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1. 发明申请

WO1997003948A1 2-SUBSTITUTED BENZOHYDROXIMOYL DERIVATIVES, INTERMEDIATE FOR THE PRODUCTION OF THE SAME AND PESTICIDE COMPRISING THE SAME AS THE ACTIVE INGREDIENT 审中-公开
标题翻译： 2-取代的苯甲酰基衍生物，其生产中间体和包含其中的活性成分的杀虫剂
公开(公告)号：WO1997003948A1
公开(公告)日：1997-02-06
申请号：PCT/JP1996001984
申请日：1996-07-17
申请人： SHIONOGI & CO., LTD. , TAKASE, Akira , KAI, Hiroyuki , NISHIDA, Kuniyoshi
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07C251/48
CPC分类号： C07D213/643 , A01N35/10 , A01N37/28 , A01N37/50 , A01N37/52 , A01N43/40 , C07C251/48 , C07C327/58
摘要： 2-Substituted benzohydroximoyl derivatives represented by general formula (I), an intermediate for the production of the same and a pesticide or bactericide comprising the same as the active ingredient, wherein R represents CHO or CH2OR (wherein R represents hydrogen, alkyl, etc.); R represents aryl, etc.; R represents alkyl, etc.; R represents hydrogen, alkyl, etc.; M represents oxygen, S(O)i (wherein i is from 0 to 2), NR (wherein R represents hydrogen, alkyl or acyl), etc.; and n is from 0 to 2.
摘要翻译： 2-取代的由通式（I）表示的苯并羟酰亚胺酰基衍生物，用于制备其的中间体和包含与活性成分相同的杀虫剂或杀菌剂，其中R 1表示CHO或CH2OR5（其中R < 5“表示氢，烷基等）; R 2表示芳基等; R 3表示烷基等; R 4表示氢，烷基等; M表示氧，S（O）i（其中i为0至2），NR 6（其中R 6表示氢，烷基或酰基）等; n为0〜2。

2. 发明申请

WO1995026956A1 OXIME DERIVATIVE AND BACTERICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译：含有活性成分的OXIME衍生物和杀菌剂
公开(公告)号：WO1995026956A1
公开(公告)日：1995-10-12
申请号：PCT/JP1995000604
申请日：1995-03-30
申请人： SHIONOGI & CO., LTD. , TAKASE, Akira , KAI, Hiroyuki , NISHIDA, Kuniyoshi , IWAKAWA, Tsuneo , UEDA, Kazuo , MASUKO, Michio
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07D231/12
CPC分类号： C07D231/06 , A01N43/50 , C07D231/12 , C07D233/64 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/32 , C07D271/06 , C07D271/10 , C07D277/10 , C07D285/06
摘要： A compound represented by general formula (I) or a salt thereof, a process for producing the same, an intermediate for the production thereof, and a bactericide containing the same as the active ingredient wherein R represents optionally substituted aryl, optionally substituted heterocycle, mono- or di-substituted methyleneamino, optionally substituted (substituted imino)methyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, substituted carbonyl or substituted sulfonyl; R represents alkyl, alkenyl, alkynyl or cycloalkyl; R represents optionally substituted heterocycle; R represents hydrogen, alkyl, alkoxy, halogen, nitro, cyano or haloalkyl; M represents oxygen, S(O)i (i being 0, 1 or 2), NR (R being hydrogen, alkyl or acyl) or a single bond; n represents 0 or 1, provided n represents 1 when R represents imidazol-1-yl or 1H-1, 2, 4-triazol-1-yl; and the symbol SIMILAR represents the E form, Z form or a mixture thereof.
摘要翻译：由通式（I）表示的化合物或其盐，其制备方法，其制备中间体和含有该活性成分的杀菌剂，其中R 1表示任选取代的芳基，任选取代的取代的亚氨基甲基，任选取代的烷基，任选取代的烯基，任选取代的炔基，取代的羰基或取代的磺酰基; R 2表示烷基，烯基，炔基或环烷基; R 3表示任选取代的杂环; R 4表示氢，烷基，烷氧基，卤素，硝基，氰基或卤代烷基; M表示氧，S（O）i（i为0,1或2），NR 16（R 16为氢，烷基或酰基）或单键; 当R 3表示咪唑-1-基或1H-1,2,4-三唑-1-基时，n表示0或1，条件是n表示1。并且符号SIMILAR表示E形式，Z形式或其混合物。

