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1. 发明申请

US20080069815A1 ANTI-OSTEOPONTIN ANTIBODY AND USE THEREOF 审中-公开
标题翻译：抗骨质疏松症抗体及其用途
公开(公告)号：US20080069815A1
公开(公告)日：2008-03-20
申请号：US11836078
申请日：2007-08-08
申请人： Toshimitsu UEDE , Shigeyuki Kon , Yukihiko Saeki , Yasuyuki Yokosaki , Masaki Noda , Nobuchika Yamamoto
发明人： Toshimitsu UEDE , Shigeyuki Kon , Yukihiko Saeki , Yasuyuki Yokosaki , Masaki Noda , Nobuchika Yamamoto
IPC分类号： A61K39/00 , A61K39/395 , A61P19/02
CPC分类号： C07K14/52 , A61K39/00 , A61K2039/505 , C07K16/24 , C07K16/2842 , C07K16/2848 , C07K2317/34
摘要： An anti-osteopontin antibody which inhibits the binding of an integrin recognizing RGD sequence to osteopontin or its fragment, and which inhibits the binding of an integrin recognizing SVVYGLR sequence or sequence equivalent thereto to osteopontin or its fragment. This antibody is useful in remedies for autoimmune diseases, remedies for rheumatism and remedies for rheumatoid arthritis. Also, a method of treating autoimmune disease, rheumatism or rheumatoid arthritis is provided. This antibody is useful in diagnostics and a diagnostic method for rheumatism too.
摘要翻译：一种抗骨桥蛋白抗体，其抑制识别RGD序列的整联蛋白与骨桥蛋白或其片段的结合，并且其抑制识别SVVYGLR序列或等同于其的序列的整联蛋白与骨桥蛋白或其片段的结合。该抗体可用于自身免疫性疾病的治疗，风湿病的治疗和类风湿性关节炎的治疗。此外，提供了治疗自身免疫性疾病，风湿病或类风湿性关节炎的方法。该抗体也可用于诊断和风湿病的诊断方法。

2. 发明申请

US20150155951A1 RECEIVER AND RECEPTION METHOD 有权
标题翻译：接收和接收方法
公开(公告)号：US20150155951A1
公开(公告)日：2015-06-04
申请号：US14402203
申请日：2012-09-27
申请人： Masaki Noda
发明人： Masaki Noda
IPC分类号： H04B10/61
CPC分类号： H04B10/616 , H03G3/3084 , H04B10/6931
摘要： A photodiode (11) of a receiver (10) outputs a current signal having a value that corresponds to the optical power of a received optical signal. A transimpedance amplifier (12) amplifies the current signal output from the photodiode (11), converts the current signal to a voltage signal, and further outputs the voltage signal that is converted from the current signal. A current detection circuit (17) generates a current having a value larger than that of the current signal output from the photodiode (11). A feedback resistor (16) changes a gain of the transimpedance amplifier (12) based on magnitude of the current generated by the current detection circuit (17).
摘要翻译：接收器（10）的光电二极管（11）输出具有对应于所接收的光信号的光功率的值的电流信号。跨阻放大器（12）放大从光电二极管（11）输出的电流信号，将电流信号转换为电压信号，并输出从电流信号转换的电压信号。电流检测电路（17）产生具有比从光电二极管（11）输出的电流信号大的值的电流。反馈电阻器（16）基于由电流检测电路（17）产生的电流的大小来改变跨阻抗放大器（12）的增益。

3. 发明申请

US20130343769A1 OPTICAL RECEIVER 有权
标题翻译：光接收机
公开(公告)号：US20130343769A1
公开(公告)日：2013-12-26
申请号：US14003139
申请日：2011-04-05
申请人： Masaki Noda , Masamichi Nogami , Junichi Nakagawa
发明人： Masaki Noda , Masamichi Nogami , Junichi Nakagawa
IPC分类号： H04B10/60
CPC分类号： H04B10/6931 , H03G3/3084 , H04B10/693
摘要： An optical receiver including: a preamplifier capable of changing a conversion gain in accordance with a reception level of a received burst signal; a gain control circuit capable of switching between a fast time constant and a slow time constant; and a convergence determination circuit for outputting a time constant switching signal in accordance with a state of the gain control circuit (transient state or steady state) and a reset signal between the burst signals. This configuration can switch the time constant of the gain control circuit at an appropriate timing.
摘要翻译：一种光接收机，包括：前置放大器，其能够根据接收到的突发信号的接收电平来改变转换增益; 能够在快速时间常数和慢时间常数之间切换的增益控制电路; 和用于根据增益控制电路的状态（瞬态或稳态）输出时间常数切换信号和突发信号之间的复位信号的会聚判定电路。该配置可以在适当的时刻切换增益控制电路的时间常数。

