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1. 发明授权

US06251036B1 Carbon fiber arrow and continuously winding method thereof 失效
标题翻译：碳纤维箭头及其连续卷绕方法
公开(公告)号：US06251036B1
公开(公告)日：2001-06-26
申请号：US09516576
申请日：2000-03-01
申请人： Xiang Wu , Qingzhu Mao , Wenhao Chen , Dahai Sun , Minyong Liu , Weifang Chen
发明人： Xiang Wu , Qingzhu Mao , Wenhao Chen , Dahai Sun , Minyong Liu , Weifang Chen
IPC分类号： F42B604
CPC分类号： F42B6/04
摘要： A carbon fiber arrow shaft comprises a hollow tube, a reinforced carbon fiber, and a resinoid binder. The hollow tube has a length between 500-900 mm, an inner diameter between 2-10 mm, and a tube wall thickness between 0.3-2 mm. The reinforced carbon fiber and the resinoid binder form a resin-impregnated carbon fiber. The carbon fiber arrow shaft is formed by directly and continuously winding the resin-impregnated carbon fiber around the hollow tube. The carbon fiber arrow shaft has a head section (L1), a middle section (L2) and a tail section (L3). A winding angle of the carbon fiber at the head section (L1) is changed from a larger winding angle to a smaller winding angle, a winding angle at the middle section (L2) stays constant, and a winding angle at the tail section (L3) is changed from a smaller winding angle to a larger winding angle. The lengths of the head section (L1) and the tail section (L3) are between 25-250 mm. The initial winding angle at the head section (L1) is between 30-90 degrees and is gradually decreased to between 2-30 degrees at the boundary of the head section (L1) and the middle section (L2). The winding angle at the middle section (L2) stays constant, and the winding angle at the tail section (L3) is gradually increased from between 2-30 degrees at the boundary of the middle section (L2) and the tail section to between 30-90 degrees at the end of the tail section (L3). The peripherally located winding angles at both the head section (L1) and the tail section (L3) are at least two times the winding angle at the middle section (L2). The shaft provides uniformity of wall thickness and eliminates overlapping joints or surface protrusions.
摘要翻译：碳纤维箭头轴包括中空管，增强碳纤维和树脂粘合剂。中空管的长度为500-900mm，内径在2-10mm之间，管壁厚在0.3-2mm之间。增强碳纤维和树脂粘合剂形成树脂浸渍的碳纤维。碳纤维箭头轴通过将树脂浸渍的碳纤维直接且连续地缠绕在中空管周围而形成。碳纤维箭头轴具有头部（L1），中间部（L2）和尾部（L3）。在头部（L1）处的碳纤维的卷绕角度从较大的卷绕角度变为较小的卷绕角度，中间部分（L2）处的卷绕角度保持恒定，并且在尾部（L3 ）从较小的卷绕角度变化到较大的卷绕角度。头部（L1）和尾部（L3）的长度在25-250mm之间。头部（L1）的初始卷绕角度在30-90度之间，并且在头部（L1）和中间部分（L2）的边界处逐渐减小到2-30度之间。中间部分（L2）处的卷绕角度保持恒定，并且尾部（L3）处的卷绕角度从中间部分（L2）和尾部部分的边界处的2-30度之间逐渐增加到30 -90度在尾部（L3）的末端。在头部部分（L1）和尾部部分（L3）处的外围定位的卷绕角度至少是中间部分（L2）处的卷绕角度的两倍。轴提供壁厚均匀性，消除重叠的接头或表面突起。

2. 发明授权

US08631840B2 Kit for repairing and inflating inflatable items 有权
标题翻译：用于修理和充气充气物品的套件
公开(公告)号：US08631840B2
公开(公告)日：2014-01-21
申请号：US13638030
申请日：2011-04-07
申请人： Sergio Lolli , Wenhao Chen
发明人： Sergio Lolli , Wenhao Chen
IPC分类号： B65B1/04
CPC分类号： B60S5/046 , B29C73/166 , B29L2030/00
摘要： A kit for repairing and inflating inflatable items comprises a housing, a compressor assembly housed within the housing, a connecting device having an inlet connected to the compressor assembly and a seat adapted to be fluidically connected to a container assembly for a sealing liquid and to the inlet, a valve configured to be opened automatically when the container assembly is connected to the connection device and elastically maintained in a first position such as to fluidically disconnect the inlet from the seat when the container assembly is disconnected from the connecting device, and a flexible tube fluidically connected to the compressor assembly. In particular, the connecting device comprises an outlet fluidically connected to the valve so as to be fluidically connected to the inlet when the valve is in the first position, and in that the flexible tube is connected to the outlet.
摘要翻译：用于修理和充气充气物品的套件包括壳体，容纳在壳体内的压缩机组件，具有连接到压缩机组件的入口和适于流体连接到用于密封液体的容器组件的座的连接装置，入口，阀，其构造成当容器组件连接到连接装置时自动打开，并且当容器组件与连接装置断开连接时弹性地保持在第一位置，以便使入口与座体流体地断开;以及柔性管流体连接到压缩机组件。特别地，连接装置包括流体连接到阀的出口，以便当阀处于第一位置时流体连接到入口，并且柔性管连接到出口。

