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1. 发明公开

EP2644198A1 ANTIANXIETY AND SLEEP DISORDER IMPROVING USE OF ALBIFLORIN OR METABOLITE THEREOF IN 有权
标题翻译：安哥拉国家安全理事会
公开(公告)号：EP2644198A1
公开(公告)日：2013-10-02
申请号：EP11842846.5
申请日：2011-11-09
申请人： Zhang, Zuoguang
发明人： Zhang, Zuoguang
IPC分类号： A61K31/7048 , A61K31/343 , A61K9/08 , A61K9/12 , A61K9/14 , A61K9/20 , A61K9/48 , A61K9/70 , A61K9/00 , A61P25/20 , A61P25/22
CPC分类号： A61K31/7048 , A23L33/105 , A61K31/365 , A61K36/65
摘要： Disclosed is a use of albiflorin or a metabolite thereof in preparation of antianxiety and sleep disorder improving drugs or health-care food. Tests prove that albiflorin has significant antianxiety effects and sleep disorder improving effects achieved by prolonging SWS and low the toxic side effects, thus being a safety monomer compound capable of effectively treating anxiety and sleep disorder.
摘要翻译：披露了白藜芦醇或其代谢物在制备抗焦虑和睡眠障碍改善药物或保健食品中的用途。测试证明，白藜芦醇具有显着的抗焦虑作用和睡眠障碍，通过延长SWS和低毒副作用而获得的改善效果，从而成为能够有效治疗焦虑和睡眠障碍的安全性单体化合物。

2. 发明公开

EP2491934A1 USE OF ALBIFLORIN FOR ANTI-DEPRESSION 失效
标题翻译： VERWENDUNG VON ALBIFLORIN GEGEN DEPRESSIONEN
公开(公告)号：EP2491934A1
公开(公告)日：2012-08-29
申请号：EP10824417.9
申请日：2010-08-24
申请人： Zhang, Zuoguang
发明人： Zhang, Zuoguang
IPC分类号： A61K31/7048 , A61K9/20 , A61K9/48 , A61K9/14 , A61K9/08 , A61K9/12 , A61P25/18 , A61P25/24
CPC分类号： A61K31/7048 , A61K9/0019 , A61K9/2059 , A61K9/4866
摘要： A pharmaceutical composition containing albiflorin and use thereof in manufacturing medicaments for preventing and treating depression are provided by the present invention.
摘要翻译：含有白藜芦醇的药物组合物及其在制备用于预防和治疗抑郁症的药物中的用途由本发明提供。

3. 发明公开

EP3263114A1 USE OF ALBIFLORIN OR PHARMACEUTICALLY ACCEPTABLE SALT FOR PREVENTION AND/OR TREATMENT OF IRRITABLE BOWEL SYNDROME 无效
标题翻译：用于预防和/或治疗可疑的肠道综合症的用于治疗或预防可疑的盐的阿尔福林或药学上可接受的盐
公开(公告)号：EP3263114A1
公开(公告)日：2018-01-03
申请号：EP15883001.8
申请日：2015-04-27
申请人： Zhang, Zuoguang
发明人： Zhang, Zuoguang
IPC分类号： A61K31/7048 , A61K31/365 , A61P1/00 , A61P1/12 , A61P25/22 , A61P25/24
CPC分类号： A61K31/7048 , A61K31/365
摘要： Disclosed is a use of albiflorin or a pharmaceutically acceptable salt for the prevention and/or treatment of irritable bowel syndrome. The experimental results demonstrate that the prevention, remission and/or treatment of irritable bowel syndrome with albiflorin or a pharmaceutically acceptable salt has significant effects and few side effects. This is a preparation derived from a natural plant for the safe, effective and multi-targeted prevention, remission and/or treatment of irritable bowel syndrome.
摘要翻译：公开了用于预防和/或治疗过敏性肠综合征的缬氨酸或其药学上可接受的盐的用途。实验结果表明，用缬氨酸或其药学上可接受的盐预防，缓解和/或治疗肠易激综合征具有显着效果并且副作用很少。这是一种来自天然植物的制剂，用于安全，有效和多靶向预防，缓解和/或治疗肠易激综合征。

