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1. 发明公开

EP1651235A4 SIGMA-1 RECEPTOR LIGAND WITH ACETYLCHOLINESTERASE INHIBITION PROPERTIES 审中-公开
标题翻译： SIGMA-1受体乙酰胆碱酯酶发炎的特性，配体
公开(公告)号：EP1651235A4
公开(公告)日：2008-12-17
申请号：EP04757425
申请日：2004-08-05
申请人： SAMARITAN PHARMACEUTICALS INC , UNIV GEORGETOWN , PAPADOPOULOS VASSILIOS , LECANU LAURENT , GREESON JANET
发明人： PAPADOPOULOS VASSILIOS , LECANU LAURENT , GREESON JANET
IPC分类号： A61K31/56 , A61K20060101 , A61K31/495 , A61P25/28 , C07D241/04
CPC分类号： A61K31/495

2. 发明公开

EP1628649A4 NEUROPROTECTIVE BENZOATE AND BENZAMIDE COMPOUNDS 审中-公开
标题翻译：神经保护苯甲酸苯甲酰胺CONNECTIONS
公开(公告)号：EP1628649A4
公开(公告)日：2010-06-02
申请号：EP04752956
申请日：2004-05-20
申请人： SAMARITAN PHARMACEUTICALS INC , UNIV GEORGETOWN , LECANU LAURENT , GREESON JANET , PAPADOPOULOS VASSILIOS
发明人： LECANU LAURENT , GREESON JANET , PAPADOPOULOS VASSILIOS
IPC分类号： A61K31/135 , A61P25/28 , C07D20060101
CPC分类号： A61K31/135 , A61K31/16 , A61K31/165

3. 发明专利

AU2004264342A1 Sigma-1 receptor ligand with acetylcholinesterase inhibition properties 未知
公开(公告)号：AU2004264342A1
公开(公告)日：2005-02-24
申请号：AU2004264342
申请日：2004-08-05
申请人： UNIV GEORGETOWN , GREESON JANET , LECANU LAURENT , PAPADOPOULOS VASSILIOS , SAMARITAN PHARMACEUTICALS INC
发明人： PAPADOPOULOS VASSILIOS , LECANU LAURENT , GREESON JANET
IPC分类号： A61K31/56 , A61K20060101

4. 发明专利

AU2004244982A1 Anti-HIV benzamide compounds 未知
公开(公告)号：AU2004244982A1
公开(公告)日：2004-12-16
申请号：AU2004244982
申请日：2004-05-20
申请人： UNIV GEORGETOWN , GREESON JANET , LECANU LAURENT , PAPADOPOULOS VASSILIOS , SAMARITAN PHARMACEUTICALS INC
发明人： LECANU LAURENT , GREESON JANET , PAPADOPOULOS VASSILIOS
IPC分类号： A61K31/135 , A61K20060101 , A61K31/33 , A61K31/497