3. 发明授权

US09018006B2 Stable Tregs and related materials and methods 有权
标题翻译：稳定的Tregs及相关材料和方法
公开(公告)号：US09018006B2
公开(公告)日：2015-04-28
申请号：US13811778
申请日：2011-07-25
申请人： Stanislaw M. Stepkowski , Wenhao Chen , Yoshihiro Miyahara
发明人： Stanislaw M. Stepkowski , Wenhao Chen , Yoshihiro Miyahara
IPC分类号： C12N5/0783 , C07K16/28 , A61K39/00
CPC分类号： C12N5/0637 , A61K35/17 , A61K2039/505 , A61K2039/507 , C07K16/2809 , C07K16/2845 , C07K2317/73 , C07K2317/74 , C12N5/0636 , C12N2501/2302 , C12N2501/2325 , C12N2501/51 , C12N2501/515 , C12N2501/599 , C12N2501/727
摘要： The present invention provides materials and methods related to culturing stable Treg cells or in vivo expansion of stable Treg cells, the cells made by the methods, treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection, and related materials. Ex vivo induction and expansion of the stable Tregs is described, including use of inducing compositions, such as certain mAbs and other compounds, along with expansion medium comprising IL-2. In vivo expansion of stable Treg cells and treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection are described, including the use of mAbs and their variants.
摘要翻译：本发明提供了与培养稳定的Treg细胞或稳定的Treg细胞的体内扩增相关的材料和方法，通过该方法制备的细胞，各种炎症/自身免疫病理学和移植/移植排斥的治疗以及相关材料。描述稳定的Treg的离体诱导和扩增，包括使用诱导组合物，例如某些mAb和其它化合物，以及包含IL-2的扩增培养基。描述了稳定的Treg细胞的体内扩增和各种炎症/自身免疫病理学和移植/移植排斥的治疗，包括使用mAb及其变体。

4. 发明申请

US20130280208A1 Stable Tregs and Related Materials and Methods 有权
标题翻译：稳定的Tregs及相关材料和方法
公开(公告)号：US20130280208A1
公开(公告)日：2013-10-24
申请号：US13811778
申请日：2011-07-25
申请人： Stanislaw M. Stepkowski , Wenhao Chen , Yoshihiro Miyahara
发明人： Stanislaw M. Stepkowski , Wenhao Chen , Yoshihiro Miyahara
IPC分类号： C12N5/0783 , A61K35/14
CPC分类号： C12N5/0637 , A61K35/17 , A61K2039/505 , A61K2039/507 , C07K16/2809 , C07K16/2845 , C07K2317/73 , C07K2317/74 , C12N5/0636 , C12N2501/2302 , C12N2501/2325 , C12N2501/51 , C12N2501/515 , C12N2501/599 , C12N2501/727
摘要： The present invention provides materials and methods related to culturing stable Treg cells or in vivo expansion of stable Treg cells, the cells made by the methods, treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection, and related materials. Ex vivo induction and expansion of the stable Tregs is described, including use of inducing compositions, such as certain mAbs and other compounds, along with expansion medium comprising IL-2. In vivo expansion of stable Treg cells and treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection are described, including the use of mAbs and their variants.
摘要翻译：本发明提供了与培养稳定的Treg细胞或稳定的Treg细胞的体内扩增相关的材料和方法，通过该方法制备的细胞，各种炎症/自身免疫病理学和移植/移植排斥的治疗以及相关材料。描述稳定的Treg的离体诱导和扩增，包括使用诱导组合物，例如某些mAb和其它化合物，以及包含IL-2的扩增培养基。描述了稳定的Treg细胞的体内扩增和各种炎症/自身免疫病理学和移植/移植排斥的治疗，包括使用mAb及其变体。

