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1. 发明申请

US20130177529A1 Pyrazole Compounds 审中-公开
标题翻译：吡唑化合物
公开(公告)号：US20130177529A1
公开(公告)日：2013-07-11
申请号：US13678449
申请日：2012-11-15
申请人： Youhong Hu , Bin Xu , Yun Liao , Kenneth Nawoschik , Yixin Liu , Anthony Sandrasagra , Reza Fathi , Zhen Yang
发明人： Youhong Hu , Bin Xu , Yun Liao , Kenneth Nawoschik , Yixin Liu , Anthony Sandrasagra , Reza Fathi , Zhen Yang
IPC分类号： C07D231/12 , C07D401/06 , A61K31/4439 , C07D405/12 , A61K31/4155 , C07D401/10 , C07D405/10 , C07D409/10 , A61K31/5377 , C07D491/052 , A61K31/4162 , C07D417/12 , A61K31/427 , A61K31/496 , A61K45/06 , A61K31/454 , A61K31/415
CPC分类号： C07D231/12 , A61K31/415 , A61K31/4155 , A61K31/4162 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D231/14 , C07D401/06 , C07D401/10 , C07D405/10 , C07D405/12 , C07D409/10 , C07D417/12 , C07D491/052
摘要： Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination with additional antiviral agents, in a therapeutically effective amount.
摘要翻译：提供了芳基取代的吡唑衍生物，以及其制备方法。本发明还提供了治疗HCV的组合物和方法，其通过以治疗有效量施用单独或与其它抗病毒剂组合的本发明化合物。

2. 发明授权

US07994360B2 Benzofuran compounds 失效
标题翻译：苯并呋喃化合物
公开(公告)号：US07994360B2
公开(公告)日：2011-08-09
申请号：US11130660
申请日：2005-05-16
申请人： Yun Liao , Youhong Hu , Kenneth Nawoschik , Reza Fathi , Zhen Yang , Yixin Liu , Anthony Sandrasagra
发明人： Yun Liao , Youhong Hu , Kenneth Nawoschik , Reza Fathi , Zhen Yang , Yixin Liu , Anthony Sandrasagra
IPC分类号： C07C69/00 , C07C39/00
CPC分类号： C07D207/08 , C07C235/34 , C07D307/80 , C07D307/84 , C07D405/06 , C07D493/14
摘要： The present invention relates to benzofuran derivatives for use in antiviral compositions. More specifically, the present invention relates to compositions and methods for the treatment of hepatitis C virus by administering the benzofuran derivatives in a therapeutically effective amount.
摘要翻译：本发明涉及用于抗病毒组合物的苯并呋喃衍生物。更具体地，本发明涉及通过以治疗有效量施用苯并呋喃衍生物来治疗丙型肝炎病毒的组合物和方法。

3. 发明授权

US08329703B2 Pyrazole compounds 失效
标题翻译：吡唑化合物
公开(公告)号：US08329703B2
公开(公告)日：2012-12-11
申请号：US11058852
申请日：2005-02-15
申请人： Youhong Hu , Bin Xu , Yun Liao , Kenneth Nawoschik , Yixin Liu , Anthony Sandrasagra , Reza Fathi , Zhen Yang
发明人： Youhong Hu , Bin Xu , Yun Liao , Kenneth Nawoschik , Yixin Liu , Anthony Sandrasagra , Reza Fathi , Zhen Yang
IPC分类号： A61K31/496 , A61K31/454 , A61K31/416
CPC分类号： C07D231/12 , A61K31/415 , A61K31/4155 , A61K31/4162 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D231/14 , C07D401/06 , C07D401/10 , C07D405/10 , C07D405/12 , C07D409/10 , C07D417/12 , C07D491/052
摘要： Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination with additional antiviral agents, in a therapeutically effective amount.
摘要翻译：提供了芳基取代的吡唑衍生物，以及其制备方法。本发明还提供了治疗HCV的组合物和方法，其通过以治疗有效量施用单独或与其它抗病毒剂组合的本发明化合物。

4. 发明申请

US20060258682A1 Benzofuran compounds 失效
标题翻译：苯并呋喃化合物
公开(公告)号：US20060258682A1
公开(公告)日：2006-11-16
申请号：US11130660
申请日：2005-05-16
申请人： Yun Liao , Youhong Hu , Kenneth Nawoschik , Reza Fathi , Zhen Yang , Yixin Liu , Anthony Sandrasagra
发明人： Yun Liao , Youhong Hu , Kenneth Nawoschik , Reza Fathi , Zhen Yang , Yixin Liu , Anthony Sandrasagra
IPC分类号： A61K31/496 , A61K31/4025 , A61K31/343 , C07D405/02
CPC分类号： C07D207/08 , C07C235/34 , C07D307/80 , C07D307/84 , C07D405/06 , C07D493/14
摘要： The present invention relates to benzofuran derivatives for use in antiviral compositions. More specifically, the present invention relates to compositions and methods for the treatment of hepatitis C virus by administering the benzofuran derivatives in a therapeutically effective amount.
摘要翻译：本发明涉及用于抗病毒组合物的苯并呋喃衍生物。更具体地，本发明涉及通过以治疗有效量施用苯并呋喃衍生物来治疗丙型肝炎病毒的组合物和方法。

