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1. 发明申请

US20090291938A1 POLO-LIKE KINASE INHIBITORS 审中-公开
标题翻译： POLO-like激素抑制剂
公开(公告)号：US20090291938A1
公开(公告)日：2009-11-26
申请号：US12274213
申请日：2008-11-19
申请人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号： A61K31/551 , C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译：提供下式的化合物用于激酶：其中变量如本文所定义。还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

2. 发明申请

US20110082111A1 POLO-LIKE KINASE INHIBITORS 失效
公开(公告)号：US20110082111A1
公开(公告)日：2011-04-07
申请号：US12962557
申请日：2010-12-07
申请人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. KALDOR , Andre A. KIRYANOV , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. KALDOR , Andre A. KIRYANOV , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号： A61K31/675 , C07D487/04 , A61K31/551 , A61K31/397 , C07F9/165 , C07D487/14 , C07C229/34 , C07C229/22 , C07C69/74 , C07C69/75 , A61P35/00
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

3. 发明申请

US20090281092A1 POLO-LIKE KINASE INHIBITORS 失效
公开(公告)号：US20090281092A1
公开(公告)日：2009-11-12
申请号：US12237306
申请日：2008-09-24
申请人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号： A61K31/5513 , C07D487/04 , A61P35/00 , A61P29/00 , A61P37/00 , A61P9/00 , A61P25/00 , A61P19/00
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

4. 发明授权

US08318727B2 Polo-like kinase inhibitors 失效
标题翻译：马球状激酶抑制剂
公开(公告)号：US08318727B2
公开(公告)日：2012-11-27
申请号：US12962557
申请日：2010-12-07
申请人： Sheldon X Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Yan Liu , Chrisopher McBride , Srinivasa Ready Natala , Zhe Nie , Jeffrey A. Stafford , Betty Lam
发明人： Sheldon X Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Yan Liu , Chrisopher McBride , Srinivasa Ready Natala , Zhe Nie , Jeffrey A. Stafford , Betty Lam
IPC分类号： C07D487/04 , A61K31/55
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译：提供下式的化合物用于激酶：其中变量如本文所定义。还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

5. 发明申请

US20100075973A1 POLO-LIKE KINASE INHIBITORS 审中-公开
标题翻译： POLO-like激素抑制剂
公开(公告)号：US20100075973A1
公开(公告)日：2010-03-25
申请号：US12544419
申请日：2009-08-20
申请人： Sheldon X. Cao , Takashi Ichikawa , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Stephen W. Kaldor , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Takashi Ichikawa , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Stephen W. Kaldor , Jeffrey A. Stafford
IPC分类号： A61K31/5025 , C07D471/14 , A61P35/00
CPC分类号： C07D487/14
摘要： The present invention provides PLK inhibitors of the formula wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using the compounds.
摘要翻译：本发明提供下式的PLK抑制剂，其中变量如本文所定义。还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 和使用该化合物的方法。

6. 发明授权

US08138168B1 Renin inhibitors 失效
标题翻译：肾素抑制剂
公开(公告)号：US08138168B1
公开(公告)日：2012-03-20
申请号：US12239538
申请日：2008-09-26
申请人： Benjamin Jones , Stephen W. Kaldor , Walter Keung , Andre A. Kiryanov , Zhe Li , Jeffrey A. Stafford , John Tyhonas , Craig Behnke
发明人： Benjamin Jones , Stephen W. Kaldor , Walter Keung , Andre A. Kiryanov , Zhe Li , Jeffrey A. Stafford , John Tyhonas , Craig Behnke
IPC分类号： A61K31/407 , A61K31/4745 , A61K31/4178 , C07D453/02
CPC分类号： C07D235/14 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The invention relates to compounds having the formulae: wherein the variables are as defined herein. The invention further relates to methods of making and using these compounds, and pharmaceutical compositions, kits and articles of manufacture comprise the compounds.
摘要翻译：本发明涉及具有下式的化合物：其中变量如本文所定义。本发明还涉及制备和使用这些化合物的方法，药物组合物，试剂盒和制品包含这些化合物。

7. 发明授权

US07790734B2 Dipeptidyl peptidase inhibitors 有权
标题翻译：二肽基肽酶抑制剂
公开(公告)号：US07790734B2
公开(公告)日：2010-09-07
申请号：US10934326
申请日：2004-09-02
申请人： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Xiao-Yi Xiao , Zhiyuan Zhang
发明人： Sheldon X. Cao , Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Xiao-Yi Xiao , Zhiyuan Zhang
IPC分类号： C07D239/47 , C07D239/48 , C07D403/12 , A61K31/505
CPC分类号： C07D401/04
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
摘要翻译：提供化合物，药物，试剂盒和方法用于包含式I的DPP-IV抑制剂：其中取代基如本文所述。