5. 发明申请

US20130199665A1 KIT FOR REPAIRING AND INFLATING INFLATABLE ITEMS 有权
标题翻译：修理和灌装可充气物品的工具包
公开(公告)号：US20130199665A1
公开(公告)日：2013-08-08
申请号：US13638030
申请日：2011-04-07
申请人： Sergio Lolli , Wenhao Chen
发明人： Sergio Lolli , Wenhao Chen
IPC分类号： B60S5/04
CPC分类号： B60S5/046 , B29C73/166 , B29L2030/00
摘要： A kit for repairing and inflating inflatable items comprises a housing, a compressor assembly housed within the housing, a connecting device having an inlet connected to the compressor assembly and a seat adapted to be fluidically connected to a container assembly for a sealing liquid and to the inlet, a valve configured to be opened automatically when the container assembly is connected to the connection device and elastically maintained in a first position such as to fluidically disconnect the inlet from the seat when the container assembly is disconnected from the connecting device, and a flexible tube fluidically connected to the compressor assembly. In particular, the connecting device comprises an outlet fluidically connected to the valve so as to be fluidically connected to the inlet when the valve is in the first position, and in that the flexible tube is connected to the outlet.
摘要翻译：用于修理和充气充气物品的套件包括壳体，容纳在壳体内的压缩机组件，具有连接到压缩机组件的入口和适于流体连接到用于密封液体的容器组件的座的连接装置，入口，阀，其构造成当容器组件连接到连接装置时自动打开，并且当容器组件与连接装置断开连接时弹性地保持在第一位置，以便使入口与座体流体地断开;以及柔性管流体连接到压缩机组件。特别地，连接装置包括流体连接到阀的出口，以便当阀处于第一位置时流体连接到入口，并且柔性管连接到出口。

6. 发明申请

US20110306539A1 PROCESS FOR MAKING PARTICLES FOR DELIVERY OF DRUG NANOPARTICLES 有权
标题翻译：制备用于输送药物纳米颗粒的颗粒的方法
公开(公告)号：US20110306539A1
公开(公告)日：2011-12-15
申请号：US13120146
申请日：2009-09-24
申请人： Zhigang Shen , Jimmy Sung Lai Yun , Jun Hu , Arvind Jugade , Jiyao Zhang , Wenhao Chen , Zhe Wang , Lingyan Gao , Jian Feng Chen
发明人： Zhigang Shen , Jimmy Sung Lai Yun , Jun Hu , Arvind Jugade , Jiyao Zhang , Wenhao Chen , Zhe Wang , Lingyan Gao , Jian Feng Chen
IPC分类号： A61K38/02 , A61K31/216 , A61K31/513 , A61K31/546 , A61K38/13 , A61K31/357 , A61K31/57 , A61K31/7052 , A61K31/277 , A61K31/197 , A61K47/38 , A61K47/24 , A61K47/26 , A61K47/10 , A61P29/00 , A61K47/32 , A61P31/04 , A61P33/02 , A61P7/02 , A61P3/10 , A61P25/24 , A61P25/08 , A61P31/10 , A61P9/12 , A61P35/00 , A61P25/06 , A61P33/00 , A61P25/16 , A61P25/18 , A61P25/20 , A61P11/14 , A61P31/12 , A61P17/00 , A61P1/00 , A61P23/00 , A61P7/04 , A61P23/02 , A61P9/08 , A61K31/56
CPC分类号： A61K9/14 , A61K9/1623 , A61K9/1652 , A61K9/1694 , A61K9/2077 , B01J2/06 , B01J19/0093 , B01J2219/00788 , B01J2219/00889
摘要： A process for making particles for delivery of drug nanoparticles is disclosed herein. The process comprises the steps of (a) forming a suspension of drug nanoparticles by mixing a precipitant solution with an anti-solvent solution under micro-mixing environment, where the formed nanoparticles have a narrow particle size distribution; (b) providing an excipient to at least one of the precipitant solution, the anti-solvent solution and the suspension of drug nanoparticles, the excipient being selected to maintain said drug nanoparticles in a dispersed state when in liquid form; and (c) drying the suspension of drug nanoparticles containing the excipient therein to remove solvent therefrom, wherein removal of the solvent causes the excipient to solidify and thereby form micro-sized matrix particles, each micro-sized particle being comprised of drug nanoparticles dispersed in a solid matrix of the excipient.
摘要翻译：本文公开了用于制备用于递送药物纳米颗粒的颗粒的方法。该方法包括以下步骤：（a）通过在微混合环境下将沉淀剂溶液与抗溶剂溶液混合形成药物纳米颗粒的悬浮液，其中所形成的纳米颗粒具有窄的粒度分布; （b）向沉淀剂溶液，抗溶剂溶液和药物纳米颗粒的悬浮液中的至少一种提供赋形剂，所述赋形剂被选择为当液体形式时将所述药物纳米颗粒维持在分散状态; 和（c）干燥其中含有赋形剂的药物纳米颗粒的悬浮液以从其中除去溶剂，其中去除溶剂导致赋形剂固化，从而形成微尺寸的基质颗粒，每个微尺寸颗粒由分散在赋形剂的固体基质。

