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1. 发明申请

US20110082086A1 MEDICAMENT FOR USE IN CONNECTION WITH CARTILAGE IMPAIRMENT 审中-公开
标题翻译：使用与药物不良有关的药物
公开(公告)号：US20110082086A1
公开(公告)日：2011-04-07
申请号：US12897313
申请日：2010-10-04
申请人： Stefan G. Pierzynowski
发明人： Stefan G. Pierzynowski
IPC分类号： A61K38/05 , A61K31/194 , A61K31/198 , A61K31/401 , A61K38/06 , A61P19/04
CPC分类号： A61K38/05 , A61K31/194 , A61K31/198 , A61K31/401 , A61K38/06 , A61K2300/00
摘要： Use of a substance for treating joint medical conditions. The use includes the use of alpha-ketoglutarate acid.
摘要翻译：使用物质治疗关节病。其用途包括使用α-酮戊二酸。

2. 发明申请

US20110105617A1 METHOD FOR TREATMENT OF NEOPLASTIC DISEASES WITH ALPHA-KETO GLUTARATE AND/OR SALTS THEREOF 审中-公开
标题翻译：用阿尔法 - 葡萄糖和/或其盐处理海藻类疾病的方法
公开(公告)号：US20110105617A1
公开(公告)日：2011-05-05
申请号：US12940573
申请日：2010-11-05
申请人： Stefan G. Pierzynowski , Martyna Kandefer-Szerszen , Wojciech Rzeski
发明人： Stefan G. Pierzynowski , Martyna Kandefer-Szerszen , Wojciech Rzeski
IPC分类号： A61K31/194 , A61P35/00
CPC分类号： A61K31/194
摘要： A method for treatment or prophylaxis of neoplastic diseases includes administering an antineoplastic preparation to a subject in need thereof. The active component of the antineoplastic preparation is alpha-ketoglutarate and/or a salt of alpha-ketoglutarate.
摘要翻译：用于治疗或预防肿瘤疾病的方法包括向有需要的受试者施用抗肿瘤制剂。抗肿瘤制剂的活性成分是α-酮戊二酸和/或α-酮戊二酸的盐。

3. 发明申请

US20100222282A1 METHOD OF DIAGNOSIS AND METHOD OF TREATMENT 审中-公开
标题翻译：诊断方法和治疗方法
公开(公告)号：US20100222282A1
公开(公告)日：2010-09-02
申请号：US12161538
申请日：2007-01-18
申请人： Stefan G. Pierzynowski
发明人： Stefan G. Pierzynowski
IPC分类号： A61K38/06 , A61K31/191 , A61K31/195 , A61K38/05 , A61K31/722 , C12Q1/02 , A61P13/12
CPC分类号： G01N33/64
摘要： The present invention relates to a method for diagnosing higher susceptibility for diseases and conditions associated with low levels of AKG in a human or animal comprising the following steps: a) obtaining a biological sample from said human or animal; b) measuring the alpha-ketoglutaric acid (AKG) level in the biological sample; and c) comparing said measured AKG level with normal average AKG levels, wherein a level of AKG in said sample lower than an average level is indicative of a higher susceptibility for various diseases. Further the invention relates to a use of a substance comprising at least one member selected from the group consisting of AKG and derivates, metabolites, analogues or salts thereof for the manufacture of a pharmaceutical preparation or a food or feed supplement for the treatment or prophylaxis of diseases and conditions associated with low levels of AKG in a human or animal with low levels of AKG compared with normal average AKG levels.
摘要翻译：本发明涉及用于诊断与人或动物中低水平AKG相关的疾病和病症的较高易感性的方法，包括以下步骤：a）从所述人或动物获得生物样品; b）测量生物样品中的α-酮戊二酸（AKG）水平; 以及c）将所述测量的AKG水平与正常平均AKG水平进行比较，其中低于平均水平的所述样品中的AKG水平表示对各种疾病的较高敏感性。此外，本发明涉及包含选自由AKG及其衍生物，代谢物，类似物或其盐组成的组中的至少一种的物质用于制备药物制剂或食品或饲料添加剂的用途，用于治疗或预防与正常平均AKG水平相比，具有低水平AKG的人或动物的低水平AKG相关的疾病和病症。