4. 发明申请

US20100221345A1 OSTEOGENIC BIOMATERIAL CONTAINING OSTEOGENESIS PROMOTING SUBSTANCE AND NANOGEL 审中-公开
标题翻译：含有生物体的生物体发生促进物质和纳米酮
公开(公告)号：US20100221345A1
公开(公告)日：2010-09-02
申请号：US12161322
申请日：2007-01-17
申请人： Kazunari Akiyoshi , Masaki Noda
发明人： Kazunari Akiyoshi , Masaki Noda
IPC分类号： A61K9/14 , A61K31/5575 , A61K38/18 , A61P19/08
CPC分类号： A61L27/52 , A61L27/227 , A61L2400/12 , A61L2430/02
摘要： An object of the present invention is to provide an osteogenic biomaterial which achieves long-term sustained release and localized functional expression of a substance which promotes the formation of bone tissue. The present inventors have found out that a nanogel efficiently encloses an osteogenesis promoting substance to suppress the substance from diffusion into blood, and that the nanogel functions as a carrier for local administration of the osteogenesis promoting substance. Furthermore, they have found out that the osteogenesis promoting substance-containing nanogel can be cross-linked with a water-soluble polymer to allow sustained release of the osteogenesis promoting substance at a local area over a long period of time. Based on these findings, the present invention was completed. The osteogenic biomaterial of the present invention which contains the osteogenesis promoting substance and the nanogel shows osteogenesis promoting activity over a long period of time, and can be used as a preventive and therapeutic agent against bone diseases.
摘要翻译：本发明的目的是提供一种能促进骨组织形成的物质的长期持续释放和局部功能表达的成骨生物材料。本发明人已经发现，纳米凝胶有效地包围成骨促进物质以抑制物质扩散到血液中，并且纳米凝胶用作局部施用成骨促进物质的载体。此外，他们发现含骨促进物质的纳米凝胶可以与水溶性聚合物交联，以允许长时间在局部区域持续释放成骨促进物质。基于这些发现，完成了本发明。含有成骨促进物质和纳米凝胶的本发明的成骨生物材料在长时间内显示成骨促进活性，并且可以用作抗骨骼疾病的预防和治疗剂。

5. 发明申请

US20070098416A1 Optical receiver and discrimination-threshold generating method 失效
标题翻译：光接收机和鉴别阈值生成方法
公开(公告)号：US20070098416A1
公开(公告)日：2007-05-03
申请号：US10585458
申请日：2005-09-28
申请人： Masamichi Nogami , Junichi Nakagawa , Masaki Noda , Toyoaki Uo
发明人： Masamichi Nogami , Junichi Nakagawa , Masaki Noda , Toyoaki Uo
IPC分类号： H04B10/06
CPC分类号： H04L25/061 , H03G3/3084 , H04B10/6931 , H04B10/695
摘要： A first average detecting circuit detects an average of output signals of a pre-amplifying unit that controls an amplification gain based on a result of comparison between an output of the first average detecting circuit and a predetermined reference voltage. A discriminating circuit receives an output signal of the pre-amplifying unit as an input signal and performs a signal discrimination of the input signal based on a threshold. A second average detecting circuit detects an average of input signals to the discriminating circuit. The discriminating circuit receives an output of the second average detecting circuit as the threshold.
摘要翻译：第一平均检测电路基于第一平均检测电路的输出与预定参考电压之间的比较结果来检测控制放大增益的预放大单元的输出信号的平均值。识别电路接收预放大单元的输出信号作为输入信号，并且基于阈值执行输入信号的信号鉴别。第二平均检测电路检测到鉴别电路的输入信号的平均值。识别电路接收第二平均检测电路的输出作为阈值。

