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1. 发明授权

US08815092B2 Method and apparatus for microfiltration to perform cell separation 有权
标题翻译：微滤法进行细胞分离的方法和装置
公开(公告)号：US08815092B2
公开(公告)日：2014-08-26
申请号：US13340516
申请日：2011-12-29
申请人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
发明人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
IPC分类号： B01D63/00 , B01D61/00
CPC分类号： B01D69/12 , B01D61/18 , B01D63/082 , B01D67/0034 , B01D71/28 , B01D2325/021
摘要： A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.
摘要翻译：一种使用具有顶部多孔膜和底部多孔膜的微量过滤装置从样品中分离诸如循环肿瘤细胞的细胞的微滤装置和方法。多孔膜由聚对二甲苯形成并使用微细加工技术组装。多孔膜被布置成使得顶部膜中的孔与底部膜中的孔偏离。

2. 发明授权

US08114289B2 Method and apparatus for microfiltration to perform cell separation 有权
标题翻译：微滤法进行细胞分离的方法和装置
公开(公告)号：US08114289B2
公开(公告)日：2012-02-14
申请号：US12360067
申请日：2009-01-26
申请人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
发明人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
IPC分类号： B01D63/00 , B41J2/175
CPC分类号： B01D69/12 , B01D61/18 , B01D63/082 , B01D67/0034 , B01D71/28 , B01D2325/021
摘要： A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.
摘要翻译：一种使用具有顶部多孔膜和底部多孔膜的微量过滤装置从样品中分离诸如循环肿瘤细胞的细胞的微滤装置和方法。多孔膜由聚对二甲苯形成并使用微细加工技术组装。多孔膜被布置成使得顶部膜中的孔与底部膜中的孔偏离。

3. 发明申请

US20090188864A1 METHOD AND APPARATUS FOR MICROFILTRATION TO PERFORM CELL SEPARATION 有权
标题翻译：用于微细分离以进行细胞分离的方法和装置
公开(公告)号：US20090188864A1
公开(公告)日：2009-07-30
申请号：US12360067
申请日：2009-01-26
申请人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
发明人： Siyang Zheng , Richard Cote , Henry Lin , Bo Lu , Yu-Chong Tai
IPC分类号： B01D69/12 , B01D61/14 , B01D65/02 , B44C1/22
CPC分类号： B01D69/12 , B01D61/18 , B01D63/082 , B01D67/0034 , B01D71/28 , B01D2325/021
摘要： A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.
摘要翻译：一种使用具有顶部多孔膜和底部多孔膜的微量过滤装置从样品中分离诸如循环肿瘤细胞的细胞的微滤装置和方法。多孔膜由聚对二甲苯形成并使用微细加工技术组装。多孔膜被布置成使得顶部膜中的孔与底部膜中的孔偏离。

4. 发明授权

US07846743B2 Uses of parylene membrane filters 有权
标题翻译：聚对二甲苯膜过滤器的使用
公开(公告)号：US07846743B2
公开(公告)日：2010-12-07
申请号：US11408499
申请日：2006-04-20
申请人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
发明人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
IPC分类号： G01N1/18
CPC分类号： B01D71/72 , B01D61/14 , B01D61/18 , B01D61/20 , B01D67/0034 , B01D67/0088 , B01D69/02 , B01D71/022 , B01D2325/021 , B01D2325/08 , B01L3/5635 , B01L2300/0681 , B01L2400/0415 , B01L2400/0487 , Y10T436/25375
摘要： The invention provides parylene membrane filters, filter devices and methods of making them and using them in the mechanical separation of cells and particles by size. The provision of parylene membrane filters with high figures of merit and finely controlled hole sizes allows the separation of cells and particles in a variety of biological and other fluids according to sizes.
摘要翻译：本发明提供聚对二甲苯膜过滤器，过滤装置和制造它们的方法，并将其用于通过尺寸机械分离细胞和颗粒。提供具有高品质因数和精细控制的孔尺寸的聚对二甲苯膜过滤器允许根据尺寸分离各种生物和其它流体中的细胞和颗粒。