4. 发明申请

US20090208597A1 HEAT PROCESSED VEGETABILIC FIBER PREPARATION AND ITS USE AS INHIBITOR OF THE EFFECTS OF CARCINOGENIC SUBSTANCES IN HUMANS OR ANIMALS 审中-公开
标题翻译：热加工蔬菜制备及其作为致癌物质在人类或动物中的作用的抑制剂
公开(公告)号：US20090208597A1
公开(公告)日：2009-08-20
申请号：US12304470
申请日：2007-06-13
申请人： Stefan G. Pierzynowski
发明人： Stefan G. Pierzynowski
IPC分类号： A61K36/899 , A61P35/00 , A61P35/04 , A61K36/81 , A61K125/00
CPC分类号： A61K36/81 , A23L19/15 , A23L33/22 , A23V2002/00 , A61K36/899 , A23V2200/308 , A23V2250/5116
摘要： The present inventions relates to a vegetabilic, preferably potato, fiber preparation and fractions thereof for use as a supplement, a functional food, a functional mix, a pro health product and a pharmaceutical composition; it further relates to a food additive, and a food product, a feed additive and a feed product, a beverage, a supplement, a functional mix, a functional food, a health food and a pharmaceutical composition for inhibition of the effects of a dietary carcinogenic substance in humans and animals; and for inhibition of the development of neoplasma upon exposure of a human or animal for a dietary carcinogenic substance. Further it relates to a medicament, and its uses for the manufacture of a medicament for inhibition of the effects of a dietary carcinogenic substance in humans and animals; and for inhibition of the development of neoplasma upon exposure of a human or animal for a dietary carcinogenic substance. Still further it relates to a method of producing such a vegetabilic, preferably potato, fiber preparation and fractions thereof.
摘要翻译：本发明涉及用作补充剂的营养性，优选马铃薯纤维制剂及其级分，功能性食品，功能性混合物，保健产品和药物组合物; 它还涉及食品添加剂，食品，饲料添加剂和饲料产品，饮料，补充剂，功能性混合物，功能食品，保健食品和用于抑制饮食效果的药物组合物人类和动物中的致癌物质; 并且用于抑制人或动物暴露于饮食致癌物质时发展肿瘤。此外，其涉及药物及其用于制备用于抑制人和动物中膳食致癌物质的作用的药物的用途; 并且用于抑制人或动物暴露于饮食致癌物质时发展肿瘤。此外，本发明涉及生产这种植物性，优选马铃薯纤维制品及其级分的方法。

5. 发明申请

US20090312427A1 Medicament for Use in Connection With Cartilage Impairment 审中-公开
标题翻译：与软骨损伤有关的药物
公开(公告)号：US20090312427A1
公开(公告)日：2009-12-17
申请号：US12084947
申请日：2006-11-15
申请人： Stefan G. Pierzynowski
发明人： Stefan G. Pierzynowski
IPC分类号： A61K31/194
CPC分类号： A61K38/05 , A61K31/194 , A61K31/198 , A61K31/401 , A61K38/06 , A61K2300/00
摘要： Use of a substance for treating medical joint conditions, e.g. arthrosis, rheumatoid arthritis and cartilage impairment. The use includes the use of alpha-ketoglutaric acid, glutamine or glutamic acid, as well as salts, amides, di- or tripeptides of the mentioned substances.
摘要翻译：用于治疗医学关节病症的物质的使用，例如关节炎，类风湿关节炎和软骨损伤。该用途包括使用α-酮戊二酸，谷氨酰胺或谷氨酸，以及所述物质的盐，酰胺，二或三肽。

6. 发明申请

US20090069429A1 Compositions Comprising Alpha-Ketoglutarate and Their Use for Modulating Muscle Performance 审中-公开
标题翻译：包含α-酮戊二酸的组合物及其用于调节肌肉功能的组合物
公开(公告)号：US20090069429A1
公开(公告)日：2009-03-12
申请号：US12297863
申请日：2007-04-20
申请人： Stefan G. Pierzynowski
发明人： Stefan G. Pierzynowski
IPC分类号： A61K31/194 , A61P21/00
CPC分类号： A61K31/198
摘要： This invention relates to a composition comprising Alpha-ketoglutarate (AKG) for modulating muscle performance in a mammal including a human being. Also contemplated is a method for modulating muscle performance in a vertebrate, including mammal and bird, and the manufacture of a composition for the prevention, alleviation or treatment of muscle performance in said vertebrate.
摘要翻译：本发明涉及包含α-酮戊二酸（AKG）的组合物，其用于调节哺乳动物包括人的肌肉性能。还考虑了一种用于调节脊椎动物（包括哺乳动物和鸟类）中的肌肉性能的方法，以及用于预防，减轻或治疗所述脊椎动物肌肉性能的组合物的制备。