6. 发明授权

US4731875A Frequency converter used for a receiver which receives signals of a UHF band or a microwave band 失效
标题翻译：用于接收UHF频带或微波频带信号的接收机的变频器
公开(公告)号：US4731875A
公开(公告)日：1988-03-15
申请号：US827626
申请日：1986-02-10
申请人： Hiroyuki Mizukami , Masaki Noda , Toshio Nagashima , Keiro Shinkawa
发明人： Hiroyuki Mizukami , Masaki Noda , Toshio Nagashima , Keiro Shinkawa
IPC分类号： H03D7/18 , H03D7/16 , H03H9/42 , H04B1/10
CPC分类号： H03D7/165 , H03D7/18
摘要： A frequency converter which is capable of rejecting unnecessary signals generated by image signals. The frequency converter has first and second local oscillation circuits which generate local oscillation signals whose frequencies are the same and whose phases are different by 90 degrees from each other. The converter further includes two mixer circuits, and a hybrid coupler. The mixer circuits generate two unnecessary signals whose phases are different by 90 degrees from each other. The hybrid coupler delays one unnecessary signal by a quarter of a wavelength to generate two unnecessary signals whose phases are different by 180 degrees from each other, so that they are cancelled by each other.
摘要翻译：一种频率转换器，其能够抑制由图像信号产生的不必要的信号。该变频器具有第一和第二本地振荡电路，其产生频率相同且相位彼此相差90度的本地振荡信号。该转换器还包括两个混频器电路和一个混合耦合器。混频器电路产生相位相差90度的两个不必要的信号。混合耦合器将一个不必要的信号延迟四分之一波长以产生相位彼此相差180度的两个不必要的信号，使得它们被彼此抵消。

7. 发明授权

US09450542B2 Preamplifier, optical receiver, optical termination device, and optical communication system 有权
标题翻译：前置放大器，光接收器，光终端设备和光通信系统
公开(公告)号：US09450542B2
公开(公告)日：2016-09-20
申请号：US14413483
申请日：2013-01-16
申请人： Daisuke Mita , Masaki Noda , Masamichi Nogami
发明人： Daisuke Mita , Masaki Noda , Masamichi Nogami
IPC分类号： H03F3/08 , H03G3/30
CPC分类号： H03F3/08 , H03G3/3084
摘要： A current bypass circuit that passes part of a photocurrent output from a photodetector is connected to an input terminal of a current-to-voltage conversion amplifier circuit. A voltage obtained by level conversion of an output voltage by a voltage level conversion circuit is input into the current bypass circuit so that the current bypass circuit is turned on at a photocurrent that is smaller than the photocurrent at which a diode connected in parallel to a feedback resistor of the current-to-voltage conversion amplifier circuit is turned on. Consequently, the current-to-voltage conversion gain is switched in three stages according to the intensity of the photocurrent corresponding to an optical signal level.
摘要翻译：将来自光电检测器的光电流输出的一部分的电流旁路电路连接到电流 - 电压转换放大器电路的输入端。通过电压电平转换电路对输出电压进行电平转换而获得的电压被输入到电流旁路电路中，使得电流旁路电路以小于并联到二极管的二极管的光电流的光电流导通电流 - 电压转换放大器电路的反馈电阻器被接通。因此，根据与光信号电平对应的光电流的强度，电流 - 电压转换增益分三级切换。

8. 发明授权

US07598479B2 Circuit for varying gain of preamplifier 失效
标题翻译：改变前置放大器增益的电路
公开(公告)号：US07598479B2
公开(公告)日：2009-10-06
申请号：US10566240
申请日：2003-07-30
申请人： Masamichi Nogami , Masaki Noda , Hitoyuki Tagami , Kuniaki Motoshima
发明人： Masamichi Nogami , Masaki Noda , Hitoyuki Tagami , Kuniaki Motoshima
IPC分类号： H03F3/08
CPC分类号： H03G3/3084 , H03F3/08 , H03G1/0047 , H03G2201/103 , H03G2201/502 , H04B10/69
摘要： A gain switching circuit switches a conversion gain of a preamplifier that is configured with a series circuit formed with a first resistor and a first switching element and a series circuit formed with a second resistor and a second switching element respectively connected in parallel with a feedback resistor. The gain switching circuit includes a first operating unit that generates a first switching element operating signal for closing the first switching element within a first gain switching period, and a second operating unit that generates a second switching element operating signal for closing the second switching element within a second gain switching period.
摘要翻译：增益切换电路切换配置有由第一电阻器和第一开关元件形成的串联电路的前置放大器的转换增益，以及与分别与反馈电阻并联连接的第二电阻器和第二开关元件形成的串联电路。增益切换电路包括第一操作单元，其在第一增益切换周期内产生用于闭合第一开关元件的第一开关元件操作信号，以及第二操作单元，其产生用于闭合第二开关元件的第二开关元件操作信号第二增益切换周期。

