专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2016165006A1 TEXAPHYRIN-PHOSPHOLIPID CONJUGATES AND METHODS OF PREPARING SAME 审中-公开
标题翻译：纺丝 - 磷脂结合体及其制备方法
公开(公告)号：WO2016165006A1
公开(公告)日：2016-10-20
申请号：PCT/CA2016/000114
申请日：2016-04-14
申请人： UNIVERSITY HEALTH NETWORK
发明人： ZHENG, Gang , KECA, Joseph
IPC分类号： C07F9/10 , A61K41/00 , A61K49/00 , A61K49/10 , A61K9/14 , A61K9/51 , C07D487/22 , C07F9/6561 , C12P17/18
CPC分类号： A61K49/227 , C07D487/22 , C07F9/106 , C07F9/6561 , C12P17/182
摘要： There is provided herein, a texaphyrin-phospholipid conjugate, wherein the texaphyrin- phospholipid conjugate comprises a texaphyrin, texaphyrin derivative or texaphyrin analog covalently attached to a lipid side chain of a phospholipid.
摘要翻译：本文提供了泰克萨菲瑞 - 磷脂缀合物，其中泰克萨菲瑞 - 磷脂缀合物包含与磷脂的脂质侧链共价连接的泰克萨菲林，泰克萨菲瑞衍生物或泰克萨菲林模拟物。

2. 发明申请

WO2009073984A1 HIGH-DENSITY LIPOPROTEIN-LIKE PEPTIDE-PHOSPHOLIPID SCAFFOLD ("HPPS") NANOPARTICLES 审中-公开
标题翻译：高密度脂蛋白胆固醇 - 磷脂酰胆碱（“HPPS”）纳米颗粒
公开(公告)号：WO2009073984A1
公开(公告)日：2009-06-18
申请号：PCT/CA2008/002203
申请日：2008-12-12
申请人： UNIVERSITY HEALTH NETWORK , ZHENG, Gang , ZHANG, Zhihong , CORBIN, Ian , CHEN, Juan
发明人： ZHENG, Gang , ZHANG, Zhihong , CORBIN, Ian , CHEN, Juan
IPC分类号： C07K17/02 , A61K47/48 , A61K48/00 , A61K49/00 , A61K51/04 , A61P35/00 , C12N15/10 , C12N15/11 , G01N33/566 , G01N33/574 , C07K14/485 , C07K14/71 , C12N15/87
CPC分类号： A61K49/0082 , A61K47/6917 , A61K47/6919 , A61K49/0002 , A61K49/0032 , A61K49/0056 , B82Y5/00 , G01N33/54346 , G01N33/587 , G01N2800/00
摘要： The present invention provides a non-naturally occurring High-Density Lipoprotein-like peptide-phospholipid scaffold ("HPPS") nanoparticle. More particularly, the invention provides a non-naturally occurring peptide-lipid nanoscaffold comprising: (a) at least one phospholipid; (b) at least one unsaturated lipid, preferably an unsaturated sterol ester, further preferably an unsaturated cholesterol ester, further preferably cholsteryl oleate; and (c) at least one peptide, the peptide comprising an amino acid sequence capable of forming at least one amphipathic a- helix; wherein the components a), b) and c) associate to form the peptide-phospholipid nanoscaffold. In embodiments of the present invention, a cell surface receptor ligand is incorporated into the HPPS. In one embodiment, the cell surface receptor ligand is covalently bonded to the peptide scaffold of the HPPS nanoparticles. In other embodiments, a cell surface receptor ligand is coupled to a lipid anchor and is displayed on the surface of the HPPS nanoparticles by incorporation of the lipid anchor into the phospholipids monolayer of the HPPS nanoparticle. The present invention also provides pharmaceutical formulations comprising HPPS nanoparticles and methods of making the HPPS nanoparticles.
摘要翻译：本发明提供非天然存在的高密度脂蛋白样肽 - 磷脂支架（“HPPS”）纳米颗粒。更具体地，本发明提供非天然存在的肽 - 脂质纳米支架，其包含：（a）至少一种磷脂; （b）至少一种不饱和脂质，优选不饱和甾醇酯，更优选不饱和胆固醇酯，更优选油酸胆甾醇酯; 和（c）至少一种肽，所述肽包含能够形成至少一种两亲α-螺旋的氨基酸序列; 其中组分a），b）和c）缔合形成肽 - 磷脂纳米支架。在本发明的实施方案中，将细胞表面受体配体掺入HPPS中。在一个实施方案中，细胞表面受体配体共价键合到HPPS纳米颗粒的肽支架上。在其它实施方案中，将细胞表面受体配体偶联到脂质锚定物上，并通过将脂质锚点掺入HPPS纳米颗粒的磷脂单层中而显示在HPPS纳米颗粒的表面上。本发明还提供了包含HPPS纳米颗粒的药物制剂和制备HPPS纳米颗粒的方法。

