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1. 发明申请

US20090131400A1 IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS 有权
标题翻译：免疫抑制剂化合物和组合物
公开(公告)号：US20090131400A1
公开(公告)日：2009-05-21
申请号：US12180479
申请日：2008-07-25
申请人： Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
发明人： Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
IPC分类号： A61K31/397 , C07D333/50 , A61K31/381 , C07D409/02 , A61K31/4535 , C07D495/02 , A61K31/4365
CPC分类号： C07D333/58 , C07D261/20 , C07D409/06 , C07D471/04 , C07D473/00 , C07D513/04
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译：本发明涉及免疫抑制剂，其生产方法及其用途和含有它们的药物组合物。本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。

2. 发明授权

US07750021B2 Immunosuppressant compounds and compositions 有权
标题翻译：免疫抑制剂化合物和组合物
公开(公告)号：US07750021B2
公开(公告)日：2010-07-06
申请号：US12180479
申请日：2008-07-25
申请人： Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
发明人： Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
IPC分类号： A61K31/343 , A61K31/352 , A61K31/396 , A61K31/4035 , A61K31/404 , A61K31/416 , A61K31/423 , A61K31/428 , A61K31/4365 , A61K31/437 , C07D263/56 , C07D277/64 , C07D231/56 , C07D209/04 , C07D513/04 , C07D493/04
CPC分类号： C07D333/58 , C07D261/20 , C07D409/06 , C07D471/04 , C07D473/00 , C07D513/04
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译：本发明涉及免疫抑制剂，其生产方法及其用途和含有它们的药物组合物。本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。

3. 发明授权

US07417065B2 Immunosuppressant compounds and compositions 有权
公开(公告)号：US07417065B2
公开(公告)日：2008-08-26
申请号：US10849458
申请日：2004-05-19
申请人： Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
发明人： Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
IPC分类号： A61K31/381 , C07D333/62
CPC分类号： C07D333/58 , C07D261/20 , C07D409/06 , C07D471/04 , C07D473/00 , C07D513/04
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.

4. 发明申请

US20050014725A1 Immunosuppressant compounds and compositions 有权
公开(公告)号：US20050014725A1
公开(公告)日：2005-01-20
申请号：US10849458
申请日：2004-05-19
申请人： Yuan Mi , Shifeng Pan , Nathanael Gray , Wenqi Gao , Yi Fan , Tao Jiang
发明人： Yuan Mi , Shifeng Pan , Nathanael Gray , Wenqi Gao , Yi Fan , Tao Jiang
IPC分类号： A61K31/185 , A61K31/195 , A61K31/41 , A61K31/66 , A61K31/675 , C07D333/60 , C07F9/28
CPC分类号： C07D333/58 , C07D261/20 , C07D409/06 , C07D471/04 , C07D473/00 , C07D513/04
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.

5. 发明授权

US07968557B2 Substituted pyrrolo[2,3-2]pyrimidines as protein kinase inhibitors 有权
标题翻译：取代的吡咯并[2,3-2]嘧啶作为蛋白激酶抑制剂
公开(公告)号：US07968557B2
公开(公告)日：2011-06-28
申请号：US10589099
申请日：2005-02-14
申请人： Ha-Soon Choi , Zhicheng Wang , Nathanael Schiander Gray , Xiang-ju Gu , Xiaohui He , Yun He , Tao Jiang , Yi Liu , Wendy Richmond , Taebo Sim , Kunyong Yang
发明人： Ha-Soon Choi , Zhicheng Wang , Nathanael Schiander Gray , Xiang-ju Gu , Xiaohui He , Yun He , Tao Jiang , Yi Liu , Wendy Richmond , Taebo Sim , Kunyong Yang
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P37/06
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the FAK, Abl, BCR-Abl, PDGF-R, c-Kit, NPM-ALK, Flt-3, JAK2 and c-Met kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及FAK异常活化的疾病或病症，Abl，BCR -AbI，PDGF-R，c-Kit，NPM-ALK，Flt-3，JAK2和c-Met激酶。

6. 发明申请

US20050014724A1 Immunosuppressant compounds and compositions 失效
公开(公告)号：US20050014724A1
公开(公告)日：2005-01-20
申请号：US10849079
申请日：2004-05-19
申请人： Thomas Marsilje , Nathanel Gray , Tao Jiang , Wenshuo Lu , Shifeng Pan
发明人： Thomas Marsilje , Nathanel Gray , Tao Jiang , Wenshuo Lu , Shifeng Pan
IPC分类号： A61K20060101 , A61K31/195 , A61K31/216 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/495 , A61K31/675 , C07C323/63 , C07D205/04 , C07D207/12 , C07D211/32 , C07D241/04 , C07F9/22 , C07F9/28
CPC分类号： C07C323/32 , C07C317/32 , C07C2601/14 , C07D205/04
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.

7. 发明授权

US07060697B2 Immunosuppressant compounds and compositions 失效
公开(公告)号：US07060697B2
公开(公告)日：2006-06-13
申请号：US10849079
申请日：2004-05-19
申请人： Thomas H. Marsilje , Nathanael S. Gray , Tao Jiang , Wenshuo Lu , Shifeng Pan
发明人： Thomas H. Marsilje , Nathanael S. Gray , Tao Jiang , Wenshuo Lu , Shifeng Pan
IPC分类号： A61K31/397 , A61K31/40 , A61K31/197 , C07D207/06 , C07D205/04
CPC分类号： C07C323/32 , C07C317/32 , C07C2601/14 , C07D205/04
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.