8. 发明申请

US20100069431A1 IMIDAZOPYRIDINE COMPOUNDS 失效
标题翻译：咪唑吡啶化合物
公开(公告)号：US20100069431A1
公开(公告)日：2010-03-18
申请号：US12065607
申请日：2006-09-01
申请人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A. Stafford , Beverly Throop
发明人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A. Stafford , Beverly Throop
IPC分类号： A61K31/437 , C07D471/02
CPC分类号： A61K31/437 , A61K9/2018 , A61K9/4858 , C07D471/02 , C07D471/04 , C12N9/1205 , C12Y207/01001
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
摘要翻译：提供化合物，药物组合物，试剂盒和方法用于含有选自式（I）的化合物的葡糖激酶，其中变量如本文所定义。

9. 发明授权

US07399884B2 Histone deacetylase inhibitors 失效
标题翻译：组蛋白脱乙酰酶抑制剂
公开(公告)号：US07399884B2
公开(公告)日：2008-07-15
申请号：US11557402
申请日：2006-11-07
申请人： Jerome C. Bressi , Sheldon X. Cao , Jeffrey A. Stafford , Phong H. Vu
发明人： Jerome C. Bressi , Sheldon X. Cao , Jeffrey A. Stafford , Phong H. Vu
IPC分类号： C07C259/04 , C07C229/34 , C07D231/16 , C07D239/22 , C07D241/36
CPC分类号： C07C259/06 , C07D231/16 , C07D239/38 , C07D241/44
摘要： Histone deacetylase inhibitors and uses thereof are provided that have the general formula wherein R1, R2, R3 and R4 are each independently selected from the group consisting of hydrogen, a substituted or unsubstituted straight chained C1-12 alkyl, C2-12 aminoalkyl or C2-12 oxaalkyl, and a substituted and unsubstituted 3, 4, 5, 6, 7 or 8 membered ring, with the proviso that R3 and R4 are not both hydrogen;R5 is selected from the group consisting of a carbonyl, a substituted or unsubstituted C1-3 alkyl, a substituted or unsubstituted —C1-3 alkyl-C(O), a substituted or unsubstituted —C(O)—C1-3 alkyl, and a substituted or unsubstituted —C(O)C(O)C1-3 alkyl;M is a substituent capable of complexing with a protein metal ion; andL is a substituent comprising a chain of 3-12 atoms connecting the M substituent to the carbon atom alpha to the L substituent.
摘要翻译：提供组蛋白脱乙酰酶抑制剂及其用途，其具有以下通式：其中R 1，R 2，R 3和R 4， / SUB>各自独立地选自氢，取代或未取代的直链C 1-12烷基，C 2-12-12氨基烷基或C 1 -C 12烷基， 2-12个氧杂烷基，以及取代和未取代的3,4,5,6,7或8元环，条件是R 3和R 4 不是氢; R 5选自羰基，取代或未取代的C 1-3烷基，取代或未取代的C 1-3烷基，烷基-C（O），取代或未取代的-C（O）-C 1-3烷基和取代或未取代的-C（O）C（O）C 1-3烷基; M是能与蛋白质金属离子络合的取代基; L是包含连接M取代基与L取代基的α原子的3-12个原子的链的取代基。

10. 发明授权

US08394843B2 Substituted isoindoles as glucokinase activators 失效
标题翻译：取代的异吲哚作为葡萄糖激酶激活剂
公开(公告)号：US08394843B2
公开(公告)日：2013-03-12
申请号：US13185166
申请日：2011-07-18
申请人： Jun Feng , Stephen L. Gwaltney , Robert J. Skene , Mingnam Tang , Sheldon X. Cao , David J. Hossfield , Jeffrey A. Stafford
发明人： Jun Feng , Stephen L. Gwaltney , Robert J. Skene , Mingnam Tang , Sheldon X. Cao , David J. Hossfield , Jeffrey A. Stafford
IPC分类号： C07D209/02 , C07D275/02 , A61K31/4035 , A61K31/4168 , C07D231/56 , C07D471/02 , C07D487/04 , A61K31/519 , A61K31/4152 , A61K31/416 , A61K31/437 , A61K31/4985 , A61P13/12
CPC分类号： C07D417/12 , C07D401/12 , C07D471/04 , C07D487/04
摘要： Compounds are provided which have the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture which contain such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to activate glucokinase.
摘要翻译：提供了具有下式的化合物：其中变量如本文所定义。还提供含有这些化合物的药物组合物，试剂盒和制品，用于制备化合物的方法和中间体，以及使用该化合物来激活葡糖激酶的方法。

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