3. 发明申请

WO2023283732A1 PORPHYRIN NANOVESICLE WITH FATTY ACID CONJUGATE 审中-公开
公开(公告)号：WO2023283732A1
公开(公告)日：2023-01-19
申请号：PCT/CA2022/051087
申请日：2022-07-12
申请人： UNIVERSITY HEALTH NETWORK
发明人： ZHENG, Gang , CHEN, Juan , HO, Tiffany , BU, Jiachuan , DING, Lili
IPC分类号： A61K47/54 , A61K9/51 , A61K41/00 , A61K47/69 , A61K49/00 , A61K51/04 , A61K51/12
摘要： There is described herein a bilayer nanovesicle comprising porphyrin-phospholipid conjugate and a chelator-fatty acid conjugate; wherein the chelator-fatty acid conjugate comprises an aminopolycarboxylic acid conjugated to a single chain fatty acid; and the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipid.

4. 发明申请

WO2012167350A1 METHOD FOR THE SYNTHESIS OF PORPHYRIN-PHOSPHOLIPID CONJUGATES 审中-公开
标题翻译：合成磷杂卟啉化合物的方法
公开(公告)号：WO2012167350A1
公开(公告)日：2012-12-13
申请号：PCT/CA2012/000500
申请日：2012-05-25
申请人： UNIVERSITY HEALTH NETWORK , ZHENG, Gang , LOVELL, Jonathan
发明人： ZHENG, Gang , LOVELL, Jonathan
IPC分类号： A61K9/127 , A61K31/704 , A61K47/22 , A61K49/00 , A61K51/12 , A61K9/14 , B01J13/02 , C12P17/18 , C12P41/00 , C07F9/6561
CPC分类号： C12P17/182 , A61K8/14 , A61K8/553 , A61K31/704 , A61K41/0071 , A61K47/544 , A61K2800/10 , A61Q19/00 , B01J13/02 , C07F9/106 , C07F9/6561 , C09B67/0097 , C09B69/108
摘要： There is herein described a nanovesicle comprising a bilayer of porphyrin-phospholipid conjugates. Each porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain at one of the sn-1 or the sn-2 positions of one phospholipid. Further, the nanovesicle has a defined regioisomeric ratio of sn-1:sn-2 porphyrin-phospholipid conjugates.
摘要翻译：本文描述了包含卟啉 - 磷脂共轭物双层的纳米囊。每个卟啉 - 磷脂缀合物包含一个卟啉，卟啉衍生物或卟啉类似物，其共价连接到一个磷脂的sn-1或sn-2位置之一的脂质侧链。此外，纳米囊具有定义的sn-1：sn-2卟啉 - 磷脂缀合物的区域异构体比例。