8. 发明授权

US09180993B2 Feeding device 有权
标题翻译：送料装置
公开(公告)号：US09180993B2
公开(公告)日：2015-11-10
申请号：US13482365
申请日：2012-05-29
申请人： Jian-Bin Zhou , Che-Yu Chou , Qun Huang , Tai-Shan Zhu , Tao Jiang , Wei-Wei Yu
发明人： Jian-Bin Zhou , Che-Yu Chou , Qun Huang , Tai-Shan Zhu , Tao Jiang , Wei-Wei Yu
IPC分类号： B65B39/00
CPC分类号： B65B39/002 , B65B39/003 , B65B39/005 , B65B2220/14
摘要： A feeding device includes a material pipe, a first container, a second container and a constant-length linkage mechanism. The material pipe is configured for feeding a first material. The first container is configured for receiving the first material and supplying a timed amount of the first material to a first material feed port. The second container is configured for storing a second material and supplying the second material to a second material feed port. The constant-length linkage mechanism is connected to the first container and the second container. When the first container is actually supplying the first material to the first material feed port, the constant-length linkage mechanism allows the second container to supply the second material to the second material feed port simultaneously.
摘要翻译：进料装置包括材料管，第一容器，第二容器和恒定长度连杆机构。材料管被配置为供给第一材料。第一容器构造成用于接收第一材料并将定时量的第一材料供应到第一材料供给口。第二容器构造成用于存储第二材料并将第二材料供应到第二材料进料口。恒定连杆机构连接到第一容器和第二容器。当第一容器实际上将第一材料供应到第一材料供给口时，恒定连杆机构允许第二容器同时将第二材料供应到第二材料进料口。

9. 发明申请

US20140253867A1 Pair of Projector Glasses 审中-公开
标题翻译：一对投影机眼镜
公开(公告)号：US20140253867A1
公开(公告)日：2014-09-11
申请号：US14198583
申请日：2014-03-05
申请人： Tao Jiang , Dazhang Zeng
发明人： Tao Jiang , Dazhang Zeng
IPC分类号： G02C11/00
CPC分类号： G02C11/10
摘要： A pair of projector glasses is an eyewear apparatus that provides a user with a convenient means of acquiring, viewing, and listening to digital content. The eyewear apparatus mainly includes a glasses frame, a pair of temples, a projector, a wireless module, a pair of headphone speakers, and a pair of portable power sources. The glasses frame and the pair of temples are used to support the eyewear apparatus on the user's head. The wireless module retrieves digital content from an external source such as a smart-phone, a computer, or the Internet. The wireless module then distributes the audio portion of the digital content to the pair of speakers and the visual portion of the digital content to the projector. The portable power sources are separately positioned on the eyewear apparatus so that each source can power the electrical components that are in close proximity to the source itself.
摘要翻译：一副投影机眼镜是一种眼镜装置，为用户提供了获取，观看和收听数字内容的便利手段。眼镜装置主要包括眼镜架，一对镜腿，投影仪，无线模块，一对耳机扬声器和一对便携式电源。眼镜架和一对镜腿用于支撑使用者头部的眼镜装置。无线模块从诸如智能电话，计算机或因特网的外部来源检索数字内容。无线模块然后将数字内容的音频部分分配给一对扬声器和数字内容的可视部分到投影仪。便携式电源分开地定位在眼镜装置上，使得每个源可以对靠近源本身的电气部件供电。

10. 发明授权

US08642561B2 Peptides whose uptake by cells is controllable 有权
标题翻译：细胞摄取的肽是可控的
公开(公告)号：US08642561B2
公开(公告)日：2014-02-04
申请号：US13314134
申请日：2011-12-07
申请人： Tao Jiang , Roger Y. Tsien
发明人： Tao Jiang , Roger Y. Tsien
IPC分类号： A61K38/06 , A61K38/16 , A61K38/10 , G01N33/533 , C07H19/04 , G03F7/00
CPC分类号： A61K49/0043 , A61K47/65 , A61K49/0056
摘要： A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. Cleavage of X allows separation of A from B, unmasking the normal ability of the basic amino acids in B to drag cargo C into cells near the cleavage event. X is cleaved extracellularly, preferably under physiological conditions. D-amino acids are preferred for the A and B portions, to minimize immunogenicity and nonspecific cleavage by background peptidases or proteases.
摘要翻译：本发明的肽的一般结构包括A-X-B-C，其中C是货物部分，B部分包括碱性氨基酸，X是可切割的接头序列，A部分包括酸性氨基酸。完整结构不被细胞所占据; 然而，在X的细胞外裂解时，B-C部分被吸收，将货物运送到靶细胞。货物可以是例如用于诊断成像的对比剂，化学治疗药物或用于治疗的放射线敏化剂。 X的裂解允许A与B分离，揭示B中碱性氨基酸的正常能力，将货物C拖入裂解事件附近的细胞。 X在细胞外裂解，优选在生理条件下。对于A和B部分，D-氨基酸是优选的，以使由背景肽酶或蛋白酶的免疫原性和非特异性切割最小化。

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