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1. 发明申请

US20070059434A1 Rate limiting barriers for implantable devices and methods for fabrication thereof 有权
公开(公告)号：US20070059434A1
公开(公告)日：2007-03-15
申请号：US11592632
申请日：2006-11-02
申请人： Wouter Roorda , Syed Hossainy , Ni Ding , Fuh-Wei Tang , Stephen Pacetti
发明人： Wouter Roorda , Syed Hossainy , Ni Ding , Fuh-Wei Tang , Stephen Pacetti
IPC分类号： A61L33/00 , B05D3/00
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416 , A61L2420/02 , A61L2420/08
摘要： A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solvent for the drug or the polymer of the first layer. The formulation can have a low surface tension value or a high Weber number value.

2. 发明申请

US20060198897A1 Polycationic peptide coatings and methods of coating implantable medical devices 有权
公开(公告)号：US20060198897A1
公开(公告)日：2006-09-07
申请号：US11213288
申请日：2005-08-26
申请人： Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
发明人： Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
IPC分类号： A61K9/50 , A61K9/16
CPC分类号： A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
摘要： Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.

3. 发明申请

US20060018944A1 Polycationic peptide coatings and methods of coating implantable medical devices 有权
公开(公告)号：US20060018944A1
公开(公告)日：2006-01-26
申请号：US11213290
申请日：2005-08-26
申请人： Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
发明人： Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
IPC分类号： A61K31/727 , A61F13/00
CPC分类号： A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
摘要： Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.

4. 发明申请

US20050106203A1 Polyacrylates coating for implantable medical devices 有权
标题翻译：用于可植入医疗器械的聚丙烯酸酯涂层
公开(公告)号：US20050106203A1
公开(公告)日：2005-05-19
申请号：US10176504
申请日：2002-06-21
申请人： Wouter Roorda , Ni Ding , Stephen Pacetti , Eugene Michal , Ashok Shah , Syed Hossainy
发明人： Wouter Roorda , Ni Ding , Stephen Pacetti , Eugene Michal , Ashok Shah , Syed Hossainy
IPC分类号： A61L31/00 , A61F2/84 , A61K31/436 , A61L27/34 , A61L31/10 , A61L31/16 , A61K47/32
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , C08L33/10 , C08L33/06
摘要： A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polyacrylate, a blend of polyacrylates, or a blend of the polyacrylate with other polymers, for example, poly(ethylene-co-vinyl alcohol).
摘要翻译：描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。涂层可以包括聚丙烯酸酯，聚丙烯酸酯的共混物或聚丙烯酸酯与其它聚合物的共混物，例如聚（乙烯 - 共 - 乙烯醇）。

5. 发明申请

US20060002974A1 Polycationic peptide coatings and methods of coating implantable medical devices 有权
公开(公告)号：US20060002974A1
公开(公告)日：2006-01-05
申请号：US11212376
申请日：2005-08-26
申请人： Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
发明人： Stephen Pacetti , Eugene Michal , Syed Hossainy , Ni Ding , Wouter Roorda
IPC分类号： A61K31/737 , A61K31/727 , A61K31/728 , A61F2/00
CPC分类号： A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
摘要： Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.

6. 发明申请

US20080124372A1 Morphology profiles for control of agent release rates from polymer matrices 审中-公开
标题翻译：用于控制聚合物基质的试剂释放速率的形态概况
公开(公告)号：US20080124372A1
公开(公告)日：2008-05-29
申请号：US11448956
申请日：2006-06-06
申请人： Syed F. A. Hossainy , Fuh-Wei Tang , Lothar Kleiner , Thierry Glauser , Yiwen Tang , Wouter Roorda , Stephen Pacetti , Gina Zhang , Yung-Ming Chen , Andrew F. McNiven , Sean A. McNiven , Brandon J. Yoe
发明人： Syed F. A. Hossainy , Fuh-Wei Tang , Lothar Kleiner , Thierry Glauser , Yiwen Tang , Wouter Roorda , Stephen Pacetti , Gina Zhang , Yung-Ming Chen , Andrew F. McNiven , Sean A. McNiven , Brandon J. Yoe
IPC分类号： A61F2/06 , B05D3/00 , A61K47/48 , A61K31/436 , A61K31/337 , A61K31/46 , A61P9/00
CPC分类号： A61L31/10 , A61L27/40 , A61L27/44 , A61L27/50 , A61L27/54 , A61L31/12 , A61L31/14 , A61L31/16 , A61L2300/00
摘要： The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.
摘要翻译：本公开教导了控制来自聚合物基质的试剂的释放速率的方法，其包括在聚合物基质中设计和产生预定的初始形态（IM）分布。教导尤其表明，对药剂释放速率的控制可以提供对药剂施用的改进控制，以及对聚合物基质的机械完整性和吸收速率的影响。

7. 发明申请

US20060002968A1 Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders 审中-公开
公开(公告)号：US20060002968A1
公开(公告)日：2006-01-05
申请号：US10882506
申请日：2004-06-30
申请人： Gordon Stewart , Gina Zhang , Nancy Kristen , Paul Consigny , Stephen Dugan , Gene Park , Christopher Feezor , Wouter Roorda , Syed Hossainy
发明人： Gordon Stewart , Gina Zhang , Nancy Kristen , Paul Consigny , Stephen Dugan , Gene Park , Christopher Feezor , Wouter Roorda , Syed Hossainy
IPC分类号： A61K31/4745 , A61F2/00
CPC分类号： A61K31/4745 , A61F2250/0067 , A61K31/436 , A61K31/573 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61K2300/00
摘要： Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.