5. 发明申请

US20070025883A1 Uses of parylene membrane filters 有权
标题翻译：聚对二甲苯膜过滤器的使用
公开(公告)号：US20070025883A1
公开(公告)日：2007-02-01
申请号：US11408499
申请日：2006-04-20
申请人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
发明人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
IPC分类号： B01L11/00
CPC分类号： B01D71/72 , B01D61/14 , B01D61/18 , B01D61/20 , B01D67/0034 , B01D67/0088 , B01D69/02 , B01D71/022 , B01D2325/021 , B01D2325/08 , B01L3/5635 , B01L2300/0681 , B01L2400/0415 , B01L2400/0487 , Y10T436/25375
摘要： The invention provides parylene membrane filters, filter devices and methods of making them and using them in the mechanical separation of cells and particles by size. The provision of parylene membrane filters with high figures of merit and finely controlled hole sizes allows the separation of cells and particles in a variety of biological and other fluids according to sizes.
摘要翻译：本发明提供聚对二甲苯膜过滤器，过滤装置和制造它们的方法，并将其用于通过尺寸机械分离细胞和颗粒。提供具有高品质因数和精细控制的孔尺寸的聚对二甲苯膜过滤器允许根据尺寸分离各种生物和其它流体中的细胞和颗粒。

6. 发明申请

US20110111412A1 Uses of Parylene Membrane Filters 有权
标题翻译：聚对二甲苯膜过滤器的使用
公开(公告)号：US20110111412A1
公开(公告)日：2011-05-12
申请号：US12943891
申请日：2010-11-10
申请人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
发明人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
IPC分类号： C12Q1/68 , C12N5/09 , C12Q1/04 , G01N33/53
CPC分类号： B01D69/02 , B01D61/14 , B01D61/18 , B01D61/20 , B01D67/0034 , B01D67/0088 , B01D71/022 , B01D71/72 , B01D2325/021 , Y10T436/25375
摘要： The invention provides parylene membrane filters, filter devices and methods of making them and using them in the mechanical separation of cells and particles by size. The provision of parylene membrane filters with high figures of merit and finely controlled hole sizes allows the separation of cells and particles in a variety of biological and other fluids according to sizes.
摘要翻译：本发明提供聚对二甲苯膜过滤器，过滤装置和制造它们的方法，并将其用于通过尺寸机械分离细胞和颗粒。提供具有高品质因数和精细控制的孔尺寸的聚对二甲苯膜过滤器允许根据尺寸分离各种生物和其它流体中的细胞和颗粒。

7. 发明授权

US08288170B2 Uses of parylene membrane filters 有权
标题翻译：聚对二甲苯膜过滤器的使用
公开(公告)号：US08288170B2
公开(公告)日：2012-10-16
申请号：US12943891
申请日：2010-11-10
申请人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
发明人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
IPC分类号： G01N1/18
CPC分类号： B01D69/02 , B01D61/14 , B01D61/18 , B01D61/20 , B01D67/0034 , B01D67/0088 , B01D71/022 , B01D71/72 , B01D2325/021 , Y10T436/25375
摘要： The invention provides parylene membrane filters, filter devices and methods of making them and using them in the mechanical separation of cells and particles by size. The provision of parylene membrane filters with high figures of merit and finely controlled hole sizes allows the separation of cells and particles in a variety of biological and other fluids according to sizes.
摘要翻译：本发明提供聚对二甲苯膜过滤器，过滤装置和制造它们的方法，并将其用于通过尺寸机械分离细胞和颗粒。提供具有高品质因数和精细控制的孔尺寸的聚对二甲苯膜过滤器允许根据尺寸分离各种生物和其它流体中的细胞和颗粒。

