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1. 发明申请

WO2007142929A3 NOVEL PDE4 INHIBITORS 审中-公开
标题翻译：新型PDE4抑制剂
公开(公告)号：WO2007142929A3
公开(公告)日：2008-04-24
申请号：PCT/US2007012668
申请日：2007-05-29
申请人： UNIV NORTH CAROLINA , UNIV GEORGIA STATE RES FOUND , HENGMING KE , KAUR GURPREET , WANG BINGHE , ZHENG SHI-LONG
发明人： HENGMING KE , KAUR GURPREET , WANG BINGHE , ZHENG SHI-LONG
IPC分类号： C07D213/643
CPC分类号： C07D405/12 , C07D307/20
摘要： PDE4 inhibitors, pharmaceutical compositions including the inhibitors, and methods of treatment using the inhibitors are disclosed. The compounds are illustrated by Formulas 1-9 in the specification. The compounds can be used to treat a variety of disorders mediated by phosphodiesterase, and TNF-a, including asthma, chronic bronchitis, chronic obstructive pulmonary disease, arthritis, respiratory distress syndrome, allergic rhinitis, neurogenic inflammation, pain, rheumatoid arthritis, central nervous system disorders, cardiovascular disorders, and tumor progression.
摘要翻译：公开了PDE4抑制剂，包括抑制剂的药物组合物和使用抑制剂的治疗方法。化合物在说明书中由式1-9表示。这些化合物可用于治疗由磷酸二酯酶介导的各种疾病，TNF-α，包括哮喘，慢性支气管炎，慢性阻塞性肺病，关节炎，呼吸窘迫综合征，过敏性鼻炎，神经源性炎症，疼痛，类风湿性关节炎，中枢神经系统疾病，心血管疾病和肿瘤进展。

2. 发明申请

WO2010019847A3 APTAMER INHIBITION OF THROMBUS FORMATION 审中-公开
标题翻译： APTAMER对血栓形成的抑制作用
公开(公告)号：WO2010019847A3
公开(公告)日：2010-05-14
申请号：PCT/US2009053825
申请日：2009-08-14
申请人： UNIV GEORGIA STATE RES FOUND , WANG BINGHE , LI MINYONG , NI NANTING , LIU YIDAN
发明人： WANG BINGHE , LI MINYONG , NI NANTING , LIU YIDAN
IPC分类号： A61K48/00 , A61K31/7088 , A61K38/36 , A61P7/02 , C07H21/00
CPC分类号： C12N15/115 , A61K31/7088 , C12N2310/16
摘要： Boronic acid-modified DNA-based aptamers can be selected to recognize fibrinogen through binding at a glycosylation site and thus are useful for probing the effect of glycosylation pattern changes on the ability for fibrinogen to mediate blood coagulation. In addition, the aptamers of the disclosure also have anticoagulation effects due to their binding to fibrinogen and its cleavage product fibrin. The present disclosure, therefore, encompasses methods for inhibiting fibrin coagulation with an aptamer capable of specifically binding to a glycosylation site of fibrinogen or fibrin. The disclosure further provides oligonucleotide aptamers comprising at least one nucleotide having a boronic acid thereon, where the aptamer is capable of selectively binding to a glycosylation site of fibrinogen, or the derivative thereof.
摘要翻译：可以选择硼酸修饰的基于DNA的适体通过在糖基化位点结合来识别纤维蛋白原，因此可用于探测糖基化模式改变对纤维蛋白原介导血液凝固的能力的影响。此外，本公开的适体由于其与纤维蛋白原及其裂解产物纤维蛋白的结合而具有抗凝作用。因此，本公开内容包括用能够特异性结合纤维蛋白原或纤维蛋白的糖基化位点的适体抑制纤维蛋白凝固的方法。本公开还提供了包含至少一个在其上具有硼酸的核苷酸的寡核苷酸适体，其中适体能够选择性地结合纤维蛋白原或其衍生物的糖基化位点。