5. 发明申请

WO2017156616A1 NANOVESICLES COMPRISING PORPHYRIN-LIPID CONJUGATES EXHIBITING ORDERED ASSEMBLY AND BATHOCHROMIC SHIFTS 审中-公开
标题翻译：包含卟啉脂质偶联物的纳米材料显示有序组装和BATHCHROMIC SHICTS
公开(公告)号：WO2017156616A1
公开(公告)日：2017-09-21
申请号：PCT/CA2017/000052
申请日：2017-03-10
申请人： UNIVERSITY HEALTH NETWORK
发明人： ZHENG, Gang , NG, Kenneth , CHEN, Juan , TAKEDA, Misa , HARMATYS, Kara
IPC分类号： A61K47/69 , A61K41/00 , A61K49/00 , A61K9/127 , A61K9/51 , A61P35/00 , C07K14/775 , C07K17/02
摘要： The application relates to liposomal nanovesicles comprising porphyrin-lipid conjugates within the liposomal lipid bilayer. Said porphyrin-lipid conjugate comprise porphyrins that are modified with a -CH(R 1 )-O-R 2 group and that chelate a metal ion. Such modifications of the porphyrin allow for ordered assembly in the lipid bilayer of the nanovesicles while resulting in a bathochromic shift in the wavelength of light absorbed by the porphyrin chromophore. These nanovesicles can be used for photothermal therapy, photodynamic therapy, photoacoustic imaging and fluorescence imaging. The application also teaches methods for preparing the porphyrin-lipid conjugates and the nanovesicles.
摘要翻译：本申请涉及在脂质体脂质双层内包含卟啉 - 脂质缀合物的脂质体纳米囊泡。所述卟啉 - 脂质缀合物包含用-CH（R 1）-O-R 2基团修饰并螯合金属离子的卟啉。卟啉的这种修饰允许在纳米囊泡的脂双层中的有序组装，同时导致由卟啉发色团吸收的光的波长发生红移。这些纳米囊泡可用于光热疗法，光动力疗法，光声成像和荧光成像。该申请还教导了用于制备卟啉 - 脂质缀合物和纳米囊泡的方法。

6. 发明申请

WO2020028324A1 LONG-CIRCULATING PSMA-TARGETED PHOTOTHERANOSTIC AGENT 审中-公开
公开(公告)号：WO2020028324A1
公开(公告)日：2020-02-06
申请号：PCT/US2019/044075
申请日：2019-07-30
申请人： THE JOHNS HOPKINS UNIVERSITY , UNIVERSITY HEALTH NETWORK
发明人： POMPER, Martin G. , MEASE, Ronnie C. , CHEN, Ying , RAY, Sangeeta , CHEN, Juan , OVERCHUCK, Marta , HARMATYS, Kara , ZHENG, Gang
IPC分类号： A61K41/00 , A61K47/54 , A61K47/65 , A61P35/00 , A61P13/08
摘要： Theranostic probes comprising a porphyrin-based photosensitizer, a D-peptide linker, and a urea-based PSMA-targeting ligand and methods of their use for treating and/or imaging PMSA-expressing tumors are disclosed.

7. 发明申请

WO2015192215A1 PEPTIDE CONTAINING PORPHYRIN LIPID NANOVESICLES 审中-公开
标题翻译：含有PORPHYRIN脂质纳米微粒的肽
公开(公告)号：WO2015192215A1
公开(公告)日：2015-12-23
申请号：PCT/CA2015/000397
申请日：2015-06-18
申请人： UNIVERSITY HEALTH NETWORK
发明人： CHEN, Juan , ZHENG, Gang , CUI, Liyang
IPC分类号： A61K9/133 , A61K41/00 , A61K47/24 , A61K47/42 , A61K49/00 , A61K9/51 , A61P35/00
CPC分类号： B82Y5/00 , A61K9/1075 , A61K9/5169 , A61K31/337 , A61K31/404 , A61K41/0071 , A61K41/0076 , A61K47/42 , A61K47/544 , A61K47/6907 , A61K49/0036 , Y10S977/773 , Y10S977/801 , Y10S977/906 , Y10S977/915
摘要： There is provided herein a nanovesicle comprising a monolayer of phospholipid, porphyrin-phospholipid conjugate and a peptide encapsulating a hydrophobic core, wherein the peptide comprises an amino acid sequence capable of forming at least one amphipathic α-helix; the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipid; the molar % of porphyrin-phospholipid conjugate to phospholipid is 35% or less; the nanovesicle is 35nm in diameter or less.
摘要翻译：本文提供了包含磷脂单层，卟啉 - 磷脂缀合物和封装疏水核心的肽的纳米囊，其中肽包含能够形成至少一个两亲性α-螺旋的氨基酸序列; 卟啉 - 磷脂缀合物包含一个磷脂的一个卟啉，卟啉衍生物或卟啉类似物共价连接到脂质侧链，优选在sn-1或sn-2位; 卟啉 - 磷脂缀合物对磷脂的摩尔％为35％以下; 纳米囊直径为35nm或更小。

