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    • 1. 发明授权
    • Process for preparing 2-(4'-hydroxyaryl)-2-(4'-aminoaryl)-propanes
    • 制备2-(4'-羟基芳基)-2-(4'-氨基芳基) - 丙烷的方法
    • US4374272A
    • 1983-02-15
    • US92175
    • 1979-11-07
    • Teruo YuasaNoboru YamazakiYoshio Morimoto
    • Teruo YuasaNoboru YamazakiYoshio Morimoto
    • C07C215/74B01J27/00B01J31/00C07C20060101C07C67/00C07C213/00C07C213/08C07C219/34C07C225/22C07C255/59C07C87/64
    • C07C213/08
    • A process for preparing 2-(4'-hydroxyaryl)-2-(4'-aminoaryl)-propanes of the general formula ##STR1## wherein R represents a hydrogen or halogen atom or an alkyl, aryl, nitro, nitrile, acyl, acyloxy or amino group, R.sup.1 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3, independently from each other, represent a hydrogen or halogen atom, a nitro group or an alkyl group having 1 to 4 carbon atoms,which comprises reacting (A) at least one isopropenyl phenol compound selected from the group consisting of isopropenyl phenol derivatives of the general formula ##STR2## wherein R is as defined, and di- to eicosa-mers of said isopropenyl phenol derivatives with (B) an aromatic amine of the general formula ##STR3## wherein R.sup.1 , R.sup.2 and R.sup.3 are as defined, in the presence of 0.00001 to 0.008 mole, per mole of said isopropenylphenol compound (A) calculated as a monomer, of a acid catalyst and in the presence or absence of a phenolic solvent.
    • 制备通式为(III)的2-(4'-羟基芳基)-2-(4'-氨基芳基) - 丙烷的方法,其中R表示氢或卤素原子或烷基,芳基,硝基,腈 ,酰基,酰氧基或氨基,R 1表示氢原子或碳原子数1〜4的烷基,R 2和R 3彼此独立地表示氢或卤素原子,硝基或具有1个 包括使(A)至少一种选自下列通式的异丙烯基苯酚衍生物(I)中的R定义的异丙烯基苯酚化合物与(A)至少一种异丙烯基苯酚化合物的反应,和 所述异丙烯基苯酚衍生物与(B)通式为其中R 1,R 2和R 3如所定义的芳族胺在0.00001至0.008摩尔存在下,每摩尔所述异丙烯基苯酚化合物(A)计算得到的 作为单体,由酸催化剂和酚类溶剂存在或不存在。
    • 6. 发明授权
    • Audio apparatus media folders and files organization
    • 音频设备媒体文件夹和文件组织
    • US08726162B2
    • 2014-05-13
    • US12837812
    • 2010-07-16
    • Takeru MishimaNoboru Yamazaki
    • Takeru MishimaNoboru Yamazaki
    • G06F13/00
    • G06F17/30749G06F17/30775
    • An audio apparatus contains a plurality of playable files stored in a database and organized in folders. The folders can be listed in a manner understandable at a glance even when viewed on a small display area and when the hierarchical structure shows a minimum level of detail. A folder selection section selects a folder from a database, and a directly-under-folder detection section detects if a playable file exists directly under a folder selected. A folder-under-folder detection section detects if a playable file exists directly under any folder located under the selected folder assuming no playable file exists directly under the selected folder.
    • 音频装置包含存储在数据库中并被组织在文件夹中的多个可播放文件。 即使在小显示区域上观看时,以及当层次结构显示最小细节时,文件夹也可以一目了然的方式列出。 文件夹选择部分从数据库中选择一个文件夹,并且直接在文件夹下的检测部分检测可直接存在于所选文件夹之下的可播放文件。 文件夹下文件夹检测部分,假定在所选择的文件夹下没有直接存在可播放文件,则检测是否可以直接存在于所选文件夹下的任何文件夹下的可播放文件。
    • 10. 发明授权
    • Fused pyrimidine derivative, process for preparation of same and
pharmaceutical preparation comprising same as active ingredient
    • 熔融嘧啶衍生物,其制备方法和包含与活性成分相同的药物制剂
    • US5378700A
    • 1995-01-03
    • US839769
    • 1992-06-09
    • Yasuji SakumaMasaichi HasegawaKenichiro KataokaKenji HoshinaNoboru YamazakiTakashi KadotaHisao Yamaguchi
    • Yasuji SakumaMasaichi HasegawaKenichiro KataokaKenji HoshinaNoboru YamazakiTakashi KadotaHisao Yamaguchi
    • A61K31/505A61K31/535A61K31/54A61K31/55C07D471/04C07D487/04
    • C07D471/04C07D487/04
    • Disclosed is a fused pyrimidine of the formula [I] ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are as defined in the specification, Y represents a linking group of the formula ##STR2## wherein n is an integer of from 4 to 6, ##STR3## wherein A is a hydrogen atom or alkyl group; and Z represents a hydrogen atom, or other substituents; or Y and Z together represent an unsubstituted or substituted alkyl, alkenyl or arylalkyl group; or a 5- to 7-member heterocyclic ring which has a nitrogen atom, and further, an oxygen or sulfur atom as a hetero atom other than the nitrogen atom, being bonded via the nitrogen atom therein to the 4-position of the pyrimidine ring of the formula (I), a 5- to 7-member unsaturated heterocyclic ring which has 1 to 3 nitrogen atoms being bonded via the nitrogen atom therein to the 4-position of the pyrimidine ring of the formula (I), or a fused biheterocyclic ring constructed with 5- or 6-membered aromatic or non-aromatic rings, which has 1 to 3 nitrogen atoms in any position, being bonded via the nitrogen atom therein to the 4-position of the pyrimidine ring of the formula (I); andm is an integer of from 1 to 3;and a pharmaceutically acceptable acid addition salt thereof, as well as a process for producing same and a pharmaceutical preparation useful for a treatment of hypoxemia associated with respiratory diseases.
    • PCT No.PCT / JP90 / 01313 Sec。 371日期:1992年6月9日 102(e)日期1992年6月9日PCT提交1990年10月11日PCT公布。 出版物WO91 / 05784 日期:1991年5月2日。公开是式[I]的融合嘧啶其中R 1,R 2和R 3如说明书中所定义,Y表示式的连接基团,其中n 是4至6的整数,其中A是氢原子或烷基; O(S) Z表示氢原子或其它取代基; 或Y和Z一起表示未取代或取代的烷基,烯基或芳基烷基; 或具有氮原子的5-至7-元杂环,以及作为氮原子以外的杂原子的氧或硫原子通过氮原子键合到嘧啶环的4-位上 式(I)的通式(I)中的氮原子数为1〜3的5〜7元不饱和杂环与式(I)的嘧啶环的4-位连接, 在其中具有1至3个氮原子的5-或6-元芳族或非芳族环经由其中的氮原子键合到式(I)的嘧啶环的4-位上构成的双杂环, ; m为1〜3的整数, 和其药学上可接受的酸加成盐,以及其制备方法和用于治疗与呼吸系统疾病相关的低氧血症的药物制剂。