3. 发明申请

WO2009012363A2 NUCLEOTIDES AND APTAMERS CONTAINING BORONIC ACID GROUPS HAVING BIASED BINDING TO GLYCOSYLATED PROTEINS, AND USES THEREOF 审中-公开
标题翻译：含有具有粘合蛋白质的蛋白质的硼酸组合的核苷酸和APTAMER及其用途
公开(公告)号：WO2009012363A2
公开(公告)日：2009-01-22
申请号：PCT/US2008070288
申请日：2008-07-17
申请人： UNIV GEORGIA STATE RES FOUND , WANG BINGHE , LI MINYONG
发明人： WANG BINGHE , LI MINYONG
IPC分类号： C12N9/16 , A61K48/00 , C07H19/04 , C07H21/00 , C12Q1/68
CPC分类号： C12N15/115 , C07H19/04 , C07H21/00 , C07H23/00 , C12N15/1048 , C12N2310/16 , C12N2310/33 , G01N33/68 , G01N33/6893 , G01N33/86
摘要： The present disclosure encompasses oligonucleotide aptamers selectively binding a target glycosylated polypeptide or protein, and having biased affinity for the glycan through a boronic acid linked to a nucleosidic base of a nucleotide(s). The disclosure further encompasses methods for isolating an aptamer(s) selectively binding a target glycosylated polypeptide, where, from a population of randomized oligonucleotides that have at least one nucleotide having a boronic acid label linked to a base, is selected a first subpopulation of aptamers binding to the target glycosylated polypeptide or protein. This subpopulation is then amplified without using boronic acid-modified TTP, and amplification products not binding to a target glycosylated polypeptide or protein are selected. The second subpopulation of aptamers is then amplified using boronic acid-modified TTP to provide a population of boronic acid-modified aptamers capable of selectively binding to a glycosylation site of a target polypeptide or protein. Other aspects of the disclosure encompass methods for the use of the modified aptamers to detect glycosylated species of a polypeptide or protein.
摘要翻译：本公开内容包括选择性结合靶糖基化多肽或蛋白质并且通过与核苷酸的核苷碱基连接的硼酸对聚糖具有偏向亲和力的寡核苷酸适体。本公开还包括用于分离选择性结合靶糖基化多肽的适体的方法，其中从具有至少一个具有与碱基连接的硼酸标记的至少一个核苷酸的随机寡核苷酸群体中选择第一适配子亚群与目标糖基化多肽或蛋白质结合。然后在不使用硼酸修饰的TTP的情况下扩增该亚群，并且选择不与靶糖基化多肽或蛋白质结合的扩增产物。然后使用硼酸修饰的TTP扩增适配体的第二亚群，以提供能够选择性结合靶多肽或蛋白质的糖基化位点的硼酸修饰的适配体群。本公开的其它方面包括使用修饰的适体检测多肽或蛋白质的糖基化物种的方法。

4. 发明申请

WO2011133659A3 INHIBITORS OF HIF AND ANGIOGENESIS 审中-公开
标题翻译： HIF和血管生成抑制剂
公开(公告)号：WO2011133659A3
公开(公告)日：2012-03-15
申请号：PCT/US2011033230
申请日：2011-04-20
申请人： UNIV EMORY , UNIV GEORGIA STATE RES FOUND , VAN MEIR ERWIN , WANG BINGHE
发明人： VAN MEIR ERWIN , WANG BINGHE
IPC分类号： C07D311/04 , A61K31/352 , A61K31/47 , A61P35/00 , C07D215/12 , C07D307/81 , C07D405/12 , C07D491/052
CPC分类号： C07D491/052 , C07D215/12 , C07D307/81 , C07D311/04 , C07D311/58 , C07D405/12
摘要： Inhibitors of the Hypoxia Inducible Factor (HIF) and angiogenesis and their methods of use including the treatment of cancer, hypoxia related pathologies, disorders leading to ischemia, for example stroke and ischemic heart disease, and non-cancerous angiogenic diseases are provided.
摘要翻译：提供了缺氧诱导因子（HIF）和血管发生的抑制剂及其使用方法，包括治疗癌症，缺氧相关病理学，导致局部缺血的疾病，例如中风和缺血性心脏病，以及非癌性血管生成疾病。