3. 发明申请

WO1997012875A1 'alpha'-ALKOXYIMINOBENZYL HETEROCYCLIC DERIVATIVES, INTERMEDIATES FOR PREPARING THE SAME, AND AGRICULTURAL CHEMICALS CONTAINING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译： α-烷氧基苯甲腈杂环衍生物，其制备中间体以及含有它们的农业化学品作为活性成分
公开(公告)号：WO1997012875A1
公开(公告)日：1997-04-10
申请号：PCT/JP1996002766
申请日：1996-09-25
申请人： SHIONOGI & CO., LTD. , TAKASE, Akira , KAI, Hiroyuki
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07D233/61
CPC分类号： A01N43/50 , A01N43/08 , A01N43/80 , A01N43/82 , C07D261/08
摘要： Compounds represented by general formula (I) wherein R represents an optionally substituted heterocyclic group; R represents an optionally substituted aryl or optionally substituted heterocyclic group; R represents an alkyl; R represents a hydrogen atom, an alkyl, an alkoxy, a halogen atom, nitro, cyano, or haloalkyl; M represents -N=C(R )- or -A-(CR R )n-; and the wavy line ( SIMILAR ) represents any configuration of E, Z or a mixture thereof; intermediates for preparing the same; and agricultural chemicals containing the same as the active ingredient.
摘要翻译：由通式（I）表示的化合物，其中R 1表示任选取代的杂环基; R 2表示任选取代的芳基或任选取代的杂环基; R 3表示烷基; R 4表示氢原子，烷基，烷氧基，卤素原子，硝基，氰基或卤代烷基; M表示-N = C（R 5） - 或-A-（CR 6 R 7）n - ; 波浪线（SIMILAR）表示E，Z或其混合物的任何构型; 制备相同的中间体; 和含有与活性成分相同的农药。

4. 发明申请

WO1997012863A1 'alpha'-SUBSTITUTED BENZYL HETEROCYCLIC DERIVATIVES, INTERMEDIATES FOR PRODUCING THE SAME, AND PESTICIDES CONTAINING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译： α-取代的苄基杂环衍生物，其生产中间体和含有它们的活性成分的杀虫剂
公开(公告)号：WO1997012863A1
公开(公告)日：1997-04-10
申请号：PCT/JP1996002765
申请日：1996-09-25
申请人： SHIONOGI & CO., LTD. , KAI, Hiroyuki , TAKASE, Akira , OHTSUKA, Toshikazu
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07D213/30
CPC分类号： C07D213/30 , A01N43/40 , A01N43/50 , A01N43/80 , A01N43/82 , C07D233/22 , C07D261/04 , C07D261/08 , C07D261/20 , C07D271/10 , C07D285/06 , C07D413/12
摘要： Compounds represented by general formula (I), wherein R represents an optionally substituted heterocyclic group; R represents an optionally substituted aryl or heterocyclic group; R represents hydrogen, alkyl, alkenyl or alkynyl; R represents hydrogen, alkyl, alkoxy, halogeno, nitro, cyano or haloalkyl; M represents O, S(O)i (wherein i is 0, 1 or 2), NR (wherein R represents hydrogen, alkyl or acyl), -Q-N=C(R )-, -B-C(R )=N-, -CH=N-N=C(R )- or -CH=N-A-(CR R )m-; and n is 0, 1 or 2.
摘要翻译：由通式（I）表示的化合物，其中R 1表示任选取代的杂环基; R 2表示任选取代的芳基或杂环基; R 3表示氢，烷基，烯基或炔基; R 4表示氢，烷基，烷氧基，卤代，硝基，氰基或卤代烷基; M表示O，S（O）i（其中i是0,1或2），NR 5（其中R 5表示氢，烷基或酰基），-QN = C（R 6） -BC（R 8）= N-，-CH = NN = C（R 9） - 或-CH = NA-（CR 10 R 11）m - ; n为0,1或2。