7. 发明授权

US11127694B2 Physical unclonable functions with copper-silicon oxide programmable metallization cells 有权
公开(公告)号：US11127694B2
公开(公告)日：2021-09-21
申请号：US16496767
申请日：2018-03-23
申请人： Michael Kozicki , Wenhao Chen
发明人： Michael Kozicki , Wenhao Chen
IPC分类号： H01L23/00 , H01L27/24 , H01L45/00
摘要： A physical unclonable functions (PUF) device including a first copper electrode, a second electrode, and a silicon oxide layer positioned directly between the first copper electrode and the second electrode; a method of producing a PUF device; an array comprising a PUF device; and a method of generating a secure key with a plurality of PUF devices.

8. 发明授权

US08835376B2 Process for making particles for delivery of drug nanoparticles 有权
标题翻译：用于制备用于递送药物纳米颗粒的颗粒的方法
公开(公告)号：US08835376B2
公开(公告)日：2014-09-16
申请号：US13120146
申请日：2009-09-24
申请人： Zhigang Shen , Jimmy Sung Lai Yun , Jun Hu , Nital Arvind Jugade , Jiyao Zhang , Wenhao Chen , Zhe Wang , Lingyan Gao , William Glover , Jian Feng Chen
发明人： Zhigang Shen , Jimmy Sung Lai Yun , Jun Hu , Nital Arvind Jugade , Jiyao Zhang , Wenhao Chen , Zhe Wang , Lingyan Gao , William Glover , Jian Feng Chen
IPC分类号： A61K38/02 , A61K31/216 , A61K31/513 , A61K31/546 , A61K38/13 , A61K31/357 , A61K31/57 , A61K31/7052 , A61K31/277 , A61K31/197 , A61K47/38 , A61K47/24 , B01J2/06 , A61K9/16 , A61K9/20 , A61K9/14 , B01J19/00
CPC分类号： A61K9/14 , A61K9/1623 , A61K9/1652 , A61K9/1694 , A61K9/2077 , B01J2/06 , B01J19/0093 , B01J2219/00788 , B01J2219/00889
摘要： A process for making particles for delivery of drug nanoparticles is disclosed herein. The process comprises the steps of (a) forming a suspension of drug nanoparticles by mixing a precipitant solution with an anti-solvent solution under micro-mixing environment, where the formed nanoparticles have a narrow particle size distribution; (b) providing an excipient to at least one of the precipitant solution, the anti-solvent solution and the suspension of drug nanoparticles, the excipient being selected to maintain said drug nanoparticles in a dispersed state when in liquid form; and (c) drying the suspension of drug nanoparticles containing the excipient therein to remove solvent therefrom, wherein removal of the solvent causes the excipient to solidify and thereby form micro-sized matrix particles, each micro-sized particle being comprised of drug nanoparticles dispersed in a solid matrix of the excipient.
摘要翻译：本文公开了用于制备用于递送药物纳米颗粒的颗粒的方法。该方法包括以下步骤：（a）通过在微混合环境下将沉淀剂溶液与抗溶剂溶液混合形成药物纳米颗粒的悬浮液，其中所形成的纳米颗粒具有窄的粒度分布; （b）向沉淀剂溶液，抗溶剂溶液和药物纳米颗粒的悬浮液中的至少一种提供赋形剂，所述赋形剂被选择为当液体形式时将所述药物纳米颗粒维持在分散状态; 和（c）干燥其中含有赋形剂的药物纳米颗粒的悬浮液以从其中除去溶剂，其中去除溶剂导致赋形剂固化，从而形成微尺寸的基质颗粒，每个微尺寸颗粒由分散在赋形剂的固体基质。

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