5. 发明申请

US20060183751A1 Pyrazole compounds 失效
标题翻译：吡唑化合物
公开(公告)号：US20060183751A1
公开(公告)日：2006-08-17
申请号：US11058852
申请日：2005-02-15
申请人： Youhong Hu , Bin Xu , Yun Liao , Kenneth Nawoschik , Yixin Liu , Anthony Sandrasagra , Reza Fathi , Zhen Yang
发明人： Youhong Hu , Bin Xu , Yun Liao , Kenneth Nawoschik , Yixin Liu , Anthony Sandrasagra , Reza Fathi , Zhen Yang
IPC分类号： A61K31/496 , A61K31/454 , A61K31/416
CPC分类号： C07D231/12 , A61K31/415 , A61K31/4155 , A61K31/4162 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D231/14 , C07D401/06 , C07D401/10 , C07D405/10 , C07D405/12 , C07D409/10 , C07D417/12 , C07D491/052
摘要： Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination with additional antiviral agents, in a therapeutically effective amount.
摘要翻译：提供了芳基取代的吡唑衍生物，以及其制备方法。本发明还提供了治疗HCV的组合物和方法，其通过以治疗有效量施用单独或与其它抗病毒剂组合的本发明化合物。

6. 发明授权

US07923004B2 4-ethynyl pyrazole derivative compounds and methods for treatment of HCV 失效
标题翻译： 4-乙炔基吡唑衍生物化合物和治疗HCV的方法
公开(公告)号：US07923004B2
公开(公告)日：2011-04-12
申请号：US11974744
申请日：2007-10-15
申请人： Guolin Li , Reza Fathi , Zhen Yang , Yun Liao , Qiang Zhu , Angela Lam , Anthony Sandrasagra , Kenneth Nawoschik , Hyun-Joon Cho , Jie Cao , Wu Ruoqiu , C. Richard Wobbe , Yixin Liu
发明人： Guolin Li , Reza Fathi , Zhen Yang , Yun Liao , Qiang Zhu , Angela Lam , Anthony Sandrasagra , Kenneth Nawoschik , Hyun-Joon Cho , Jie Cao , Wu Ruoqiu , C. Richard Wobbe , Yixin Liu
IPC分类号： A61K38/21
CPC分类号： C07D401/12 , C07D405/14 , C07D409/14 , C07D413/12
摘要： Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination with additional antiviral agents, in a therapeutically effective amount.
摘要翻译：提供了芳基取代的吡唑衍生物，以及其制备方法。本发明还提供了治疗HCV的组合物和方法，其通过以治疗有效量施用单独或与其它抗病毒剂组合的本发明化合物。

7. 发明申请

US20090041723A1 Compounds and methods for treatment of HCV 失效
标题翻译：用于治疗HCV的化合物和方法
公开(公告)号：US20090041723A1
公开(公告)日：2009-02-12
申请号：US11974744
申请日：2007-10-15
申请人： Guolin Li , Reza Fathi , Zhen Yang , Yun Liao , Qiang Zhu , Angela Man Iu Lam , Anthony Sandrasagra , Kenneth Nawoschik , Hyun-Joon Cho , Jie Cao , Wu Rouqiu , C. Richard Wobbe
发明人： Guolin Li , Reza Fathi , Zhen Yang , Yun Liao , Qiang Zhu , Angela Man Iu Lam , Anthony Sandrasagra , Kenneth Nawoschik , Hyun-Joon Cho , Jie Cao , Wu Rouqiu , C. Richard Wobbe
IPC分类号： A61K38/21 , A61K31/454 , C07D401/08 , A61K38/05 , C07D413/12 , C07D417/12 , A61K38/43 , A61P31/12
CPC分类号： C07D401/12 , C07D405/14 , C07D409/14 , C07D413/12
摘要： Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination with additional antiviral agents, in a therapeutically effective amount.
摘要翻译：提供了芳基取代的吡唑衍生物，以及其制备方法。本发明还提供了治疗HCV的组合物和方法，其通过以治疗有效量施用单独或与其它抗病毒剂组合的本发明化合物。

