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1. 发明授权

US09134304B2 Protein screening methods 有权
标题翻译：蛋白筛选方法
公开(公告)号：US09134304B2
公开(公告)日：2015-09-15
申请号：US13009500
申请日：2011-01-19
申请人： Richard W. Wagner , Alexander Litovchick , Yan Chen
发明人： Richard W. Wagner , Alexander Litovchick , Yan Chen
IPC分类号： C12N15/10 , G01N33/53 , G01N33/543 , G01N33/68
CPC分类号： C12N15/1086 , C07K19/00 , C07K2317/10 , C07K2317/40 , C07K2317/56 , C12N15/1062 , C12N15/1075 , G01N33/5308 , G01N33/54366 , G01N33/6845
摘要： The invention provides methods and compositions useful for identifying polypeptides with desired characteristics in vitro.
摘要翻译：本发明提供了可用于在体外鉴定具有所需特征的多肽的方法和组合物。

2. 发明申请

US20140315762A1 METHODS FOR TAGGING DNA-ENCODED LIBRARIES 审中-公开
标题翻译：标记DNA编码的图书馆的方法
公开(公告)号：US20140315762A1
公开(公告)日：2014-10-23
申请号：US14343306
申请日：2012-09-07
申请人： Anthony D. Keefe , Richard W. Wagner , Alexander Litovchick , Matthew Clark , John W. Cuozzo , Ying Zhang , Paolo A. Centrella , Christopher D. Hupp
发明人： Anthony D. Keefe , Richard W. Wagner , Alexander Litovchick , Matthew Clark , John W. Cuozzo , Ying Zhang , Paolo A. Centrella , Christopher D. Hupp
IPC分类号： C12N15/10
CPC分类号： C12N15/1065 , C07B2200/11 , C12N15/10 , C12N15/1068 , C12N15/1093 , C40B50/16
摘要： The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2′-substituted nucleotides, such as 2′-O-methyl or 2′-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.
摘要翻译：本发明涉及寡核苷酸编码的文库和标记这些文库的方法。特别地，所述方法和寡核苷酸可以包括一个或多个2'-取代的核苷酸，例如2'-O-甲基或2'-氟核苷酸，以及用于增强酶连接的一些或多种化学功能的其它条件或试剂，以支持化学结扎。

3. 发明授权

US06642365B1 Anti-(retro)viral conjugates of saccharides and acetamidino or guanidino compounds 失效
标题翻译：糖（乙酰脒或胍基）化合物的抗（复）病毒偶联物
公开(公告)号：US06642365B1
公开(公告)日：2003-11-04
申请号：US09869437
申请日：2001-06-28
申请人： Aviva Lapidot , Alexander Litovchick , Artem G. Evdokimov
发明人： Aviva Lapidot , Alexander Litovchick , Artem G. Evdokimov
IPC分类号： C07H100
CPC分类号： C07H15/04 , C07H3/04 , C07H3/06 , C07H7/00
摘要： Conjugates of a saccharide and an acetamidino- or guanidino-compound, of the formula: wherein A is CH3 or NH2; X is a linear or branched C1-C8 alkyl chain optionally containing hydroxy, amino and/or oxo groups; n is an integer from 1 to 6, and Sac is the residue of a mono-or oligo-saccharide, provided that when A is NH2 and X is -(CH2)3—CH(NH2)—C(=O)-, the monosaccharide residue is not substituted at the position 1, and n is an integer from 2 to 6 when Sac is the residue of an oligosaccharide, are useful as antiviral, particularly as antiretroviral, agents, and can be used either alone or together with other compounds used in AIDS treatment such as AZT and/or protease inhibitors, for the treatment of HIV-infection, AIDS and manifestations of AIDS such as Kaposi sarcoma. Particularly preferred compounds are aminoglycoside-arginine conjugates in which the saccharide is a natural aminoglycoside antibiotic such as kanamycin, gentamycin and neomycin that is conjugated to arginine residues.
摘要翻译：糖和乙酰胺基 - 或胍基 - 化合物的共轭物，其具有下式：其中A是CH 3或NH 2; X是任选含有羟基，氨基和/或氧代基的直链或支链C 1 -C 8烷基链; n为1至6的整数，Sac为单糖或寡糖的残基，条件是当A为NH 2且X为 - （CH 2）3 -CH（NH 2）-C（= O） - 时，单糖残基在第1位没有被取代，当Sac是寡糖的残基时，n是2-6的整数，可以作为抗病毒剂，特别是作为抗逆转录病毒剂，可以单独使用或与其他物质一起使用用于艾滋病治疗的化合物如AZT和/或蛋白酶抑制剂用于治疗艾滋病毒感染，艾滋病和艾滋病的表现如卡波西肉瘤。特别优选的化合物是氨基糖苷 - 精氨酸缀合物，其中糖类是天然的氨基糖苷类抗生素，例如卡那霉素，庆大霉素和新霉素，其与精氨酸残基缀合。

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