4. 发明公开

EP2110135A3 A pharmaceutical composition for treating depression and method for preparation thereof 有权
标题翻译：用于治疗抑郁症和方法，用于其生产的药物组合物
公开(公告)号：EP2110135A3
公开(公告)日：2010-12-22
申请号：EP09157704.9
申请日：2005-10-31
申请人： Beijing Wonner Biotech Ltd. Co. , ZHANG, Zuoguang , CHI, Yuh-Fen
发明人： Zhang, Zuoguang
IPC分类号： A61K36/725 , A61K36/484 , A61K36/258 , A61P25/24
CPC分类号： A61K31/704 , A61K31/7076 , A61K36/258 , A61K36/484 , A61K36/725 , A61K38/51 , A61K2300/00
摘要： A pharmaceutical composition for treating a depression, comprising:
a ginseng water extract or a ginseng ethanol extract extracted from 3 ∼ 10 parts by weight of a ginseng; and 0.2 ∼ 0.8 part by weight of a glycyrrhizic acid or a glycyrrhetic acid.
摘要翻译：用于治疗抑郁症和方法，用于制备一种药物组合物及其设置。药物组合物包括人参，甘草，和/或它们的wässrige或醇提取物。因此大枣或它们的wässrige或醇提取物可以被包括在药物组合物。

5. 发明公开

EP3566707A1 APPLICATION OF ALBIFLORIN AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITOR 审中-公开
公开(公告)号：EP3566707A1
公开(公告)日：2019-11-13
申请号：EP17890044.5
申请日：2017-08-04
申请人： Zhang, Zuoguang
发明人： Zhang, Zuoguang
IPC分类号： A61K31/7048 , A61P37/00 , A61P35/00 , A61P25/16 , A61P25/24 , A61P25/28 , A61P27/12
摘要： Use of albiflorin or a pharmaceutically acceptable salt thereof as an IDO inhibitor. Albiflorin or a pharmaceutically acceptable salt thereof as an IDO inhibitor can be used for the preparation of a drug, a food, a health care product, a food additive or a nutritional supplement for the prevention or treatment of diseases having a pathological feature involving tryptophan metabolic pathway mediated by overactivation of IDO, and these diseases are selected from one or more of cancer, depression, Alzheimer's disease, and Parkinson's disease.

6. 发明授权

EP2491934B1 USE OF ALBIFLORIN FOR ANTI-DEPRESSION 失效
标题翻译：白芍针对抑郁USE
公开(公告)号：EP2491934B1
公开(公告)日：2016-03-09
申请号：EP10824417.9
申请日：2010-08-24
申请人： Zhang, Zuoguang
发明人： Zhang, Zuoguang
IPC分类号： A61K31/7048 , A61K9/20 , A61K9/48 , A61K9/14 , A61K9/08 , A61K9/12 , A61P25/18 , A61P25/24
CPC分类号： A61K31/7048 , A61K9/0019 , A61K9/2059 , A61K9/4866

