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1. 发明授权

US07439335B2 MHC class II antigen-presenting systems and methods for activating CD4+ T cells 有权
标题翻译： MHC II类抗原呈递系统和激活CD4 + T细胞的方法
公开(公告)号：US07439335B2
公开(公告)日：2008-10-21
申请号：US10822173
申请日：2004-04-08
申请人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
发明人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
IPC分类号： C12N5/00 , C07K14/74
CPC分类号： C07K14/70596 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C12N5/0601 , C12N2510/00 , Y10S424/81
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.
摘要翻译：本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。一种这样的基质是已被转染以产生具有一种或多种辅助分子的MHC抗原呈递分子的细胞。这些基质用于激活幼稚的CD4 + T细胞，以及将正在进行的激活状态转移到Th1或Th2细胞的优选的分化群体中。

2. 发明授权

US07402430B2 MHC class II antigen-presenting systems and methods for activating CD4+ T cells 有权
公开(公告)号：US07402430B2
公开(公告)日：2008-07-22
申请号：US10903213
申请日：2004-07-29
申请人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
发明人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
IPC分类号： C12N5/16 , G01N33/53 , A01N63/00
CPC分类号： C07K14/70596 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C12N5/0601 , C12N2510/00 , Y10S424/81
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.

3. 发明授权

US06355479B1 MHC class II antigen-presenting systems and methods for activating CD4+ T cells 有权
标题翻译： MHC II类抗原呈递系统和激活CD4 + T细胞的方法
公开(公告)号：US06355479B1
公开(公告)日：2002-03-12
申请号：US09194285
申请日：1999-04-12
申请人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
发明人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
IPC分类号： C12N510
CPC分类号： C07K14/70596 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C12N5/0601 , C12N2510/00 , Y10S424/81
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.
摘要翻译：本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。一种这样的基质是已被转染以产生具有一种或多种辅助分子的MHC抗原呈递分子的细胞。这些基质用于激活幼稚的CD4 + T细胞，并将正在进行的激活状态转移到Th1或Th2细胞的优选分化群体中。

4. 发明申请

US20050059144A1 MHC class II antigen-presenting systems and methods for activating CD4+ T cells 有权
标题翻译： MHC II类抗原呈递系统和激活CD4 + T细胞的方法
公开(公告)号：US20050059144A1
公开(公告)日：2005-03-17
申请号：US10903213
申请日：2004-07-29
申请人： Susan Webb , Ola Winqvist , Lars Karlsson , Michael Jackson , Per Peterson
发明人： Susan Webb , Ola Winqvist , Lars Karlsson , Michael Jackson , Per Peterson
IPC分类号： C12N15/09 , A61K31/00 , A61K35/26 , A61K38/00 , A61K39/00 , A61K48/00 , A61P3/00 , A61P3/10 , A61P21/00 , A61P21/04 , A61P37/00 , A61P37/04 , A61P37/08 , C07K14/705 , C12N5/07 , C12N5/10 , C12N15/12 , C12N5/06 , C12N5/08
CPC分类号： C07K14/70596 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C12N5/0601 , C12N2510/00 , Y10S424/81
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.
摘要翻译：本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。一种这样的基质是已被转染以产生具有一种或多种辅助分子的MHC抗原呈递分子的细胞。这些基质用于激活幼稚的CD4 + T细胞，并将正在进行的激活状态转移到Th1或Th2细胞的优选分化群体中。