5. 发明申请

WO2008073450A2 BENZAMIDE COMPOUNDS 审中-公开
标题翻译：苯酰胺化合物
公开(公告)号：WO2008073450A2
公开(公告)日：2008-06-19
申请号：PCT/US2007025390
申请日：2007-12-12
申请人： UNIV GEORGETOWN , SAMARITAN PHARMACEUTICALS INC , LECANU LAURENT , GREESON JANET , PAPADOPOULOS VASSILIOS , XU JING
发明人： LECANU LAURENT , GREESON JANET , PAPADOPOULOS VASSILIOS , XU JING
IPC分类号： A61K31/497
CPC分类号： A61K31/497 , C07D209/20
摘要： The invention provides a therapeutic method for preventing or treating a pathological condition or symptom in a mammal, such as a human, wherein the infectivity of a pathogen toward mammalian cells is implicated and inhibition of its infectivity is desired comprising administering to a mammal in need of such therapy, an effective amount of an N-benzamide derivative of a piperazinyl amide of an amino acid thereof that inhibits pathogenic infectivity, including pharmaceutically acceptable salts thereof, wherein the pathogen is Avian Influenza, Avian Influenza A, Influenza A, Influenza B, hepatitis B virus, or hepatitis C virus. The invention also provides a therapeutic method for preventing or treating a neuropathological condition or symptom in a mammal, such as human, comprising administering to a mammal in need of such therapy, an effective amount of an N-benzamide derivative of a piperazinyl amide of an amino acid thereof, including pharmaceutically acceptable salts thereof.
摘要翻译：本发明提供了用于预防或治疗哺乳动物例如人的病理状态或症状的治疗方法，其中涉及病原体对哺乳动物细胞的感染性并且需要抑制其感染性，包括对需要这种疗法是有效量的抑制病原性感染性的氨基酸哌嗪酰胺的N-苯甲酰胺衍生物，包括其药学上可接受的盐，其中病原体是禽流感，甲型禽流感，甲型流感，甲型流感，乙型肝炎 B病毒或丙型肝炎病毒。本发明还提供了用于预防或治疗哺乳动物（例如人）的神经病理状况或症状的治疗方法，其包括向需要这种治疗的哺乳动物施用有效量的本发明的哌嗪基酰胺的N-苯甲酰胺衍生物其氨基酸，包括其药学上可接受的盐。

6. 发明申请

WO2006107902A2 USE OF SPIROSTENOLS TO TREAT MITOCHONDRIAL DISORDERS 审中-公开
标题翻译：使用螺旋体治疗麻醉病
公开(公告)号：WO2006107902A2
公开(公告)日：2006-10-12
申请号：PCT/US2006012380
申请日：2006-03-31
申请人： SAMARITAN PHARMACEUTICALS INC , UNIV GEORGETOWN , LECANU LAURENT , TILLEMENT LAURENT , PAPADOPOULOS VASSILIOS , YAO WENGUO , GREESON JANET
发明人： LECANU LAURENT , TILLEMENT LAURENT , PAPADOPOULOS VASSILIOS , YAO WENGUO , GREESON JANET
IPC分类号： A61K31/58 , A61P3/10 , A61P9/00 , A61P9/10 , A61P21/00 , A61P27/00
CPC分类号： A61K31/58
摘要： The present invention relates to methods and compositions for treating, preventing or reducing the risk of developing a mitochondrial disorder or disease or the symptoms associated with a mitochondrial disorder or disease.
摘要翻译：本发明涉及用于治疗，预防或降低发展线粒体疾病或疾病或与线粒体疾病或疾病相关的症状的风险的方法和组合物。

7. 发明公开

EP1631289A4 ANTI-HIV BENZAMIDE COMPOUNDS 审中-公开
标题翻译：抗HIV活性物质苯甲酰胺
公开(公告)号：EP1631289A4
公开(公告)日：2010-06-02
申请号：EP04752748
申请日：2004-05-20
申请人： SAMARITAN PHARMACEUTICALS INC , UNIV GEORGETOWN , PAPADOPOULOS VASSILIOS , GREESON JANET , LECANU LAURENT
发明人： PAPADOPOULOS VASSILIOS , GREESON JANET , LECANU LAURENT
IPC分类号： A61K31/497 , A61K20060101 , A61K31/33 , A61P31/00 , A61P31/18
CPC分类号： A61K31/497 , A61K31/33

8. 发明公开

EP1628660A4 METHODS AND COMPOSITIONS FOR MODULATING SERUM CORTISOL LEVELS 审中-公开
标题翻译：方法和组合物调制皮质醇血清水平
公开(公告)号：EP1628660A4
公开(公告)日：2010-06-02
申请号：EP04753024
申请日：2004-05-20
申请人： SAMARITAN PHARMACEUTICALS INC , UNIV GEORGETOWN , LECANU LAURENT , GREESON JANET , PAPADOPOULOS VASSILIOS , XU JING
发明人： LECANU LAURENT , GREESON JANET , PAPADOPOULOS VASSILIOS , XU JING
IPC分类号： A61K31/497 , A61K20060101 , A61K31/33 , A61K31/405 , A61K31/495 , A61K31/50 , A61P25/28
CPC分类号： A61K31/497 , A61K31/33 , A61K31/496