5. 发明申请

WO2009029317A3 COMPOSITIONS FOR REGULATING OR MODULATING QUORUM SENSING IN BACTERIA, METHODS OF USING THE COMPOUNDS, AND METHODS OF REGULATING OR MODULATING QUORUM SENSING IN BACTERIA 审中-公开
标题翻译：用于调节或调节细菌中的相同感测的组合物，使用该化合物的方法，以及调节或调节细菌感测方法
公开(公告)号：WO2009029317A3
公开(公告)日：2009-08-20
申请号：PCT/US2008066028
申请日：2008-06-06
申请人： UNIV GEORGIA STATE RES FOUND , WANG BINGHE , NI NANTING , WANG JUNFENG , LU CHUNG-DAR , CHOU HAN-TING , LI MINYONG , ZHENG SHILONG , CHENG YUNFENG , PENG HANJING
发明人： WANG BINGHE , NI NANTING , WANG JUNFENG , LU CHUNG-DAR , CHOU HAN-TING , LI MINYONG , ZHENG SHILONG , CHENG YUNFENG , PENG HANJING
IPC分类号： C07D291/08 , A61P31/04 , C07D215/04 , C07D307/91 , C07D333/76
CPC分类号： C07D333/34 , C07F5/025
摘要： The present disclosure encompasses compounds and compositions that are useful as specific AI-2 antagonists for the control of bacterial quorum sensing. Although the AI-2 antagonists according to the present disclosure may not have bactericidal effect, their ability to attenuate virulence, drug resistance, and/or biofilm formation have therapeutic benefits. In addition, the AI-2 antagonists of the present disclosure can also be used as tools to probe bacterial AI-2 functions. The present disclosure also encompasses methods for inhibiting or attenuating microbial virulence, biofilm formation, and drug resistance. The methods are suitable for preventing bacteria from accruing and forming extensive biofilms that may be a health or hygiene hazard or a physical issue, such as in the blockage of water or fuel lines.
摘要翻译：本公开涵盖可用作用于控制细菌群体感测的特异性AI-2拮抗剂的化合物和组合物。虽然根据本公开的AI-2拮抗剂可能不具有杀菌作用，但是它们减轻毒力，耐药性和/或生物膜形成的能力具有治疗益处。此外，本公开的AI-2拮抗剂也可以用作探针细菌AI-2功能的工具。本公开还包括抑制或减弱微生物毒力，生物膜形成和耐药性的方法。这些方法适合于防止细菌产生和形成广泛的生物膜，这些生物膜可能是健康或卫生危害或物理问题，例如在水或燃料管线的堵塞中。

6. 发明申请

WO2010011998A9 ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：抗微生物组合物和使用方法
公开(公告)号：WO2010011998A9
公开(公告)日：2010-03-18
申请号：PCT/US2009051862
申请日：2009-07-27
申请人： UNIV GEORGIA STATE RES FOUND , DERBY CHARLES , KO KO-CHUN , KAMIO MICHIYA , WANG BINGHE , TAI PANG C
发明人： DERBY CHARLES , KO KO-CHUN , KAMIO MICHIYA , WANG BINGHE , TAI PANG C
IPC分类号： A01N37/00
CPC分类号： A61K31/197 , A01N25/02 , A01N37/44 , A01N43/40 , A01N59/00 , A61K31/4425 , A61K33/40 , A01N25/22 , A01N31/02 , A01N37/42 , A01N37/50 , A01N2300/00
摘要： Disclosed herein are antimicrobial compositions, kits, and articles of manufacture. Further disclosed herein are methods for treating surfaces, including tissue, inter alia, wounds, with the disclosed compositions.
摘要翻译：本文公开了抗微生物组合物，试剂盒和制品。本文进一步公开的是用公开的组合物处理表面（包括组织，特别是伤口）的方法。

7. 发明申请

WO2013184755A2 SECA INHIBITORS AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译： SECA抑制剂及其制备和使用方法
公开(公告)号：WO2013184755A2
公开(公告)日：2013-12-12
申请号：PCT/US2013044243
申请日：2013-06-05
申请人： UNIV GEORGIA STATE RES FOUND
发明人： WANG BINGHE , TAI PHANG-CHENG , JIN JINSHAN , HSIEH YINGHSIN , RITTER YING-JU , CUI JIANMEI , CHAUDHARY ARPANA S , DAI CHAOFENG , DAMERA KRISHNA , CHEN WEIXUAN
IPC分类号： C07D401/14
CPC分类号： C07D311/86 , A61K31/496 , C07C63/331 , C07D239/20 , C07D239/22 , C07D239/38 , C07D239/56 , C07D239/60 , C07D249/12 , C07D311/58 , C07D311/74 , C07D311/82 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/10 , C07D491/20 , C07D493/10 , C07D495/04 , C07D497/04 , C09B11/24 , G01N33/6872 , G01N2333/4706
摘要： Inhibitors of SecA, and methods of making and using thereof, are described herein. The compounds described herein can be used to treat or prevent microbial infections, such as bacterial infections.
摘要翻译：本文描述了SecA的抑制剂及其制备和使用方法。本文所述的化合物可用于治疗或预防微生物感染，例如细菌感染。