5. 发明申请

US20050054090A1 MHC class II antigen-presenting systems and methods for activating CD4cells 有权
标题翻译： MHC II类抗原呈递系统和激活CD4细胞的方法
公开(公告)号：US20050054090A1
公开(公告)日：2005-03-10
申请号：US10822173
申请日：2004-04-08
申请人： Susan Webb , Ola Winqvist , Lars Karlsson , Michael Jackson , Per Peterson
发明人： Susan Webb , Ola Winqvist , Lars Karlsson , Michael Jackson , Per Peterson
IPC分类号： C12N15/09 , A61K31/00 , A61K35/26 , A61K38/00 , A61K39/00 , A61K48/00 , A61P3/00 , A61P3/10 , A61P21/00 , A61P21/04 , A61P37/00 , A61P37/04 , A61P37/08 , C07K14/705 , C12N5/07 , C12N5/10 , C12N15/12 , C12N5/06 , C12N5/08
CPC分类号： C07K14/70596 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C12N5/0601 , C12N2510/00 , Y10S424/81
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.
摘要翻译：本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。一种这样的基质是已被转染以产生具有一种或多种辅助分子的MHC抗原呈递分子的细胞。这些基质用于激活幼稚的CD4 + T细胞，并将正在进行的激活状态转移到Th1或Th2细胞的优选分化群体中。

6. 发明授权

US08206702B2 Method for expansion of tumour-reactive T-lymphocytes for immunotherapy of patients with cancer 有权
标题翻译：扩大肿瘤反应性T淋巴细胞免疫治疗癌症患者的方法
公开(公告)号：US08206702B2
公开(公告)日：2012-06-26
申请号：US12158686
申请日：2006-12-20
申请人： Ola Winqvist , Magnus Thörn
发明人： Ola Winqvist , Magnus Thörn
IPC分类号： A01N63/02 , A61K35/02 , A61K35/26
CPC分类号： C12N5/0636 , A61K2039/5158 , C12N5/0651
摘要： The present invention discloses an improved method for expansion and activation of tumor-reactive lymphocytes, in particular CD4+ helper and/or CD8+ T-lymphocytes, which may be used for treating and/or preventing cancer. The method provides high numbers of tumor-reactive T-lymphocytes within a short time span and the possibility of directing development of tumor-reactive CD4+ helper and/or CD8+ T-lymphocytes towards specific subpopulations. The method comprises a first phase of stimulating tumor-reactive CD4+ T helper and/or CD8+ T-lymphocytes with tumor-derived antigen together with at least one substance having agonistic activity towards the IL-2 receptor to promote survival of tumor-reactive CD4+ T helper and/or CD8+ T-lymphocytes; and a second phase of activating and promoting growth of tumor-reactive CD4+ T helper and/or CD8+ T-lymphocytes, wherein the second phase is initiated when the CD25 cell surface marker (or IL-2R marker) is down-regulated on CD4+ T helper and/or CD8+ T-lymphocytes.
摘要翻译：本发明公开了可用于治疗和/或预防癌症的肿瘤反应性淋巴细胞，特别是CD4 +辅助和/或CD8 + T淋巴细胞的扩增和活化的改进方法。该方法在短时间内提供了大量的肿瘤反应性T淋巴细胞，以及将肿瘤反应性CD4 +辅助细胞和/或CD8 + T淋巴细胞向特定亚群发展的可能性。该方法包括用肿瘤衍生的抗原刺激肿瘤反应性CD4 + T辅助细胞和/或CD8 + T淋巴细胞的第一阶段以及至少一种对IL-2受体具有激动作用的物质以促进肿瘤反应性CD4 + T的存活辅助和/或CD8 + T淋巴细胞; 以及激活和促进肿瘤反应性CD4 + T辅助细胞和/或CD8 + T淋巴细胞生长的第二阶段，其中当CD25细胞表面标志物（或IL-2R标志物）在CD4 + T上下调时启动第二阶段辅助和/或CD8 + T淋巴细胞。