9. 发明申请

WO2006107902A9 USE OF SPIROSTENOLS TO TREAT MITOCHONDRIAL DISORDERS 审中-公开
标题翻译：使用螺旋体治疗麻醉病
公开(公告)号：WO2006107902A9
公开(公告)日：2007-01-18
申请号：PCT/US2006012380
申请日：2006-03-31
申请人： SAMARITAN PHARMACEUTICALS INC , UNIV GEORGETOWN , LECANU LAURENT , TILLEMENT LAURENT , PAPADOPOULOS VASSILIOS , YAO WENGUO , GREESON JANET
发明人： LECANU LAURENT , TILLEMENT LAURENT , PAPADOPOULOS VASSILIOS , YAO WENGUO , GREESON JANET
IPC分类号： A61K31/58 , A61P3/10 , A61P9/00 , A61P9/10 , A61P21/00 , A61P27/00
CPC分类号： A61K31/58
摘要： The present invention relates to methods and compositions for treating, preventing or reducing the risk of developing a mitochondrial disorder or disease or the symptoms associated with a mitochondrial disorder or disease.
摘要翻译：本发明涉及用于治疗，预防或降低发展线粒体疾病或疾病或与线粒体疾病或疾病相关的症状的风险的方法和组合物。

10. 发明申请

WO2004080416A3 ANIMAL MODEL SIMULATING NEUROLOGIC DISEASE 审中-公开
标题翻译：动物模型模拟神经疾病
公开(公告)号：WO2004080416A3
公开(公告)日：2004-12-23
申请号：PCT/US2004007457
申请日：2004-03-11
申请人： SAMARITAN PHARMACEUTICALS INC , UNIV GEORGETOWN , LECANU LAURENT , GREESON JANET , PAPADOPOULOS VASSILIOS
发明人： LECANU LAURENT , GREESON JANET , PAPADOPOULOS VASSILIOS
IPC分类号： A01K67/00 , A01K67/027 , A61K20060101 , A61K38/00 , A61K49/00 , G01N33/00
CPC分类号： A01K67/027 , A01K2227/105 , A01K2267/0312 , A61K49/0008
摘要： The present invention relates to the development of a pharmacological non-human animal model that associates memory loss to histopathological features found in the brain of a subject having Alzheimer's Disease. In one embodiment, a four-week continuous infusion of a Fe , Abeta42 and buthionine sulfoximine (FAB) solution in the left ventricle of young adult Long-Evans rats induced memory impairment accompanied by increased hyperphosphorylated Tau protein levels in cerebrospinal fluid. Brains from treated animals displayed neuritic plaques, tangles, neuronal loss, astrogliosis and microgliosis in hippocampus and cortex. The present invention may be utilized in evaluating preventive, therapeutic and diagnostic means for neurologic diseases.
摘要翻译：本发明涉及药理学非人动物模型的发展，其将记忆丧失与在患有阿尔茨海默病的受试者的脑中发现的组织病理学特征相关联。在一个实施方案中，在年轻成人Long-Evans大鼠的左心室中四个星期连续输注Fe 2+，Abeta42和丁硫氨酸砜亚胺（FAB）溶液诱导伴随脑脊液中过度磷酸化Tau蛋白水平增加的记忆障碍。来自治疗动物的大脑在海马和皮质中显示神经炎斑块，缠结，神经元丢失，星形胶质细胞增生和小神经胶质细胞增生症。本发明可用于评估神经疾病的预防，治疗和诊断手段。

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