5. 发明申请

WO1995001330A1 PROCESS FOR PRODUCING alpha-ALKOXYIMINOPHENYLACETONITRILE DERIVATIVE 审中-公开
标题翻译：生产α-羟基亚氨基乙酰胺衍生物的方法
公开(公告)号：WO1995001330A1
公开(公告)日：1995-01-12
申请号：PCT/JP1994001077
申请日：1994-07-01
申请人： SHIONOGI & CO., LTD. , SUMITOMO CHEMICAL COMPANY, LIMITED , TAKASE, Akira , KAI, Hiroyuki , MASUI, Moriyasu , MASUMOTO, Katuhisa , NAKAMURA, Akihiko , KIYOSHIMA, Yujiro , SASAKI, Mikio
发明人： SHIONOGI & CO., LTD. , SUMITOMO CHEMICAL COMPANY, LIMITED
IPC分类号： C07C255/62
CPC分类号： C07C251/48 , C07C253/30 , C07C255/61 , C07C319/20
摘要： A process for producing an alpha -alkoxyiminophenylacetonitrile represented by general formula [III], (wherein R , R , R and Y are each as defined in the specification) by reacting an alkali metal salt of an alpha -hydroxyiminophenylacetonitrile, represented by general formula [I], (wherein R , R , Y and A are each as defined in the specification) with a dialkyl sulfate represented by the general formula [II]: (R )2SO4, (wherein R is as defined in the specification) in the presence of a phase transfer catalyst in a solvent mixture composed of a hydrocarbon solvent and water. It is possible by using the above catalyst and solvent mixture to inhibit the formation of a nitrone derivative as a by-product to thereby produce a highly pure alkoxyimino compound in a high yield.
摘要翻译：由通式[III]表示的α-烷氧基亚氨基苯基乙腈（其中R 1，R 2，R 3和Y各自如说明书中所定义）的制备方法，通过使由通式[I]表示的α-羟基亚氨基苯基乙腈（其中R 1，R 2，Y和A各自如说明书中所定义）与由通式[II]表示的二烷基硫酸盐反应：（R 3SO4）（其中R 3如本说明书中所定义）在相转移催化剂存在下，在由烃溶剂和水组成的溶剂混合物中。可以通过使用上述催化剂和溶剂混合物抑制作为副产物的硝酮衍生物的形成，从而以高产率制备高纯度烷氧基亚氨基化合物。

6. 发明申请

WO1995001328A1 PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE 审中-公开
标题翻译：生产羧酸衍生物的方法
公开(公告)号：WO1995001328A1
公开(公告)日：1995-01-12
申请号：PCT/JP1994001075
申请日：1994-07-01
申请人： SHIONOGI & CO., LTD. , SUMITOMO CHEMICAL COMPANY, LIMITED , TAKASE, Akira , KAI, Hiroyuki , MASUI, Moriyasu , MASUMOTO, Katuhisa , NAKAMURA, Akihiko , KIYOSHIMA, Yujiro , SASAKI, Mikio
发明人： SHIONOGI & CO., LTD. , SUMITOMO CHEMICAL COMPANY, LIMITED
IPC分类号： C07C251/48
CPC分类号： C07C249/12 , C07C251/48
摘要： A process for producing a carboxylic acid derivative represented by general formula [VIII], (wherein R , R , R and L are each as defined in the specification), which comprises reacting a benzyl halide with a cyano compound to give a phenylacetonitrile, reacting the nitrile with an alkyl nitrite in the presence of a base to give an alpha -hydroxyiminophenylacetonitrile, reacting the hydroxy nitrile with an alkylating agent to give an alpha -alkoxyiminophenylacetonitrile, hydrolyzing the alkoxy nitrile in the presence of a base, optionally after hydration and acid treatment, to give an alpha -alkoxyiminophenylacetic acid, and finally reacting the acid with a halogenating agent, or converting the acid into a corresponding metal salt and reacting the salt with an alkylating agent, or reacting the acid with a lower alcohol in the presence of an acidic catalyst. According to this process, the reactions can be advanced through the respective steps under mild conditions, and the target derivative [VIII] can be produced even without resort to high-pressure steam equipment, high-temperature heat medium equipment, refrigerator, and so forth. Further, this process is advantageous in that only a single solvent will suffice without the necessity for using various solvents according to the respective steps.
摘要翻译：制备由通式[Ⅷ]表示的羧酸衍生物的方法（其中R 1，R 2，R 3和L各自如说明书中所定义），其中包括使苄基卤与氰基化合物，得到苯基乙腈，在碱的存在下使腈与亚硝酸烷基酯反应，得到α-羟基亚氨基苯基乙腈，使羟基腈与烷基化剂反应，得到α-烷氧基亚氨基苯基乙腈，在存在下水解烷氧基腈的碱，任选地在水合和酸处理之后，得到α-烷氧基亚氨基苯基乙酸，最后使酸与卤化剂反应，或将酸转化成相应的金属盐，并使该盐与烷基化剂反应，或使在酸性催化剂存在下用低级醇酸化。根据该方法，可以在温和条件下通过各自的步骤进行反应，即使不使用高压蒸汽设备，高温热介质设备，冰箱等，也可以生产目标衍生物[Ⅷ] 。此外，该方法的优点在于，仅根据相应步骤仅需要使用各种溶剂即可满足单一溶剂即可。