7. 发明申请

US20110224645A1 TREATING INFLAMMATORY CONDITIONS 有权
标题翻译：处理危害条件
公开(公告)号：US20110224645A1
公开(公告)日：2011-09-15
申请号：US13063038
申请日：2009-09-10
申请人： Ola Winqvist , Graham Cotton
发明人： Ola Winqvist , Graham Cotton
IPC分类号： A61M1/34 , C07K14/52
CPC分类号： A61M1/3679 , A61M1/3618 , B01J20/262 , B01J20/267 , B01J20/28004 , B01J20/28009 , B01J20/28016 , B01J20/3085 , B01J20/3212 , B01J20/3219 , B01J20/3242 , B01J20/3272 , B01J20/3274 , B01J2220/58 , C07K14/52 , C07K14/521 , C07K17/06 , C07K17/10
摘要： An apheresis column loaded with a solid support comprises one or more chemokines, in particular biotinylated chemokines, immobilized directly or indirectly on the support, in particular on a support carrying streptavidin. Also disclosed are uses of the column and the support and a method of depleting cells, in particular leukocytes, from the peripheral blood of a person suffering from an inflammatory condition such as Inflammatory Bowel Disease (IBD).
摘要翻译：负载有固体支持物的单采血液柱包含一个或多个趋化因子，特别是生物素化的趋化因子，其直接或间接地固定在载体上，特别是在携带链霉亲和素的载体上。还公开了柱和载体的使用以及从患有炎症性肠炎（IBD）的人的外周血中消耗细胞，特别是白细胞的方法。

8. 发明授权

US08852581B2 Treatment of inflammatory bowel disease 有权
标题翻译：炎症性肠病的治疗
公开(公告)号：US08852581B2
公开(公告)日：2014-10-07
申请号：US12065047
申请日：2006-08-22
申请人： Ola Winqvist , Magnus Thorn
发明人： Ola Winqvist , Magnus Thorn
IPC分类号： A61K35/26 , C12N5/0783 , A61K35/12
CPC分类号： A61K35/26 , A61K2035/124 , C12N5/0636 , C12N2501/10 , C12N2501/15 , C12N2501/23 , C12N2501/24 , C12N2501/25 , C12N2501/51 , C12N2501/515
摘要： A method of treating inflammatory bowel disease (IBD) comprises collecting regulatory T cells in an activated or non-activated state from a patient's sentinel lymph nodes draining bowel segments with or without IBD, optionally activating the cells by contacting them with a cytokine and an antigen extract obtained from an inflamed bowel segment, expanding the T cells in vitro, and re-infusing the expanded T cell to the patient. Also disclosed are methods for obtaining sentinel nodes, for expanding T cells, for re-establishing the TH1/TH2 balance in the patient suffering from Crohn's disease, and corresponding uses of the expanded T cells, the cytokine and of antigen extract, as well as of correspondingly activated and expanded T cells.
摘要翻译：一种治疗炎症性肠病（IBD）的方法包括从有或没有IBD引流肠段的患者前哨淋巴结收集活化或非活化状态的调节性T细胞，任选地通过使细胞与细胞因子和抗原接触而激活细胞从发炎肠段获得的提取物，在体外扩增T细胞，并将扩张的T细胞重新注入患者体内。还公开了用于获得前哨淋巴结的方法，用于扩增T细胞，用于在患有克罗恩病的患者中重新建立TH1 / TH2平衡，以及扩增的T细胞，细胞因子和抗原提取物的相应用途，以及的相应的活化和扩增的T细胞。