8. 发明公开

EP2734043A4 CELLULAR RECOGNITION CONJUGATES AND METHODS OF USE FOR THE HISTOLOGICAL ANALYSIS OF CANCER TISSUE USING MALDI-MS IMAGING 审中-公开
标题翻译： ZELLENERKENNUNGSKONJUGATE和使用MALDI-MS-成像癌组织的组织学分析方法
公开(公告)号：EP2734043A4
公开(公告)日：2015-07-29
申请号：EP12815146
申请日：2012-07-20
申请人： UNIV GEORGIA STATE RES FOUND
发明人： DAI CHAOFENG , CAZARES LISA H , WANG BINGHE , WANG LIFANG , CHU YONG , WANG SIMING L , TROYER DEAN A , DRAKE RICHARD R , CHEN WEIXUAN
IPC分类号： A01N43/58
CPC分类号： G01N33/57492 , C09B1/005 , C09B11/06 , C09B57/00
摘要： Disclosed are conjugates that can bind to one or more site on cancer cell surface, for example, surface proteins, compound specific receptors and carbohydrates that comprise the surface of specific cell types. The disclosed conjugates can thereby serve as indicators identifying the presence of cancerous tissue.
摘要翻译：本发明公开了共轭物那样可结合对癌细胞表面上的一个或多个位点，例如，表面蛋白，化合物特异性受体和碳水化合物都包括特定细胞类型的表面上。盘游离缺失缀合物可由此用作指标识别癌组织的存在。

9. 发明公开

EP2326171A4 ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： VERFAHREN ZU IHRER VERWENDUNG的抗菌素ZUSAMMENSETZUNGEN
公开(公告)号：EP2326171A4
公开(公告)日：2014-06-25
申请号：EP09801118
申请日：2009-07-27
申请人： UNIV GEORGIA STATE RES FOUND
发明人： DERBY CHARLES , KO KO-CHUN , KAMIO MICHIYA , WANG BINGHE , TAI PANG C
IPC分类号： A01N37/00
CPC分类号： A61K31/197 , A01N25/02 , A01N37/44 , A01N43/40 , A01N59/00 , A61K31/4425 , A61K33/40 , A01N25/22 , A01N31/02 , A01N37/42 , A01N37/50 , A01N2300/00
摘要： Disclosed herein are antimicrobial compositions, kits, and articles of manufacture. Further disclosed herein are methods for treating surfaces, including tissue, inter alia, wounds, with the disclosed compositions.
摘要翻译：本文公开了抗微生物组合物，试剂盒和制品。本文进一步公开的是用所述组合物处理表面，包括组织，特别是伤口的方法。

10. 发明公开

EP2176277A4 NUCLEOTIDES AND APTAMERS CONTAINING BORONIC ACID GROUPS HAVING BIASED BINDING TO GLYCOSYLATED PROTEINS, AND USES THEREOF 有权
标题翻译：核苷酸和适体，优选的含硼基团的糖基化的约束蛋白质含有及其用途
公开(公告)号：EP2176277A4
公开(公告)日：2013-07-17
申请号：EP08781954
申请日：2008-07-17
申请人： UNIV GEORGIA STATE RES FOUND
发明人： WANG BINGHE , LI MINYONG , HUANG ZHEN , LIN NA
IPC分类号： C07H19/00 , A61K48/00 , C07H19/04 , C07H21/00 , C12Q1/68
CPC分类号： C12N15/115 , C07H19/04 , C07H21/00 , C07H23/00 , C12N15/1048 , C12N2310/16 , C12N2310/33 , G01N33/68 , G01N33/6893 , G01N33/86

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