7. 发明申请

WO1998016517A1 PROCESS FOR PRODUCING ISOXAZOLE DERIVATIVES AND INTERMEDIATES FOR PRODUCING THE SAME 审中-公开
标题翻译：用于生产异噻唑衍生物的方法和用于生产异噻唑衍生物的中间体
公开(公告)号：WO1998016517A1
公开(公告)日：1998-04-23
申请号：PCT/JP1997003584
申请日：1997-10-07
申请人： SHIONOGI & CO., LTD. , KAI, Hiroyuki , TAKASE, Akira , TOMIDA, Minoru
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07D261/08
CPC分类号： C07C251/36 , C07D261/08
摘要： A process for producing compounds represented by general formula (I) (wherein R and R represent each hydrogen, alkyl, alkoxy, halogeno or -(CH2)n-M-R (wherein R represents optionally substituted aryl, etc.; M represents oxygen, etc.; and n is 0 or 1)), characterized by reacting a compound represented by general formula (II) (wherein R and R are as defined above) with acetylene under basic conditions; and a process for producing compounds represented by general formula (VII) which are useful as agricultural germicides from the compounds represented by general formulae (I) and (II) as given above.
摘要翻译：一种制备由通式（I）表示的化合物的方法（其中R 1和R 2代表各自的氢，烷基，烷氧基，卤代或 - （CH 2）nMR 3（其中R 3表示任选取代的芳基等; M表示氧等，n为0或1）），其特征在于使通式（II）表示的化合物（其中R 1和R 2如上定义）与通式乙炔在碱性条件下; 以及由通式（Ⅶ）表示的化合物的制备方法，其由上述通式（I）和（II）表示的化合物可用作农业杀菌剂。

8. 发明申请

WO1996020164A1 PROCESS FOR PRODUCING 2-(2-HYDROXYMETHYLPHENYL)ACETAMIDE DERIVATIVE AND INTERMEDIATE FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：生产2-（2-羟基甲基苯基）乙酰胺衍生物的方法及其制备方法
公开(公告)号：WO1996020164A1
公开(公告)日：1996-07-04
申请号：PCT/JP1995002621
申请日：1995-12-21
申请人： SHIONOGI & CO., LTD. , TAKASE, Akira , KAI, Hiroyuki , MURASHI, Takami
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07C251/48
CPC分类号： C07C233/56 , C07C69/738 , C07C249/08 , C07C249/12 , C07C251/48 , C07F7/1804 , Y02P20/55
摘要： A process for producing a compound represented by general formula (I) (E-isomer), wherein R and R are the same or different and each represents hydrogen or alkyl; and R represents hydrogen or alkyl which comprises eliminating the protecting group (P) of the hydroxyl group in the compound represented by general formula (II), wherein R , R and R are as defined above; P represents a protecting group of a hydroxyl group; and SIMILAR represents the configuration of an E- or Z-isomer or a mixture thereof; and an intermediate for the production of compound (I).
摘要翻译：制备由通式（I）表示的化合物（E-异构体）的方法，其中R 1和R 2相同或不同，各自表示氢或烷基; 并且R表示氢或烷基，其包括除去通式（II）表示的化合物中的羟基的保护基（P），其中R 1，R 2和R如上定义; P表示羟基的保护基; 和SIMILAR表示E-或Z-异构体或其混合物的构型; 和用于制备化合物（I）的中间体。