9. 发明申请

US20090220472A1 Method for Treating Malignant Melanoma 有权
标题翻译：治疗恶性黑色素瘤的方法
公开(公告)号：US20090220472A1
公开(公告)日：2009-09-03
申请号：US12158681
申请日：2006-12-20
申请人： Ola Winqvist , Magnus Thörn
发明人： Ola Winqvist , Magnus Thörn
IPC分类号： A61K35/12
CPC分类号： A61K39/0011 , A61K38/21 , A61K2039/5158 , C12N5/0636 , C12N2501/23 , G01N2333/57
摘要： The present invention discloses an immunotherapeutic method for treating patients suffering from malignant melanoma, by administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes obtainable from one or more sentinel or metinel lymph nodes draining a malignant melanoma or a metastasis arising from malignant melanoma. The present invention provides a new effective method for treating malignant melanoma and metastatic malignant melanoma, without adverse side effects associated with the known treatments. The method comprises identification of in a patient one or more sentinel and/or metinel lymph nodes draining a malignant melanoma or a metastasis there from, resection of the one or more nodes and, optionally all or part of the tumour or metastasis, isolation of tumour-reactive T-lymphocytes from said lymph nodes, in vitro expansion of said tumour-reactive T-lymphocytes, and administration of the thus obtained tumour-reactive T-lymphocytes to the patient, wherein the T-lymphocytes are CD4+ helper and/or CD8+ T-lymphocytes.
摘要翻译：本发明公开了一种用于治疗患有恶性黑色素瘤的患者的免疫治疗方法，其通过施用扩增的肿瘤反应性CD4 +辅助细胞和/或CD8 + T淋巴细胞，所述扩增的肿瘤反应性CD4 +辅助细胞和/或CD8 + T淋巴细胞可从排除恶性黑素瘤的一个或多个前哨淋巴结或met淋巴结或由恶性黑素瘤引起的转移黑色素瘤本发明提供了治疗恶性黑素瘤和转移性恶性黑素瘤的新型有效方法，其与已知治疗相关的无副作用。该方法包括在患者中识别排出恶性黑素瘤或其中的转移的一个或多个前哨淋巴结和/或met淋巴结，切除一个或多个淋巴结，以及任选全部或部分肿瘤或转移，分离肿瘤来自所述淋巴结的反应性T淋巴细胞，所述肿瘤反应性T淋巴细胞的体外扩增，以及由此获得的肿瘤反应性T淋巴细胞给予患者，其中T淋巴细胞是CD4 +辅助和/或CD8 + T淋巴细胞。

10. 发明申请

US20090074714A1 Method for Treating Urinary Bladder Cancer 有权
标题翻译：尿膀胱癌的治疗方法
公开(公告)号：US20090074714A1
公开(公告)日：2009-03-19
申请号：US12158680
申请日：2006-12-20
申请人： Ola Winqvist , Magnus Thorn
发明人： Ola Winqvist , Magnus Thorn
IPC分类号： A61K38/20 , A61K35/12 , A61K39/395
CPC分类号： A61K39/0011 , C12N5/0636 , C12N2501/23 , C12N2501/505
摘要： The present invention discloses an immunotherapeutic method for treating a patient suffering from urinary bladder cancer by administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes obtainable from one or more sentinel or metinel lymph nodes draining a tumour in the bladder or a metastasis arising from a tumour in the bladder The method provides a new effective method for treating urinary bladder cancer and metastatic bladder cancer, without adverse side effects associated with the known treatments. The method comprises identification of in a patient one or more sentinel and/or metinel lymph nodes draining a tumour in the bladder or a metastasis from a tumour in the bladder, resection of the one or more nodes and, optionally all or part of the tumour or metastasis, isolation of tumour-reactive T-lymphocytes from said lymph nodes, in vitro expansion of said tumour-reactive T-lymphocytes, and administration of the thus obtained tumour-reactive T-lymphocytes to the patient, wherein the T-lymphocytes are CD4+helper and/or CD8+ T-lymphocytes.
摘要翻译：本发明公开了一种用于治疗患有膀胱癌的患者的免疫治疗方法，其通过施用扩增的肿瘤反应性CD4 +辅助细胞和/或CD8 + T淋巴细胞，所述淋巴细胞可从膀胱中的一个或多个前哨淋巴结或met淋巴结排出肿瘤或转移由膀胱肿瘤引起的这种方法提供了一种治疗膀胱癌和转移性膀胱癌的新型有效方法，没有与已知治疗相关的副作用。该方法包括在患者中识别排出膀胱中的肿瘤或来自膀胱中的肿瘤的转移的一个或多个哨兵和/或met淋巴结，切除一个或多个节点以及任选的全部或部分肿瘤或转移，从所述淋巴结分离肿瘤反应性T淋巴细胞，所述肿瘤反应性T淋巴细胞的体外扩增，以及由此获得的肿瘤反应性T淋巴细胞给予患者，其中T淋巴细胞为 CD4 +辅助细胞和/或CD8 + T淋巴细胞。

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