7. 发明公开

EP2650301A1 METHOD FOR PREPARING ALBIFLORIN AND PAEONIFLORIN 失效
标题翻译： PAERONIFLORIN的VERFAHREN ZUR HERSTELLUNG VON ALBIFLORIN
公开(公告)号：EP2650301A1
公开(公告)日：2013-10-16
申请号：EP10859598.4
申请日：2010-11-10
申请人： Zhang, Zuoguang
发明人： Zhang, Zuoguang
IPC分类号： C07H17/04 , C07H1/08
CPC分类号： C07H17/04 , C07H1/08
摘要： The present invention discloses a method for preparing high purity paeoniflorin and albiflorin simultaneously comprising: extraction of the raw material Paeonia Lactiflora by percolation or heating under reflux to obtain the Paeonia Lactiflora extract solution, then purification by macroporous absorption resin, alumina column and silica gel column in turn to obtain high purity paeoniflorin and albiflorin. The preparation method of the invention can provide high purity paeoniflorin and albiflorin with low price and energy-consumption by the identical procedure. The process is simple. The purification efficacy is high and the purification time is short.
摘要翻译：本发明公开了一种制备高纯度芍药苷和白藜芦醇的方法，包括：通过渗滤或加热回流提取原料芍药，得到芍药提取物溶液，然后通过大孔吸附树脂，氧化铝柱和硅胶柱纯化反过来获得高纯度芍药苷和白芍素。本发明的制备方法可以通过相同的方法提供低价格和能量消耗的高纯度芍药苷和白芍。这个过程很简单。纯化效率高，净化时间短。

8. 发明授权

EP2650301B1 METHOD FOR PREPARING ALBIFLORIN AND PAEONIFLORIN 失效
标题翻译：制备阿拉伯林和芍药苷的方法
公开(公告)号：EP2650301B1
公开(公告)日：2018-02-28
申请号：EP10859598.4
申请日：2010-11-10
申请人： Zhang, Zuoguang
发明人： Zhang, Zuoguang
IPC分类号： C07H17/04 , C07H1/08
CPC分类号： C07H17/04 , C07H1/08
摘要： The present invention discloses a method for preparing high purity paeoniflorin and albiflorin simultaneously comprising: extraction of the raw material Paeonia Lactiflora by percolation or heating under reflux to obtain the Paeonia Lactiflora extract solution, then purification by macroporous absorption resin, alumina column and silica gel column in turn to obtain high purity paeoniflorin and albiflorin. The preparation method of the invention can provide high purity paeoniflorin and albiflorin with low price and energy-consumption by the identical procedure. The process is simple. The purification efficacy is high and the purification time is short.

9. 发明授权

EP2644198B1 ANTIANXIETY AND SLEEP DISORDER IMPROVING USE OF ALBIFLORIN 有权
标题翻译：抗焦虑和SCHLAFSTÖRUNGSLINDERNDE使用白芍的
公开(公告)号：EP2644198B1
公开(公告)日：2017-04-12
申请号：EP11842846.5
申请日：2011-11-09
申请人： Zhang, Zuoguang
发明人： Zhang, Zuoguang
IPC分类号： A61K31/365 , A61K31/7048 , A61K36/65 , A61P25/20 , A61P25/22
CPC分类号： A61K31/7048 , A23L33/105 , A61K31/365 , A61K36/65

10. 发明公开

EP2110135A2 A pharmaceutical composition for treating depression and method for preparation thereof 有权
标题翻译：用于治疗抑郁症和方法，用于其生产的药物组合物
公开(公告)号：EP2110135A2
公开(公告)日：2009-10-21
申请号：EP09157704.9
申请日：2005-10-31
申请人： Beijing Wonner Biotech Ltd. Co. , ZHANG, Zuoguang , CHI, Yuh-Fen
发明人： Zhang, Zuoguang
IPC分类号： A61K36/725 , A61K36/484 , A61K36/258 , A61P25/24
CPC分类号： A61K31/704 , A61K31/7076 , A61K36/258 , A61K36/484 , A61K36/725 , A61K38/51 , A61K2300/00
摘要： A pharmaceutical composition for treating a depression, comprising:
a ginseng water extract or a ginseng ethanol extract extracted from 3 ∼ 10 parts by weight of a ginseng; and 0.2 ∼ 0.8 part by weight of a glycyrrhizic acid or a glycyrrhetic acid.
摘要翻译：用于治疗抑郁症，其包括药物组合物：a人参水提取物或从3¼10重量份的人参提取的人参乙醇提取物; 和0.2¼0.8重量份甘草酸或甘草次酸的。

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