9. 发明授权

US07280811B2 Multimode wireless terminal and wireless transmitter-receiver unit 失效
标题翻译：多模无线终端和无线收发单元
公开(公告)号：US07280811B2
公开(公告)日：2007-10-09
申请号：US10874459
申请日：2004-06-22
申请人： Yoshikazu Sugiyama , Masaki Noda , Makoto Katagishi , Yutaka Igarashi
发明人： Yoshikazu Sugiyama , Masaki Noda , Makoto Katagishi , Yutaka Igarashi
IPC分类号： H04B1/18
CPC分类号： H04B1/406 , H04B1/109
摘要： A multimode wireless terminal suitable for received level monitoring for a base station serving as an intersystem handover destination includes a first wireless transmitter-receiver unit for GSM, a second wireless transmitter-receiver unit for WCDMA, and a communication processor unit and an antenna switch unit connected to these wireless transmitter-receiver units. While conducting communication with a WCDMA network system via the second wireless transmitter-receiver unit, a level of a signal received from a GSM base station is monitored via the first wireless transmitter-receiver unit. A communication processor unit determines whether the level monitoring is interfered with by a WCDMA transmission signal, on the basis of a relation between a WCDMA transmission frequency and a reception frequency supplied from the GSM base station. If interference occurs, then the communication processor unit changes circuit characteristics of the first or second wireless transmitter-receiver unit, and thereby suppresses the interference.
摘要翻译：适用于作为系统间切换目的地的基站的接收电平监视的多模无线终端包括用于GSM的第一无线发射机 - 接收机单元，用于WCDMA的第二无线发射机 - 接收机单元，以及通信处理器单元和天线切换单元连接到这些无线发射机 - 接收机单元。在经由第二无线发射机 - 接收机单元与WCDMA网络系统进行通信时，经由第一无线发射机 - 接收机单元监测从GSM基站接收的信号的电平。通信处理器单元基于WCDMA发送频率与从GSM基站提供的接收频率之间的关系来确定电平监视是否被WCDMA发送信号干扰。如果发生干扰，则通信处理器单元改变第一或第二无线发射机 - 接收机单元的电路特性，从而抑制干扰。

10. 发明授权

US07268628B2 Preamplifier 有权
标题翻译：前置放大器
公开(公告)号：US07268628B2
公开(公告)日：2007-09-11
申请号：US10543390
申请日：2004-03-25
申请人： Masaki Noda
发明人： Masaki Noda
IPC分类号： H03F3/08
CPC分类号： H03F3/08 , H03F1/34 , H03F3/082
摘要： A preamplifier includes a negative-feedback amplifier circuit that converts a current signal from a photodetector into a voltage signal; and a conversion-gain control circuit that simultaneously controls a resistance value of a feedback resistor portion of the negative-feedback amplifier circuit and a resistance value of a load resistor portion of the negative-feedback amplifier circuit, based on the voltage signal from the negative-feedback amplifier circuit. Each of the feedback resistor portion and the load resistor portion includes a fixed resistor element, a MOSFET element, and a diode-connected transistor, connected in parallel.
摘要翻译：前置放大器包括将来自光电检测器的电流信号转换为电压信号的负反馈放大器电路; 以及转换增益控制电路，其基于来自负的反馈放大器电路的电压信号同时控制负反馈放大器电路的反馈电阻部分的电阻值和负反馈放大器电路的负载电阻器部分的电阻值反馈放大器电路。反馈电阻器部分和负载电阻器部分中的每一个包括并联连接的固定电阻器元件，MOSFET元件和二极管连接的晶体管。

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