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    • 2. 发明申请
    • Algorithm for the automatic determination of optimal pacing intervals
    • 自动确定最佳起搏间隔的算法
    • US20060271117A1
    • 2006-11-30
    • US11135921
    • 2005-05-24
    • John BurnesDavid IgelJohn RueterYong ChoLuc MongeonHarold StoneJodi Zilinski
    • John BurnesDavid IgelJohn RueterYong ChoLuc MongeonHarold StoneJodi Zilinski
    • A61N1/362
    • A61N1/36521
    • Impedance, e.g. sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change. Other methods vary the AA interval to maximize impedance change over the entire cardiac cycle or during the atrial cycle.
    • 阻抗,例如 亚阈值阻抗是在选定心脏周期时间内心脏测量的,作为腔室扩张或收缩的量度。 为了设定AV间隔,一个实施例测量长AV间隔上的阻抗以获得指示最大心室扩张的最小阻抗。 另一个实施例测量一个周期的阻抗变化,并且改变二进制搜索中的AV步速间隔以收敛于AV间隔,从而引起指示最大心室输出的最大阻抗变化。 另一种方法将右心室改变为左心室(VV)间隔,以收敛于指示最终心脏收缩最小心脏容积的阻抗最大值。 另一实施例改变VV间隔以最大化阻抗变化。 其他方法改变AA间隔以最大化整个心动周期或心房周期期间的阻抗变化。