8. 发明申请

US20080147178A1 ZWITTERIONIC COPOLYMERS, METHOD OF MAKING AND USE ON MEDICAL DEVICES 有权
标题翻译： ZWITTERICIC共聚物，制备和使用医疗设备的方法
公开(公告)号：US20080147178A1
公开(公告)日：2008-06-19
申请号：US11942693
申请日：2007-11-19
申请人： Stephen Pacetti , Wouter Roorda
发明人： Stephen Pacetti , Wouter Roorda
IPC分类号： A61F2/82 , A61M25/10 , A61K47/32 , C08F218/02 , A61B17/00
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L27/18
摘要： Biocompatible copolymers are manufactured to include a zwitterionic monomer and an alkoxy acrylate monomer. The alkoxy acrylate monomer can be a 2-methoxyethyl methacrylate (MOEMA) or a 2-methoxyethyl methacrylate (EOEMA). Alternatively, the alkoxy acrylate can be 2-methoxyethyl acrylate (MOEA) or 2-ethoxyethyl acrylate (EOEA). The alkoxy acrylate monomers advantageously give the zwitterionic copolymers greater ductility, strength, and toughness while maintaining a desired amount of hydrophilicity. The improved toughness allows the zwitterionic copolymers to be processed without cross-linking, which improves the elongation properties of the zwitterionic copolymer, and reduces the risk of cracking during use.
摘要翻译：制造生物相容性共聚物以包括两性离子单体和烷氧基丙烯酸酯单体。烷氧基丙烯酸酯单体可以是甲基丙烯酸2-甲氧基乙酯（MOEMA）或甲基丙烯酸2-甲氧基乙酯（EOEMA）。或者，烷氧基丙烯酸酯可以是丙烯酸2-甲氧基乙酯（MOEA）或丙烯酸2-乙氧基乙酯（EOEA）。烷氧基丙烯酸酯单体有利地使两性离子共聚物具有更高的延展性，强度和韧性，同时保持所需量的亲水性。改进的韧性使得两性离子共聚物在不交联的情况下进行加工，这提高了两性离子共聚物的伸长性能，并降低了使用过程中的开裂风险。

9. 发明申请

US20050142202A1 Compositions for achieving a therapeutic effect in an anatomical structure 审中-公开
标题翻译：用于在解剖结构中获得治疗效果的组合物
公开(公告)号：US20050142202A1
公开(公告)日：2005-06-30
申请号：US11015943
申请日：2004-12-17
申请人： Wouter Roorda , Stephen Pacetti
发明人： Wouter Roorda , Stephen Pacetti
IPC分类号： A61K9/16 , A61K31/727 , A61K48/00 , A61K9/14 , A61K38/18
CPC分类号： A61K9/14 , A61K9/1617 , A61K9/1647 , A61K9/1658 , A61K9/1694 , A61K31/573 , A61K31/727 , A61K38/1825 , A61K47/26 , A61K47/36 , A61K48/00
摘要： Compositions and methods of using the compositions to achieve a therapeutic effect are provided.
摘要翻译：提供了使组合物达到治疗效果的组合物和方法。

10. 发明授权

US07781551B2 Zwitterionic copolymers, method of making and use on medical devices 有权
标题翻译：两性离子共聚物，制造和使用在医疗器械上的方法
公开(公告)号：US07781551B2
公开(公告)日：2010-08-24
申请号：US11942693
申请日：2007-11-19
申请人： Stephen Pacetti , Wouter Roorda
发明人： Stephen Pacetti , Wouter Roorda
IPC分类号： C08F12/30 , C08F12/26 , C08F20/26
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L27/18
摘要： Biocompatible copolymers are manufactured to include a zwitterionic monomer and an alkoxy acrylate monomer. The alkoxy acrylate monomer can be a 2-methoxyethyl methacrylate (MOEMA) or 2-ethoxyethyl methacrylate (EOEMA). Alternatively, the alkoxy acrylate can be 2-methoxyethyl acrylate (MOEA) or 2-ethoxyethyl acrylate (EOEA). The alkoxy acrylate monomers advantageously give the zwitterionic copolymers greater ductility, strength, and toughness while maintaining a desired amount of hydrophilicity. The improved toughness allows the zwitterionic copolymers to be processed without cross-linking, which improves the elongation properties of the zwitterionic copolymer, and reduces the risk of cracking during use.
摘要翻译：制造生物相容性共聚物以包括两性离子单体和烷氧基丙烯酸酯单体。烷氧基丙烯酸酯单体可以是甲基丙烯酸2-甲氧基乙酯（MOEMA）或甲基丙烯酸2-乙氧基乙酯（EOEMA）。或者，烷氧基丙烯酸酯可以是丙烯酸2-甲氧基乙酯（MOEA）或丙烯酸2-乙氧基乙酯（EOEA）。烷氧基丙烯酸酯单体有利地使两性离子共聚物具有更高的延展性，强度和韧性，同时保持所需量的亲水性。改进的韧性使得两性离子共聚物在不交联的情况下进行加工，这提高了两性离子共聚物的伸长性能，并降低了使用过程中的开裂风险。

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