7. 发明申请

US20110039935A1 USE OF PHARMACOLOGICALLY ACTIVE CHEMICAL COMPOUNDS 审中-公开
标题翻译：使用药物活性化学化合物
公开(公告)号：US20110039935A1
公开(公告)日：2011-02-17
申请号：US12667040
申请日：2008-06-27
申请人： Stefan G. Pierzynowski
发明人： Stefan G. Pierzynowski
IPC分类号： A61K31/194 , A61P9/12 , A61P9/00
CPC分类号： A61K31/194 , A23L33/10 , A61K31/198 , A61K38/05 , A61K38/06 , A61K2300/00
摘要： The present invention relates to the new use of alpha-ketoglutarate, amides, and salts and mixtures thereof for the manufacture of a pharmaceutical preparation or a food or feed supplement for the in vivo therapeutic improvement of blood vessel elasticity, in particular arterial elasticity in a subject in need thereof. Improving the blood vessel elasticity may be used in the for the treatment and/or prophylaxis of hypertension, pulmonary arterial hypertension, cardiovascular disease, retinal vascular disease, heart failure, atherosclerosis, ventricular hypertrophy, stroke, arterial aneurysm, kidney failure, nephrosclerosis and diseases related to hypertension.
摘要翻译：本发明涉及α-酮戊二酸，酰胺和其盐及其混合物在制备药物制剂或食品或饲料添加剂中的新用途，用于体内治疗性改善血管弹性，特别是动脉弹性受到需要。改善血管弹性可用于治疗和/或预防高血压，肺动脉高压，心血管疾病，视网膜血管疾病，心力衰竭，动脉粥样硬化，心室肥大，中风，动脉瘤，肾衰竭，肾硬化和疾病与高血压相关。

8. 发明申请

US20090238895A1 NUTRITIONAL AND/OR PHARMACEUTICAL PREPARATION FOR USE IN PROPHYLAXIS AND TREATMENT OF DISTURBANCES IN MICROELEMENTS ABSORPTION FROM THE ALIMENTARY CANAL 审中-公开
标题翻译：营养和/或药物制剂用于预防和治疗微量元素中的干扰物从阿根廷罐头中吸收
公开(公告)号：US20090238895A1
公开(公告)日：2009-09-24
申请号：US11577892
申请日：2005-10-28
申请人： Stefan G. Pierzynowski , Lukasz Pierzynowski , Kacper Pierzynowski
发明人： Stefan G. Pierzynowski , Lukasz Pierzynowski , Kacper Pierzynowski
IPC分类号： A61K33/26 , A61K38/06 , A61K38/05
CPC分类号： A23K20/142 , A23K20/105 , A23K20/147 , A23L33/175 , A23L33/18 , A61K31/06 , A61K31/198 , A61K33/24 , A61K33/26 , A61K38/05 , A61K38/06 , A61K45/06 , A61K2300/00
摘要： The invention dissolves the problem of the pharmaceutical preparation being a factor stimulating the absorption of microelements. The essence of the invention is that the preparation contains alpha-keto-glutarate or/and glutamine or/and glutamate or/and ornithine of alpha-keto-glutarate, dipeptide of glutamine and other amino acids or/and tripeptides of glutamine and other amino acids or/and glutamate with other amino acid or/and salts of alpha-keto-glutarate or/and glutamine or/and glutamate or/and ornithine of alpha-keto-glutarate, dipepetides of glutamine or glutamate with other amino acid in a dose 0.01-0.5 g/kg/day and administered orally stimulates the absorption of iron, zinc, copper, manganese, strontium, calcium, phosphorus and other microelements from the alimentary canal to the blood ensuring proper—physiological—curative level of these compounds in the blood of people and animals.
摘要翻译：本发明解决了作为刺激微量元素吸收的因素的药物制剂的问题。本发明的精髓在于该制剂含有α-酮戊二酸盐或/和谷氨酰胺或/和谷氨酸或/和鸟氨酸的α-酮戊二酸盐，谷氨酰胺和其它氨基酸二肽或/和谷氨酰胺和其他氨基三肽酸或/和谷氨酸盐与α-酮戊二酸盐或/和谷氨酰胺或/和谷氨酸盐或/和α-酮戊二酸的鸟氨酸的其它氨基酸或/和盐，或其他氨基酸的谷氨酰胺或谷氨酸二酯的剂量口服0.01-0.5 g / kg /日，口服刺激从消化道向血液吸收铁，锌，铜，锰，锶，钙，磷等微量元素，从而确保这些化合物的适当生理水平人和动物的血液。

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