8. 发明授权

US06855822B2 Benzo[b]furan dimers 失效
标题翻译：苯并[b]呋喃二聚体
公开(公告)号：US06855822B2
公开(公告)日：2005-02-15
申请号：US10602341
申请日：2003-06-23
申请人： Yun Liao , Reza Fathi , Zhen Yang
发明人： Yun Liao , Reza Fathi , Zhen Yang
IPC分类号： C07D307/86 , C07D405/14 , C07D241/02 , C07D303/38 , C07D405/00
CPC分类号： C07D405/14 , C07D307/86
摘要： Benzo[b]furan dimers and processes for their preparation are provided. The invention provides a synthetic process for the preparation of benzo[b]furan dimer using mild reaction conditions, which provides a high substituent tolerance and is appropriate for use in solid phase syntheses for producing a library of benzo[b]furan dimers for biological screening.
摘要翻译：提供了苯并[b]呋喃二聚体及其制备方法。本发明提供了一种使用温和的反应条件制备苯并[b]呋喃二聚体的合成方法，其提供高的取代基耐受性，并且适用于制备用于生物筛选的苯并[b]呋喃二聚体文库的固相合成。

9. 发明授权

US08734011B2 Distributed optical fiber temperature sensor based on optical fiber delay 有权
标题翻译：基于光纤延迟的分布式光纤温度传感器
公开(公告)号：US08734011B2
公开(公告)日：2014-05-27
申请号：US13464991
申请日：2012-05-06
申请人： Qi Qiu , Jun Su , Shuangjin Shi , Yun Liao , Caidong Xiong
发明人： Qi Qiu , Jun Su , Shuangjin Shi , Yun Liao , Caidong Xiong
IPC分类号： G01K11/00 , G02B6/00
CPC分类号： G01K11/32
摘要： The present invention discloses distributed optical fiber temperature sensor based on optical fiber delay technology, including a tunable optical transmitter module, an optical receiver module, a signal processing and controlling module and multiple distributed sensing modules connected in series via transmission fibers. The multiple wavelengths optical signals transmitted from the tunable optical transmitter module respectively are transmitted into the first sensing module, and then transmitted out from the last sensing module. The output multiple wavelengths optical signals arrive at the optical receiver module. The optical receiver module converts optical signals of all wavelengths into electrical signals and transmits them into the signal processing and controlling module. The signal processing and controlling module measures transmission delay time of optical signal of each wavelength respectively, and calculates and obtains the temperature parameters of corresponding distributed testing positions based on the relative delay time.
摘要翻译：本发明公开了一种基于光纤延迟技术的分布式光纤温度传感器，包括可调谐光发射机模块，光接收模块，信号处理和控制模块以及通过传输光纤串联连接的多个分布式感测模块。从可调谐光发射机模块发送的多波长光信号分别传送到第一感测模块，然后从最后一个感测模块传出。输出多波长光信号到达光接收模块。光接收模块将所有波长的光信号转换为电信号，并将其传输到信号处理和控制模块。信号处理和控制模块分别测量每个波长的光信号的传输延迟时间，并根据相对延迟时间计算并获得相应的分布测试位置的温度参数。

10. 发明申请

US20130148691A1 Distributed optical fiber temperature sensor based on optical fiber delay 有权
标题翻译：基于光纤延迟的分布式光纤温度传感器
公开(公告)号：US20130148691A1
公开(公告)日：2013-06-13
申请号：US13464991
申请日：2012-05-06
申请人： Qi Qiu , Jun Su , Shuangjin Shi , Yun Liao , Caidong Xiong
发明人： Qi Qiu , Jun Su , Shuangjin Shi , Yun Liao , Caidong Xiong
IPC分类号： G01K11/32
CPC分类号： G01K11/32
摘要： The present invention discloses distributed optical fiber temperature sensor based on optical fiber delay technology, including a tunable optical transmitter module, an optical receiver module, a signal processing and controlling module and multiple distributed sensing modules connected in series via transmission fibers. The multiple wavelengths optical signals transmitted from the tunable optical transmitter module respectively are transmitted into the first sensing module, and then transmitted out from the last sensing module. The output multiple wavelengths optical signals arrive at the optical receiver module. The optical receiver module converts optical signals of all wavelengths into electrical signals and transmits them into the signal processing and controlling module. The signal processing and controlling module measures transmission delay time of optical signal of each wavelength respectively, and calculates and obtains the temperature parameters of corresponding distributed testing positions based on the relative delay time.
摘要翻译：本发明公开了一种基于光纤延迟技术的分布式光纤温度传感器，包括可调谐光发射机模块，光接收模块，信号处理和控制模块以及通过传输光纤串联连接的多个分布式感测模块。从可调谐光发射机模块发送的多波长光信号分别传送到第一感测模块，然后从最后一个感测模块传出。输出多波长光信号到达光接收模块。光接收模块将所有波长的光信号转换为电信号，并将其传输到信号处理和控制模块。信号处理和控制模块分别测量每个波长的光信号的传输延迟时间，并根据相对延迟时间计算并获得相应的分布测试位置的温度参数。

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