, and methods for identifying a patient suffering from and/or susceptible to autoimmune disease who might be likely to respond to treatment with CXCL12 and/or CXCR4 antagonists. The present invention provides novel CXCL12 and/or CXCR4 antagonists, methods of identifying novel CXCL12 and/or CXCR4 antagonists, and methods involving the use of these in the treatment of autoimmune disease.
摘要翻译：本发明提供用于鉴定患有和/或易感自身免疫性疾病的患者的组合物，系统和方法，其可能对CXCL12和/或CXCR4拮抗剂的治疗有反应。本发明提供了新的CXCL12和/或CXCR4拮抗剂，鉴定新型CXCL12和/或CXCR4拮抗剂的方法，以及涉及使用这些治疗自身免疫性疾病的方法。

10. 发明申请

US20100136072A1 Polymeric Coatings that Inactivate Viruses and Bacteria 审中-公开
标题翻译：激活病毒和细菌的聚合物涂层
公开(公告)号：US20100136072A1
公开(公告)日：2010-06-03
申请号：US12514101
申请日：2007-11-08
申请人： Jayanta Haldar , Deqiang An , Luis Álvarez de Cienguegos , Jianzhu Chen , Alexander M. Klibanov
发明人： Jayanta Haldar , Deqiang An , Luis Álvarez de Cienguegos , Jianzhu Chen , Alexander M. Klibanov
IPC分类号： A61K31/785 , A01N25/34 , A01P1/00 , A61P31/12 , A01N43/00
CPC分类号： C09D5/14 , A01N25/10 , A01N33/04 , A01N33/12 , A01N37/18 , A01N43/40 , A01N57/34 , C09D179/02
摘要： Hydrophobic polymeric coatings which can be non-covalently applied to solid surfaces such as metals, plastics, glass, polymers, textiles, and other substrates such as fabrics, gauze, bandages, tissues, and other fibers, in the same manner as paint, for example, by brushing, spraying, or dipping, to make the surfaces virucidal and bactericidal, have been developed.
摘要翻译：疏水性聚合物涂层可以以与油漆相同的方式非共价地施加到固体表面如金属，塑料，玻璃，聚合物，纺织品和其它基材如织物，纱布，绷带，纸巾和其它纤维上，用于例如，通过刷涂，喷雾或浸渍，以使表面具有杀病毒和杀菌作用。

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