8. 发明申请

WO2013082702A1 GIANT PORPHYRIN-PHOSPHOLIPID VESICLES 审中-公开
标题翻译：大卟啉 - 磷脂体
公开(公告)号：WO2013082702A1
公开(公告)日：2013-06-13
申请号：PCT/CA2012/001122
申请日：2012-12-05
申请人： UNIVERSITY HEALTH NETWORK
发明人： ZHENG, Gang , LOVELL, Jonathan , HUYNH, Elizabeth
IPC分类号： C12Q1/68 , B01J13/02 , C12N11/04 , C12P1/00 , C12Q1/00 , C12N15/88
CPC分类号： C12Q1/6806 , A61K41/0028 , B01J13/02 , C12N11/04 , C12N13/00 , C12N15/88 , C12P1/00 , G01N1/28 , Y10T436/143333
摘要： There is provided herein vesicles comprising a bilayer comprising porphyrin-phospholipid conjugate, wherein the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipids, wherein the vesicle is 1-100 microns in diameter.
摘要翻译：提供了包含包含卟啉 - 磷脂缀合物的双层的囊泡，其中卟啉 - 磷脂缀合物包含共价连接到脂质侧链上的卟啉，卟啉衍生物或卟啉类似物，优选在sn-1或sn-2位，的一种磷脂，其中囊泡的直径为1-100微米。

9. 发明申请

WO2011044671A1 PORPHYRIN NANOVESICLES 审中-公开
公开(公告)号：WO2011044671A1
公开(公告)日：2011-04-21
申请号：PCT/CA2010/001573
申请日：2010-10-05
申请人： UNIVERSITY HEALTH NETWORK , ZHENG, Gang , LOVELL, Jonathan F.
发明人： ZHENG, Gang , LOVELL, Jonathan F.
IPC分类号： A61K47/24 , A61K41/00 , A61K49/00 , A61K51/04 , A61K9/127
CPC分类号： A61K41/0071 , A61K47/544 , A61K49/0036 , A61K49/0084 , Y10T428/2991
摘要： The application relates to a nanovesicle comprising a bilayer of at least 15 mol% porphyrin-phospholipid conjugate, wherein the conjugate comprises a porphyrin, porphyrin derivative or porphyrin analog covalently attached to the phospholipid side chain. The nanovesicle can be used for photothermal therapy, photoacoustic imaging, and fluorescence imaging. The application also discloses a method of preparing the said nanovesicle.
摘要翻译：本申请涉及包含至少15mol％卟啉 - 磷脂缀合物的双层的纳米囊，其中所述缀合物包含共价连接到磷脂侧链的卟啉，卟啉衍生物或卟啉类似物。纳米囊可用于光热治疗，光声成像和荧光成像。本申请还公开了一种制备所述纳米囊的方法。

10. 发明申请

WO2013159185A1 PORPHYRIN-LIPID STABILIZED NANOPARTICLES FOR SURFACE ENHANCED RAMAN SCATTERING BASED IMAGING 审中-公开
标题翻译：用于表面增强拉曼散射成像的PORPHYRIN-脂质稳定纳米颗粒
公开(公告)号：WO2013159185A1
公开(公告)日：2013-10-31
申请号：PCT/CA2013/000372
申请日：2013-04-19
申请人： UNIVERSITY HEALTH NETWORK
发明人： ZHENG, Gang , TAM, Natalie
IPC分类号： A61K49/00 , A61K47/24 , A61K9/14
CPC分类号： G01N21/658 , G01N33/57423 , G01N33/587
摘要： Herein are provided nanoparticles comprising a nanocore of Raman-scattering material stabilized by a bilayer comprising a porphyrin-phospholipid conjugate, methods of making the same and their use in Surface Enhanced Raman Scattering.
摘要翻译：本文提供了包含由包含卟啉 - 磷脂缀合物的双层稳定的拉曼散射材料的纳米孔的纳米颗粒，其制备方法及其在表面增强拉曼散射中的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式