8. 发明申请

US20060254972A1 Membrane filter for capturing circulating tumor cells 有权
标题翻译：用于捕获循环肿瘤细胞的膜过滤器
公开(公告)号：US20060254972A1
公开(公告)日：2006-11-16
申请号：US11408501
申请日：2006-04-20
申请人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
发明人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
IPC分类号： B01D63/00
CPC分类号： B01D69/02 , B01D61/14 , B01D61/18 , B01D61/20 , B01D67/0034 , B01D67/0088 , B01D71/022 , B01D71/72 , B01D2325/021 , Y10T436/25375
摘要： The present invention provides a parylene-based membrane filter device for capturing of circulating tumor cells (CTC). The membrane filter has an array of holes having a predetermined geometric design with precisely controlled size, shape and density. In one aspect, the device has a stack of substantially parallel membrane filters with uniformly-spaced and/or monodispersed holes.
摘要翻译：本发明提供了一种用于捕获循环肿瘤细胞（CTC）的聚对二甲苯基膜过滤装置。膜过滤器具有具有预定几何设计并具有精确控制的尺寸，形状和密度的孔阵列。在一个方面，该装置具有基本上平行的具有均匀间隔和/或单分散孔的膜过滤器的堆叠。

9. 发明授权

US07846393B2 Membrane filter for capturing circulating tumor cells 有权
标题翻译：用于捕获循环肿瘤细胞的膜过滤器
公开(公告)号：US07846393B2
公开(公告)日：2010-12-07
申请号：US11408501
申请日：2006-04-20
申请人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
发明人： Yu-Chong Tai , Siyang Zheng , Henry Lin , Ram Datar , Richard Cote
IPC分类号： B01L99/00
CPC分类号： B01D69/02 , B01D61/14 , B01D61/18 , B01D61/20 , B01D67/0034 , B01D67/0088 , B01D71/022 , B01D71/72 , B01D2325/021 , Y10T436/25375
摘要： The present invention provides a parylene-based membrane filter device for capturing of circulating tumor cells (CTC). The membrane filter has an array of holes having a predetermined geometric design with precisely controlled size, shape and density. In one aspect, the device has a stack of substantially parallel membrane filters with uniformly-spaced and/or monodispersed holes.
摘要翻译：本发明提供了一种用于捕获循环肿瘤细胞（CTC）的聚对二甲苯基膜过滤装置。膜过滤器具有具有预定几何设计并具有精确控制的尺寸，形状和密度的孔阵列。在一个方面，该装置具有基本上平行的具有均匀间隔和/或单分散孔的膜过滤器的堆叠。

10. 发明申请

US20150262511A1 SYSTEMS AND METHODS FOR MEDICAL DEVICE SIMULATOR SCORING 审中-公开
标题翻译：用于医疗设备模拟器分级的系统和方法
公开(公告)号：US20150262511A1
公开(公告)日：2015-09-17
申请号：US14660641
申请日：2015-03-17
申请人： Henry Lin , Peter Dominick
发明人： Henry Lin , Peter Dominick
IPC分类号： G09B23/28
CPC分类号： G09B23/28
摘要： A system for scoring a teleoperated surgical training session comprises a memory and a processor, the memory comprising instructions, which when executed by the processor, cause the processor to implement a computerized training module to: determine a performance efficiency component of the teleoperated surgical training session performed by a user; determine a penalty component of the teleoperated surgical training session; compute a training session score as a function of at least the performance efficiency component and the penalty component; and present the training session score to the user.
摘要翻译：用于对远程手术外科训练会话进行评分的系统包括存储器和处理器，所述存储器包括指令，当所述处理器执行时，所述存储器使得所述处理器实施计算机化的训练模块，以：确定所述远程手术外科训练课程的性能效率组件由用户执行; 确定远程手术外科训练课程的一个惩罚部分; 计算作为至少性能效率分量和惩罚分量的函数的训练会话得分; 并向用户呈现训练课程得分。

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