9. 发明申请

WO1995001329A1 PROCESS FOR PRODUCING alpha-HYDROXYIMINOPHENYLACETONITRILE 审中-公开
标题翻译：生产α-羟基亚氨基乙酸乙酯的方法
公开(公告)号：WO1995001329A1
公开(公告)日：1995-01-12
申请号：PCT/JP1994001076
申请日：1994-07-01
申请人： SHIONOGI & CO., LTD. , SUMITOMO CHEMICAL COMPANY, LIMITED , TAKASE, Akira , KAI, Hiroyuki , MASUI, Moriyasu , MASUMOTO, Katuhisa , NAKAMURA, Akihiko , KIYOSHIMA, Yujiro , SASAKI, Mikio
发明人： SHIONOGI & CO., LTD. , SUMITOMO CHEMICAL COMPANY, LIMITED
IPC分类号： C07C255/62
CPC分类号： C07C251/48 , C07C253/14 , C07C253/30 , C07C255/64
摘要： A process for producing an alpha -hydroxyiminophenylacetonitrile represented by general formula [II], (wherein R , R , R and Z are each as defined in the specification) by reacting a crude nitrile containing a phenylacetonitrile represented by general formula [I], (wherein R , R , R and Z are each as defined in the specification) with an alkyl nitrite in the presence of a base, extracting the reaction mixture with water, and neutralizing the separated water layer with an acid. This process enables target alpha -hydroxyiminophenylacetonitriles to be readily produced in a highly pure form in high yield by extracting the reaction mass with water and neutralizing the separated water layer with an acid.
摘要翻译：由通式[II]表示的α-羟基亚氨基苯基乙腈的制备方法（其中R 1，R 2，R 3和Z各自如说明书中所定义），通过使含有苯乙腈的粗腈由通式[I]表示，其中R 1，R 2，R 3和Z各自如说明书中所定义）与亚烷基烷基酯在碱的存在下反应，用水，并用酸中和分离的水层。该方法能够通过用水萃取反应物料并用酸中和分离的水层，以高产率容易地以高纯度形式产生目标α-羟基亚氨基苯基乙腈。

10. 发明申请

WO1998016499A1 OXIME DERIVATIVES, HYDRAZONE DERIVATIVES, AND USE THEREOF 审中-公开
标题翻译： OXIME衍生物，HYDRAZONE衍生物及其用途
公开(公告)号：WO1998016499A1
公开(公告)日：1998-04-23
申请号：PCT/JP1997003585
申请日：1997-10-07
申请人： SHIONOGI & CO., LTD. , MASUI, Moriyasu , TANIMOTO, Norihiko , NISHIDA, Kuniyoshi
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07C251/36
CPC分类号： C07D213/30 , A01N37/50 , A01N41/06 , A01N41/10 , A01N43/40 , A01N43/46 , A01N43/80 , A01N47/16 , C07C251/36 , C07C251/48 , C07C251/52 , C07C251/54 , C07C251/74 , C07C259/06 , C07D207/12 , C07D211/42 , C07D211/46 , C07D211/58 , C07D211/72 , C07D243/08 , C07D261/02 , C07D295/185 , C07D295/26 , C07D333/16 , C07D401/12
摘要： Compounds having bactericidal activities and represented by general formula (I) and salts and hydrates thereof wherein R represents an optionally substituted aryl, an optionally substituted alkyl or the like; R represents an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted aryl, an optionally substituted heterocyclic group or the like; R represents an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted arylsulfonyl, an optionally substituted heterocyclic group or the like; R and R , which may be the same or different, represent each a hydrogen atom, an optionally substituted alkyl, or an optionally substituted alkoxy, or R and R may form together with the adjacent nitrogen atom an optionally substituted monocycle or polycycle; X and Y, which may be the same or different, represents each an oxygen atom or NR (wherein R represents a hydrogen atom, an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted alkanoyl, or an optionally substituted aroyl); Z represents an oxygen atom or a sulfur atom; and a wavy line ( SIMILAR ) represents the configuration of an E isomer, a Z isomer, or a mixture thereof.
摘要翻译：具有杀菌活性并由通式（I）表示的化合物及其盐和水合物，其中R 1表示任选取代的芳基，任选取代的烷基等; R 2表示任选取代的烷基，任选取代的烯基，任选取代的炔基，任选取代的芳基，任选取代的杂环基等; R 3表示任选取代的烷基，任选取代的烯基，任选取代的炔基，任选取代的芳基磺酰基，任选取代的杂环基等; R 4和R 5可以相同或不同，表示氢原子，任选取代的烷基或任选取代的烷氧基，或者R 4和R 5可以与相邻氮原子，任选取代的单环或多环; X和Y可以相同或不同，表示每个氧原子或NR 6（其中R 6表示氢原子，任选取代的烷基，任选取代的芳基，任选取代的烷酰基或任选取代的芳酰基）; Z表示氧原子或硫原子; 和波浪线（SIMILAR）表示E异构体，Z异构体或其混合物的构型。

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